公开(公告)号：US09029775B2

公开(公告)日：2015-05-12

申请号：US13565021

申请日：2012-08-02

Applicant: Joseph R. Demers ,  Ronald T. Logan, Jr.

Inventor： Joseph R. Demers ,  Ronald T. Logan, Jr.

IPC: G01N21/35 ,  G01J3/10 ,  G01J3/42 ,  G01J3/453 ,  G01N21/3581 ,  G01N21/39 ,  G01N21/3586

CPC classification number: G01J3/10 ,  G01J3/42 ,  G01J3/4531 ,  G01N21/3581 ,  G01N21/3586 ,  G01N21/39

Abstract: An apparatus for analyzing, identifying or imaging an target including first and second laser beams coupled to a pair of photoconductive switches to produce CW signals in one or more bands in a range of frequencies greater than 100 GHz focused on, and transmitted through or reflected from the target; and a detector for acquiring spectral information from signals received from the target and using a multi-spectral heterodyne process to generate an electrical signal representative of some characteristics of the target. The lasers are tuned to different frequencies and a phase modulator in the path of one laser beam allows the constructive or destructive interference of the signals on the detector as the laser beams are swept in frequency to be adjusted to achieve greater resolution in one or more selected frequency bands.

Abstract translation: 一种用于分析，识别或成像目标的装置，包括耦合到一对光电导开关的第一和第二激光束，以在大于100GHz的频率的范围内的一个或多个频带中产生CW信号，该信号聚焦并透过或反射 目标; 以及检测器，用于从从目标接收的信号中获取光谱信息，并使用多光谱外差处理产生表示目标的某些特性的电信号。 将激光器调谐到不同的频率，并且在一个激光束的路径中的相位调制器允许在检测器上的信号的建构性或相消干涉，因为激光束被扫频以被调整以在一个或多个选定的 频带。

公开(公告)号：US09019507B2

公开(公告)日：2015-04-28

申请号：US13735092

申请日：2013-01-07

Applicant: Hitachi, Ltd.

Inventor： Shigeharu Kimura ,  Masataka Shirai ,  Koichi Watanabe

IPC: G01J3/45 ,  G01J3/44 ,  G01J3/453

CPC classification number: G01J3/45 ,  G01J3/44 ,  G01J3/453

Abstract: A signal is amplified by making a CARS beam from an observed body and a reference beam which is a portion of a super continuum beam and has a frequency of ωAS=2ωP−ωST interfere with each other and taking out the signal from an interference beam of the CARS beam and the reference beam.

Abstract translation: 通过从观察体制作CARS光束，作为超连续光束的一部分且具有ωAS=2ωP-ωST的频率的参考光束相互干扰并从干涉光束中取出信号，来放大信号 CARS光束和参考光束。

公开(公告)号：US08577639B2

公开(公告)日：2013-11-05

申请号：US13031182

申请日：2011-02-19

Applicant: Robert C. Youngquist ,  Stephen M. Simmons

Inventor： Robert C. Youngquist ,  Stephen M. Simmons

IPC: G01J3/00 ,  G01J3/453 ,  G01J3/45

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/28

Abstract: A calibration assembly for a spectrometer is provided. The assembly includes a spectrometer having n detector elements, where each detector element is assigned a predetermined wavelength value. A first source emitting first radiation is used to calibrate the spectrometer. A device is placed in the path of the first radiation to split the first radiation into a first beam and a second beam. The assembly is configured so that one of the first and second beams travels a path-difference distance longer than the other of the first and second beams. An output signal is generated by the spectrometer when the first and second beams enter the spectrometer. The assembly includes a controller operable for processing the output signal and adapted to calculate correction factors for the respective predetermined wavelength values assigned to each detector element.

