公开(公告)号：US08068222B2

公开(公告)日：2011-11-29

申请号：US11757146

申请日：2007-06-01

Applicant: Jingyun Zhang

Inventor： Jingyun Zhang

IPC: G01J3/44

CPC classification number: G01J3/2823 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/44 ,  G02B6/06

Abstract: A novel approach for chemical imaging is disclosed. In one embodiment, the disclosure relates to a system for producing a spatially accurate wavelength-resolved image of a sample from photons scattered from the sample, comprising an optical lens; a first optical fiber bundle of M fibers; a second optical fiber bundle of N fibers; an optical fiber switch; and a charge coupled device, wherein the image comprises plural sub-images, and wherein each sub-image is formed from photons scattered from a predetermined two spatial dimension portion of the sample, and wherein the scattered photons forming each sub-image have a predetermined wavelength different from a predetermined wavelength of scattered photons forming the other sub-images, and wherein the scattered photons for each sub-image are collected substantially simultaneously.

Abstract translation: 公开了一种新颖的化学成像方法。 在一个实施例中，本公开涉及一种用于从包含光学透镜的样品散射的光子产生样品的空间上准确的波长分辨图像的系统; M纤维的第一光纤束; N纤维的第二光纤束; 光纤交换机; 以及电荷耦合器件，其中所述图像包括多个子图像，并且其中每个子图像由从样本的预定的两个空间维度部分散射的光子形成，并且其中形成每个子图像的散射光子具有预定的 波长不同于形成其他子图像的散射光子的预定波长，并且其中基本上同时收集每个子图像的散射光子。

公开(公告)号：US08064064B2

公开(公告)日：2011-11-22

申请号：US12370581

申请日：2009-02-12

Applicant: Dug Young Kim ,  Seung Bum Cho

Inventor： Dug Young Kim ,  Seung Bum Cho

IPC: G01J3/45

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2021/653

Abstract: Disclosed is an apparatus and method for obtaining images using coherent anti-stokes Raman scattering. The apparatus for obtaining images using coherent anti-stokes Raman scattering according to the present invention comprises: a pump light source and a stokes light source that irradiate pump light and stokes light on a sample to generate anti-stokes light having anti-stokes frequency; a reference light source that generates reference light; and an image obtaining unit that obtains the images of the sample using a change in phase of the reference light due to a change in the refractive index of the sample in the vicinity of the anti-stokes frequency. Thereby, the present invention can provide the apparatus for obtaining images using coherent anti-stokes Raman scattering that is not affected by a non-resonant background signal phenomenon, strong resistance against noise even in a weak signal, and has excellent sensitivity and resolution.

Abstract translation: 公开了一种使用相干反斯托克斯拉曼散射获得图像的装置和方法。 根据本发明的使用相干反斯托克斯拉曼散射获得图像的装置包括：泵浦光源和斯托克斯光源，其照射泵浦光并将光束照射在样品上以产生具有反斯托克斯频率的反斯托克斯光; 产生参考光的参考光源; 以及图像获取单元，其由于在反斯托克斯频率附近的样品的折射率的变化而使用参考光的相位变化来获得样本的图像。 因此，本发明可以提供使用不受非谐振背景信号现象影响的相干反斯托克斯拉曼散射获得图像的装置，即使在弱信号中也具有很强的抵抗噪声，并且具有优异的灵敏度和分辨率。

公开(公告)号：US08054461B2

公开(公告)日：2011-11-08

申请号：US12286490

申请日：2008-09-30

Applicant: Huei Pei Kuo ,  Jing Tang ,  Alexandre M. Bratkovski ,  Theodore I. Kamins ,  Wei Wu ,  Michael Renne Ty Tan ,  Shih-Yuan Wang

Inventor： Huei Pei Kuo ,  Jing Tang ,  Alexandre M. Bratkovski ,  Theodore I. Kamins ,  Wei Wu ,  Michael Renne Ty Tan ,  Shih-Yuan Wang

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/0291 ,  G01N21/658 ,  G01N2021/651

Abstract: Various embodiments of the present invention relate generally to systems for performing Raman spectroscopy. In one embodiment, a system for performing Raman spectroscopy comprises an analyte holder having a surface configured to retain an analyte and a light concentrator configured to receive an incident beam of light, split the incident beam into one or more beams, and direct the one or more beams to substantially intersect at the surface. The system may also include a collector configured to focus each of the one or more beams onto the surface, collect the Raman scattered light emitted from the analyte, and direct the Raman scattered light away from the surface.

