公开(公告)号：US20130271760A1

公开(公告)日：2013-10-17

申请号：US13995094

申请日：2011-12-20

Applicant: Emmanuel Froigneux ,  Philippe De Bettignies

Inventor： Emmanuel Froigneux ,  Philippe De Bettignies

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0248 ,  G01J3/10 ,  G01N21/65

Abstract: The present invention relates to a method and optical device for Raman spectroscopy and for observing a sample, said device including an optical means for superimposing an excitation laser beam having a spectral band B0 and an observation beam having a spectral band BV so as to form a combined excitation and observation incident beam, and an optical separation means arranged in the path of a collected beam coming from scattering on the sample and including a first filtering means, a second filtering means capable of spatially separating said collected beam into a first secondary beam and two tertiary beams, each of which includes a spectral band selected from the spectral band B0 of the laser, the spectral band BV of the observation beam, and the spectral band BR of the Raman scattering beam, respectively.

Abstract translation: 本发明涉及拉曼光谱法和用于观察样品的方法和光学装置，所述装置包括用于叠加具有光谱带B0的激发激光束和具有光谱带BV的观察光束的光学装置，以形成 组合激励和观察入射光束，以及光学分离装置，布置在来自散射在样本上的收集光束的路径中，并且包括第一滤光装置，第二滤光装置，其能够将所述收集的光束空间分离成第一次光束， 两个三级光束分别包括从激光的光谱带B0选择的光谱带，观察光束的光谱带BV和拉曼散射光束的光谱带BR。

公开(公告)号：US08382812B2

公开(公告)日：2013-02-26

申请号：US12473745

申请日：2009-05-28

Applicant: Uk Kang ,  Garri. V Papayan

Inventor： Uk Kang ,  Garri. V Papayan

IPC: A61N5/06

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  A61N5/0601 ,  A61N5/062 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/12 ,  G01J3/36 ,  G01J3/4406 ,  G01N21/255 ,  G01N21/29 ,  G01N21/31 ,  G01N21/4738 ,  G01N21/6456 ,  G01N2201/0618

Abstract: The present invention provides an apparatus for photodynamic therapy and fluorescence detection, in which a combined light source is provided to illuminate an object body and a multispectral fluorescence-reflectance image is provided to reproduce various and complex spectral images for an object tissue, thus performing effective photodynamic therapy for various diseases both outside and inside of the body.For this purpose, the present invention provides an apparatus for photodynamic therapy and photodetection, which provides illumination with light of various wavelengths and multispectral images, the apparatus including: an optical imaging system producing an image of an object tissue and transmitting the image to a naked eye or an imaging device; a combined light source including a plurality of coherent and non-coherent light sources and a light guide guiding incident light emitted from the light sources; a multispectral imaging system including at least one image sensor; and a computer system outputting an image of the object tissue to the outside. Thus, the apparatus for photodynamic therapy and photodetection of the present invention can effectively perform the photodynamic therapy and photodetection by means of the combined light source capable of irradiating light having various spectral components to an object tissue and the multispectral imaging system capable of obtaining images from several spectral portions for these various spectral ranges at the same time, thus improving the accuracy of diagnosis and efficiency of the photodynamic therapy.

Abstract translation: 本发明提供了一种用于光动力学治疗和荧光检测的装置，其中提供组合光源以照射物体，并且提供多光谱荧光反射图像以再现对象组织的各种和复杂的光谱图像，从而执行有效 身体各种疾病的光动力治疗。 为此，本发明提供了一种用于光动力学治疗和光电检测的装置，其提供具有各种波长和多光谱图像的光的照明，所述装置包括：光学成像系统，其产生对象组织的图像并将图像发送到裸体 眼睛或成像装置; 包括多个相干和非相干光源的组合光源和引导从光源发射的入射光的光导; 包括至少一个图像传感器的多光谱成像系统; 以及将对象组织的图像输出到外部的计算机系统。 因此，本发明的光动力学治疗和光电检测装置可以通过能够将具有各种光谱成分的光照射到对象组织上的组合光源和能够获得图像的多光谱成像系统而有效地进行光动力学治疗和光电检测 同时对于这些不同光谱范围的几个光谱部分，从而提高光动力疗法的诊断准确性和效率。

