公开(公告)号：US20040217280A1

公开(公告)日：2004-11-04

申请号：US10778424

申请日：2004-02-13

Applicant: MDS Sciex

Inventor： Bradley Schneider ,  Thomas R. Covey

IPC: H01J049/00

CPC classification number: H01J49/06 ,  H01J49/044

Abstract: An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

公开(公告)号：US06639212B1

公开(公告)日：2003-10-28

申请号：US09762236

申请日：2001-04-12

Applicant: Roger Guevremont ,  Randy Purves ,  David Barnett

Inventor： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC: H01J4940

CPC classification number: G01N27/624 ,  B01D59/46 ,  B01D59/48 ,  H01J49/004 ,  H01J49/044

Abstract: The present invention relates to a method of separating ions having the same mass to charge ratio but different ion mobility characteristics, based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry. Isomers including gas-phase molecular anions of the amino acids leucine and isoleucine are separable by the method of the present invention. Identification of different conformers of ions at the same charge state, including conformers present at certain charge states of the protein bovine ubiquitin, is also possible using the method of the present invention.

Abstract translation: 本发明涉及一种基于高场非对称波形离子淌度光谱法的离子聚焦原理，分离具有相同质荷比但离子迁移特性不同的离子的方法。 包括氨基酸亮氨酸和异亮氨酸的气相分子阴离子的异构体可以通过本发明的方法分离。 使用本发明的方法，可以鉴定在相同电荷状态的不同构象异构体，包括存在于蛋白质牛泛蛋白的某些电荷状态的构象异构体。

公开(公告)号：US06541767B1

公开(公告)日：2003-04-01

申请号：US09417167

申请日：1999-10-12

Applicant: Yoshiaki Kato

Inventor： Yoshiaki Kato

IPC: B01D5944

CPC classification number: H01J49/044 ,  Y10T436/24 ,  Y10T436/25

Abstract: A solution containing nonvolatile salts is pumped from a pump to an electrospray nebulization probe in the LC/MS interface, and spouted out from a tip of the probe into an atmospheric pressure environment in a form of fine liquid droplets having charges. The sample ions contained in the droplets are deflected by a deflector and enter into a mass analysis portion through an ion sampling aperture to be mass analyzed. On the other hand, the nonvolatile salts travel straight without being affected by the deflector, and collide against and are collected on a wall of a particle collector. The collected salts are precipitated in a form of crystals. The collected salts are washed away by spraying a particle washing solution from the washing nozzle. The above-described structure can provide an atmospheric pressure ionization mass spectrometer which can prevent effects of nonvolatile salts on the mass analysis without deteriorating the vacuum condition of the mass analysis portion by the preventing action.

Abstract translation: 将包含非挥发性盐的溶液从泵泵送到LC / MS界面中的电喷雾雾化探针，并从具有电荷的细液滴的形式从探针的尖端喷出到大气压环境中。 包含在液滴中的样品离子被偏转器偏转并通过离子采样孔进入质量分析部分进行质量分析。 另一方面，非挥发性盐直接行进而不受偏转器的影响，并且碰撞并收集在颗粒收集器的壁上。 收集的盐以晶体的形式沉淀。 通过从洗涤喷嘴喷射颗粒洗涤溶液来洗涤收集的盐。 上述结构可以提供大气压离子化质谱仪，其能够防止非挥发性盐对质量分析的影响，而不会由于防止作用而使质量分析部的真空状态恶化。

公开(公告)号：US06459081B2

公开(公告)日：2002-10-01

申请号：US09931910

申请日：2001-08-20

Applicant: Yoshiaki Kato

Inventor： Yoshiaki Kato

IPC: H01J4912

CPC classification number: H01J49/044 ,  Y10T436/24 ,  Y10T436/25

Abstract: A solution containing nonvolatile salts is pumped from a pump to an electrospray nebulization probe in the LC/MS interface, and spouted out from a tip of the probe into an atmospheric pressure environment in a form of fine liquid droplets having charges. The sample ions contained in the droplets are deflected by a deflector and enter into a mass analysis portion through an ion sampling aperture to be mass analyzed. On the other hand, the nonvolatile salts travel straight without being affected by the deflector, and collide against and are collected on a wall of a particle collector. The collected salts are precipitated in a form of crystals. The collected salts are washed away by spraying a particle washing solution from the washing nozzle. The above-described structure can provide an atmospheric pressure ionization mass spectrometer which can prevent effects of nonvolatile salts on the mass analysis without deteriorating the vacuum condition of the mass analysis portion by the preventing action.

