公开(公告)号：US20120133775A1

公开(公告)日：2012-05-31

申请号：US13020997

申请日：2011-02-04

Applicant: Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

Inventor： Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

IPC: H01L27/146 ,  H04N5/33

CPC classification number: G01J3/32 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/36 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N33/0057

Abstract: A system and method for hyperspectral imaging to detect hazardous agents including explosive agents. A system comprising a tunable laser, a collection optics, and one or more hyperspectral imaging detectors configured for hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material via a tunable laser to thereby generate a plurality of interacted photons. Detecting said interacted photons to generate at least one hyperspectral image representative of the target. One or more hyperspectral images may be obtained including SWIR, MWIR, and LWIR hyperspectral images. Algorithms and chemometric techniques may be applied to assess the hyperspectral images to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using hyperspectral imaging.

Abstract translation: 用于高光谱成像检测危险物质（包括爆炸物）的系统和方法。 一种包括可调激光器，收集光学器件和一个或多个高光谱成像检测器的系统，其被配置用于包含未知材料的靶的超光谱成像。 一种方法，包括通过可调激光照射包括未知材料的靶，从而产生多个相互作用的光子。 检测所述相互作用的光子以产生代表目标的至少一个高光谱图像。 可以获得一个或多个高光谱图像，包括SWIR，MWIR和LWIR高光谱图像。 可以应用算法和化学计量技术来评估高光谱图像以将未知材料识别为包括爆炸剂或非爆炸剂。 视频成像装置还可以被配置为提供感兴趣区域的视频图像，其可以被评估以使用高光谱成像识别用于询问的目标。

公开(公告)号：US08184285B2

公开(公告)日：2012-05-22

申请号：US13157265

申请日：2011-06-09

Applicant: Christophe Moser ,  Frank Havermeyer

Inventor： Christophe Moser ,  Frank Havermeyer

IPC: G01J3/44

CPC classification number: G01J3/02 ,  G01J3/0227 ,  G01J3/44 ,  G02B5/32 ,  G03H1/0248

Abstract: The invention disclosed here teaches methods to fabricate and utilize a non-dispersive holographic wavelength blocker. The invention enables the observation of the Raman signal near the excitation wavelength (˜9 cm−1) with the compactness of standard thin film/holographic notch filter. The novelty is contacting several individual volume holographic blocking notch filter (VHBF) to form one high optical density blocking filter without creating spurious multiple diffractions that degrade the filter performance. Such ultra-narrow-band VHBF can be used in existing compact Raman instruments and thus will help bring high-end research to a greater number of users at a lower cost.

Abstract translation: 这里公开的发明教导了制造和利用非色散全息波长阻挡剂的方法。 本发明能够以标准薄膜/全息陷波滤波器的紧凑度观察激发波长（〜9cm -1）附近的拉曼信号。 新颖的是接触几个单独的体积全息阻塞陷波滤波器（VHBF）以形成一个高光密度阻塞滤波器，而不会产生降低滤波器性能的伪多重衍射。 这种超窄带VHBF可以用于现有的紧凑型拉曼仪器，从而有助于以更低的成本为更多的用户带来高端研究。

公开(公告)号：US08179526B2

公开(公告)日：2012-05-15

申请号：US12458815

申请日：2009-07-23

Applicant: Robert Bennett ,  Ian P. Hayward ,  Brian J. E. Smith

Inventor： Robert Bennett ,  Ian P. Hayward ,  Brian J. E. Smith

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0237 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/2803 ,  G01N21/65

Abstract: In a Raman spectroscopy apparatus, exciting light is focussed on a sample (26) as a line focus 38. Spectra from points in the line focus are dispersed in rows 46 on a CCD detector 34, having a two-dimensional array of pixels. The line focus moves longitudinally in a direction Y (arrow 48) relative to the sample. Simultaneously and synchronously, charge is shifted in a parallel direction Y′ (arrow 50) within the CCD, so that data from a given point in the sample continues to accumulate. This ensures that the data from each sample point arises from illumination which is integrated along the line focus, and makes it easier to stitch the data together subsequently to form an image of the sample. In order to provide averaging in the X direction during fast, low resolution scanning, the line focus is swept across the sample in a zig-zag fashion, between boundary lines 60.

Abstract translation: 在拉曼光谱仪器中，激发光聚焦在作为线焦点38的样品（26）上。来自线焦点中的点的光谱分散在具有二维像素阵列的CCD检测器34上的行46中。 线对焦相对于样品沿Y方向（箭头48）纵向移动。 同时同步地，电荷在CCD内沿平行方向Y'（箭头50）移动，使得来自样品中给定点的数据继续积累。 这确保来自每个采样点的数据来自沿着线焦点集成的照明，并且使得更容易将数据拼接在一起以形成样本的图像。 为了在快速，低分辨率扫描期间在X方向上提供平均，在边界线60之间以线锯方式扫描线对焦。

