公开(公告)号：US10983045B2

公开(公告)日：2021-04-20

申请号：US16340550

申请日：2017-10-11

Applicant: VICTORIA LINK LIMITED

Inventor： Brendan Liam Darby ,  Eric Le Ru ,  Matthias Meyer

IPC: G01J3/02 ,  G01J3/08 ,  G01N21/25 ,  G01J3/42 ,  G01J3/44 ,  G01N21/03

Abstract: A spectrometer apparatus for measuring spectra of a liquid sample, such as a beverage like wine. The apparatus has an integrating cavity with a reflective inner wall to receive a cuvette containing the liquid sample within the integrating cavity. A combination of light inlet ports and light outlet ports are provided to receive light from at least one light source and deliver light to a spectrometer. A light path adjuster is configured to selectively adjust a light path through the integrating cavity so at least two distinct light paths are provided wherein when the light path adjuster is in a first configuration, the apparatus is in transmission mode in which light from the light source follows a first light path; when the light path adjuster is in a second configuration, the apparatus is in a diffusely reflecting mode in which light from the light source follows a second light path.

公开(公告)号：US10976577B1

公开(公告)日：2021-04-13

申请号：US16691560

申请日：2019-11-21

Applicant: National Central University

Inventor： Kun-Yu Lai ,  Fan-Ching Chien

IPC: G02F1/017 ,  G01J3/44 ,  G01J3/02 ,  G01N21/65

Abstract: A sensing substrate including a substrate, a quantum well structure, a sensing surface and metal nanoparticles is provided. The quantum well structure is disposed on the substrate, and the quantum well structure includes at least one first metal nitride layer and second metal nitride layers. The first metal nitride layers and the second metal nitride layers are stacked on the substrate in alternation manner. The quantum well structure is located between the sensing surface and the substrate. The metal nanoparticles are disposed on the sensing surface, and the sensing surface is a rough surface. A manufacturing method of the sensing substrate and a sensor are also provided.

公开(公告)号：US10962482B2

公开(公告)日：2021-03-30

申请号：US16533787

申请日：2019-08-07

Applicant: NATIONAL TSING HUA UNIVERSITY

Inventor： yu-hsuan Chen ,  Hsuen-Li Chen ,  De-hui Wan

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/58

Abstract: A surface enhanced Raman scattering device includes a substrate including a substrate surface having a substrate surface energy; a modulation layer formed on the substrate surface and including a modulation layer surface having a modulation layer surface energy; and a surface enhanced Raman scattering structure formed on the modulation layer surface. The modulation layer surface energy is less than the substrate surface energy. A method of manufacturing the surface enhanced Raman scattering device is also provided.

公开(公告)号：US10958855B2

公开(公告)日：2021-03-23

申请号：US16450374

申请日：2019-06-24

Applicant: Palo Alto Research Center Incorporated

Inventor： Alex Hegyi ,  Joerg Martini

IPC: G01J3/00 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  H04N5/33 ,  G02F1/13 ,  G01J3/12 ,  G02F1/01 ,  G02F1/133 ,  G02F1/1347 ,  G02F1/139

Abstract: A medical system comprising a hand-held imaging device comprising optical components including a light source to illuminate an area of medical interest, a liquid crystal variable retarder to receive light from the area of medical interest, and a retardance controller to provide a driving waveform to the variable retarder that controls retardance. The device also includes an image sensor configured to receive light from the variable retarder and to convert the received light into an output voltage signal for either the camera operation or the hyperspectral imaging operation, and communication circuitry configured to communicate imaging information based on the output voltage signal to a medical diagnostic system. The hand-held imaging device is configured to switchably perform a hyperspectral imaging and a camera operation such that the operations share at least one optical component. The diagnostic device is configured to receive the imaging information and to provide diagnostic information based thereon.

公开(公告)号：US10942123B2

公开(公告)日：2021-03-09

申请号：US16345061

申请日：2017-10-27

Applicant: UNITED KINGDOM RESEARCH AND INNOVATION

Inventor： Pavel Matousek ,  Nicholas Stone ,  Benjamin Gardner

IPC: G01J3/44 ,  G01N21/65 ,  G01N33/483

Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.