Abstract translation: 将包含非挥发性盐的溶液从泵泵送到LC / MS界面中的电喷雾雾化探针，并从具有电荷的细液滴的形式从探针的尖端喷出到大气压环境中。 包含在液滴中的样品离子被偏转器偏转并通过离子采样孔进入质量分析部分进行质量分析。 另一方面，非挥发性盐直接行进而不受偏转器的影响，并且碰撞并收集在颗粒收集器的壁上。 收集的盐以晶体的形式沉淀。 通过从洗涤喷嘴喷射颗粒洗涤溶液来洗涤收集的盐。 上述结构可以提供大气压离子化质谱仪，其能够防止非挥发性盐对质量分析的影响，而不会由于防止作用而使质量分析部的真空状态恶化。

公开(公告)号：US20020134932A1

公开(公告)日：2002-09-26

申请号：US09321820

申请日：1999-05-28

Inventor： ROGER GUEVREMONT ,  RANDY W. PURVES

IPC: H01J049/00

CPC classification number: G01N27/624 ,  B01D59/46 ,  B01D59/48 ,  H01J49/004 ,  H01J49/044

Abstract: This invention provides an apparatus and method for desolvating and selectively transmitting and focussing ions, including ions produced by electrospray ionization (ESI), based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry (FAIMS), for introduction into a mass spectrometer. The ion focussing, trapping and desolvating effects of FAIMS, as identified by the inventors, provides high ion transmission efficiency and high sensitivity for the detection of ions. An apparatus comprising an ESI source, a FAIMS device and a mass spectrometer provides a way of desolvating and selectively transmitting highly solvated ions for introduction into a mass spectrometer for analysis.

Abstract translation: 本发明提供了一种基于高场非对称波形离子淌度光谱法（FAIMS）的离子聚焦原理，通过电喷雾离子化（ESI）产生的离子来去离子并选择性地透射和聚焦离子的设备和方法，用于引入质谱仪 。 如本发明人所确定的，FAIMS的离子聚焦，捕获和脱溶剂效应为离子的检测提供了高离子传输效率和高灵敏度。 包括ESI源，FAIMS装置和质谱仪的装置提供了一种解吸和选择性地透射高度溶剂化的离子以引入质谱仪进行分析的方法。

公开(公告)号：US06248999B1

公开(公告)日：2001-06-19

申请号：US09160502

申请日：1998-09-24

Applicant: Iain C. Mylchreest ,  Kegi Tang

Inventor： Iain C. Mylchreest ,  Kegi Tang

IPC: H01J4904

CPC classification number: H01J49/044

Abstract: An ion transmission system for transferring ions from an atmospheric pressure ionization source to an analyzer including a capillary having an input orifice which is indirectly coupled to the ion source.

Abstract translation: 一种离子传输系统，用于将离子从大气压离子源传输到包括具有间接耦合到离子源的输入孔的毛细管的分析器。

公开(公告)号：US6005245A

公开(公告)日：1999-12-21

申请号：US919785

申请日：1997-08-29

Applicant: Minoru Sakairi ,  Tadao Mimura ,  Yasuaki Takada ,  Takayuki Nabeshima ,  Hideaki Koizumi

Inventor： Minoru Sakairi ,  Tadao Mimura ,  Yasuaki Takada ,  Takayuki Nabeshima ,  Hideaki Koizumi

IPC: H01J49/04 ,  H01J49/06

CPC classification number: H01J49/061 ,  H01J49/044

Abstract: A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.

Abstract translation: 将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为 大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。

公开(公告)号：US5986259A

公开(公告)日：1999-11-16

申请号：US837216

申请日：1997-04-22

Applicant: Yukiko Hirabayashi ,  Takayuki Nabeshima ,  Yasuaki Takada ,  Minoru Sakairi ,  Hideaki Koizumi

Inventor： Yukiko Hirabayashi ,  Takayuki Nabeshima ,  Yasuaki Takada ,  Minoru Sakairi ,  Hideaki Koizumi

IPC: H01J49/04 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/067 ,  H01J49/044 ,  H01J49/045

Abstract: In a mass spectrometer using a sonic spray ion source, a technique of controlling the density of droplets in a nebulized sample solution which is passed into a mass spectrometer at high vacuum to an appropriate value to thereby reduce analysis noises is disclosed. A sample solution in a sample solution injection unit 1 is introduced into a capillary 2 disposed in an ion source 6. A gas is introduced from a gas supply unit 4 by way of a gas pipe 5 into the ion source 6 and is caused to flow along the outer circumferential surface at the top end of the capillary 2 and is jetted out from the orifice 3 as a gas flow into atmospheric air. The sample solution jetted from the top end of the capillary 2 is ionized by the gas flow in the atmospheric air. Fine droplets or ions formed by the sonic spray method are collide against a diffuser 7, droplets and ions reduced for the density by the diffusion pass through the holes 8 disposed in the diffuser 7, and pass from the sample orifice 10 into a mass spectrometer 11 and mass analyzed. Provision of the diffuser 7 can suppress generation of analysis noises caused by the clustering phenomenon resulting from introduction of droplets or ions at high density into the mass spectrometer 11, thereby enabling to conduct analysis at high S/N ratio.

