公开(公告)号：US20130003044A1

公开(公告)日：2013-01-03

申请号：US13541171

申请日：2012-07-03

Applicant: John Maier ,  Jeffrey Cohen ,  Ryan Priore

Inventor： John Maier ,  Jeffrey Cohen ,  Ryan Priore

IPC: G01J3/28 ,  G01J3/44

CPC classification number: G01N21/84 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J5/0846 ,  G01J2005/0077 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/129 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

Abstract translation: 本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。 可以照射生物样品，从而产生一个或多个相互作用的光子。 可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。 可以将生成的光谱数据集与至少一个参考数据集进行比较。 每个参考数据集可以与已知分析物的已知暴露相关联。 本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。 可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。

公开(公告)号：US20120154792A1

公开(公告)日：2012-06-21

申请号：US13068542

申请日：2011-05-12

Applicant: Patrick J. Treado ,  Matthew Nelson ,  Charles W. Gardner, JR. ,  Thomas Voigt ,  Jeffrey Beckstead

Inventor： Patrick J. Treado ,  Matthew Nelson ,  Charles W. Gardner, JR. ,  Thomas Voigt ,  Jeffrey Beckstead

IPC: G01J3/00

CPC classification number: G01J3/0208 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823

Abstract: The disclosure provides for a portable device for detecting hazardous agents, including explosives using SWIR hyperspectral imaging. The device may comprise a collection optics, a SWIR multi-conjugate filter, a SWIR camera, and a display. The device may also comprise an RGB camera. The disclosure also provides for a method of using said portable device wherein interacted photons are collected and passed through a SWIR multi-conjugate filter. The interacted photons are detected to generate at least one SWIR hyperspectral image. The SWIR hyperspectral image may be analyzed to determine the presence or absence of a hazardous agent on a target. An RGB image of a target may also be generated and analyzed to survey a sample scene.

Abstract translation: 本公开提供了用于检测危险剂的便携式装置，包括使用SWIR高光谱成像的爆炸物。 该装置可以包括收集光学器件，SWIR多共轭滤光器，SWIR相机和显示器。 该设备还可以包括RGB相机。 本公开还提供了使用所述便携式设备的方法，其中相互作用的光子被收集并通过SWIR多重共轭滤波器。 检测相互作用的光子以产生至少一个SWIR高光谱图像。 可以分析SWIR高光谱图像以确定目标上是否存在危险剂。 还可以生成和分析目标的RGB图像以对样本场景进行调查。

公开(公告)号：US20120050727A1

公开(公告)日：2012-03-01

申请号：US13221484

申请日：2011-08-30

Applicant: Yusuke Yamamoto

Inventor： Yusuke Yamamoto

IPC: G01J1/42

CPC classification number: G01J3/0248 ,  G01J3/0208 ,  G01J3/2803 ,  G02B21/0004 ,  G02B21/367

Abstract: An imaging system may include an optical system that forms an image of light irradiated onto a sample in a predetermined focal plane, an imaging element that includes a pixel array in which a plurality of pixels are arranged in a two-dimensional matrix, each of the pixels detecting at least a part of the light of the image of the sample formed in the focal plane, the imaging element obtaining the image of the sample corresponding to the light detected by the pixel array, a spectrum detecting unit arranged to be adjacent to the pixel array, the spectrum detecting unit detecting a spectrum of the light in the focal plane to output spectrum information, and a correcting unit that corrects the image of the sample obtained by the imaging element based on the spectrum information output from the spectrum detecting unit.

