公开(公告)号：US20110300135A1

公开(公告)日：2011-12-08

申请号：US13107082

申请日：2011-05-13

Applicant: Brian Lobo ,  Sabrina Lo ,  Aditya Wakankar ,  Yuchang John Wang ,  Rita L. Wong ,  Pierre Goldbach ,  Hanns-Christian Mahler

Inventor： Brian Lobo ,  Sabrina Lo ,  Aditya Wakankar ,  Yuchang John Wang ,  Rita L. Wong ,  Pierre Goldbach ,  Hanns-Christian Mahler

IPC: A61K39/395 ,  A61P35/00 ,  A61P19/02 ,  G01J3/00 ,  A61P29/00 ,  A61P17/06 ,  A61P3/10 ,  A61P35/02 ,  A61P25/00

CPC classification number: A61K47/32 ,  A61K9/0019 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2887 ,  C07K2317/24

Abstract: The invention provides a method for reducing aggregation and inhibiting flocculation of a macromolecule, such as a protein, under physiological conditions, by the addition of 5% to 20% polyvinylpyrrolidone (PVP) with a molecular weight range of 2000 to 54,000 daltons. The invention further provides a method to minimize inflammation at the injection site during subcutaneous administration of a macromolecule. In further aspects, the invention provides pharmaceutical formulations for subcutaneous administration of a macromolecule, and methods of treating a CD20 positive cancer or an autoimmune disease, comprising administering a humanized anti-CD20 antibody in a pharmaceutical formulation of the invention. The invention further provides an in vitro dialysis method to evaluate the ability of an excipient to reduce aggregation of an antibody or other macromolecule under physiological conditions.

Abstract translation: 本发明提供了一种通过加入分子量范围为2000至54,000道尔顿的5％至20％的聚乙烯吡咯烷酮（PVP），在生理条件下减少聚合并抑制大分子如蛋白质的絮凝的方法。 本发明还提供了一种在大分子皮下给药期间最小化注射部位的炎症的方法。 在另外的方面，本发明提供用于皮下施用大分子的药物制剂，以及治疗CD20阳性癌症或自身免疫性疾病的方法，包括在本发明的药物制剂中施用人源化抗CD20抗体。 本发明还提供一种体外透析方法，用于评价赋形剂在生理条件下减少抗体或其它大分子聚集的能力。

公开(公告)号：US20110270093A1

公开(公告)日：2011-11-03

申请号：US13142485

申请日：2010-01-18

Applicant: Adrien Emmanuel Desjardins ,  Martinus Bernardus Van Der Mark ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft

Inventor： Adrien Emmanuel Desjardins ,  Martinus Bernardus Van Der Mark ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Gert 'T Hooft

IPC: A61B6/00 ,  H01L27/00 ,  G01J3/00 ,  H01J5/02 ,  G01J1/42

CPC classification number: A61B5/0075 ,  A61B5/0062 ,  A61B5/0084 ,  A61B5/6848

Abstract: An optical examination device (10) adapted to be at least partially inserted into a turbid medium is provided. The optical examination device comprises a shaft portion (21) adapted to be inserted into the turbid medium, the shaft portion (21) comprising a tip portion (22) adapted to be the foremost portion during insertion into the turbid medium. At least one light source device adapted to emit abeam (11) of broad-band light is provided in the region of the tip portion (21). The beam (11) of broad-band light comprises different wavelength bands (2a, 2b, . . . , 2n) which are differently modulated. At least one photodetector (27a, 27b, 27c) for detecting broad-band light is provided in a region adapted to be inserted into the turbid medium of the shaft portion (21).

Abstract translation: 提供了适于至少部分地插入混浊介质中的光学检查装置（10）。 光学检查装置包括适于插入混浊介质的轴部分（21），该轴部分（21）包括在插入混浊介质期间适于最前部分的末端部分（22）。 在尖端部分（21）的区域中设置适于发射宽带光的光束（11）的至少一个光源装置。 宽带光束（11）包括不同调制的不同波长带（2a，2b，...，2n）。 用于检测宽带光的至少一个光电检测器（27a，27b，27c）设置在适于插入到轴部（21）的混浊介质中的区域中。

公开(公告)号：US20110242531A1

公开(公告)日：2011-10-06

申请号：US13139660

申请日：2009-12-23

Applicant: Michael J. Natan

Inventor： Michael J. Natan

IPC: G01J3/00

CPC classification number: G01N21/658 ,  G01N33/54373 ,  Y10T436/13

Abstract: Embodiments include types of programmable surface-enhanced spectroscopy (SES) particles (PSPs), including PSP 200 having a SES-active surface 202 and a programmable reporter 206 associated with the SES surface 202 and methods of fabricating and using same. The programmable reporter 206 provides that the PSP 200 will return a controlled but variable signal in response to spectroscopic interrogation. The spectroscopic signal can be triggered to change externally or the signal may naturally vary over time.