公开(公告)号：US20120092662A1

公开(公告)日：2012-04-19

申请号：US13257194

申请日：2010-03-19

Applicant: Wolfgang Langbein ,  Paola Borri

Inventor： Wolfgang Langbein ,  Paola Borri

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/44 ,  G01N2021/653

Abstract: A coherent anti-Stokes Raman spectroscopy (CARS) system comprises a laser light source for emitting pulsed light, a dichroic beam splitter for splitting a light pulse from the light source into a pump pulse and a Stokes pulse and directing these pulses along respective distinct paths, chirping means, e.g. dispersive glass blocks for chirping the pump and Stokes pulses, directing means for directing the chirped pump and Stokes samples to a sample in time overlap, and detecting means for detecting light stimulated from the sample by the interaction of the pump and Stokes pulses. The system may comprise a reflector connected to a linear motor, for adjusting the period between the arrival at the sample of the starts of the chirped pump and Stokes pulses. The system may further comprise a pulse replicating unit for converting a pulse from the light source into a plurality of pulses distributed in time.

Abstract translation: 相干的反斯托克斯拉曼光谱（CARS）系统包括用于发射脉冲光的激光光源，用于将来自光源的光脉冲分解为泵脉冲和斯托克斯脉冲的二向色分束器，并将这些脉冲引导到相应的不同路径 啁啾手段，例如 用于啁啾泵和斯托克斯脉冲的分散玻璃块，用于将啁啾的泵和斯托克斯样品以时间重叠的方式引导到样品的引导装置，以及用于通过泵和斯托克斯脉冲的相互作用检测从样品刺激的光的检测装置。 系统可以包括连接到线性电动机的反射器，用于调节到达啁啾泵的起始点与斯托克斯脉冲之间的时间段。 该系统还可以包括用于将来自光源的脉冲转换成在时间上分布的多个脉冲的脉冲复制单元。

公开(公告)号：US20120050731A1

公开(公告)日：2012-03-01

申请号：US12574379

申请日：2009-10-06

Applicant: David A. Fattal ,  Zhiyong Li ,  Qiangfei Xia

Inventor： David A. Fattal ,  Zhiyong Li ,  Qiangfei Xia

IPC: G01J3/44 ,  B23P11/02

CPC classification number: G01J3/44 ,  G01N21/658 ,  Y10T29/49865

Abstract: An optical device for surface enhanced Raman spectroscopy includes a substrate, and at least one antenna established thereon. The at least one antenna including at least two segments, where each segment is formed of a metal having a predetermined volume and a predetermined contact angle with respect to the substrate. A gap is located between the two segments. The gap has a controllable size such that the at least one antenna resonates at a predetermined frequency that corresponds with the gap.

Abstract translation: 用于表面增强拉曼光谱的光学装置包括衬底和建立在其上的至少一个天线。 所述至少一个天线包括至少两个段，其中每个段由具有预定体积的金属和相对于衬底的预定接触角形成。 两个部分之间有间隙。 间隙具有可控制的尺寸，使得至少一个天线以与间隙对应的预定频率谐振。

公开(公告)号：US08114022B2

公开(公告)日：2012-02-14

申请号：US11449937

申请日：2006-06-09

Applicant: Jonathan Mark Crowther ,  Anke Sieg ,  Paul Jonathan Matts ,  Peter Blenkiron

Inventor： Jonathan Mark Crowther ,  Anke Sieg ,  Paul Jonathan Matts ,  Peter Blenkiron

IPC: A61B5/00 ,  A61B6/00

CPC classification number: G01J3/44 ,  G01N21/65 ,  G01N2021/656 ,  G06Q30/0242 ,  G06Q30/0269

Abstract: Business method for generating advertising claims by utilizing Confocal Raman Spectroscopy (CRS) for dermatological studies. The methods of the invention can be carried in vitro (either artificial skin or a sample of skin) or in vivo (directly on the human skin of a person).

Abstract translation: 通过利用共焦拉曼光谱法（CRS）进行皮肤病学研究来产生广告宣称的商业方法。 本发明的方法可以在体外（人造皮肤或皮肤样品）或体内（直接在人的人皮肤上）进行。

公开(公告)号：US08102525B2

公开(公告)日：2012-01-24

申请号：US12403522

申请日：2009-03-13

Applicant: Xun Guo ,  Hong Wang ,  Chunwei Liu

Inventor： Xun Guo ,  Hong Wang ,  Chunwei Liu

IPC: G01J3/44

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/44 ,  G01N21/15 ,  G01N21/658 ,  G01N21/94 ,  G01N2021/656

Abstract: A method for detecting an ingredient in a food product or detecting a disease includes allowing a food sample solution obtained from a food product or a body fluid from an individual to come to contact with a nano-scale surface structure in a sensor, wherein the nano-scale surface structure comprises a plurality of columns over a substrate or a plurality of holes in a substrate. The method includes illuminating the food sample solution or the body fluid on the nano-scale surface structure on the sensor by a laser beam; obtaining a Raman spectrum from the scattered light using a spectral analyzer; and identifying the spectral signature in the Raman spectrum to determine the existence of the chemical substance in the food product or identifying a disease in the individual.

