公开(公告)号：US20190164740A1

公开(公告)日：2019-05-30

申请号：US16262011

申请日：2019-01-30

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander A. MAKAROV ,  Eduard V. DENISOV ,  Gerhard JUNG ,  Wilko BALSCHUN ,  Stevan R. HORNING

IPC: H01J49/42 ,  H01J49/02 ,  H01J49/00 ,  H01J49/28 ,  H01J49/40

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, ϕ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, ϕ, z) is the result of a perturbation W to an ideal field U(r, ϕ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ϕ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2π radians over an ion detection period Tm.

公开(公告)号：US10049867B2

公开(公告)日：2018-08-14

申请号：US15695969

申请日：2017-09-05

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28 ,  H01J49/42 ,  H01J49/40 ,  H01J49/00 ,  H01J49/06

Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.

公开(公告)号：US20170365457A1

公开(公告)日：2017-12-21

申请号：US15696770

申请日：2017-09-06

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28 ,  H01J49/06 ,  H01J49/00 ,  H01J49/42 ,  H01J49/40

CPC classification number: H01J49/282 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/062 ,  H01J49/40 ,  H01J49/401 ,  H01J49/406 ,  H01J49/4245

Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.

公开(公告)号：US09786482B2

公开(公告)日：2017-10-10

申请号：US14798260

申请日：2015-07-13

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28 ,  H01J49/42 ,  H01J49/40 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/282 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/062 ,  H01J49/40 ,  H01J49/401 ,  H01J49/406 ,  H01J49/4245

Abstract: A mass spectrometer including an ion source, an ion guide, a pulsed converter, and an electrostatic analyzer is disclosed, along with a method of mass spectrometry and an ion injector. The ion source generates ions, such as ions within a continuous or a quasi-continuous ion beam. The ion guide receives a portion of the ions generated by the ion source. The pulsed converter, which receives ions from the ion guide, includes at least one electrode connected to a RF signal. The pulsed converter may include a means for ejecting the ions in the form of ion packets. The electrostatic analyzer forms a two-dimensional electrostatic field in an X-Y plane. The electrostatic field is substantially extended in a Z-direction that is locally orthogonal to the X-Y plane and may be curved or linear. Ions undergo isochronous ion oscillations in the electrostatic field. The pulsed converter and electrostatic analyzer are Z-directionally elongated.

公开(公告)号：US20170117130A1

公开(公告)日：2017-04-27

申请号：US15398101

申请日：2017-01-04

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander A. MAKAROV ,  Eduard V. DENISOV ,  Gerhard JUNG ,  Wilko BALSCHUN ,  Stevan R. HORNING

IPC: H01J49/42 ,  H01J49/28 ,  H01J49/40 ,  H01J49/00

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.

公开(公告)号：US09520280B2

公开(公告)日：2016-12-13

申请号：US13993316

申请日：2011-12-14

Applicant: Alexander A. Makarov

Inventor： Alexander A. Makarov

IPC: H01J49/00 ,  H01J49/28 ,  H01J49/02 ,  H01J49/38 ,  H01J49/42

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

公开(公告)号：US09312114B2

公开(公告)日：2016-04-12

申请号：US14717369

申请日：2015-05-20

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Christian Albrecht Hock ,  Dmitry Grinfeld ,  Richard Heming

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/04 ,  H01J49/40 ,  H01J49/42 ,  H01J49/28

CPC classification number: H01J49/427 ,  H01J49/0031 ,  H01J49/0481 ,  H01J49/063 ,  H01J49/282 ,  H01J49/40 ,  H01J49/4225 ,  H01J49/424 ,  H01J49/4245

Abstract: A method of ejecting ions to be analyzed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analyzed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analyzed from the quadrupole ion trap.

Abstract translation: 从四极离子阱中排出要分析的离子的方法，其中通过施加到阱的一个或多个电极的一个或多个RF电压产生捕获场，该方法包括以下步骤：将待分析的离子冷却在 四极离子阱，直到离子被热化，减少施加到四极离子阱的一个或多个RF电压的幅度，并且在一个或多个RF电压已经达到过零点之后将减小幅度的RF电压施加一个半周期，转动 关闭施加到四极离子阱的RF电压，并从四极离子阱中喷射待分析的离子。

公开(公告)号：US09147565B1

公开(公告)日：2015-09-29

申请号：US14586503

申请日：2014-12-30

Applicant: MORPHO DETECTION, LLC

Inventor： Lyndon Karl Goedecke

IPC: B01D59/44 ,  H01J49/00 ,  H01J49/28 ,  H01J49/40 ,  H01J49/02 ,  G01N27/62

CPC classification number: G01N27/622

Abstract: A method of detecting constituents in a sample includes generating a plurality of ions in an ionization region. The method also includes preventing the plurality of ions in the ionization region from flowing into a drift region through inducing a first voltage in a device positioned between the two regions. The method further includes injecting at least a portion of the ions from the ionization region into the drift region. The method also includes regulating the voltage in the device to a second voltage for a first predetermined temporal period, the second voltage less than the first voltage. The method further includes regulating the voltage in the device to the first voltage. The method also includes regulating the voltage in the device to the second voltage for a second predetermined temporal period, the second predetermined temporal period different from the first predetermined temporal period.