Abstract translation: 实施例包括可编程表面增强光谱（SES）颗粒（PSP）的类型，包括具有SES活性表面202的PSP 200和与SES表面202相关联的可编程报告器206及其制造和使用方法。 可编程报告器206提供了响应于光谱询问，PSP 200将返回受控但可变的信号。 可以触发光谱信号以从外部改变，或者信号可能随时间而变化。

公开(公告)号：US20110211763A1

公开(公告)日：2011-09-01

申请号：US12931868

申请日：2011-02-11

Applicant: John Maier ,  Michael Fuhrman

Inventor： John Maier ,  Michael Fuhrman

IPC: G06K9/68 ,  G01J3/44 ,  G01J5/10 ,  G01J3/00

CPC classification number: G01J3/02 ,  G01J3/0297 ,  G01J3/44 ,  G01N21/276 ,  G01N21/65 ,  G01N2201/1293

Abstract: A system and method for providing an instrument response correction. A sample is illuminated to generate a first plurality and a second plurality of interacted photons. The first plurality of interacted photons may be detected by a dispersive spectrometer to generate a reference spectrum representative of the sample. The second plurality of interacted photons may be passed through a tunable filter and detected using an imaging detector to generate at least one hyperspectral image. This hyperspectral image may comprise a Raman hyperspectral image or an infrared hyperspectral image. A system may comprise an illumination source, a collection optics, a dispersive spectrometer, a fiber optic, a tunable filter, and an imaging detector.

Abstract translation: 一种用于提供仪器响应校正的系统和方法。 照射样品以产生第一多个和第二多个相互作用的光子。 可以通过色散光谱仪检测第一组多个相互作用的光子，以产生代表样品的参考光谱。 可以将第二多个相互作用的光子通过可调滤光器并使用成像检测器进行检测，以产生至少一个高光谱图像。 该高光谱图像可以包括拉曼高光谱图像或红外光谱图像。 系统可以包括照明源，收集光学器件，分散光谱仪，光纤，可调谐滤光器和成像检测器。

公开(公告)号：US07999933B2

公开(公告)日：2011-08-16

申请号：US12541586

申请日：2009-08-14

Applicant: Jason McClure

Inventor： Jason McClure

IPC: G01J3/00

CPC classification number: G01J3/28 ,  G01J2003/2866

Abstract: Disclosed is a method for calibrating optical spectrographs, and in particular optical spectrographs having focal plane array detectors. The method comprises the steps of detecting a spectrum of a known source, referencing a table of known spectral wavelengths and relative intensities, and deriving a spectrograph model based on the spectrograph's physical properties to approximate the observed spectrum, wherein non-linear optimization techniques refine the theoretical model parameters, thereby minimizing the residual difference between observed and calculated spectral intensities in an iterative process producing a set of physical model parameters that best describe the modeling spectrograph for calibration of subsequent spectral acquisitions.

Abstract translation: 公开了一种用于校准光学光谱仪的方法，特别是具有焦平面阵列检测器的光学光谱仪。 该方法包括以下步骤：检测已知源的光谱，参考已知光谱波长和相对强度的表格，以及基于所述光谱仪的物理特性导出近似观测光谱的光谱仪模型，其中非线性优化技术改进 理论模型参数，从而最小化迭代过程中观察和计算的光谱强度之间的剩余差异，产生最佳描述建模光谱仪的一组物理模型参数，用于后续光谱采集的校准。