Abstract translation: 成像系统可以包括形成在预定焦平面中照射到样本上的光的图像的光学系统，包括其中多个像素被布置在二维矩阵中的像素阵列的成像元件， 像素，其检测形成在焦平面中的样本的图像的光的至少一部分，所述成像元件获得与由像素阵列检测到的光相对应的样本的图像;频谱检测单元，被布置为与 像素阵列，频谱检测单元检测焦平面中的光的频谱以输出频谱信息;以及校正单元，其基于从频谱检测单元输出的频谱信息校正由成像元件获得的样本的图像。

公开(公告)号：US20110109735A1

公开(公告)日：2011-05-12

申请号：US12942223

申请日：2010-11-09

Applicant: Takeshi OTSUKA

Inventor： Takeshi OTSUKA

IPC: H04N7/18

CPC classification number: G01J3/02 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/08 ,  G01J3/32 ,  G01J3/42 ,  G02B21/365

Abstract: A virtual microscope system capable of obtaining a stained sample image and a statistical data of spectra in a short period of time is provided, the virtual microscope system includes an image obtaining unit for obtaining a stained sample image, a spectrum obtaining unit for obtaining a spectrum of the stained sample image, an optical path setting unit for setting an optical path of a light flux passed through the stained sample with respect to the image obtaining unit and the spectrum obtaining unit and a control unit for controlling to repeat obtaining the stained sample image by the image obtaining unit and obtaining the spectrum of the stained sample image by the spectrum obtaining unit in the observation field of the stained sample to create a virtual slide and a spectrum table of the stained sample.

Abstract translation: 提供了能够在短时间内获得染色的样本图像和光谱的统计数据的虚拟显微镜系统，虚拟显微镜系统包括用于获得染色样本图像的图像获取单元，用于获得光谱的光谱获取单元 所述光路设定单元设置相对于所述图像获取单元和所述光谱获取单元设定穿过所述染色样品的光束的光路，以及控制单元，用于控制重复获得所述染色样本图像 通过图像获取单元获取染色样本的观察区域中的光谱获取单元的染色样品图像的光谱，以创建染色样品的虚拟幻灯片和光谱表。

公开(公告)号：US20100145416A1

公开(公告)日：2010-06-10

申请号：US12473745

申请日：2009-05-28

Applicant: Uk KANG ,  Garri. V Papayan

Inventor： Uk KANG ,  Garri. V Papayan

IPC: A61N5/067 ,  A61N5/06

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  A61N5/0601 ,  A61N5/062 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/12 ,  G01J3/36 ,  G01J3/4406 ,  G01N21/255 ,  G01N21/29 ,  G01N21/31 ,  G01N21/4738 ,  G01N21/6456 ,  G01N2201/0618

Abstract: The present invention provides an apparatus for photodynamic therapy and fluorescence detection, in which a combined light source is provided to illuminate an object body and a multispectral fluorescence-reflectance image is provided to reproduce various and complex spectral images for an object tissue, thus performing effective photodynamic therapy for various diseases both outside and inside of the body.For this purpose, the present invention provides an apparatus for photodynamic therapy and photodetection, which provides illumination with light of various wavelengths and multispectral images, the apparatus including: an optical imaging system producing an image of an object tissue and transmitting the image to a naked eye or an imaging device; a combined light source including a plurality of coherent and non-coherent light sources and a light guide guiding incident light emitted from the light sources; a multispectral imaging system including at least one image sensor; and a computer system outputting an image of the object tissue to the outside. Thus, the apparatus for photodynamic therapy and photodetection of the present invention can effectively perform the photodynamic therapy and photodetection by means of the combined light source capable of irradiating light having various spectral components to an object tissue and the multispectral imaging system capable of obtaining images from several spectral portions for these various spectral ranges at the same time, thus improving the accuracy of diagnosis and efficiency of the photodynamic therapy.

