公开(公告)号：US20230326026A1

公开(公告)日：2023-10-12

申请号：US18334123

申请日：2023-06-13

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph DACOSTA

IPC: G06T7/00 ,  A61B5/00

CPC classification number: G06T7/0016 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/445 ,  G06T2207/10024 ,  G06T2207/10064 ,  G01N21/6486

Abstract: Systems and methods for determining bacterial load in targets are disclosed. An autofluorescence detection and collection device includes a light source configured to illuminate a target with excitation light causing at least one biomarker in the illuminated target to fluoresce. Bacterial autofluorescence data regarding the target is collected and analyzed to determine bacterial load the target. The autofluorescence data may be analyzed using pixel intensity.

公开(公告)号：US20230324301A1

公开(公告)日：2023-10-12

申请号：US18202823

申请日：2023-05-26

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01N21/64 ,  G01N21/47 ,  G01B11/22 ,  G01N33/483

CPC classification number: G01N21/6456 ,  G01B11/22 ,  G01N21/4795 ,  G01N33/4833 ,  G01N2201/062

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US20230265524A1

公开(公告)日：2023-08-24

申请号：US18008053

申请日：2021-06-03

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Daniel DINIZ DE CARVALHO ,  Parinaz MEHDIPOUR ,  Sajid MARHON

IPC: C12Q1/6886 ,  A61K31/706 ,  A61P35/00

CPC classification number: C12Q1/6886 ,  A61K31/706 ,  A61P35/00 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/154

Abstract: There is described herein a method of assessing a subject's responsiveness to cancer therapy, comprising: providing a sample from the subject comprising cancers cells or suspected cancer cells; measuring or estimating the expression levels of inverted repeats (IR) Alus in the cells; and determining that the subject would be responsive to 5 cancer therapy if the subject cells exhibit expression levels of inverted repeats (IR) Alus with reference to expression levels in control samples.

公开(公告)号：US20230265391A1

公开(公告)日：2023-08-24

申请号：US17924040

申请日：2021-05-07

Applicant: University Health Network

Inventor： Gordon M. Keller ,  Alexander Mikryukov ,  Amine Mazine ,  Ian Fernandes

IPC: C12N5/077 ,  C12N5/071

CPC classification number: C12N5/0657 ,  C12N5/069 ,  C12N2501/155 ,  C12N2501/415 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/165 ,  C12N2506/02

Abstract: Methods and compositions for making endocardial cells from pluripotent stem cells are described, as are methods and compositions for using such cells.

公开(公告)号：US20230265079A1

公开(公告)日：2023-08-24

申请号：US18096397

申请日：2023-01-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Donald WEAVER ,  Michael G. BRANT ,  Stephanie WOHNIG ,  Fan WU ,  Jake GOODWIN-TINDALL ,  Autumn MEEK ,  Paolo SCHIAVINI

IPC: C07D403/04 ,  C07D401/14

CPC classification number: C07D403/04 ,  C07D401/14

Abstract: Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of IDO, syntheses, and uses thereof are provided.

公开(公告)号：US11735309B2

公开(公告)日：2023-08-22

申请号：US15927414

申请日：2018-03-21

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Thomas G. Purdie ,  Christopher James McIntosh ,  Igor Svistoun

IPC: G16H20/40 ,  A61N5/10 ,  G16H40/20 ,  G16H20/30 ,  G16H20/10 ,  G16H30/40 ,  G16H10/60 ,  G16H50/70 ,  G16H50/20

CPC classification number: G16H20/40 ,  A61N5/103 ,  G16H10/60 ,  G16H20/10 ,  G16H20/30 ,  G16H30/40 ,  G16H40/20 ,  G16H50/20 ,  G16H50/70 ,  A61N5/1038 ,  A61N5/1048 ,  A61N2005/1041

Abstract: Methods and systems for evaluating a proposed treatment plan for radiation therapy, for evaluating one or more delineated regions of interest for radiation therapy, and/or for generating a proposed treatment plan for radiation therapy. Machine learning based on historical data may be used.

公开(公告)号：US11730545B2

公开(公告)日：2023-08-22

申请号：US17886195

申请日：2022-08-11

Applicant: University Health Network

Inventor： Zigang Jimmy Qiu ,  Stefan Hofer ,  Blake Murphy ,  Tomas J. Saun ,  Lukasz Brzozowski ,  Trinette Wright ,  Xun Lin

IPC: A61B34/10 ,  G06T15/00 ,  G06T19/00 ,  G06T15/06

CPC classification number: A61B34/10 ,  G06T15/005 ,  G06T19/006 ,  A61B2034/101 ,  G06T15/06

Abstract: Methods and related systems and devices are described for performing various AR medical applications, including a method of guiding augmented reality (AR) intervention. In one aspect, a primary client device: receives model sets, an intervention plan having an intervention field, and session information about a session related to the AR intervention from a server; receives first real-time input data from a first input device; generates metrics by evaluating an execution of the intervention plan by comparing the intervention plan to the first real-time input data; displays real-time graphics, based at least in part on the metrics, spatially over the intervention field; receives real-time status data, from the server, about a replicate client device that joins the session; sends the first real-time input data, the metrics and the evaluation computed from the intervention plan, through the server, to the replicate client device.

公开(公告)号：US20230227821A1

公开(公告)日：2023-07-20

申请号：US17916981

申请日：2021-04-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Daniel DINIZ DE CARVALHO ,  Housheng HE ,  Ilias ETTAYEBI ,  Fraser SOARES ,  Helen LOO YAU

IPC: C12N15/113 ,  C12N5/0783 ,  A61K35/17 ,  A61P35/00

CPC classification number: C12N15/113 ,  C12N5/0636 ,  A61K35/17 ,  A61P35/00 ,  C12N2310/20

Abstract: Methods of increasing T cell effector function in a T cell population are provided that involve inhibiting one or more genetic subunits of the SAGA (Spt-Ada-Gcn5-acetyltransferase) gene regulation complex in the T cell population. Also provided are methods of using such T cell populations in the treatment of cancer patients.

公开(公告)号：US11607454B2

公开(公告)日：2023-03-21

申请号：US16303400

申请日：2017-05-19

Applicant: UNIVERSITY HEALTH NETWORK ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Brian Wilson ,  Christine Allen

IPC: A61K41/00 ,  A61N5/10

Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.

公开(公告)号：US20230011889A1

公开(公告)日：2023-01-12

申请号：US17782071

申请日：2020-12-07

Applicant: University Health Network

Inventor： Li Zhang ,  Jong Bok Lee ,  Daniel Vasic ,  Ismat Khatri ,  Dalam Ly ,  Yuki Sze Long Leung

IPC: A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61P35/00

Abstract: The disclosure relates to the development and use of CD4− CD8− double negative T (DNT) cells genetically modified to bind to one or more target antigens to enhance DNT cell anti-cancer activity such as with a chimeric antigen receptor (CAR). Genetically modified DNT cells can be generated ex vivo and expanded from allogeneic healthy donor cells and used as off-the-shelf therapy to overcome allogeneic graft-versus-host disease (GvHD) and/or host-versus-graft rejection in the treatment of cancer.