公开(公告)号：US4755058A

公开(公告)日：1988-07-05

申请号：US866730

申请日：1986-05-27

Applicant: Gerald H. Shaffer

Inventor： Gerald H. Shaffer

IPC: G01N21/47 ,  G01N21/86 ,  G01N21/31

CPC classification number: G01N21/8483 ,  G01N21/474 ,  G01N2021/478 ,  G01N2201/06146 ,  G01N2201/0621 ,  G01N2201/0696

Abstract: A device for making accurate, reproducible light reflectance measurements on an optically nonuniform specimen comprises means for holding the specimen in a fixed position. In one embodiment the specimen is illuminated by light sources that are arranged at acute angles relative to the specimen and (360.degree./N.+-.1.degree.) apart in azimuth, where N=the total number of light sources. The light sources are sequentially energized and deenergized to illuminate the specimen. A light detector receives light reflecting from the surface and generates an electrical signal, which is subsequently processed. In another embodiment the light sources are arranged in pairs in which the two light sources in a pair are simultaneously energized and deenergized and the pairs are sequentially energized and deenergized. A method for measuring reflected light is also provided. The device and method are useful for making biochemical assays with reagent test strips by measuring the tone of coloration of the strips after treatment with a target substance being examined.

Abstract translation: 用于在光学不均匀样品上进行准确，可再现的光反射测量的装置包括用于将样品保持在固定位置的装置。 在一个实施例中，样品被相对于试样以锐角排列并且在方位角（360°/ N +/- 1°）分开的光源照射，其中N =光源的总数。 光源依次通电并断电以照射样品。 光检测器接收从表面反射的光并产生随后处理的电信号。 在另一个实施例中，光源成对地布置，其中一对中的两个光源同时通电并断电，并且对依次通电并断电。 还提供了一种用于测量反射光的方法。 该装置和方法可用于通过用待检测的目标物质测量处理后条带的着色色调来对试剂测试条进行生化测定。

公开(公告)号：US4683579A

公开(公告)日：1987-07-28

申请号：US813978

申请日：1985-12-27

Applicant: Stephen C. Wardlaw

Inventor： Stephen C. Wardlaw

IPC: G01N15/04 ,  G01N15/05 ,  G01N21/35 ,  G01N21/59 ,  G01N15/02 ,  G01N21/00

CPC classification number: G01N33/491 ,  G01N21/5911 ,  G01N15/05 ,  G01N2015/045 ,  G01N2021/5969 ,  G01N21/35 ,  G01N21/359 ,  G01N2201/0621 ,  G01N2201/126

Abstract: Blood constituents such as red cells, white cells, and platelets are centrifuged into layers in a capillary tube and the true extent of one or more of the layers is measured photometrically. Each layer to be measured is optically scanned by a sequence of scanning operations with the actual extent of each layer traverse being recorded in a computer. After each layer has been completely circumferentially scanned and each traverse recorded, the computer determines the true average axial dimension for each layer and computes, through prior input, the actual constituent count for each constituent layer.

Abstract translation: 将血液成分如红细胞，白细胞和血小板在毛细管中离心分层，并用光度法测量一层或多层的真实程度。 通过扫描操作的顺序光学地扫描要测量的每个层，每个层横穿的实际程度被记录在计算机中。 在每个层被完全周向扫描并且每个遍历记录之后，计算机确定每个层的真实平均轴向尺寸，并且通过现有输入计算每个构成层的实际构成计数。

公开(公告)号：US10060889B2

公开(公告)日：2018-08-28

申请号：US14713328

申请日：2015-05-15

Applicant: BRIGHAM YOUNG UNIVERSITY

Inventor： Paul B. Farnsworth ,  Sonika Sharma ,  H. Dennis Tolley ,  Milton L. Lee

IPC: G01N30/74 ,  G01N21/05 ,  G01N21/33 ,  G01N21/03

CPC classification number: G01N30/74 ,  G01N21/05 ,  G01N21/33 ,  G01N2021/0346 ,  G01N2201/0221 ,  G01N2201/0621 ,  G01N2201/0693

Abstract: A system and method for performing UV LED-based absorption detection for capillary liquid chromatography for detecting and quantifying compounds in a liquid, wherein a simplified system eliminates the need for a beam splitter and a reference cell by using a stable UV source, and power requirements are reduced, resulting in a portable and substantially smaller system with relatively low detection limits.

公开(公告)号：US20180236448A1

公开(公告)日：2018-08-23

申请号：US15957023

申请日：2018-04-19

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller

IPC: B01L3/00 ,  G01N33/543 ,  G01N33/574 ,  G01N21/59

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

公开(公告)号：US20180188021A1

公开(公告)日：2018-07-05

申请号：US15740124

申请日：2016-07-05

Applicant: SAC SIRIUS ADVANCED CYBERNETICS GMBH

Inventor： Christoph WAGNER

IPC: G01B11/25 ,  G01B11/30 ,  G03B15/05 ,  G01N21/88

CPC classification number: G01B11/2513 ,  G01B11/30 ,  G01N21/8803 ,  G01N21/8806 ,  G01N2201/0621 ,  G03B15/05 ,  G03B2215/0514

Abstract: The invention related to an apparatus for illuminating objects, having an emitting surface and at least two illumination devices, wherein the at least two illumination devices are arranged and designed to generated at least two different illumination distributions on the at least one emitting surface.

