公开(公告)号：US20130264493A1

公开(公告)日：2013-10-10

申请号：US13821148

申请日：2011-09-14

Applicant: Thomas R. Covey ,  Stanislaw Potyrala ,  Bradley B. Schneider

Inventor： Thomas R. Covey ,  Stanislaw Potyrala ,  Bradley B. Schneider

IPC: H01J49/02

CPC classification number: H01J49/02 ,  H01J49/044

Abstract: A system and method for mass spectrometry including a curtain gas chamber defined by a curtain plate having an aperture for receiving ions from an ion source and an orifice plate having an inlet into a mass spectrometer. At least one barrier separates the curtain chamber into a first curtain gas chamber region and a second curtain gas chamber region. At least one gas source provides a gas inflow into the second curtain gas chamber region and a gas outflow into the first curtain gas chamber region, a portion of the gas outflow directed out of the aperture. A heating element heats the gas inflow, a portion of the heated gas inflow directed into the inlet of the mass spectrometer wherein the portion of the heated gas inflow can be at a substantially higher temperature than the portion of the gas outflow.

Abstract translation: 一种用于质谱的系统和方法，包括由具有用于从离子源接收离子的孔的幕板限定的帘式气室和具有入口进入质谱仪的孔板。 至少一个屏障将幕帘室分隔成第一帘式气体室区域和第二帘式气体室区域。 至少一个气体源提供气体流入第二帘式气体室区域，并且气体流入第一帘式气体室区域，一部分气体流出物被引导出孔。 加热元件加热气体流入，一部分加热气体流入引导到质谱仪的入口，其中加热气体流入的部分可以处于比气体流出部分显着更高的温度。

公开(公告)号：US08461524B2

公开(公告)日：2013-06-11

申请号：US13073880

申请日：2011-03-28

Applicant: Jean Jacques Dunyach ,  August A. Specht ,  R. Paul Atherton

Inventor： Jean Jacques Dunyach ,  August A. Specht ,  R. Paul Atherton

IPC: H01J49/44 ,  H01J49/26

CPC classification number: H01J49/063 ,  H01J49/044 ,  H01J49/24

Abstract: A mass spectrometry system arrangement includes a curved ion guide, where the curve of the ion guide is positioned such that a portion of the ion optics are visible from at the ion guide entrance, e.g. line of sight or z-axis. There are four electrodes parallel with each other and the central curved axis. Each electrode is equally radially spaced from the curved central axis. For each cross section of the ion guide, the central curved axis being positioned at the origin, the curved electrodes being radially positioned at 45°, 135°, 225°, and 315°. Depending upon the system, a blocking device is positioned external to the ion guide but within the “line of sight” or positioned tangential to the rising section of the bent ion guide.

Abstract translation: 质谱系统布置包括弯曲离子导向器，其中离子导向器的曲线被定位成使得离子光学器件的一部分可以在离子导向入口处可见，例如离子导向器。 视线或z轴。 有四个电极彼此平行和中心弯曲的轴线。 每个电极与弯曲的中心轴线径向间隔开。 对于离子导向件的每个横截面，中心弯曲轴线位于原点，弯曲电极径向定位在45°，135°，225°和315°处。 取决于系统，阻挡装置位于离子导向器的外部，但位于“视线”内或定位成与弯曲离子导向件的上升部分相切。

公开(公告)号：US20120298853A1

公开(公告)日：2012-11-29

申请号：US13114869

申请日：2011-05-24

Applicant: Ruwan T. Kurulugama ,  Mikhail E. Belov

Inventor： Ruwan T. Kurulugama ,  Mikhail E. Belov

IPC: H01J49/22 ,  H01J49/00

CPC classification number: H01J49/065 ,  H01J49/0404 ,  H01J49/044

Abstract: An orthogonal ion injection apparatus and process are described in which ions are directly injected into an ion guide orthogonal to the ion guide axis through an inlet opening located on a side of the ion guide. The end of the heated capillary is placed inside the ion guide such that the ions are directly injected into DC and RF fields inside the ion guide, which efficiently confines ions inside the ion guide. Liquid droplets created by the ionization source that are carried through the capillary into the ion guide are removed from the ion guide by a strong directional gas flow through an inlet opening on the opposite side of the ion guide. Strong DC and RF fields divert ions into the ion guide. In-guide orthogonal injection yields a noise level that is a factor of 1.5 to 2 lower than conventional inline injection known in the art. Signal intensities for low m/z ions are greater compared to convention inline injection under the same processing conditions.