Abstract translation: 本发明的各种实施方案一般涉及用于进行拉曼光谱的系统。 在一个实施例中，用于执行拉曼光谱的系统包括分析物保持器，其具有被配置为保持分析物的表面和被配置为接收入射光束的光聚集器，将入射光束分成一个或多个光束， 更多的光束在表面上基本相交。 该系统还可以包括集电器，其被配置为将一个或多个光束中的每一个聚焦到表面上，收集从分析物发射的拉曼散射光，并将拉曼散射光引导离开表面。

公开(公告)号：US20110213746A1

公开(公告)日：2011-09-01

申请号：US12713318

申请日：2010-02-26

Applicant: Edita Botonjic-Sehic ,  James H. Grassi ,  Hacene Boudries ,  Ivan E. Freeman, JR. ,  Young Kyo Lee ,  Sridhar Venkataraman Dasaratha ,  Thirukazhukundram Subrahmaniam Vignesh ,  Saratchandra Shanmukh ,  Malathi Yarra

Inventor： Edita Botonjic-Sehic ,  James H. Grassi ,  Hacene Boudries ,  Ivan E. Freeman, JR. ,  Young Kyo Lee ,  Sridhar Venkataraman Dasaratha ,  Thirukazhukundram Subrahmaniam Vignesh ,  Saratchandra Shanmukh ,  Malathi Yarra

IPC: G06N7/02 ,  C40B30/02 ,  C40B60/12 ,  G06F17/30

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/44 ,  G01N2201/0221 ,  G01N2201/1293 ,  G01N2201/1296

Abstract: A method for analyzing a mixture includes identifying a plurality of possible components of the mixture, calculating at least one feature for at least a portion of the plurality of possible components, and calculating a probability value for at least a portion of the plurality of possible components based on the at least one feature and at least one transfer function

Abstract translation: 一种用于分析混合物的方法包括识别所述混合物的多个可能的分量，计算所述多个可能分量的至少一部分的至少一个特征，以及计算所述多个可能分量的至少一部分的概率值 基于所述至少一个特征和至少一个传递函数

公开(公告)号：US08005772B2

公开(公告)日：2011-08-23

申请号：US11914991

申请日：2006-06-15

Applicant: Larry Eshelman

Inventor： Larry Eshelman

IPC: G06F15/18 ,  G06N3/00 ,  G06N3/12

CPC classification number: G01J3/44 ,  G01N21/274 ,  G01N21/65 ,  G01N2201/129 ,  G01N2201/1293 ,  G06K9/00523

Abstract: Cross over (S560) in a genetic algorithm (128) is adapted for deriving an optimal mask (S540), or set of segments of a line. Each mask of a chromosome is subject to cross over with the respective mask of the other parent. Any overlapping part, whether a filtering (320) or pass-through part (350), is retained in the child (334) to preserve commonality. The part is preferably, potentially extended, according to one parent or the other, as decided pseudo-randomly (430). In a preferred application, spectrums of candidate blood constituents are masked for fitting to ensemble spectrums of test blood samples (S610, S620). The developed masks are applicable to constituent spectrums to create masked spectrums (S710) which are then applicable to an actual blood sample to be analyzed (S720).

