公开(公告)号：US09664680B2

公开(公告)日：2017-05-30

申请号：US15059797

申请日：2016-03-03

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James Baker ,  Peter Abel ,  Robert William Lea

IPC: G01N33/49 ,  G01N33/574 ,  G01N21/552 ,  G01N33/00 ,  G01N33/566 ,  C40B30/04 ,  G01N21/35 ,  G01J3/433 ,  G01N21/63 ,  G01N30/74 ,  G01N21/31

CPC classification number: G01N33/57407 ,  G01J3/433 ,  G01N21/35 ,  G01N21/552 ,  G01N21/63 ,  G01N33/49 ,  G01N33/574 ,  G01N2021/3196 ,  G01N2021/3595 ,  G01N2030/743 ,  G01N2201/129 ,  G01N2800/52 ,  G01N2800/7028

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

公开(公告)号：US09645076B2

公开(公告)日：2017-05-09

申请号：US14583288

申请日：2014-12-26

Applicant: General Electric Company

Inventor： Nagapriya Kavoori Sethumadhavan ,  Sandip Maity ,  Samhitha Palanganda Poonacha ,  Moitrayee Mukherjee ,  Purbasha Halder ,  Harish Sasikumar ,  Prasenjit Pandey

IPC: G01N21/25 ,  G01N21/31 ,  G01J3/433 ,  G01N21/39 ,  G01N21/03 ,  G01N21/3504

CPC classification number: G01N21/31 ,  G01J3/433 ,  G01N21/03 ,  G01N21/3504 ,  G01N21/39 ,  G01N2201/061

Abstract: A method for determining a concentration of at least one individual gas present in a gas-mixture includes irradiating a first component by incident modulated-light-beams characterized by a determined absorption wavelength range, modulation frequencies and a modulation amplitudes to generate first transmitted-light-beams, irradiating a second component, comprising a determined concentration of the at least one individual gas, by the first incident modulated-light-beams to generate second transmitted-light-beams, generating noise signals representative of a characteristic of the first transmitted-light-beams, generating noise-free signals representative of a characteristic of the second transmitted-light-beams, selecting an optimal modulation frequency and an optimal modulation amplitude from the modulation frequencies and the modulation amplitudes based on the noise signals and the noise-free signals, and determining a concentration of the at least one individual gas in the gas-mixture based on the optimal modulation frequency and the optimal modulation amplitude of the determined absorption wavelength range.

公开(公告)号：US09606057B2

公开(公告)日：2017-03-28

申请号：US13701262

申请日：2011-06-01

Applicant: Joseph Kapelushnik ,  Shaul Mordechai ,  Ilana Nathan ,  Udi Zelig ,  Rami Zigdon

Inventor： Joseph Kapelushnik ,  Shaul Mordechai ,  Ilana Nathan ,  Udi Zelig ,  Rami Zigdon

IPC: G01N33/48 ,  C12Q1/04 ,  G01N21/63 ,  G01J3/433 ,  G01N21/35 ,  G01N21/3563

CPC classification number: G01N21/63 ,  G01J3/433 ,  G01N15/1456 ,  G01N21/35 ,  G01N21/3563 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2021/3595 ,  G01N2201/12

Abstract: A method is provided comprising, obtaining an infrared (IR) spectrum of a Peripheral Blood Mononuclear Cells (PBMC) sample by analyzing the sample by infrared spectroscopy; and based on the infrared spectrum, generating an output indicative of the presence of a solid tumor or a pre-malignant condition. Other embodiments are also provided.

