公开(公告)号：AU2004261545B2

公开(公告)日：2010-06-24

申请号：AU2004261545

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： DEININGER DAVID D ,  DRUMM JOSEPH ,  LIAO YUSHENG ,  WANG TIANSHENG ,  STAMOS DEAN ,  GRILLOT ANNE-LAURE ,  CHARIFSON PAUL S ,  PEROLA EMAUELE ,  LETIRAN ARNAUD ,  RONKIN STEVEN M

IPC: C07D403/14 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：DK1592686T3

公开(公告)日：2009-10-19

申请号：DK04775744

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LE TIRAN ARNAUD

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：AU2004261545A1

公开(公告)日：2005-02-10

申请号：AU2004261545

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  LETIRAN ARNAUD ,  DRUMM JOSEPH ,  CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE

IPC: A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D403/10 ,  A61K31/4184

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：PT1592686E

公开(公告)日：2009-08-25

申请号：PT04775744

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： DEININGER DAVID D ,  STAMOS DEAN ,  CHARIFSON PAUL S ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  TIRAN ARNAUD LE ,  DRUMM JOSEPH

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

公开(公告)号：DE602004021904D1

公开(公告)日：2009-08-20

申请号：DE602004021904

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  LE TIRAN ARNAUD ,  DRUMM JOSEPH

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：AT435859T

公开(公告)日：2009-07-15

申请号：AT04775744

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DEININGER DAVID ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN ,  STAMOS DEAN ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  LE TIRAN ARNAUD ,  DRUMM JOSEPH

IPC: C07D403/14 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：HK1087699A1

公开(公告)日：2006-10-20

申请号：HK06107863

申请日：2006-07-14

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  YUSHENG LIAO ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE ,  TIANSHENG WANG ,  LETIRAN ARNAUD ,  DRUMM JOSEPH

IPC: A61K20090101 ,  A61P20090101 ,  A61P31/04 ,  C07D20090101 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：SI1592686T1

公开(公告)日：2009-12-31

申请号：SI200431228

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  LE TIRAN ARNAUD ,  DRUMM JOSEPH

IPC: C07D403/00 ,  A61K31/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/00 ,  C07D405/04 ,  C07D405/14 ,  C07D413/00 ,  C07D413/14 ,  C07D417/00 ,  C07D417/14 ,  C07D471/00 ,  C07D471/04 ,  C07D487/00 ,  C07D487/04 ,  C07D491/00 ,  C07D491/04

公开(公告)号：NZ541885A

公开(公告)日：2009-01-31

申请号：NZ54188504

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  LETIRAN ARNAUD ,  DRUMM JOSEPH

IPC: A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D403/10 ,  A61K31/4184

Abstract: Disclosed is a compound of formula I or a pharmaceutically acceptable salt thereof, wherein the substituents are disclosed within the specification. Also disclosed is the use of a composition comprising of the above compound and a pharmaceutically acceptable carrier, adjuvant or vehicle in the production of a composition for inhibiting gyrase activity, inhibiting TopoIV activity, or decreasing bacterial quantity in a biological sample or in a patient.

公开(公告)号：CA2513463A1

公开(公告)日：2005-02-10

申请号：CA2513463

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  DEININGER DAVID D ,  LETIRAN ARNAUD ,  CHARIFSON PAUL S ,  WANG TIANSHENG ,  LIAO YUSHENG ,  PEROLA EMAUELE ,  RONKIN STEVEN M ,  STAMOS DEAN

IPC: A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D403/10 ,  A61K31/4184

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.