Abstract translation: 描述了一种正交离子注入装置和方法，其中离子通过位于离子导向器一侧的入口直接注入垂直于离子引导轴的离子导向器中。 加热的毛细管的末端放置在离子导向器内，使得离子直接注入到离子导向器内的DC和RF场中，这有效地将离子限制在离子导向器内。 由电离源产生的通过毛细管进入离子导向器的液滴通过强力的定向气流从离子导向器的相反侧的入口开口从离子导向器移除。 强直流和射频场将离子转移到离子导向器中。 导向正交注入产生比现有技术中已知的常规在线注入低1.5至2倍的噪声电平。 在相同的处理条件下，与常规的直线注入相比，低m / z离子的信号强度更大。

公开(公告)号：US20110042567A1

公开(公告)日：2011-02-24

申请号：US12933058

申请日：2008-03-17

Applicant: Shinichi Yamaguchi

Inventor： Shinichi Yamaguchi

IPC: H01J49/10

CPC classification number: G01N27/62 ,  H01J49/044 ,  H01J49/165

Abstract: A sample solution containing a sample component is sprayed onto an atmosphere at atmospheric approximately pressure while being applied with electric charge from the tip of a nozzle (1). A sample molecule is released as an ion in a process where charged minute liquid droplets collide with an atmospheric gas and are broken apart, and a solvent is vaporized from the respective liquid droplets. A reflectron (7) in the shape of a half-cut spheroid is arranged in such a manner that a second focal point (F2) is positioned in front of an ion-introducing portion (4) in the spray flow. A discharge electrode (8) is disposed in a position at a first focal point (F1) of the reflectron (7). When pulsed high voltage is applied to the discharge electrode (8), an electric discharge occurs, causing shock waves to be generated. The shock waves reflected on the reflectron (7) are converged on the second focal point (F2). Due to the converged shock waves, the vicinity of the second focal point (F2) rises to a high temperature, and a large pressure is also applied thereto. Therefore, vaporization of a solvent from the respective liquid droplets is further accelerated, allowing an ion to be easily generated. In addition, direct ionization can be expected. This makes it possible to improve ion generation efficiency.

Abstract translation: 将包含样品组分的样品溶液在大气压大气压下喷雾，同时从喷嘴（1）的尖端施加电荷。 在带电的微小液滴与大气气体碰撞并分离开的过程中，样品分子作为离子释放，并且溶剂从各个液滴中汽化。 以半切球体形状的反射镜（7）以这样的方式布置，使得第二焦点（F2）位于喷射流中的离子引入部分（4）的前面。 放电电极（8）设置在反射器（7）的第一焦点（F1）的位置。 当向放电电极（8）施加脉冲高电压时，发生放电，产生冲击波。 在反射镜（7）上反射的冲击波会聚在第二焦点（F2）上。 由于会聚的冲击波，第二焦点（F2）的附近上升到高温，也施加大的压力。 因此，来自各液滴的溶剂的蒸发进一步加速，容易产生离子。 此外，可以预期直接电离。 这使得可以提高离子产生效率。

公开(公告)号：US20090159794A1

公开(公告)日：2009-06-25

申请号：US11963843

申请日：2007-12-23

Applicant: Arthur SCHLEIFER ,  Steven Michael FISCHER

Inventor： Arthur SCHLEIFER ,  Steven Michael FISCHER

IPC: H01J49/00

CPC classification number: H01J49/044 ,  H01J49/0445

Abstract: A method of obtaining ions of an analyte is disclosed. The method includes aerosolizing a sample using a thermal liquid jetting device or a piezoelectric liquid jetting device to obtain an aerosol without ionizing the sample. The sample includes the analyte in a solvent. The method further includes drying the aerosol to obtain gas phase solvent and gas phase analyte, and ionizing the gas phase analyte to obtain ions thereof. An ion source using the method for obtaining ions of an analyte is also disclosed.

Abstract translation: 公开了一种获得分析物离子的方法。 该方法包括使用热液体喷射装置或压电液体喷射装置使样品雾化，以获得不使样品电离的气溶胶。 样品包括溶剂中的分析物。 该方法还包括干燥气溶胶以获得气相溶剂和气相分析物，并将气相分析物电离以获得其离子。 还公开了使用获得分析物的离子的方法的离子源。

公开(公告)号：US20080258052A1

公开(公告)日：2008-10-23

申请号：US12163030

申请日：2008-06-27

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/28

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

Abstract translation: 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。

公开(公告)号：US20080116371A1

公开(公告)日：2008-05-22

申请号：US11601343

申请日：2006-11-17

Applicant: Eloy R. Wouters ,  Maurizio Splendore

Inventor： Eloy R. Wouters ,  Maurizio Splendore

IPC: H01J49/04

CPC classification number: H01J49/067 ,  H01J49/044

Abstract: A method and apparatus for directing ions from an ionization source to a mass analyzer is provided. The method includes producing ions from a sample in an ionization source. Some of the ions are transferred to a first region via a passageway that is in fluid communication with the ionization source. Next, some of the ions are sampled from the first region into a second region via an aperture that is defined thorough a partition element. The aperture is centered about a longitudinal axis that passes through an ion transfer element within the second region. An electric field is established for deflecting some of the ions that pass through the aperture of the partition element. In particular, the electric field is directed transverse to the longitudinal axis such that relatively more ions enter an input end of the ion transfer element compared to when the ions are not deflected.