Abstract translation: 检测样品中成分的方法包括在电离区域中产生多个离子。 该方法还包括通过在位于两个区域之间的器件中引发第一电压来防止电离区域中的多个离子流入漂移区域。 该方法还包括将至少一部分离子从电离区注入漂移区。 该方法还包括将器件中的电压调节到第一预定时间周期的第二电压，第二电压小于第一电压。 该方法还包括将器件中的电压调节到第一电压。 该方法还包括在第二预定时间周期内将器件中的电压调节到第二电压，第二预定时间周期不同于第一预定时间周期。

公开(公告)号：US09129783B2

公开(公告)日：2015-09-08

申请号：US14390451

申请日：2013-04-05

Applicant: Micromass UK Limited ,  The University of British Columbia

Inventor： Jeffery Mark Brown ,  Damon Robb

IPC: B01D59/44 ,  H01J49/28 ,  H01J49/00

CPC classification number: H01J49/0054 ,  H01J49/0031 ,  H01J49/0072

Abstract: A method of mass spectrometry is disclosed comprising providing a mixture of different analyte ions and supplying electrons or reagent ions to said mixture so as to transfer charge to the analyte ions. The transfer of charge causes at least some of the analyte ions to dissociate and others of the analyte ions not to dissociate, but to form intermediate ions of altered charge state. These intermediate ions are then isolated from other ions and excited so as to dissociate into daughter ions. The intermediate ions and their daughter ions are analyzed and associated with each other so that the intermediate can be identified from their daughter ions. The analyte ions can then be identified from the intermediate ions, since they differ only in charge state. The disclosed method enables analyte ions to be associated with their fragment ions, and therefore identified, without having to isolate individual analyte ions prior to their interactions with the electrons or reagent ions.

Abstract translation: 公开了一种质谱法，其包括提供不同分析物离子的混合物并向所述混合物提供电子或试剂离子，以将电荷转移到分析物离子。 电荷转移导致至少一些分析物离子解离，其他分析物离子不会离解，而是形成具有改变的电荷状态的中间离子。 然后将这些中间离子与其他离子分离并被激发，以便解离成子离子。 中间离子及其子离子被分析并相互关联，使得中间体可以从它们的子离子中鉴定出来。 然后可以从中间离子鉴定分析物离子，因为它们仅在电荷状态不同。 所公开的方法使得分析物离子与它们的碎片离子相关联，因此被鉴定，而不必在与电子或试剂离子相互作用之前分离单独的分析物离子。

公开(公告)号：US09082604B2

公开(公告)日：2015-07-14

申请号：US13522458

申请日：2010-11-24

Applicant: Anatoly Verenchikov

Inventor： Anatoly Verenchikov

IPC: H01J49/28 ,  H01J49/42 ,  H01J49/40

CPC classification number: H01J49/282 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/062 ,  H01J49/40 ,  H01J49/401 ,  H01J49/406 ,  H01J49/4245

Abstract: Electrostatic trap mass spectrometers are disclosed that may comprise at least two parallel sets of electrodes separated by a field-free space, wherein said at least two parallel electrode sets extend along a curved Z-direction locally orthogonal to said X-Y plane such that each of said two electrode sets define a volume with a two-dimensional electrostatic field in an X-Y plane and define either planar or torroidal field regions; means for adjusting the torroidal field regions to provide both (i) stable trapping of ions passing between said fields within said X-Y plane and (ii) isochronous repetitive ion oscillations within said X-Y plane such that the stable ion motion does not require any orbital or side motion; and an ion bounding means in the curved Z-direction configured to compensate time-of-flight distortions at Z-edges of the trap.

Abstract translation: 公开了静电捕获质谱仪，其可以包括由无场空间分开的至少两个平行的电极组，其中所述至少两个平行电极组沿着与所述XY平面正交的局部弯曲的Z方向延伸，使得每个所述 两个电极组限定了在XY平面中具有二维静电场的体积并且限定了平面或环形场区域; 用于调节环形场区以提供（i）在所述XY平面内的所述场之间通过的离子的稳定捕获和（ii）所述XY平面内的同步重复离子振荡的装置，使得稳定的离子运动不需要任何轨道或​​侧面 运动; 并且弯曲Z方向上的离子界限装置被配置为补偿陷阱的Z边缘处的飞行时间失真。