Abstract translation: 提供了一种用于光谱仪的校准组件。 组件包括具有n个检测器元件的光谱仪，其中每个检测器元件被分配预定的波长值。 使用发射第一辐射的第一个光源来校准光谱仪。 将装置放置在第一辐射的路径中以将第一辐射分裂成第一光束和第二光束。 组件被配置成使得第一和第二光束中的一个光束行进比第一和第二光束中的另一个更长的路径差距离。 当第一和第二光束进入光谱仪时，由光谱仪产生输出信号。 组件包括可操作用于处理输出信号并适于计算分配给每个检测器元件的相应预定波长值的校正因子的控制器。

公开(公告)号：US20050248769A1

公开(公告)日：2005-11-10

申请号：US10521516

申请日：2002-07-15

Applicant: Thilo Weitzel

Inventor： Thilo Weitzel

IPC: G01J3/12 ,  G01J3/14 ,  G01J3/18 ,  G01J3/32 ,  G01J3/36 ,  G01J3/45 ,  G01J3/453 ,  G01B9/02

CPC classification number: G01J3/453

Abstract: The present invention relates to an apparatus and a method for optical spectroscopy and for optical sensory technology and to the use of the apparatus. An apparatus having high spectral resolution with simultaneously comparatively low demands on the quality of the optical components is provided in that the apparatus for optical spectroscopy comprises means for the generation of an interference pattern, means for the coupling of the incoming light field to be examined such that only one or several individual spatial modes of the field are permitted, and a detector which can record the intensity of the generated interference pattern at a plurality of spatially different positions, with the wavefronts and/or the propagation direction of at least one of the light fields involved in the interference pattern being changed by spectrally dispersive or diffractive optical elements in dependence on the wavelength. The present invention furthermore relates to a method of determining the optical spectrum and/or of other measurands encoded or transmitted by an optical spectrum by analysis of the interference pattern measured using an apparatus in accordance with the invention or using an apparatus in accordance with the invention.

Abstract translation: 本发明涉及一种用于光学光学和光学感测技术的装置和方法以及该装置的使用。 提供了一种具有高光谱分辨率并且对光学部件的质量要求相对较低的要求的装置，其特征在于，用于光学光学的装置包括用于产生干涉图案的装置，用于耦合待检测的入射光场的装置 允许场的只有一个或几个单独的空间模式，以及可以在多个空间不同的位置记录生成的干涉图案的强度的检测器，其中波前和/或传播方向至少是 根据波长，通过光谱色散或衍射光学元件改变涉及干涉图案的光场。 本发明还涉及一种通过分析使用根据本发明的装置或使用根据本发明的装置测量的干涉图案来确定由光谱编码或传输的其他被测量的光谱和/或其他被测量的方法 。

公开(公告)号：US06963405B1

公开(公告)日：2005-11-08

申请号：US10894216

申请日：2004-07-19

Applicant: Peter J. Wheel ,  Loren M. Woody

Inventor： Peter J. Wheel ,  Loren M. Woody

IPC: G01B9/02 ,  G01J3/28 ,  G01J3/453 ,  G01S7/495

CPC classification number: G01J3/2823 ,  G01J3/453 ,  G01S7/495

Abstract: In an imaging system providing an image of a target of interest, a method of reducing interference from a laser beam includes the steps of: (a) receiving optical energy from the target of interest and the laser beam; (b) forming an interferogram of spectral energy, at each spatial position of an image, based on the optical energy received in step (a); (c) detecting the interferogram of spectral energy, at each of the spatial positions, to provide a corresponding spectral band of intensity values; (d) selecting an intensity level in the spectral band, detected in step (c), that is greater than a predetermined value, and reducing the selected intensity level; and (e) forming an image of the target of interest, after reducing the selected intensity level of step (d).

Abstract translation: 在提供感兴趣的目标的图像的成像系统中，减少来自激光束的干扰的方法包括以下步骤：（a）从感兴趣的目标物体和激光束接收光能; （b）基于在步骤（a）中接收的光能量，在图像的每个空间位置处形成光谱能量的干涉图; （c）在每个空间位置处检测光谱能量的干涉图，以提供强度值的相应光谱带; （d）选择在步骤（c）中检测到的大于预定值的频谱带中的强度水平，并减小所选择的强度水平; 以及（e）在减小所选择的步骤（d）的强度水平之后，形成目标目标的图像。

公开(公告)号：US06940599B1

公开(公告)日：2005-09-06

申请号：US10364777

申请日：2003-02-10

Applicant: David Christian Hovde

Inventor： David Christian Hovde

IPC: G01C3/08 ,  G01J3/433 ,  G01J3/453 ,  G01N21/00 ,  G01N21/35 ,  G01N21/39

CPC classification number: G01J3/433 ,  G01J3/453 ,  G01N2021/3595 ,  G01N2021/399

Abstract: A spectrometer and spectrometry method comprising modulating a light source with a carrier waveform multiplied by an envelope function, directing light from the light source through a sample region and to a photodetector, and demodulating current from the photodetector at a reference frequency. Also a method for computing a modulation waveform comprising specifying a target detection efficiency in a Fourier space, computing a response of a waveform that comprises a carrier wave multiplied by an envelope function, and modifying the envelope function using nonlinear optimization means to minimize a difference between the computed response and a predetermined target gain spectrum.

