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公开(公告)号：HRP20090491T1
公开(公告)日：2009-11-30
申请号：HRP20090491
申请日：2009-09-15
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , DEININGER DAVID D , GRILLOT ANNE-LAURE , LIAO YUSHENG , RONKIN STEVEN M , STAMOS DEAN , PEROLA EMANUELE , WANG TIANSHENG , TIRAN ARNAUD LE , DRUMM JOSEPH
IPC: C07D491/04 , A61K31/4184 , A61K31/4439 , A61K31/506 , A61P31/00 , A61P31/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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公开(公告)号：NO20081467A
公开(公告)日：2008-05-15
申请号：NO20081467
申请日：2008-03-25
Applicant: VERTEX PHARMA
Inventor： PEROLA EMANUELE , COTTRELL KEVIN M , MAXWELL JOHN , TANG QING , GRILLOT ANNE-LAURE , TIRAN ARNAUD LE
IPC: C07D498/10 , C07K5/08
CPC classification number: C07D498/10 , A61K38/00 , C07D498/20 , C07D519/00 , C07K5/06026 , C07K5/06191 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0827
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公开(公告)号：AU2009236380A1
公开(公告)日：2009-10-22
申请号：AU2009236380
申请日：2009-04-14
Applicant: VERTEX PHARMA
Inventor： TIRAN ARNAUD LE , LEDOBOER MARK , WANG TIANSHANG , MESSERSMITH DAVID , COTTRELL KEVIN , ARONOV ALEXANDER , MARONE VALERIE , MALTAIS FRANCOIS , CORNEBISE MARK , COME JON H , BOTELA GABRIEL MARTINEZ
IPC: C07D417/04 , A61K31/428 , A61K31/4365 , A61P37/00 , C07D513/04
Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：PT1592686E
公开(公告)日：2009-08-25
申请号：PT04775744
申请日：2004-01-29
Applicant: VERTEX PHARMA
Inventor： DEININGER DAVID D , STAMOS DEAN , CHARIFSON PAUL S , GRILLOT ANNE-LAURE , LIAO YUSHENG , RONKIN STEVEN M , PEROLA EMAUELE , WANG TIANSHENG , TIRAN ARNAUD LE , DRUMM JOSEPH
IPC: C07D403/14 , A61K31/4184 , A61P31/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
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5.发明专利
公开(公告)号：AU2008335409A1
公开(公告)日：2009-06-18
申请号：AU2008335409
申请日：2008-12-05
Applicant: VERTEX PHARMA
Inventor： ALARGOVA ROSSITZA , KADIYALA IRINA , TIRAN ARNAUD LE , ZHANG YUEGANG
IPC: C07D401/14 , A61K31/4184 , A61P31/00 , C07D403/14
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Patent Agency Ranking
公开(公告)号：AU2008219689A1
公开(公告)日：2008-09-04
申请号：AU2008219689
申请日：2008-02-27
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN , COTTRELL KEVIN M , TIRAN ARNAUD LE , GRILLOT ANNE-LAURE , PEROLA EMANUELE , TANG QING
IPC: C07D498/10 , A61K31/24 , A61P31/12
Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
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公开(公告)号：MX339455B
公开(公告)日：2016-05-27
申请号：MX2013008162
申请日：2012-01-13
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANNE-LAURE , PEROLA EMANUELE , CHARIFSON PAUL S , TIRAN ARNAUD LE , BENNANI YOUSSEF LAAFIRET , O'DOWD HARDWIN
IPC: C07D405/14 , A61K31/506 , A61P31/04 , C07F9/6558
Abstract: La presente invención se refiere a un compuesto de la fórmula (I) o una sal farmacéuticamente aceptable del mismo en donde X y R son como se definen en este documento. Los compuestos de la fórmula (I) son útiles como inhibidores de girasa y/o topoisomerasa IV para tratar infecciones bacterianas. Los compuestos de la fórmula (I) poseen ya sea un amplio intervalo de actividad anti-bacteriana y propiedades toxicológicas ventajosas o son profármacos de compuestos que tienen la actividad.
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公开(公告)号：MX2011008645A
公开(公告)日：2011-09-30
申请号：MX2011008645
申请日：2010-02-16
Applicant: VERTEX PHARMA
Inventor： DAVIES ROBERT , LEDEBOER MARK , LIAO YUSHENG , XU JINWANG , LEDFORD BRIAN , MESSERSMITH DAVID , TIRAN ARNAUD LE , WANG TIANSHENG , COTTRELL KEVIN , ARONOV ALEX , BANDARAGE UPUL KEERTHI , KRUEGER ELAINE
IPC: C07D513/04 , A61K31/4365 , A61P25/00
Abstract: La presente invención se refiere a los compuestos (I) útiles como inhibidores de PI3K, particularmente de PI3KY. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos y métodos para el uso de las composiciones en el tratamiento de diversas enfermedades, afecciones o trastornos.
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9.发明专利
公开(公告)号：MX2009009174A
公开(公告)日：2009-09-07
申请号：MX2009009174
申请日：2008-02-27
Applicant: VERTEX PHARMA
Inventor： TANG QING , GRILLOT ANNE-LAURE , PEROLA EMANUELE , COTTRELL KEVIN M , MAXWELL JOHN , TIRAN ARNAUD LE
IPC: C07D498/10 , A61K31/24 , A61P31/12
Abstract: La presente invención se refiere a compuestos de la fórmula (I): o una sal farmacéuticamente aceptable del mismo. Estos compuestos inhiben serina-proteasas, particularmente la proteasa NS3-NS4A del virus de hepatitis C.
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公开(公告)号：AU2004322641A1
公开(公告)日：2006-03-02
申请号：AU2004322641
申请日：2004-10-21
Applicant: VERTEX PHARMA
Inventor： PEROLA EMANUELE , DEININGER DAVID D , TIRAN ARNAUD LE , GRILLOT ANNE-LAURE , RONKIN STEVEN M , WANG TIANSHENG , STAMOS DEAN , CHARIFSON PAUL S , LIAO YUSHENG , DRUMM JOSEPH
IPC: C07D491/04 , A61K31/4184 , A61K31/4439 , A61K31/506 , A61P31/00 , A61P31/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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