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公开(公告)号：US20240355606A1
公开(公告)日：2024-10-24
申请号：US18758956
申请日：2024-06-28
Applicant: Micromass UK Limited
Inventor： Kevin Giles , David J. Langridge , Jason Lee Wildgoose
IPC: H01J49/06 , G01N27/622 , G01N27/623 , H01J49/00 , H01J49/42 , H01J49/40
CPC classification number: H01J49/062 , G01N27/622 , G01N27/623 , H01J49/0031 , H01J49/061 , H01J49/422 , H01J49/408
Abstract: A method of introducing and ejecting ions from an ion entry/exit device 4 is disclosed. The ion entry/exit device 4 has at least two arrays of electrodes 20,22. The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays 20,22 in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays 20,22 in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.
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公开(公告)号：US12051583B2
公开(公告)日：2024-07-30
申请号：US18053916
申请日：2022-11-09
Applicant: Micromass UK Limited
Inventor： Kevin Giles , David J. Langridge , Jason Lee Wildgoose
IPC: H01J49/06 , G01N27/622 , G01N27/623 , H01J49/00 , H01J49/42 , H01J49/40
CPC classification number: H01J49/062 , G01N27/622 , G01N27/623 , H01J49/0031 , H01J49/061 , H01J49/422 , H01J49/408
Abstract: A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.
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公开(公告)号：US11942318B2
公开(公告)日：2024-03-26
申请号：US16919460
申请日：2020-07-02
Applicant: SHIMADZU CORPORATION
Inventor： Vyacheslav Shchepunov
CPC classification number: H01J49/4245 , H01J49/061 , H01J49/062 , H01J49/401 , H01J49/403 , H01J49/408
Abstract: A mass analyser for use in a mass spectrometer, the mass analyser having: a set of sector electrodes spatially arranged to provide an electrostatic field in a 2D reference plane suitable for guiding ions along an orbit in the 2D reference plane, wherein the set of sector electrodes extend along a drift path that is locally orthogonal to the reference plane so that, in use, the set of sector electrodes provide a 3D electrostatic field region; and an injection interface configured to inject ions into the mass analyser via an injection opening such that the ions injected into the mass analyser are guided by the 3D electrostatic field region along a 3D reference trajectory according to which ions perform multiple turns within the mass analyser whilst drifting along the drift path, wherein each turn corresponds to a completed orbit in the 2D reference plane. The injection interface includes at least one injection deflector located within the mass analyser, the at least one injection deflector being configured to deflect ions injected into the mass analyser in the direction of the drift path, wherein the injection interface is preferably configured so that ions guided along the 3D reference trajectory are, after injection into the mass analyser, kept adequately distant from the injection opening such that they are substantially unaffected by electric field distortions around the injection opening.
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公开(公告)号：US20240079226A1
公开(公告)日：2024-03-07
申请号：US18268649
申请日：2021-12-21
Inventor： Ankur Chaudhuri , Liqian Li , James Johnston , Martin-Lee Cusick
CPC classification number: H01J49/408 , H01J49/0022 , H01J49/164 , H01J49/24
Abstract: An apparatus for and a method of analyzing a sample. A laser section may include a laser arranged to direct a laser beam in a first direction towards the sample. The laser beam ablating and ionizing at least a portion of the sample to generate ions. An ion source section may include a sample holder for holding the sample. At least one component is arranged to apply an electric field for extracting at least a portion of the ions to form an ion beam traveling in a second direction. A time-of-flight section may include a detector arranged to receive the ion beam.
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公开(公告)号：US20230170203A1
公开(公告)日：2023-06-01
申请号：US18053916
申请日：2022-11-09
Applicant: Micromass UK Limited
Inventor： Kevin Giles , David J. Langridge , Jason Lee Wildgoose
IPC: H01J49/06 , H01J49/42 , G01N27/623 , G01N27/622 , H01J49/00
CPC classification number: H01J49/062 , H01J49/422 , G01N27/623 , G01N27/622 , H01J49/061 , H01J49/0031 , H01J49/408
Abstract: A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.
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Patent Agency Ranking
公开(公告)号：US20190189418A1
公开(公告)日：2019-06-20
申请号：US16226003
申请日：2018-12-19
Applicant: SHIMADZU CORPORATION
Inventor： Hiroyuki MIURA , Hideaki IZUMI , Kiyoshi OGAWA
CPC classification number: H01J49/408 , H01J49/022 , H01J49/025
Abstract: A microchannel plate (MCP) 41 in an ion detection section 4 multiplies electrons. An anode 42 detects those electrons and produces a current signal. An amplifier 44 converts this signal into a voltage signal. A low-pass filter 5A acting as a smoothing section 5 is located at the output end of the amplifier 44. A waveform-shaping time adjuster 6 adjusts the time constant of the low-pass filter 5A beforehand according to the response time of the MCP 41, mass-to-charge ratio of an ion species to be subjected to the measurement, and duration of the spread of the ion species which depends on device-specific parameters. A plurality of peaks which sequentially appear in the detection signal corresponding to one ion species are thereby smoothed into a single broad peak. Thus, the distinguishability between signal waves and noise components is improved.