Abstract translation: 提供了用于将离子从电离源引导到质量分析器的方法和装置。 该方法包括从电离源中的样品产生离子。 一些离子通过与电离源流体连通的通道转移到第一区域。 接下来，一些离子通过经过分隔元件定义的孔从第一区域采样到第二区域。 孔围绕穿过第二区域内的离子转移元件的纵向轴线居中。 建立电场以偏转通过分隔元件的孔的一些离子。 特别地，电场横向于纵向轴线，使得相对较多的离子进入离子转移元件的输入端，与离子没有偏转时相比较。

公开(公告)号：US07098452B2

公开(公告)日：2006-08-29

申请号：US10778424

申请日：2004-02-13

Applicant: Bradley Schneider ,  Thomas R. Covey

Inventor： Bradley Schneider ,  Thomas R. Covey

IPC: H01J49/04

CPC classification number: H01J49/06 ,  H01J49/044

Abstract: An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

公开(公告)号：US06977369B2

公开(公告)日：2005-12-20

申请号：US10343329

申请日：2002-06-05

Applicant: Kentaro Yamaguchi ,  Tatsuji Kobayashi

Inventor： Kentaro Yamaguchi ,  Tatsuji Kobayashi

IPC: H01J49/04 ,  H01J49/00

CPC classification number: H01J49/0468 ,  B05B5/001 ,  B05B5/0255 ,  H01J49/044 ,  H01J49/165

Abstract: The instrument cold sprays a solution sample at a low temperature and desolvates the sample. Under this condition, a mass analysis is performed. The instrument comprises a needle pipe (8) through which the solution sample is passed, a sheath tube (24) formed coaxially with the needle pipe (8) and passing a temperature-controlled nebulizing gas therethrough, the above-described desolvation block (3), means for cooling the block (15), means for heating the block (4), and a temperature sensor (5) for detecting the temperature of the block (3). The block (3) has a passage for charged liquid droplets of the solution sample cold sprayed from the tip of the needle pipe (8), and acts to remove the solvent from the charged liquid droplets flowing through the passage. A coldspray mass spectrometer is offered which has a desolvation block whose temperature can be easily controlled. In the instrument, condensation of water and electrical leakage are prevented for a long time. The instrument can perform measurements stably and is easy to handle.

Abstract translation: 仪器冷却在低温下喷射溶液样品并使样品脱水。 在这种条件下，进行质量分析。 该仪器包括通过溶液样品的针管（8），与针管（8）同轴形成并通过温度控制的雾化气体的鞘管（24），上述去溶剂化块（3） ），用于冷却块（15）的装置，用于加热块（4）的装置和用于检测块（3）的温度的温度传感器（5）。 块（3）具有从针管（8）的尖端冷喷射的溶液样品的带电液滴的通道，并且用于从流经通道的带电液滴中除去溶剂。 提供了一种冷喷射质谱仪，其具有一个去溶剂化块，其温度可以容易地控制。 在仪器中，长时间防止水和漏电的结露。 仪器可以稳定地进行测量并且易于处理。

公开(公告)号：US20050230634A1

公开(公告)日：2005-10-20

申请号：US11051608

申请日：2005-02-04

Applicant: Stevan Bajic ,  Robert Bateman

Inventor： Stevan Bajic ,  Robert Bateman

IPC: H01J27/00 ,  H01J49/16

CPC classification number: H01J49/168 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0468 ,  H01J49/165

Abstract: An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising two co-axial capillary tubes 2,3. A blue-flame gas torch 6 is provided downstream of the probe 1 as a combustion source. An analyte solution is sprayed from an inner capillary tube 2 of the probe 1 and a combustible gas is supplied to an outer capillary tube 3 of the probe 1. The combustible gas supplies heat to aid desolvation of the droplets emerging from the probe 1 via combustion with the surrounding oxygen-containing atmosphere when combusted by the blue flame torch 6.

Abstract translation: 公开了一种电喷雾离子源和大气压化学电离离子源，其包括包含两个同轴毛细管2,3的探针1。 蓝色火焰焰炬6设置在探头1的下游，作为燃烧源。 从探针1的内部毛细管2喷射分析物溶液，将可燃气体供给到探针1的外部毛细管3。 当由蓝色火焰焰炬6燃烧时，可燃气体通过与周围的含氧气氛的燃烧而提供热量以帮助从探针1出来的液滴的去溶剂化。