公开(公告)号：US20170082421A1

公开(公告)日：2017-03-23

申请号：US15305713

申请日：2015-04-23

Applicant: UNIVERSITEIT GENT ,  IMEC VZW

Inventor： Roeland BAETS ,  Danaë DELBEKE ,  Günther ROELKENS ,  Wim BOGAERTS

IPC: G01B9/02 ,  G02B6/12 ,  G01J3/433 ,  G01N21/35

CPC classification number: G01B9/02051 ,  G01B9/02044 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/32 ,  G01J3/433 ,  G01N21/35 ,  G02B6/12019

Abstract: An integrated waveguide based spectrometer is described. The spectrometer comprises a sensing region for receiving multi-wavelength radiation for irradiating a sample in the sensing region, a wavelength demultiplexing element arranged for capturing said multi-wavelength radiation after interaction with the sample and for providing a number of wavelength demultiplexed radiation outputs or a number of different groups of wavelength demultiplexed radiation outputs, an integrated modulator for differently modulating the different demultiplexed radiation outputs or different groups of demultiplexed radiation outputs, and a multiplexer element for multiplexing the differently modulated demultiplexed radiation outputs or the differently grouped demultiplexed radiation outputs.

公开(公告)号：US20170045446A1

公开(公告)日：2017-02-16

申请号：US15223726

申请日：2016-07-29

Applicant: SICK AG

Inventor： Thomas BEYER ,  Julian EDLER

IPC: G01N21/39 ,  G01J3/433

CPC classification number: G01N21/39 ,  G01J3/10 ,  G01J3/433 ,  G01J2003/4332 ,  G01N2021/399 ,  G01N2201/12

Abstract: The invention relates to a method and to a spectrometer for determining the concentration of a gas component, wherein a light source of the spectrometer is operated as in WMS and thus a determination of the concentration can also take place in accordance with WMS and the measured data can, however, additionally be processed, namely a sorting takes place on the time axis, such that the concentration can be determined using the methods of DAS.

Abstract translation: 本发明涉及一种用于确定气体组分浓度的方法和光谱仪，其中光谱仪的光源像WMS那样操作，因此也可以根据WMS和测量数据进行浓度测定 然而，可以另外处理，即在时间轴上进行排序，使得可以使用DAS的方法确定浓度。

公开(公告)号：US20160370228A1

公开(公告)日：2016-12-22

申请号：US14898759

申请日：2014-10-24

Applicant: EINST TECHNOLOGY PTE LTD

Inventor： Wee Lee Tok ,  Eddie Khay Ming Tan

IPC: G01J3/02 ,  G01N21/65 ,  G02B26/04 ,  G01J3/44

CPC classification number: G01J3/0205 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/433 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/65 ,  G01N2201/06113 ,  G02B21/16 ,  G02B26/04

Abstract: According to various embodiments, a Raman spectroscopy method is provided for reduction of background fluorescence signal. The method may utilize a high speed optical chopper configured to periodically interrupt the laser light beam between the laser light source and the sample; and using the high speed optical chopper to provide a synchronized time-gated optical window for receiving mostly Raman signal while rejecting most or some of the fluorescence signal transmitted from the sample in response to the laser light beam before reaching the sensor

Abstract translation: 根据各种实施方案，提供拉曼光谱法以减少背景荧光信号。 该方法可以利用配置为周期性地中断激光光源和样品之间的激光束的高速光斩波器; 并且使用高速光斩波器来提供用于大部分拉曼信号的同步的时间门控窗口，同时在到达传感器之前响应于激光束排斥从样品传送的大部分或一些荧光信号

公开(公告)号：US20160252449A1

公开(公告)日：2016-09-01

申请号：US14423382

申请日：2014-03-07

Applicant: HALLIBURTON ENERGY SERVICES, INC.

Inventor： James M. Price ,  David L. Perkins

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01J3/0224 ,  G01J3/12 ,  G01J3/42 ,  G01J3/433 ,  G01N21/21 ,  G01N21/39 ,  G01N2201/0683

Abstract: Multivariate optical computing using polarizers to modulate the intensity of sample-interacted light. The polarizer(s), along with other device components, produce a spectroscopic intensity profile that mimics the regression vector that corresponds to the sample characteristic(s) of interest.

