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公开(公告)号：PT2941432T
公开(公告)日：2018-06-01
申请号：PT13811716
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： NADIA AHMAD , DEAN BOYALL , JEAN-DAMIEN CHARRIER , CHRIS DAVIS , REBECCA DAVIS , STEVEN DURRANT , JARDI GORKA ETXEBARRIA I , DAMIEN FRAYSSE , JUAN-MIGUEL JIMENEZ , DAVID KAY , RONALD KNEGTEL , DONALD MIDDLETON , MICHAEL ODONNELL , MANINDER PANESAR , FRANCOISE PIERARD , JOANNE PINDER , DAVID SHAW , PIERRE-HENRI STORCK , JOHN STUDLEY , HEATHER TWIN
IPC: C07D487/04 , A61K31/495 , A61P35/00
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公开(公告)号：ZA201503871B
公开(公告)日：2016-11-30
申请号：ZA201503871
申请日：2015-05-29
Applicant: VERTEX PHARMA
Inventor： HEATHER TWIN , JOHN STUDLEY , PIERRE-HENRI STORCK , DAVID SHAW , JOANNE PINDER , FRANCOISE PIERARD , MANINDER PANESAR , MICHAEL ODONNELL , DONALD MIDDLETON , RONALD KNEGTEL , DAVID KAY , JUAN-MIGUEL JIMENEZ , DAMIEN FRAYSSE , GORKA ETXEBARRIA I JARDI , STEVEN DURRANT , REBECCA DAVIS , CHRIS DAVIS , JEAN-DAMIEN CHARRIER , DEAN BOYALL , NADIA AHMAD
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
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公开(公告)号：AU2005219861B2
公开(公告)日：2011-08-11
申请号：AU2005219861
申请日：2005-02-28
Applicant: VERTEX PHARMA
Inventor： STUDLEY JOHN R , MICHAEL MORTIMORE , JEAN-DAMIEN CHARRIER , ALISTAIR RUTHERFORD , ADAM LOOKER , MICHAEL O'DONNELL , MARTIN TRUDEAU , SHARN RAMAYA , STEVEN DURRANT
IPC: C07D207/16 , A61K38/04 , A61K38/06 , C07D209/52 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/04
Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.
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公开(公告)号：AU2009327357A1
公开(公告)日：2011-07-28
申请号：AU2009327357
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： JEAN-DAMIEN CHARRIER , STEVEN DURRANT , DAVID KAY , RONALD KNEGTEL , SOMHAIRLE MACCORMICK , MICHAEL MORTIMORE , MICHAEL O'DONNELL , JOANNE PINDER , ALISTAIR RUTHERFORD , NIZARALI VIRANI ANISA , STEPHEN YOUNG , MICHAEL REAPER PHILIP
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I):wherein the variables are as defined herein.
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公开(公告)号：PT2376485T
公开(公告)日：2018-03-12
申请号：PT09798991
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： MICHAEL MORTIMORE , JEAN-DAMIEN CHARRIER , STEVEN DURRANT , DAVID KAY , RONALD KNEGTEL , SOMHAIRLE MACCORMICK , MICHAEL O'DONNELL , JOANNE PINDER , ALISTAIR RUTHERFORD , ANISA NIZARALI VIRANI , STEPHEN YOUNG , PHILIP MICHAEL REAPER
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
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Patent Agency Ranking
公开(公告)号：ZA200704971B
公开(公告)日：2008-09-25
申请号：ZA200704971
申请日：2005-12-15
Applicant: VERTEX PHARMA
Inventor： JEAN-DAMIEN CHARRIER , STEVEN DURRANT , SHARN RAMAYA , JUAN-MIGUEL JIMENEZ , ALISTAIR RUTHERFORD
IPC: A61K20090101 , A61P20090101 , C07D20090101
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公开(公告)号：UY28333A1
公开(公告)日：2004-12-31
申请号：UY28333
申请日：2004-05-27
Applicant: VERTEX PHARMA
Inventor： GUY BRENCHLEY , JEAN-DAMIEN CHARRIER , STEVEN DURRANT , RONALD KNEGTEL , MICHAEL MORTIMORE , STUDLEY JOHN R
IPC: C07D213/75 , C07D213/82 , C07D405/12 , C07D417/12 , C07D213/00
Abstract: La presente invención provee un compuesto de la fórmula I: donde R1, R2, R3, R4, y R5 son como definimos aquí anteriormente. La presente invención además provee composiciones farmacéuticas y métodos para utilizar dichas composiciones para el tratamiento de enfermedades mediadas por la caspasa y los procesos para preparar los compuestos de la invención.