Abstract translation: 遗传算法（128）中的交叉（S560）适于导出最佳掩码（S540）或一行的段的集合。 染色体的每个掩模与另一个亲本的相应掩模交叉。 任何重叠的部分，无论是过滤（320）还是直通部分（350）都保留在子（334）中以保持共同性。 该部分优选地，根据一个父或另一个，如伪随机地确定（430）潜在地扩展。 在优选的应用中，候选血液成分的光谱被掩蔽以适合测试血液样品的综合谱（S610，S620）。 开发的掩模适用于构成光谱的组件光谱（S710），然后将其应用于待分析的实际血液样本（S720）。

公开(公告)号：US07967910B2

公开(公告)日：2011-06-28

申请号：US11601822

申请日：2006-11-20

Applicant: Yuki Matsunami

Inventor： Yuki Matsunami

IPC: C30B29/62

CPC classification number: G01N21/658 ,  B22F2998/00 ,  B82Y15/00 ,  G01J3/44 ,  Y10T117/1008 ,  B22F1/0025

Abstract: A fine structure body comprises: (i) a base body, and (ii) a plurality of metal nanorods, which have been distributed and located on a surface of the base body, a proportion X being equal to at least 15%, the proportion X being calculated with the formula: X=(A−B)/C×100[%] wherein A represents the sum total of the projected areas of all of the metal nanorods, B represents the sum total of the projected areas of certain metal nanorods, each of which is located as an isolated metal nanorod at a spacing larger than 10 nm from the closest metal nanorod, and C represents the entire projected area of the fine structure body, including regions free from the metal nanorods.

Abstract translation: 精细结构体包括：（i）基体，和（ii）分布并位于基体表面上的多个金属纳米棒，比例X等于至少15％，比例 X用下式计算：X =（A-B）/ C×100 [％]其中A表示所有金属纳米棒的投影面积的总和，B表示某些金属的投影面积的总和 纳米棒各自作为离离最近的金属纳米棒的距离大于10nm的隔离金属纳米棒，C表示精细结构体的整个投影面积，包括没有金属纳米棒的区域。

公开(公告)号：US20110151586A1

公开(公告)日：2011-06-23

申请号：US12994006

申请日：2009-05-22

Applicant: Hongyu Chen ,  Miaoxin Yang ,  Jun Xu ,  Yuhua Feng

Inventor： Hongyu Chen ,  Miaoxin Yang ,  Jun Xu ,  Yuhua Feng

IPC: G01N21/65 ,  G01N33/545 ,  B05D3/00

CPC classification number: G01J3/44 ,  B22F1/0062 ,  B22F2998/00 ,  B22F2998/10 ,  B82Y15/00 ,  G01N21/658 ,  G01N33/532 ,  G01N33/553 ,  B22F1/0018 ,  B22F2202/17

Abstract: The present invention refers to a Raman active composite material comprising a metal particle; a coating layer of a Raman active molecule bound to the metal particle; and an encapsulating layer of an amphiphilic polymer bound to the metal particle. The present invention also refers to methods of manufacturing a Raman active composite material described herein and their uses.

Abstract translation: 本发明涉及包含金属颗粒的拉曼活性复合材料; 与金属颗粒结合的拉曼活性分子的涂层; 以及与金属颗粒结合的两亲性聚合物的包封层。 本发明还涉及本文所述的拉曼活性复合材料的制造方法及其用途。

公开(公告)号：US20110141582A1

公开(公告)日：2011-06-16

申请号：US12961357

申请日：2010-12-06

Applicant: Greg S. Mungas ,  John Boynton ,  Cesar A. Sepulveda ,  Alicia Nunes de Sepulveda ,  Yekta Gursel

Inventor： Greg S. Mungas ,  John Boynton ,  Cesar A. Sepulveda ,  Alicia Nunes de Sepulveda ,  Yekta Gursel

IPC: G02B9/60

CPC classification number: G01J3/0237 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/44 ,  G02B9/64 ,  G02B15/161 ,  G02B27/0018

Abstract: An optical system comprising two lens cells, each lens cell comprising multiple lens elements, to provide imaging over a very wide image distance and within a wide range of magnification by changing the distance between the two lens cells. An embodiment also provides scannable laser spectroscopic measurements within the field-of-view of the instrument.