Abstract translation: 一种光谱仪和光谱测定方法，包括用载体波形乘以包络函数调制光源，将来自光源的光引导通过样品区域和光电检测器，以及以参考频率解调来自光电检测器的电流。 还有一种用于计算调制波形的方法，包括在傅里叶空间中指定目标检测效率，计算包括乘以包络函数的载波的波形的响应，以及使用非线性优化装置修改包络函数，以最小化 计算的响应和预定的目标增益谱。

公开(公告)号：US20050056785A1

公开(公告)日：2005-03-17

申请号：US10663310

申请日：2003-09-16

Applicant: Mau-Song Chou ,  Larry Yujiri ,  David Dixon

Inventor： Mau-Song Chou ,  Larry Yujiri ,  David Dixon

IPC: G01J3/453 ,  G01J5/06 ,  G01N21/35 ,  G01J5/00

CPC classification number: G01N21/3581 ,  G01J3/453 ,  G01J5/061 ,  G01N21/3504

Abstract: A system for detecting and analyzing chemical and biological materials in a sample. The system includes a spectrometer for passively receiving emissions from the sample in the terahertz frequency band to detect the materials therein. A telescope or other device can be used to confine the field-of-view of the spectrometer. A cold surface is positioned filling the field-of-view of the spectrometer at an opposite side of the sample from the spectrometer. The cold surface provides a low temperature background relative to the sample so as to reduce the background emission and enhance the detection of the emission from the sample.

Abstract translation: 用于检测和分析样品中化学和生物材料的系统。 该系统包括用于被动地接收来自太赫兹频带中的样本的发射的光谱仪，以检测其中的材料。 望远镜或其他设备可用于限制光谱仪的视场。 将冷表面放置在样品与光谱仪相反的一侧，填充光谱仪的视场。 冷表面相对于样品提供了低温背景，以便减少背景辐射并增强对样品的发射的检测。

公开(公告)号：US20050046862A1

公开(公告)日：2005-03-03

申请号：US10647176

申请日：2003-08-25

Applicant: Ivan Melnyk

Inventor： Ivan Melnyk

IPC: G01B9/02 ,  G01D5/353 ,  G01J3/02 ,  G01J3/10 ,  G01J3/26 ,  G01J3/453 ,  G01N21/45

CPC classification number: G01J3/02 ,  G01D5/35303 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/26 ,  G01J3/453 ,  G01N21/45

Abstract: A fiber optic sensing device uses a Fabry-Perot cavity to sense a physical parameter. The cavity modulates the incident polychromatic light. The modulated light is recorded by an optical spectrometer means. The spectrum is analyzed in a signal processing unit which normalizes the spectrum and determines the phase of the modulated signal. The phase, accumulated over whole range of wavelengths, has been used for identification of the physical parameter using a look-up-table. The cavity, the polychromatic light source and the spectroscope means are connected by fiber optic means.

Abstract translation: 光纤感测装置使用法布里 - 珀罗腔来感测物理参数。 空腔调制入射的多色光。 调制光由光谱仪装置记录。 频谱在信号处理单元中进行分析，该信号处理单元对频谱进行归一化并确定调制信号的相位。 在整个波长范围内累积的相位已被用于使用查找表识别物理参数。 空腔，多色光源和分光装置通过光纤装置连接。

公开(公告)号：US20050003642A1

公开(公告)日：2005-01-06

申请号：US10835259

申请日：2004-04-30

Applicant: Thomas Hecht ,  Uwe Schroder ,  Ulrich Mantz ,  Stefan Jakschik ,  Andreas Orth

Inventor： Thomas Hecht ,  Uwe Schroder ,  Ulrich Mantz ,  Stefan Jakschik ,  Andreas Orth

IPC: G01B11/22 ,  G01J3/453 ,  G01N21/21 ,  H01L21/337

CPC classification number: G01N21/211 ,  G01B11/22 ,  G01J3/453

Abstract: The present invention relates to a method for determining the depth of a buried structure in a semiconductor wafer. According to the invention, the layer behavior of the semiconductor wafer which is brought about by the buried structure when the semiconductor wafer is irradiated with electromagnetic radiation in the infrared range and arises as a result of the significantly longer wavelengths of the radiation used in comparison with the lateral dimensions of the buried structure is utilized to determine the depth of the buried structure by spectrometric and/or ellipsometric methods.