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公开(公告)号：BR112020015328A2
公开(公告)日：2020-12-08
申请号：BR112020015328
申请日：2019-01-28
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： ALISTAIR RUTHERFORD , ANDREW BAYLY , DAMIEN FRAYSSE , FILIPPOS PORICHIS , GORKA ETXEBARRIA I JARDI , HEATHER CLARE TWIN , IGOR MOCHALKIN , JAMES DODD , JEAN-DAMIEN CHARRIER , KIRI NORTH , MATTHEW BLEICH , MEREDITH SUZANNE ENO , MICHAEL MORTIMORE , PIERRE-HENRI STORCK , ROBERT PULLIN , RONALD KNEGTEL , SHAZIA KELLY , SIMON EVERITT , STEVEN DURRANT , YUFANG XIAO
IPC: A61K31/495 , A61K31/505 , A61K31/519 , C07D487/00 , C07D487/02 , C07D487/04
Abstract: a presente invenção refere-se a compostos, composições dos mesmos e métodos de uso dos mesmos.
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公开(公告)号：BRPI0924084A2
公开(公告)日：2020-11-10
申请号：BRPI0924084
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： ALISTAIR RUTHERFORD , ANISA NIZARALI VIRANI , DAVID KAY , JEAN-DAMIEN CHARRIER , JOANNE PINDER , MICHAEL MORTIMORE , MICHAEL O'DONNELL , PHILIP MICHAEL REAPER , RONALD KNEGTEL , SOMHAIRLE MACCORMICK , STEPHEN YOUNG , STEVEN DURRANT
IPC: C07D401/14 , A61K31/497 , A61P35/00 , C07D403/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: derivados de pirazina úteis como inibidores de atr quinase, seu uso, composição farmacêutica que os compreende e método de inibir atr em uma amostra biológica. a presente invenção refere-se a compostos de pirazina úteis como inibidores de proteína atr quinase. a invenção também se refere a composições farmaceuticamente aceitáveis compreendendo os compostos desta invenção; métodos de tratamento de várias doenças, distúrbios, e condições usando os compostos desta invenção; processos para a preparação os compostos desta invenção; intermediários para a preparação dos compostos desta invenção; e métodos de uso dos compostos em aplicações in vitro, tal como o estudo de quinases em fenômenos biológicos e patológicos; o estudo de trilhas de transdução de sinal intracelular mediadas por tais quinases; e a avaliação comparativa de novos inibidores de quinase. os compostos desta invenção têm a fórmula (i), (i) em que as variáveis são como definidas aqui.
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公开(公告)号：BR112015012454A8
公开(公告)日：2019-10-01
申请号：BR112015012454
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： CHRIS DAVIS , DAMIEN FRAYSSE , DAVID KAY , DAVID SHAW , DEAN BOYALL , DONALD MIDDLETON , FRANCOISE PIERARD , GORKA ETXEBARRIA I JARDI , HEATHER TWIN , JEAN-DAMIEN CHARRIER , JOANNE PINDER , JOHN STUDLEY , JUAN-MIGUEL JIMENEZ , MANINDER PANESAR , MICHAEL ODONNELL , NADIA AHMAD , PIERRE-HENRI STORCK , REBECCA DAVIS , RONALD KNEGTEL , STEVEN DURRANT
IPC: A61K31/495 , A61P35/00 , C07D487/04
Abstract: abstract [0001] the present invention relates to compounds useful as inhibitors of atr protein kinase. the invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. [0002] the compounds of this invention have formula i: i or a pharmaceutically acceptable salt, wherein the variables are as devined herein. [0003] moreover, the compounds of this invention have formula i-a: i-a or a pharmaceutically acceptable salt, wherein the variables are as defined herein. tradução do resumo resumo: patente de invenção para "compostos úteis como inibidores de atr cinase". a presente invenção refere-se aos compostos úteis como inibidores de atr proteína cinase. a invenção da mesma forma refere-se a composições farmaceuticamente aceitáveis compreendendo os compostos desta invenção; métodos de tratamento de várias doenças, distúrbios, e condições usando os compostos desta invenção; processos para preparar os compostos desta invenção; intermediários para a preparação dos compostos desta invenção; e métodos de usar os compostos em aplicações in vitro, tal como o estudo de cinases em fenômenos biológicos e patológicos; o estudo de séries de reação de transdução de sinal intracelulares mediadas por tais cinases; e a avaliação comparativa de novos inibidores de cinase. os compostos desta invenção têm a fórmula (i) ou a sal farmaceuticamente aceitável, em que as variáveis são como definidas aqui. além disso, os compostos desta invenção têm a fórmula (i-a) ou um sal farmaceuticamente aceitável, em que as variáveis são como definidas aqui. 2/3
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