Abstract translation: 一种包括两个透镜单元的光学系统，每个透镜单元包括多个透镜元件，以通过改变两个透镜单元之间的距离在非常宽的图像距离内和在宽的倍率范围内提供成像。 实施例还提供了在仪器的视场内的可扫描的激光光谱测量。

公开(公告)号：US07956997B2

公开(公告)日：2011-06-07

申请号：US12246616

申请日：2008-10-07

Applicant: Hong Wang ,  Xun Guo ,  Chunwei Liu

Inventor： Hong Wang ,  Xun Guo ,  Chunwei Liu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01N21/15 ,  G01N21/658 ,  G01N21/94 ,  G01N2021/656

Abstract: A method for detecting an ingredient in a food product includes establishing a spectral signature in a Raman spectrum obtained from a chemical substance; allowing a food sample solution obtained from a food product to come to contact with a first nano-scale surface structure in a first sensor, wherein the first sensor comprises a substrate, wherein the nano-scale surface structure comprises a plurality of columns over the substrate or a plurality of holes in the substrate; illuminating the food sample solution and the first nano-scale surface structure on the first sensor by a laser beam; scattering the laser beam by the food sample solution and the first nano-scale surface structure to produce a scattered light; obtaining a first Raman spectrum from the scattered light using a spectral analyzer; and identifying the spectral signature in the first Raman spectrum to determine the existence of the chemical substance in the food product.

Abstract translation: 检测食品中成分的方法包括：以化学物质获得的拉曼光谱建立光谱特征; 允许从食品获得的食品样品溶液与第一传感器中的第一纳米级表面结构接触，其中所述第一传感器包括基底，其中所述纳米级表面结构包括在所述基底上的多个柱 或基板中的多个孔; 通过激光束照射第一传感器上的食物样品溶液和第一纳米级表面结构; 通过食品样品溶液和第一纳米级表面结构散射激光束以产生散射光; 使用光谱分析仪从散射光获得第一拉曼光谱; 并确定第一拉曼光谱中的光谱特征，以确定食品中化学物质的存在。

公开(公告)号：US20110102565A1

公开(公告)日：2011-05-05

申请号：US12441420

申请日：2007-09-28

Applicant: Xinghua Wang ,  Patrick Treado ,  Charles W. Gardner ,  David Tuschell ,  Jingyun Zhang

Inventor： Xinghua Wang ,  Patrick Treado ,  Charles W. Gardner ,  David Tuschell ,  Jingyun Zhang

IPC: H04N7/18

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/32 ,  G01J3/36 ,  G01J3/447

Abstract: Macroscopic and microscopic samples are imaged through a spectral filter operable into the short wave infrared, e.g., to approximately 3200 nm. The sample is illuminated for reflective, transmissive, fluorescent and/or Raman imaging by a laser or metal-halide arc beam. The filter has tunable birefringent retarders distributed rotationally and stacked in stages leading up to a selection polarizer. Image forming optics and CCD cameras collect the luminance of each pixel in the spatially resolved image, at multiple wavelengths to which the filter is tuned successively. The filter stages have comb shaped transmission characteristics. Two filter stages with distinctly different characteristics can be cascaded, one or both being tunable. The combined transmission characteristic has narrow passbands where the bandpass peaks of the stages coincide and wide free spectral range where the peaks do not coincide. Embodiments are disclosed for forensic analysis, material composition and morphology, chemical compound identification and detection of biological species.

Abstract translation: 宏观和微观样品通过可操作成短波红外光谱的光谱滤光片成像，例如达到约3200nm。 通过激光或金属卤化物弧光束对样品进行反射，透射，荧光和/或拉曼成像。 滤光器具有可调谐的双折射延迟器，其分级旋转并且分级地分层导向选择偏振器。 图像形成光学器件和CCD照相机在多个波长下收集空间分辨图像中每个像素的亮度，其中滤波器依次被调谐到这些波长。 过滤器级具有梳状传动特性。 可以级联具有明显不同特性的两个过滤器级，一个或两个可调谐。 组合传输特性具有窄通带，其中级的带通峰重合，峰的自由光谱范围不一致。 公开了用于法医分析，材料组成和形态，化学化合物鉴定和生物物种检测的实施例。