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公开(公告)号：US20210214412A1
公开(公告)日：2021-07-15
申请号：US17040973
申请日：2019-04-15
Applicant: University of Utah Research Foundation
Inventor： Danny Hung-Chieh Chou
Abstract: The present disclosure is concerned with insulin-based peptides, methods of making the peptides, and methods of treating diabetes using these peptides. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20210189432A1
公开(公告)日：2021-06-24
申请号：US16610408
申请日：2018-05-10
Applicant: University of Utah Research Foundation
Inventor： Jason D. Shepherd , Cameron Day , Elissa Pastuzyn
IPC: C12N15/88 , C12N7/00 , C12N15/113 , C07K14/005
Abstract: Disclosed are recombinant Arc capsids. Disclosed are vectors comprising a nucleic acid sequence capable of encoding an Arc protein. Disclosed are cells comprising vectors comprising a nucleic acid sequence capable of encoding an Arc protein. Disclosed are methods of delivering mRNA to a cell comprising administering an Arc capsid to a cell, wherein the Arc capsid comprises an mRNA of interest. Disclosed are methods of delivering mRNA to a cell comprising administering any one of the disclosed vectors to a cell; and administering a mRNA of interest to the cell; wherein the nucleic acid sequence encodes an Arc protein within the cell and Arc capsids are formed, wherein the Arc capsids encapsulate the mRNA of interest. Disclosed are methods of forming Arc capsids comprising administering a vector comprising a nucleic acid sequence capable of encoding an Arc protein to a solution comprising cells, wherein the nucleic acid sequence encodes an Arc protein within the cells and Arc capsids are formed.
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公开(公告)号：US20210177986A1
公开(公告)日：2021-06-17
申请号：US17151898
申请日：2021-01-19
Applicant: University of Utah Research Foundation
Inventor： Youngwook Won , David A. Bull , Kwangsuk Lim
IPC: A61K47/68 , C07K16/32 , A61K9/00 , A61K31/27 , A61K31/337
Abstract: Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains that captures the therapeutic agent without the formation of a chemical bond, and one or more therapeutic agents physiologically acceptable compositions including them; and methods of administering the bi-functional allosteric protein-drug molecule to patients for the treatment of cancer.
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公开(公告)号：US20210175439A1
公开(公告)日：2021-06-10
申请号：US17109668
申请日：2020-12-02
Applicant: Alliance for Sustainable Energy, LLC , University of Utah Research Foundation , Duke University
Inventor： Matthew C. BEARD , Haipeng LU , Annalise Elizabeth MAUGHAN , Joseph Jonathan BERRY , Zeev Valentine VARDENY , Chuanxiao XIAO , Volker Wolfgang BLUM , David Brian MITZI
Abstract: The present disclosure relates to a composition that includes a perovskite of A2BX4, where A includes an R-form of a chiral molecule of at least one of and/or an S-form of the chiral molecule, B includes a cation, X includes an anion, R1 includes a first carbon chain having between 2 and 5 carbon atoms, R2 includes at least one of a hydrogen atom, a halogen atom, a carboxylic acid group, an alkoxy group, and/or a second carbon chain, and R3 includes a third carbon chain.
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公开(公告)号：US20210172855A1
公开(公告)日：2021-06-10
申请号：US17106031
申请日：2020-11-27
Applicant: University of Utah Research Foundation
Inventor： Tim Garrett , Dhiraj Kumar Singh , Karlie Rees , Eric Pardyjak
Abstract: A differential emissivity imaging device for measuring evaporable particle properties can include a heated plate, a thermal camera, a memory device, and an output interface. The heated plate can have an upper surface oriented to receive falling evaporable particles. The evaporable particles have a particle emissivity and the upper surface has a plate surface emissivity. The thermal camera can be oriented to produce a thermal image of the upper surface. A memory device can include instructions that cause the imaging device to calculate a mass of the individual evaporable particle via heat conduction using a calculated surface area and an evaporation time.
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Patent Agency Ranking
公开(公告)号：US20210162290A1
公开(公告)日：2021-06-03
申请号：US17045074
申请日：2019-04-10
Applicant: University of Utah Research Foundation
Inventor： Doug Benson , John Erdmann
Abstract: A portable rehabilitation assembly (100) for pre-gait rehabilitation comprises first and second lower support bars (102a, 102b) coupled together by an adjustable cross-member (104). A first pair of vertical frame members (108a) can be coupled to the first lower support bar (102a), and a second pair of vertical frame members (108b) can be coupled to the second lower support bar (102b). First and second hand rails (110a, 110b) can be coupled to respective vertical frame members (108a, 108b) to form an unobstructed walkway (W) from the front region (106a) to a back region (106b). First and second pairs of wheels (112a-d) can be coupled to respective lower support bars (102a, 102b). At least one actuation mechanism (114a, 114b) operates to move the assembly (100) from a stationary rehabilitation position to a portable position by causing the wheels (H2a-d) to lift the lower support bars (102a, 102b) from the ground surface for transport.
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公开(公告)号：US11009482B1
公开(公告)日：2021-05-18
申请号：US17080517
申请日：2020-10-26
Applicant: University of Utah Research Foundation
Inventor： Massood Tabib-Azar
IPC: G01N27/414 , G01N33/543 , G01N33/569
Abstract: A field effect transistor (FET) biosensor for virus detection of a selected virus within a sample volume is disclosed. The FET comprises a semiconductor substrate, a source and drain electrode on the substrate, the electrodes spaced to form a channel. A gate electrode carried on the substrate and located in the channel between the source and drain electrodes. An insulating layer is coupled to a top surface of the gate electrode and a bottom surface of the source and drain electrodes, with an open channel above the insulating layer. A channel material is coupled to the insulating layer. Aptamers are oriented within the open channel to bind to the channel material and with the selected virus to enable a detection of the selected virus by the FET biosensor based on a change in drain-source current at a selected gate voltage.
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公开(公告)号：US11009341B2
公开(公告)日：2021-05-18
申请号：US16526851
申请日：2019-07-30
Applicant: University of Utah Research Foundation
Inventor： Clayton C. Williams
Abstract: Devices, systems, and methods for determining a distance between at least two points are disclosed and described, wherein interferometry technology is utilized to determine such distances.
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公开(公告)号：US20210077631A1
公开(公告)日：2021-03-18
申请号：US17107107
申请日：2020-11-30
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Young-Wook WON , David A. BULL , Amit N. PATEL
Abstract: Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.
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公开(公告)号：US20200376250A1
公开(公告)日：2020-12-03
申请号：US16994575
申请日：2020-08-15
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Dustin Williams , Nicholas Ashton
Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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