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公开(公告)号：US09881782B2
公开(公告)日：2018-01-30
申请号：US15125396
申请日：2015-03-10
Applicant: Micromass UK Limited
Inventor： Jason Lee Wildgoose
CPC classification number: H01J49/427 , G01N27/622 , H01J49/062 , H01J49/408
Abstract: A method of separating ions according to a physicochemical property is disclosed. The method comprises causing ions to perform a plurality of cycles along or around an ion guiding path such that the ions separate according to said physicochemical property. The ions are ejected from an ion exit region by applying a force to the ions such that only having a physicochemical property value that is either above or below a threshold value are ejected as they pass through the exit region, but ions having a physicochemical property value either below or above said threshold value, respectively, remain within the ion guiding path. The force applied to the ions within the exit region is varied with time such that the physicochemical property value of the ions ejected from the ion guiding region varies with time.
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公开(公告)号：US20170278689A1
公开(公告)日：2017-09-28
申请号：US15618959
申请日：2017-06-09
Applicant: SHIMADZU CORPORATION
Inventor： Li DING , Mikhail SUDAKOV , Sumio KUMASHIRO
CPC classification number: H01J49/027 , H01J49/0031 , H01J49/061 , H01J49/406 , H01J49/408 , H01J49/4245
Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.
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公开(公告)号：US09330896B2
公开(公告)日：2016-05-03
申请号：US14430788
申请日：2013-09-24
Applicant: Yoshinori Sano
Inventor： Yoshinori Sano
CPC classification number: H01J49/401 , G01N27/62 , H01J49/0086 , H01J49/061 , H01J49/067 , H01J49/408 , H01J49/421
Abstract: An object of the present invention is to provide a mass spectrometer and a mass separator whose design and performance are less restricted by problems arising from the principle of operation, and which have in principle no limitation on the mass-to-charge ratio range to be able to deal with and are each capable of repeatedly analyzing or extracting plural ionic species of different mass-to-charge ratios in a short time.A mass spectrometer (10) is configured from an ion source (1), an ion introduction unit (2), a mass analyzer (3), an ion detection unit (4), and the like. Crude ions are introduced into a separation space (5) at a predetermined acceleration voltage as a pulse synchronized with the phase of a one-dimensional high-frequency electric field. In the separation space (5), each ion travels in an incident direction by inertia, and besides they are displaced by force received from the one-dimensional high-frequency electric field which acts in the y-direction crossing the incident direction. Ionic species having different mass-to-charge ratios with each other are separated by the difference in displacement magnitude. At this time, the acceleration voltage and the period of the one-dimensional high-frequency electric field are set in order that the measured ionic species may exit from the separation space (5) having received the action of the electric field for one period.
Abstract translation: 本发明的目的是提供一种质谱仪和质量分离器，其设计和性能较少受到操作原理引起的问题的限制，并且原则上不限于质荷比范围为 能够处理并且能够在短时间内反复分析或提取不同质荷比的多种离子种类。 质谱仪（10）由离子源（1），离子引入单元（2），质量分析器（3），离子检测单元（4）等构成。 将粗离子作为与一维高频电场的相位同步的脉冲以预定的加速电压被引入到分离空间（5）中。 在分离空间（5）中，每个离子通过惯性在入射方向上行进，并且除了通过沿与入射方向交叉的y方向作用的一维高频电场接收的力的位移外， 具有彼此具有不同质荷比的离子物质由位移大小的差异分开。 此时，设定加速电压和一维高频电场的周期，使得测量的离子物质可以从已经接收到电场作用的分离空间（5）退出一个周期。
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公开(公告)号：US08598516B2
公开(公告)日：2013-12-03
申请号：US13737018
申请日：2013-01-09
IPC: B01D59/44
CPC classification number: H01J49/405 , G01N30/72 , H01J49/406 , H01J49/408
Abstract: The present invention relates to the analytical electronics used to identify compositions and structures of substances, in particular, to the analyzers comprising at least one mass-spectrometer (MS) and may be applied in such fields as medicine, biology, gas and oil industry, metallurgy, energy, geochemistry, hydrology, ecology.Technical result provides the increase in MS resolution, gain in sensitivity, precision and measurement rates of substances compositions and structures concurrently with enhancement of analyzer functional capabilities, downsizing and mass reduction.In claimed invention the ion flux generation and its guiding are performed in off-axis single-flow mode; parallel multi-stage mode; through use of three-dimensional field with mean meridian surface including without limitation three-dimensional reflecting and dual-zoned reflecting modes or by method of multi-reflection arrays.Devices to implement the claimed method are embodied.Proposed schematic ion optical diagrams allow developing different MS types notable for their minimized material intensity and geometrical dimensions.
Abstract translation: 本发明涉及用于识别物质的组成和结构的分析电子装置，特别是包括至少一种质谱仪（MS）的分析仪，并且可以应用于医药，生物学，燃气和石油工业等领域， 冶金，能源，地球化学，水文学，生态学。 技术结果同时提高了分析仪的功能能力，缩小尺寸和减少质量，同时提高了MS分辨率，灵敏度增益，精度和测量速度。 在要求保护的发明中，离子通量产生及其引导在离轴单流模式下进行; 并行多级模式; 通过使用具有平均子午线表面的三维场，包括但不限于三维反射和双分区反射模式，或通过多反射阵列的方法。 具体实现所要求保护的方法的装置。 提出的示意图光学图表允许开发不同于其最小化材料强度和几何尺寸的不同MS类型。
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