公开(公告)号：US10928324B2

公开(公告)日：2021-02-23

申请号：US16470119

申请日：2017-12-14

Applicant: Purdue Research Foundation ,  Chien-Sheng Liao ,  Pu Wang ,  Ji-Xin Cheng

Inventor： Chien-Sheng Liao ,  Pu Wang ,  Ji-Xin Cheng

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/10 ,  G01J3/433

Abstract: A microsecond-scale stimulated Raman spectroscopic imaging system having a light source, such as a laser output that provides two femtosecond laser beams and a modulator to modulate the laser intensity at frequency between about 1 and about 100 megahertz. The system can further include a medium that chirps the two femtosecond beams to generate a spectral focus in a specimen, and a galvo mirror or resonant mirror pair to scan the two femtosecond beams in two dimension on the specimen. An objective lens can focus the two laser beams into a specimen or sample and a resonant delay scanner configured to produce an optical delay to the pair of chirped beams in said specimen and a tuned amplifier or lock-in amplifier can be used to extract the stimulated Raman-signal shift at the aforementioned modulation frequency.

公开(公告)号：US10921187B2

公开(公告)日：2021-02-16

申请号：US16351174

申请日：2019-03-12

Applicant: Daryoosh Vakhshoori ,  Romain Blanchard ,  Peili Chen ,  Masud Azimi ,  Tobias Mansuripur ,  Kalyani Krishnamurthy ,  Arran M. Bibby ,  Fred R. Huettig, III ,  Gokhan Ulu ,  Greg Vander Rhodes

Inventor： Daryoosh Vakhshoori ,  Romain Blanchard ,  Peili Chen ,  Masud Azimi ,  Tobias Mansuripur ,  Kalyani Krishnamurthy ,  Arran M. Bibby ,  Fred R. Huettig, III ,  Gokhan Ulu ,  Greg Vander Rhodes

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/28 ,  G01J3/06 ,  H01S3/00 ,  G01K11/3213 ,  H01S3/094 ,  H01S3/108 ,  H01S3/30 ,  G01K11/32

Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.

公开(公告)号：US10921184B2

公开(公告)日：2021-02-16

申请号：US16487197

申请日：2017-03-30

Applicant: OPTIQGAIN LTD.

Inventor： Ram Alon ,  Rotem Tzuk

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/10 ,  G01N21/65 ,  H01S5/00 ,  H01S5/40

Abstract: The present application describes embodiments of a stimulated Raman scattering (SRS) spectroscope based on a passive Q-switch system for high-resolution, real-time, on-site and multi-point industrial molecular analysis.

公开(公告)号：US10914682B2

公开(公告)日：2021-02-09

申请号：US16028998

申请日：2018-07-06

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Ozan Akkus ,  Shan Yang

IPC: G01N21/65 ,  G01J3/28 ,  G01J3/44 ,  G01J3/02 ,  G01J3/10 ,  G01J3/26 ,  G01J3/50

Abstract: A hyperspectral Raman imaging system having the ability to focus on excitation laser beam over a relatively wide field of view due to the use of a lens array, in particular a microlens array. Hyperspectral selection is provided in one embodiment through the use of dual-axis controlled dielectric filtration. Methods for analyzing materials with the system are disclosed. The device or system can be used in generally any application where investigation of materials is required.

公开(公告)号：US20210025757A1

公开(公告)日：2021-01-28

申请号：US16604557

申请日：2018-04-12

Applicant: CAPTL LLC

Inventor： Masanobu Yamamoto ,  Keegan Hernandez ,  J. Paul Robinson

IPC: G01J3/44 ,  G01J3/02

Abstract: A measurement system includes an optical source (e.g., laser) to irradiate a sample (e.g., a cell); a solid-state photon detector (SSPD) to receive resultant light from the sample; and a photon counter to count photons received by the SSPD. The photon counter can include a differentiator to provide a differentiated photon signal and a crossing detector configured to count photons based on a number of times the differentiated photon signal crosses a predetermined threshold level. In some examples, a pulse detector can provide a pulse-width signal from the SSPD output photon signal, and a pulse counter can count based on both a number of pulses and widths of the pulses. The SSPD can include a silicon photomultiplier (SiPM) array or a solid-state photomultiplier. Some examples use the measurement system to measure samples in fluids, e.g., in flow cytometers or multi-well plates.