公开(公告)号：US07999822B2

公开(公告)日：2011-08-16

申请号：US12108033

申请日：2008-04-23

Applicant: Toshiyuki Ishii

Inventor： Toshiyuki Ishii

IPC: G09G5/00 ,  G09G5/02 ,  H04N1/46 ,  H04N1/60 ,  H04N5/57 ,  G03F3/08 ,  G06K9/00 ,  H04N17/00 ,  H04N9/73 ,  H04N5/202 ,  G06K9/40 ,  G06K9/32 ,  G01J3/00 ,  G01J3/52

CPC classification number: H04N1/6086 ,  G01J3/46 ,  G01J3/462 ,  H04N1/6097

Abstract: In order to obtain colorimetric data close to the color appearance under an actual viewing condition, a plurality of conversion data for converting colorimetric data measured under the first geometric condition of colorimetry into that measured under the second geometric condition of colorimetry are held, and the information of a viewing illuminant and colorimetric data measured under the first geometric condition of colorimetry are obtained. Conversion data which corresponds to the information of the viewing illuminant is interpolated from the plurality of conversion data which are held. The colorimetric data measured under the first geometric condition of colorimetry is converted into that measured under the second geometric condition of colorimetry using the interpolated conversion data.

Abstract translation: 为了在实际观察条件下获得接近于颜色外观的比色数据，将用于将在比色法的第一几何条件下测量的比色数据转换成在比色法的第二几何条件下测量的比色数据的多个转换数据被保存，并且信息 获得在比色法的第一几何条件下测量的观察光源和比色数据。 从保持的多个转换数据插入与观看光源的信息对应的转换数据。 在比色法的第一几何条件下测量的比色数据使用内插转换数据转换成在比色法的第二几何条件下测量的比色数据。

公开(公告)号：US20110173727A1

公开(公告)日：2011-07-14

申请号：US12447217

申请日：2007-10-24

Applicant: John David Miller ,  Greg William Adams

Inventor： John David Miller ,  Greg William Adams

IPC: A01H7/00 ,  A01N65/00 ,  A01P3/00 ,  A01P7/04 ,  G01N33/53 ,  C12Q1/68 ,  C07K16/14 ,  G01J3/00

CPC classification number: A01N63/04 ,  A01H3/00 ,  A01H7/00 ,  A01H17/00 ,  C07K16/14 ,  C12R1/645 ,  G01N33/56961

Abstract: The invention provides methods for preparing a conifer seedling with increased tolerance to a pest. A conifer seedling is inoculated with an isolated endophyte when the conifer seedling is susceptible to colonization by the endophyte.

Abstract translation: 本发明提供了制备具有对害虫的耐受性增加的针叶树幼苗的方法。 当针叶树幼苗易受内生真菌定植时，用分离的内生真菌接种针叶树幼苗。

公开(公告)号：US20110164715A1

公开(公告)日：2011-07-07

申请号：US12963343

申请日：2010-12-08

Applicant: Jei-Won Yeon ,  Kyuseok Song ,  Euo-Chang Jung

Inventor： Jei-Won Yeon ,  Kyuseok Song ,  Euo-Chang Jung

IPC: G21C17/02 ,  G01J3/30 ,  G01J3/00

CPC classification number: G21C17/002 ,  G01J3/443 ,  G01N21/718 ,  G21C17/02

Abstract: System and method for detecting and/or predicting in a field the leakage of nuclear reactor coolant that may occur at the pressure boundary of the primary system of a nuclear reactor. The system and method for detecting the leakage of nuclear reactor coolant uses a laser induced emission spectrum. The leakage of coolant is detected by detecting boron (B), a main component of the coolant, in corrosive products generated at the nuclear reactor pressure boundary on the basis of laser spectroscopy. An embodiment of the system for detecting leakage of nuclear reactor coolant may include a laser generator, a laser focusing lens, an emission collector, and emission spectrum analyzer.

Abstract translation: 用于在现场检测和/或预测可能在核反应堆的主要系统的压力边界处发生的核反应堆冷却剂的泄漏的系统和方法。 用于检测核反应堆冷却剂泄漏的系统和方法使用激光诱发发射光谱。 通过基于激光光谱法检测在核反应堆压力边界产生的腐蚀产物中的硼（B），即冷却剂的主要成分来检测冷却剂的泄漏。 用于检测核反应堆冷却剂泄漏的系统的实施例可以包括激光发生器，激光聚焦透镜，发射集电器和发射光谱分析仪。