Abstract translation: 本发明涉及一种用于确定半导体晶片中的掩埋结构的深度的方法。 根据本发明，当半导体晶片在红外范围内被电磁辐射照射时，由掩埋结构引起的半导体晶片的层行为，并且由于与所使用的辐射相比显着更长的辐射波长而产生 掩埋结构的横向尺寸用于通过光谱测量和/或椭偏方法确定掩埋结构的深度。

公开(公告)号：US6146897A

公开(公告)日：2000-11-14

申请号：US851776

申请日：1997-05-06

Applicant: Menashi A. Cohenford ,  Prashant S. Bhandare ,  Basil Rigas

Inventor： Menashi A. Cohenford ,  Prashant S. Bhandare ,  Basil Rigas

IPC: G01J3/28 ,  G01J3/453 ,  G01N21/35 ,  G01N33/48

CPC classification number: G01J3/28 ,  G01J3/453 ,  G01J2003/2866 ,  G01N2021/3595 ,  G01N21/35

Abstract: This invention teaches a method to identify cellular abnormalities which are associated with disease states. The method utilizes infrared (IR) spectra of cell samples which are dried on an infrared-transparent matrix and scanned at the frequency range from 3000-950 cm.sup.-1. The identification of samples is based on establishing a reference using a representative set of spectra of normal and/or diseased specimens. During the reference assembly process, multivariate techniques such as Principal Component Analysis (PCA) and/or Partial Least Squares (PLS) are used. PCA and PLS reduce the data based on maximum variations between the spectra, and generate clusters in a multidimensional space representing the different populations. The utilization of Mahalinobis distances, or linear regression (e.g., Principle Component Regression on the reduced data from PCA) form the basis for the discrimination. In one embodiment, the invention is a method to distinguish premalignant and malignant stages of cervical cancer from normal cervical cells. This method is simple to use and achieves statistically reliable distinction between the following groups of cervical smears: normal (individuals with no prior history of dysplasia), dysplasia and malignant samples. Further, this invention discloses a method to obtain the IR spectrum of individual cervical cells fixed on an infrared-transparent matrix and to use the spectra of the individual cells in the method described above. In another aspect, the invention is a method for using vibrational spectroscopic imaging to distinguish between normal and diseased cells. In another aspect, the invention is a method to identify women at a high risk for developing cervical dysplasia.

Abstract translation: 本发明教导了鉴定与疾病状态相关的细胞异常的方法。 该方法利用在红外线透明矩阵上干燥并在3000-950cm -1的频率范围内扫描的细胞样品的红外（IR）光谱。 样品的鉴定基于使用正常和/或患病样品的代表性的一组光谱建立参考。 在参考组装过程中，使用多变量技术，如主成分分析（PCA）和/或部分最小二乘法（PLS）。 PCA和PLS基于光谱之间的最大变化减少数据，并在表示不同种群的多维空间中生成簇。 马哈利诺比斯距离的使用或线性回归（例如，来自PCA的简化数据的原理组件回归）构成了歧视的基础。 在一个实施方案中，本发明是将宫颈癌的恶化前期和恶化阶段与正常宫颈细胞区分开的方法。 这种方法使用简单，可以在以下几组宫颈涂片之间进行统计学上可靠的区分：正常（不具有发育异常史的个体），发育异常和恶性样本。 此外，本发明公开了一种获得固定在红外线透明基质上的各个子宫颈细胞的IR光谱并使用上述方法中的各个细胞的光谱的方法。 另一方面，本发明是使用振动光谱成像来区分正常细胞和患病细胞的方法。 在另一方面，本发明是鉴定发生子宫颈发育不良的高风险妇女的方法。