公开(公告)号：US10003752B2

公开(公告)日：2018-06-19

申请号：US15429940

申请日：2017-02-10

Applicant: SCREEN Holdings Co., Ltd.

Inventor： Kunio Ikefuji ,  Jiro Tsumura ,  Yoshihiro Kurimura

IPC: H04N5/235 ,  G01N21/25 ,  G06T5/00 ,  G06T7/00 ,  G01N21/17

CPC classification number: H04N5/2352 ,  G01N21/253 ,  G01N2021/1772 ,  G01N2201/0621 ,  G06T3/4053 ,  G06T5/009 ,  G06T7/0012 ,  G06T2207/10024 ,  G06T2207/30024 ,  H04N5/23212 ,  H04N5/23235 ,  H04N5/23245 ,  H04N5/2355

Abstract: An imaging system for imaging a sample in a medium carried in a container as an imaging object, in which the imaging system includes an imager which obtains an original image by imaging the imaging object; and a data processor which generates multi-gradation image data by performing a gradation correction on the original image, wherein the data processor associates a luminance value corresponding to a luminance of the medium in the original image with a maximum gradation value in the gradation correction.

公开(公告)号：US09969358B2

公开(公告)日：2018-05-15

申请号：US15269486

申请日：2016-09-19

Applicant: Hyundai Motor Company ,  Kia Motors Corporation

Inventor： Jong Min Park ,  Nak Kyoung Kong ,  Keon Soo Jin ,  Ki Hong Lee ,  Jin Sang Lee

IPC: B60S1/08 ,  G01N21/3577 ,  G01N21/55 ,  G02B17/06

CPC classification number: B60S1/0833 ,  B60S1/0837 ,  G01N21/3577 ,  G01N21/55 ,  G01N21/552 ,  G01N2201/0621 ,  G02B17/0621

Abstract: A multifocal rain sensor includes: at least one light emitting unit configured to output light; a first reflective plate corresponding to the at least one light emitting unit and disposed at a position spaced apart from the at least one light emitting unit by a predetermined distance; a glass part reflecting light after the light is reflected by the first reflective plate and forming a sensing region; a second reflective plate re-reflecting the light reflected by the glass part; and a light receiving unit configured to receive the light reflected by the second reflective plate. The second reflective plate includes a multifocal reflective plate having a plurality of focuses based on a vertical height of incident light that varies according to a change in thickness of the glass part.

公开(公告)号：US20180106786A1

公开(公告)日：2018-04-19

申请号：US15833629

申请日：2017-12-06

Applicant: VIASPHERE, LLC

Inventor： Nicolas Arab ,  Ross Johnson

IPC: G01N33/50 ,  G01N21/64 ,  G01N33/58 ,  C12Q1/18 ,  C12Q1/04

CPC classification number: G01N33/5091 ,  C12Q1/04 ,  C12Q1/18 ,  G01N15/1463 ,  G01N21/6428 ,  G01N33/5011 ,  G01N33/582 ,  G01N2015/1006 ,  G01N2015/1406 ,  G01N2015/1481 ,  G01N2201/0621 ,  G01N2800/26

Abstract: Certain embodiments of the invention are directed to evaluating and identifying cells by recording and interpreting a time-dependent signal produced by unique cell respiration and permeability attributes of isolated viable cells.

公开(公告)号：US20170307517A1

公开(公告)日：2017-10-26

申请号：US15612564

申请日：2017-06-02

Applicant: Hinds Instruments, Inc.

Inventor： John Freudenthal ,  Andy Leadbetter ,  Baoliang Wang

IPC: G01N21/23 ,  G01N21/21 ,  G01J4/00

CPC classification number: G01N21/23 ,  G01J4/00 ,  G01N21/21 ,  G01N2201/0621 ,  G01N2201/0683

Abstract: This disclosure is generally directed to systems for imaging polarization properties of optical-material samples. As one aspect, there is provided a system for precise, simultaneous imaging of both the in-plane and out-of-plane birefringence properties of sample material over a wide range of incidence angles. The spatially resolved imaging approach described here is amenable to determination of a wide range of polarimetric properties, in addition to the in-plane and out-of-plane birefringence measure discussed as a preferred embodiment.

公开(公告)号：US20170276599A1

公开(公告)日：2017-09-28

申请号：US15468186

申请日：2017-03-24

Applicant: XiuJun Li

Inventor： XiuJun Li

IPC: G01N21/27 ,  B01L7/00 ,  C12Q1/68 ,  B01L3/00

CPC classification number: C12Q1/6844 ,  B01L3/502715 ,  B01L7/52 ,  G01N21/253 ,  G01N21/78 ,  G01N21/82 ,  G01N2021/6432 ,  G01N2021/7786 ,  G01N2201/0221 ,  G01N2201/0621 ,  G01N2201/064 ,  G01N2201/0693 ,  G01N2201/08 ,  C12Q2565/60 ,  C12Q2565/629

Abstract: Certain embodiments are directed to a low-cost battery-powered spectrophotometric system (BASS) coupled with a microfluidic chip for POC analysis, as well as methods of using the same.