公开(公告)号：US20110101239A1

公开(公告)日：2011-05-05

申请号：US12991324

申请日：2009-05-08

Applicant: Iain Woodhouse ,  Caroline Nichol ,  Genevieve Patenaude ,  Timothy John Malthus

Inventor： Iain Woodhouse ,  Caroline Nichol ,  Genevieve Patenaude ,  Timothy John Malthus

IPC: G01J1/58 ,  G01N21/84 ,  G01J3/42 ,  G01J3/00

CPC classification number: G01S7/4802 ,  G01S7/499 ,  G01S17/87 ,  G01S17/89

Abstract: An airborne the multi-spectral lidar instrument emits and/or detects radiation from target vegetation to assess the condition of the foliage. Time of flight analysis at multiple wavelengths permits three dimensional measurements to discriminate material at different heights, from ground to top of canopy. Radiation at 531 nm (emission and detection, vertically resolved) is used to measure de-epoxidation of the xanthophyll pigments (used for PRI), and also for stimulation of fluorescence. Radiation at 550 and/or 570 or 571 nm (emission and detection, vertically resolved) serves as a reference waveband unaffected by the de-epoxidation (used for PRI). Radiation at 690 and 740 nm (Detection only, no height resolution) or other lines for chlorophyll fluorescence, optionally using Fraunhofer/Oxygen wavelength windows and/or time gating to improve SNR. Wavelengths of 860 and 1200 nm, or similar (emission and detection, vertically resolved) are applied to measurement of water absorption and estimation of NDWI. Results are combined with known available radiation to estimate primary productivity.

Abstract translation: 机载多光谱激光雷达仪器发射和/或检测来自目标植被的辐射，以评估叶子的状况。 在多个波长的飞行时间分析允许三维测量来区分不同高度，从地面到顶盖的材料。 531nm的辐射（发射和检测，垂直分辨）用于测量叶黄素颜料（用于PRI）的去环氧化，也用于刺激荧光。 在550和/或570或571nm（发射和检测，垂直分辨）的辐射用作不受去环氧化影响的参考波段（用于PRI）。 在690和740 nm处的辐射（仅检测，无高度分辨率）或其他叶绿素荧光线，可选地使用Fraunhofer /氧气波长窗口和/或时间门控来提高SNR。 将860和1200nm的波长或类似（发射和检测，垂直分辨）应用于NDWI的吸水率和估计。 结果与已知的可用辐射相结合以估计初级生产力。

公开(公告)号：US20110075127A1

公开(公告)日：2011-03-31

申请号：US12616992

申请日：2009-11-12

Applicant: Shigeki NISHINA ,  Motoki IMAMURA

Inventor： Shigeki NISHINA ,  Motoki IMAMURA

IPC: G01J3/00

CPC classification number: G01N21/3581

Abstract: A desired spatial resolution upon a measurement can be attained by making an electromagnetic wave including a terahertz wave (frequency thereof is equal to or more than 0.01 [THz], and equal to or less than 100 [THz]) incident to a device under test. An electromagnetic wave measurement device includes an incident lens which makes an electromagnetic wave to be measured having a frequency equal to or more than 0.01 [THz] and equal to or less than 100 [THz] incident to a device under a test while decreasing a beam diameter of the electromagnetic wave to be measured, a scanning stage which rotates, about a line orthogonal to an optical axis of the incident lens as a rotational axis, the device under the test or the optical axis, and an electromagnetic wave detector which detects the electromagnetic wave to be measured which has transmitted through the device under the test, where a coordinate on the optical axis of a position which gives the minimum value d of the beam diameter is different from a coordinate on the optical axis of the rotational axis.

Abstract translation: 测量时的期望空间分辨率可以通过使包含入射到被测器件的太赫兹波（其频率等于或大于0.01 [THz]，等于或小于100 [THz]）的电磁波来实现 。 电磁波测量装置包括入射透镜，该入射透镜使得测量的电磁波具有等于或大于在测试时入射到设备的0.01 [THz]且等于或小于100 [THz]的频率，同时减小光束 要测量的电磁波的直径，围绕与入射透镜的光轴正交的线作为旋转轴旋转的扫描台，被测装置或光轴的电磁波检测器，以及检测 通过测试中的装置传输的要测量的电磁波，其中给出光束直径的最小值d的位置的光轴上的坐标不同于旋转轴的光轴上的坐标。