公开(公告)号：US08320637B2

公开(公告)日：2012-11-27

申请号：US12850202

申请日：2010-08-04

Applicant: Charles W. Gardner, Jr. ,  David Exline ,  Sara Nedley

Inventor： Charles W. Gardner, Jr. ,  David Exline ,  Sara Nedley

IPC: G06K9/00 ,  G01J3/44

CPC classification number: G06K9/00442 ,  G01J3/02 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/28 ,  G01J3/32 ,  G01N21/27 ,  G01N21/4738 ,  G01N21/55 ,  G01N21/6456 ,  G01N2021/6423 ,  G01N2021/6493 ,  G06K9/4652

Abstract: The present disclosure provides for a method for analyzing treated fingerprints on a document. A sample document is provided. A digital image of the sample document is obtained. The sample document is treated with a reagent and a hyperspectral image of the document is obtained. The hyperspectral image of the document is analyzed to determine a region of interest and a hyperspectal image is obtained of the region of interest. The present disclosure also provides for a system comprising a carrier frame, an imaging station for obtaining a digital image of the sample document, a first processing station for treating the document and a second processing station for developing the treated document, a second imaging station for obtaining a hyperspectral image of at least one of the document and a region of interest of the document, and a robotic subsystem for transporting the document through the system.

Abstract translation: 本公开提供了一种用于分析文档上经处理的指纹的方法。 提供样品文件。 获得样品文件的数字图像。 样品文件用试剂处理，得到文件的高光谱图像。 分析文档的高光谱图像以确定感兴趣的区域，并且获得感兴趣区域的超光谱图像。 本公开还提供了一种系统，其包括载体框架，用于获得样本文档的数字图像的成像站，用于处理文件的第一处理站和用于开发经处理的文档的第二处理站，用于 获得文档中的至少一个文档和感兴趣区域的超光谱图像，以及用于通过系统传送文档的机器人子系统。

公开(公告)号：US20120133944A1

公开(公告)日：2012-05-31

申请号：US13285512

申请日：2011-10-31

Applicant: Masanori Iwasaki

Inventor： Masanori Iwasaki

IPC: G01N21/55

CPC classification number: G01J3/0294 ,  G01J3/0205 ,  G01J3/0248 ,  G01J3/0256 ,  G01J3/1804 ,  G02B27/108 ,  G02B27/1086

Abstract: An optical device includes: an image-forming optical system forming an image of light from a subject; an imaging unit receiving light of the image formed by the image-forming optical system; a reflection spectroscopic device covering a given area in an imaging area of the imaging unit; and a spectrum detection unit detecting a spectroscopic spectrum of light reflected by the reflection spectroscopic device.

Abstract translation: 光学装置包括：成像光学系统，形成来自被摄体的光的图像; 摄像单元，接收由图像形成光学系统形成的图像的光; 覆盖成像单元的成像区域中的给定区域的反射分光装置; 以及频谱检测单元，其检测由所述反射光谱装置反射的光的光谱。

公开(公告)号：US20120050720A1

公开(公告)日：2012-03-01

申请号：US13320014

申请日：2009-05-11

Applicant: Se Hwa Kim ,  Jae Yong Lee ,  Eun Seong Lee ,  Dae Won Moon

Inventor： Se Hwa Kim ,  Jae Yong Lee ,  Eun Seong Lee ,  Dae Won Moon

IPC: G01J3/44

CPC classification number: G02B21/002 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/653 ,  G02B21/0088 ,  G02B21/16

Abstract: Disclosed is a system for diagnosing the pathological change in lipids in blood vessels using coherent anti-strokes raman microscopy which can image lipids abnormally deposited on the deep intima of blood vessels and analyze the components of the imaged lipids, without labeling or destroying blood vessels, to diagnose minute pathological changes in the blood vessels, whereby the stage of progression of lipid-related diseases can be determined.