Abstract translation: 用于检测食品中的成分或检测疾病的方法包括使得从个体的食品或体液获得的食品样品溶液与传感器中的纳米级表面结构接触，其中所述纳米 尺寸表面结构包括在衬底上的多个柱或衬底中的多个孔。 该方法包括通过激光束照射传感器上的纳米级表面结构上的食物样品溶液或体液; 使用光谱分析仪从散射光获得拉曼光谱; 并确定拉曼光谱中的光谱特征，以确定食品中化学物质的存在或识别个体中的疾病。

公开(公告)号：US08094384B2

公开(公告)日：2012-01-10

申请号：US12961357

申请日：2010-12-06

Applicant: Greg S. Mungas ,  John Boynton ,  Cesar A. Sepulveda ,  Alicia Nunes de Sepulveda, legal representative ,  Yekta Gursel

Inventor： Greg S. Mungas ,  John Boynton ,  Cesar A. Sepulveda ,  Yekta Gursel

IPC: G02B9/60

CPC classification number: G01J3/0237 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/44 ,  G02B9/64 ,  G02B15/161 ,  G02B27/0018

Abstract: An optical system comprising two lens cells, each lens cell comprising multiple lens elements, to provide imaging over a very wide image distance and within a wide range of magnification by changing the distance between the two lens cells. An embodiment also provides scannable laser spectroscopic measurements within the field-of-view of the instrument.

Abstract translation: 一种包括两个透镜单元的光学系统，每个透镜单元包括多个透镜元件，以通过改变两个透镜单元之间的距离在非常宽的图像距离内和在宽的倍率范围内提供成像。 实施例还提供了在仪器的视场内的可扫描的激光光谱测量。

公开(公告)号：US08094302B2

公开(公告)日：2012-01-10

申请号：US12488510

申请日：2009-06-19

Applicant: Hiroyuki Minato

Inventor： Hiroyuki Minato

IPC: G01N21/64

CPC classification number: G01J3/44 ,  G01J3/28 ,  G01N21/05 ,  G01N21/645 ,  G01N30/74 ,  G01N2021/6419 ,  G01N2021/6421

Abstract: Disclosed herein is a spectrophotometer. The spectrophotometer includes a CPU having a signal prediction part and a comparison/calculation part. The signal prediction part predicts the strength of an output signal from a photodetection unit during the next period based on the strength of the output signal from the photodetection unit. The comparison/calculation part compares a reference value, which defines the limit value of electrical current passing through a photomultiplier tube, of the strength of an output signal from an AD converter with a predicted value predicted by the signal prediction part. In a case where the predicted value exceeds the reference value, a voltage applied to the photomultiplier tube is calculated so that the strength of an output signal from the photodetection unit during the next period does not exceed the reference value. An applied voltage control part is configured to perform applied voltage control based on an applied voltage value calculated by the comparison/calculation part when the predicted value of the strength of an output signal from the photodetection unit during the next period exceeds the reference value.

Abstract translation: 本文公开了一种分光光度计。 分光光度计包括具有信号预测部和比较/计算部的CPU。 信号预测部基于来自光检测单元的输出信号的强度来预测在下一周期期间来自光电检测单元的输出信号的强度。 比较/计算部分将通过光电倍增管的电流的限制值的参考值与来自AD转换器的输出信号的强度与由信号预测部预测的预测值进行比较。 在预测值超过参考值的情况下，计算施加到光电倍增管的电压，使得在下一时段期间来自光电检测单元的输出信号的强度不超过参考值。 施加电压控制部被配置为当在下一周期期间来自光电检测单元的输出信号的强度的预测值超过参考值时，基于由比较/计算部分计算的施加电压值来执行施加的电压控制。

公开(公告)号：US08081309B2

公开(公告)日：2011-12-20

申请号：US12591584

申请日：2009-11-24

Applicant: Minoru Kobayashi ,  Taisuke Ota ,  Takahiro Ode

Inventor： Minoru Kobayashi ,  Taisuke Ota ,  Takahiro Ode

IPC: G01J3/30

CPC classification number: G01J3/44 ,  G01J3/0278 ,  G01J3/06 ,  G02B7/36 ,  G02B21/241

Abstract: An optical microscope applies laser light to a sample through the an objective lens, detects reflected light reflected by the sample through the objective lens, changes a focal position of the laser light in an optical axis direction, extracts a focal position for spectrum measurement based on a detection result of the reflected light when the focal position of the laser light is changed, adjusts the focal position to coincide with the extracted focal position, separates outgoing light exiting from the sample by application of the laser light with the adjusted focal position from the laser light, and measures a spectrum of the outgoing light separated from the laser light with a spectroscope.

Abstract translation: 光学显微镜通过物镜对样品施加激光，通过物镜检测由样品反射的反射光，在光轴方向上改变激光的焦点位置，提取用于光谱测量的焦点位置，基于 当激光的焦点位置改变时反射光的检测结果调整焦点位置与提取的焦点位置一致，通过从调色剂焦点位置施加具有激光的出射光， 激光，并用分光镜测量与激光分离的出射光谱。