Abstract translation: 本发明提供了一种用于光动力学治疗和荧光检测的装置，其中提供组合光源以照射物体，并且提供多光谱荧光反射图像以再现对象组织的各种和复杂的光谱图像，从而执行有效 身体各种疾病的光动力治疗。 为此，本发明提供了一种用于光动力学治疗和光电检测的装置，其提供具有各种波长和多光谱图像的光的照明，所述装置包括：光学成像系统，其产生对象组织的图像并将图像发送到裸体 眼睛或成像装置; 包括多个相干和非相干光源的组合光源和引导从光源发射的入射光的光导; 包括至少一个图像传感器的多光谱成像系统; 以及将对象组织的图像输出到外部的计算机系统。 因此，本发明的光动力学治疗和光电检测装置可以通过能够将具有各种光谱成分的光照射到对象组织上的组合光源和能够获得图像的多光谱成像系统而有效地进行光动力学治疗和光电检测 同时对于这些不同光谱范围的几个光谱部分，从而提高光动力疗法的诊断准确性和效率。

公开(公告)号：US06765609B1

公开(公告)日：2004-07-20

申请号：US09577622

申请日：2000-05-25

Applicant: Katsuyuki Kinoshita

Inventor： Katsuyuki Kinoshita

IPC: H04N5228

CPC classification number: G01J3/2823 ,  G01J3/0243 ,  G01J3/0248 ,  G01J3/2803 ,  H04N5/33

Abstract: A solid-state image sensor, which has a two-dimensional matrix of a plurality of pixels used to sense the two-dimensional spatial distribution of radioactive rays, light rays, electrons, ions, or the like, is provided with an aperture that extends through a substrate at an image sensing unit on which the pixels are arranged, and a signal transfer path that connects signal transfer electrodes for reading images of the respective pixels kept clear of the aperture. Furthermore, the image sensing unit is divided into at least two regions by a boundary including the aperture, and these regions have individual signal read registers. With this structure, the image sensor serves as both an image sensor for sensing the two-dimensional distribution of radiation or the like, and an aperture for passing such radiation.

Abstract translation: 具有用于感测放射线，光线，电子，离子等的二维空间分布的多个像素的二维矩阵的固态图像传感器设置有延伸的孔径 通过其上布置有像素的图像感测单元的衬底以及连接用于读取各个像素的图像的信号传送电极的信号传送路径保持远离孔径。 此外，图像感测单元通过包括孔径的边界被划分为至少两个区域，并且这些区域具有单独的信号读取寄存器。 利用这种结构，图像传感器用作用于感测辐射等的二维分布的图像传感器和用于通过这种辐射的孔。

公开(公告)号：US4708477A

公开(公告)日：1987-11-24

申请号：US829273

申请日：1986-02-13

Applicant: Yabusaki Kenji ,  Tozawa Hitoshi ,  Noda Akira ,  Ito Takashi

Inventor： Yabusaki Kenji ,  Tozawa Hitoshi ,  Noda Akira ,  Ito Takashi

IPC: G01J1/08 ,  G01J1/42 ,  G01J1/44

CPC classification number: G01J1/04 ,  G01J1/02 ,  G01J1/0228 ,  G01J1/0455 ,  G01J1/0466 ,  G01J1/08 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/0243 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/1804 ,  G01J3/42 ,  G01J2001/086 ,  G01J2001/4453 ,  G01J2001/446

Abstract: A photometrical apparatus has a first light receiving element, and a second light receiving element less sensitive to temperature and other environmental influences than said first light receiving element whereby a value Pm of measured quantity of light from the subject is calculated from the following formula ##EQU1## Pr designates a quantity of light from a standard light source, Dr and Dm designate outputs of the first light receiving element generated by the light from the standard light source and the subject, Dpo and Dpt designate outputs of the first light receiving element generated by the light from the reference light source and the subject, and Dso and Dst designate outputs of the second light receiving element generated by the light from the reference light source and the subject.

Abstract translation: 光度测量装置具有第一光接收元件和对所述第一光接收元件的温度和其他环境影响不敏感的第二光接收元件，从而根据以下公式计算来自被摄体的测量光量的值Pm Pr表示来自标准光源的光量，Dr和Dm表示由来自标准光源和被摄体的光产生的第一光接收元件的输出，Dpo和Dpt表示由第一光接收元件产生的第一光接收元件的输出， 来自参考光源和被摄体的光，Dso和Dst表示由来自参考光源和被摄体的光产生的第二光接收元件的输出。