Abstract translation: 公开了一种用于使用相干抗冲击拉曼显微镜诊断血管中脂质的病理变化的系统，其可以将血液中的脂质异常沉积在血管的深内膜上并分析成像的脂质的成分，而不标记或破坏血管， 诊断血管的微小病理变化，由此可以确定与脂质相关的疾病进展的阶段。

公开(公告)号：US20110188714A1

公开(公告)日：2011-08-04

申请号：US12850202

申请日：2010-08-04

Applicant: Charles W. Gardner, JR. ,  David Exline ,  Sara Nedley

Inventor： Charles W. Gardner, JR. ,  David Exline ,  Sara Nedley

IPC: G06K9/00

CPC classification number: G06K9/00442 ,  G01J3/02 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/28 ,  G01J3/32 ,  G01N21/27 ,  G01N21/4738 ,  G01N21/55 ,  G01N21/6456 ,  G01N2021/6423 ,  G01N2021/6493 ,  G06K9/4652

Abstract: The present disclosure provides for a method for analyzing treated fingerprints on a document. A sample document is provided. A digital image of the sample document is obtained. The sample document is treated with a reagent and a hyperspectral image of the document is obtained. The hyperspectral image of the document is analyzed to determine a region of interest and a hyperspectal image is obtained of the region of interest. The present disclosure also provides for a system comprising a carrier frame, an imaging station for obtaining a digital image of the sample document, a first processing station for treating the document and a second processing station for developing the treated document, a second imaging station for obtaining a hyperspectral image of at least one of the document and a region of interest of the document, and a robotic subsystem for transporting the document through the system.

Abstract translation: 本公开提供了一种用于分析文档上经处理的指纹的方法。 提供样品文件。 获得样品文件的数字图像。 样品文件用试剂处理，得到文件的高光谱图像。 分析文档的高光谱图像以确定感兴趣的区域，并且获得感兴趣区域的超光谱图像。 本公开还提供了一种系统，其包括载体框架，用于获得样本文档的数字图像的成像站，用于处理文件的第一处理站和用于开发经处理的文档的第二处理站，用于 获得文档中的至少一个文档和感兴趣区域的超光谱图像，以及用于通过系统传送文档的机器人子系统。

公开(公告)号：US06459484B1

公开(公告)日：2002-10-01

申请号：US09692141

申请日：2000-10-20

Applicant: Eiji Yokoi

Inventor： Eiji Yokoi

IPC: G01N2164

CPC classification number: G01N21/6456 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0248 ,  G01J3/14 ,  G01J3/36 ,  G01J3/4406 ,  G01N2021/6441 ,  G02B21/0076 ,  G02B21/008

Abstract: A scanning optical apparatus includes a light source unit, an objective lens, a scanning device, an imaging optical system, a confocal aperture, a plurality of photodetectors, a spectrum decomposing element, and a light-deflecting microelement array. The light source unit is located at the position where illumination light from the light source unit is incident through the light-deflecting microelement array on the confocal aperture. Each of light-deflecting microelements constituting the light-deflecting microelement array has deflection angles for selectively deflecting light passing through the confocal aperture toward the plurality of photodetectors and a deflection angle for deflecting the light from the light source unit toward the confocal aperture so that each of the light-deflecting microelements is capable of selecting one of these deflection angles.

Abstract translation: 扫描光学装置包括光源单元，物镜，扫描装置，成像光学系统，共焦孔，多个光电检测器，光谱分解元件和光偏转微元件阵列。 光源单元位于通过共焦孔径上的光偏转微元件阵列入射来自光源单元的照明光的位置。 构成光偏转微元件阵列的每个光偏转微元件具有用于选择性地将通过共焦孔的光朝向多个光电检测器偏转的偏转角以及用于将来自光源单元的光偏转到共焦孔的偏转角， 的光偏转微元件能够选择这些偏转角之一。

公开(公告)号：US5301007A

公开(公告)日：1994-04-05

申请号：US607313

申请日：1990-10-31

Applicant: Juichiro Ukon

Inventor： Juichiro Ukon

IPC: G01N21/27 ,  G02B21/00 ,  G02B21/18 ,  G01J3/28 ,  G01N21/00

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/0248 ,  G01J3/0289 ,  G01J3/04 ,  G02B21/0096 ,  G02B21/18

Abstract: A microscopic spectrometer having a separate optical path for masking light from a sample for spectrometric measurements. In the preferred embodiment, a beam splitter is disposed behind an object lens to form two branched optical paths. One of the optical paths is provided with masks at a point of focus along the path, allowing part of the image to be masked. The second optical path allows optical throughput and observation of the entire image. These two optical paths are rejoined, and a final image is obtained for visual inspection by synthesizing the two optical paths.