Abstract translation: 在使用声波喷射离子源的质谱仪中，公开了一种在雾化样品溶液中控制液滴的密度的技术，其以高真空度进入质谱仪至适当的值，从而降低分析噪声。 将样品溶液注入单元1中的样品溶液引入设置在离子源6中的毛细管2.将气体从气体供给单元4通过气体管道5引入离子源6中并使其流动 沿着毛细管2的顶端的外周面，并且作为气流从孔3喷出到大气中。 从毛细管2的顶端喷出的样品溶液通过大气中的气流被离子化。 通过声波喷射法形成的细小液滴或离子与扩散器7碰撞，通过扩散通过设置在扩散器7中的孔8而使密度减小的液滴和离子，并从样品孔10通过到质谱仪11 并进行质量分析。 扩散器7的设置可以抑制由高密度地将液滴或离子引入质谱仪11而产生的聚集现象引起的分析噪声的产生，从而能够以高S / N比进行分析。

公开(公告)号：US5917184A

公开(公告)日：1999-06-29

申请号：US797088

申请日：1997-02-07

Applicant: William W. Carson ,  Stephen C. Gabeler ,  Yin Liang F. Hsieh ,  Stephen A. Martin ,  Michael J. Tomany ,  Anotoli Verentchikov

Inventor： William W. Carson ,  Stephen C. Gabeler ,  Yin Liang F. Hsieh ,  Stephen A. Martin ,  Michael J. Tomany ,  Anotoli Verentchikov

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/044 ,  H01J49/165

Abstract: An interface apparatus for introducing a sample for analysis from a liquid flow into a mass spectrometer as a plurality of charged droplets is disclosed. The interface apparatus includes interface body which defines a spray chamber and an orifice, a spray means defining a liquid-flow inlet channel and an excess-sample-flow exit channel and having an open end disposed inside the spray chamber, and a voltage device for applying a voltage to the sample to form a plurality of charged droplets. The charged droplets pass through the orifice in the interface body and are introduced into a mass spectrometer for analysis. The interface includes a valve for regulating the flow of sample into the sample inlet channel and a device for imposing a pressure gradient on the sample at the open end which induces the sample to flow from the sample inlet channel through the excess sample outlet channel.

Abstract translation: 公开了一种用于将用于分析的样品从液体流引入质谱仪作为多个带电液滴的界面装置。 接口装置包括限定喷雾室和孔口的界面体，限定液流入口通道的喷射装置和多余样品流出口通道，并且具有设置在喷雾室内部的开口端;以及电压装置， 向样品施加电压以形成多个带电液滴。 带电液滴通过界面体中的孔口，并引入质谱仪进行分析。 该界面包括用于调节样品流入样品入口通道的阀和用于在开口端施加样品上的压力梯度的装置，其引起样品从样品入口通道流过多余的样品出口通道。

公开(公告)号：US5481107A

公开(公告)日：1996-01-02

申请号：US302555

申请日：1994-09-08

Applicant: Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Youichi Ose

Inventor： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Youichi Ose

IPC: G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/06 ,  H01J49/22 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/044 ,  G01N30/728 ,  H01J49/061 ,  G01N30/7266 ,  G01N30/7293

Abstract: A mass spectrometer comprising an ionization region for ionizing a sample under atmospheric pressure, an ion sampling aperture for introducing ions generated by the ionization region into a vacuum, and a mass analysis region for mass analyzing the ions on the basis of a high-frequency electric field, wherein: an electrostatic lens for deflecting the direction of the movement of the ion from the center axis of the ion sampling aperture is disposed between the ionization region and the mass analysis region; the center axis of an aperture for introducing ions into the mass analysis region and the center axis of the ion sampling aperture are disposed so as to be shifted in parallel from each other; and the center axis of the ion sampling aperture and the center axis of a cylindrical inner electrode constituting the electrostatic lens are disposed so as to be shifted in parallel from each other to thereby prevent charged droplets or droplets without charge from flowing into the mass analysis region.

Abstract translation: 一种质谱仪，其特征在于，包括用于在大气压下使样品离子化的电离区域，用于将由离子化区域产生的离子引入真空的离子取样孔，以及质量分析区域，用于基于高频电力 其特征在于，在所述电离区域和所述质量分析区域之间配置用于使所述离子从所述离子取样孔的中心轴线移动的方向偏转的静电透镜; 用于将离子引入质量分析区域和离子采样孔的中心轴的孔的中心轴线彼此平行地移位; 并且离子采样孔的中心轴线和构成静电透镜的圆柱形内部电极的中心轴线彼此平行地移位，从而防止带电液滴或液滴而不带电流入质量分析区域 。