Abstract translation: 具有用于掩蔽来自样品的光的单独光路的微观光谱仪用于光谱测量。 在优选实施例中，分束器设置在物镜后面以形成两个分支的光路。 光路中的一个在沿着路径的焦点处设置有掩模，允许图像的一部分被掩蔽。 第二光路允许光学吞吐量和整个图像的观察。 这两个光路被重新连接，并通过合成两个光路获得最终的图像用于目视检查。

公开(公告)号：US4844617A

公开(公告)日：1989-07-04

申请号：US146046

申请日：1988-01-20

Applicant: Herman F. Kelderman ,  Michael E. Fein ,  Alan E. Loh ,  Arnold Adams ,  Armand P. Neukermans

Inventor： Herman F. Kelderman ,  Michael E. Fein ,  Alan E. Loh ,  Arnold Adams ,  Armand P. Neukermans

IPC: G01B9/04 ,  G01J3/02 ,  G01J3/18 ,  G01J3/28 ,  G02B21/00

CPC classification number: G01B9/04 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0243 ,  G01J3/0248 ,  G02B21/006 ,  G01J3/18 ,  G01J3/2803

Abstract: A confocal measuring microscope including a spectrometer and autofocus system sharing common optical elements in which the intensity of light entering the spectrometer from a particular spot on a workpiece is used to determine a focus condition for the same spot. The microscope includes at least one light source, an illumination field stop, and a microscope objective that images the stop onto a workpiece supported by a movable platform. The objective also forms an image of the illuminated portion of the object. An aperture in a second stop and intersecting the image plane passes light from part of the image to the spectrometer, while viewing optics are used to view the image. In one embodiment, a detector is placed at the zero order position, while in another embodiment a laser is placed at the zero order position. In the later embodiment an integrator circuit connected to the detector array replaces the zero order detector for measuring the total intensity of light entering the spectrometer. A best focus condition occurs when the total intensity is a maximum for a positive confocal configuration, i.e. where source and detector are on opposite sides of their respective field stops from said workpiece, and a minimum for a negative confocal configuration, i.e. where the source and workpiece are on the same side of a reflective illumination field stop with aperture. The movable platform may be scanned axially to achieve and maintain object focus as the object is scanned transversely.

Abstract translation: 共焦测量显微镜包括分光光度计和自动聚焦系统，共享共同的光学元件，其中使用从工件上的特定光点进入光谱仪的光的强度来确定同一光斑的聚焦条件。 显微镜包括至少一个光源，照明场停止器和将停止点图像到由可移动平台支撑的工件上的显微镜物镜。 该目的也形成对象的被照亮部分的图像。 在第二个停止点和与图像平面相交的孔将光从图像的一部分传递到光谱仪，而观察光学元件用于观看图像。 在一个实施例中，检测器被放置在零级位置，而在另一个实施例中，激光被放置在零级位置。 在后面的实施例中，连接到检测器阵列的积分器电路取代了用于测量进入光谱仪的光的总强度的零级检测器。 当总强度为正共焦配置的最大值时，即源和检测器位于其与所述工件相应的场停止位置的相对侧上，并且对于共焦焦配置为最小，即源和 工件位于具有孔径的反射照明场停止的同一侧。 当物体被横向扫描时，可移动平台可被轴向地扫描以实现和维持物体焦点。

公开(公告)号：US12050132B2

公开(公告)日：2024-07-30

申请号：US17753463

申请日：2020-08-28

Applicant: Konica Minolta, Inc.

Inventor： Yasuhisa Kinto

IPC: G01J3/02 ,  G01J3/50

CPC classification number: G01J3/50 ,  G01J3/0248 ,  G01J3/0251

Abstract: A colorimetry device includes an integrating sphere having a measurement opening part and a trap hole, a trap disposed to be able to open and close the trap hole, a lid that is non-reflective and disposed to be able to open and close the trap hole, an imaging means disposed at a position that allows taking, through the trap hole, an image of a specimen facing the measurement opening part, and a display means that displays an image taken by the imaging means. The trap is to move to a position at which the trap hole is closed by the trap at a time of measurement of light with an SCI method, the light being reflected from the specimen, and the lid is moved to a position at which the trap hole is closed by the lid at a time of measurement of the light with an SCE method.