Abstract translation: 使用偏振器的多变量光学计算来调制样品相互作用光的强度。 偏振器与其它器件组件一起产生光谱强度分布，其模拟对应于感兴趣的样本特征的回归矢量。

公开(公告)号：US20160245755A1

公开(公告)日：2016-08-25

申请号：US15145840

申请日：2016-05-04

Applicant: Roche Diabetes Care, Inc.

Inventor： Gertrud Albrecht ,  Edgar Baumann ,  Markus Genthner-Riegler ,  Stefan Kalveram ,  Christian Niesporek ,  Kai-Oliver Schwenker ,  Markus Serr ,  Frederic Wehowski ,  Klaus Wettengel

IPC: G01N21/75

CPC classification number: G01N21/75 ,  G01J3/433 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/48707 ,  G01N33/4875 ,  G01N2021/7786 ,  G01N2201/0612 ,  G01N2201/0621 ,  G01N2201/0697

Abstract: Methods, analytical devices and analytical systems are provided for determining at least one analyte concentration in a body fluid sample. The methods, which may be incorporated into the devices and systems, can include the following steps: applying a body fluid to a test carrier; illuminating the test carrier by at least one light source, where the at least one light source is modulated by using at least two modulation frequencies; receiving light remitted by the test carrier by using at least one detector; determining an analyte concentration by evaluating at least one detector signal generated by the detector, where the detector signal is demodulated with the at least two modulation frequencies to generate at least two demodulated detector signals, each demodulated signal corresponding to one of the modulation frequencies; and detecting a fault by comparing the at least two demodulated detector signals.

Abstract translation: 提供了用于确定体液样品中至少一种分析物浓度的方法，分析装置和分析系统。 可以结合到装置和系统中的方法可以包括以下步骤：将体液施加到测试载体上; 通过至少一个光源照射测试载体，其中通过使用至少两个调制频率来调制至少一个光源; 通过使用至少一个检测器接收被测试载体所汇出的光; 通过评估由检测器产生的至少一个检测器信号来确定分析物浓度，其中检测器信号用至少两个调制频率解调以产生至少两个解调的检测器信号，每个解调信号对应于调制频率之一; 以及通过比较所述至少两个解调的检测器信号来检测故障。

公开(公告)号：US20160187252A1

公开(公告)日：2016-06-30

申请号：US14911365

申请日：2013-10-04

Applicant: HALLIBURTON ENERGY SERVICES INC.

Inventor： Michael T. Pelletier ,  David L. Perkins ,  Li Gao

IPC: G01N21/31 ,  G01V8/00 ,  G01J3/433

CPC classification number: G01N21/31 ,  G01J3/433 ,  G01N21/255 ,  G01N2021/3137 ,  G01N2021/317 ,  G01V8/00

Abstract: A system and method are disclosed for configuring an integrated computational element (ICE) to measure a property of a sample of interest. The system includes an illumination source to provide a sample light which is reflected from or transmitted through a sample. A dispersive element disperses the sample light into wavelength portions. An intensity modulation device having an array of electronically controllable modulation elements is disclosed that forms a pattern which modulates the dispersed sample light. Collection optics focuses the modulated sample light on a detector, which generates a signal that correlates to a property of the sample. The electronically controllable modulation elements can be readily altered to conform to a different measurable property of a sample of interest as desired.

Abstract translation: 公开了一种用于配置集成计算元件（ICE）以测量感兴趣样本的属性的系统和方法。 该系统包括照明源，以提供从样品反射或透射通过样品的样品光。 分散元件将样品光分散成波长部分。 公开了一种具有电子可控调制元件阵列的强度调制装置，其形成调制分散样品光的图案。 采集光学器件将调制的样品光聚焦在检测器上，其产生与样品的性质相关的信号。 可以根据需要容易地改变电子可控调制元件以符合感兴趣样品的不同的可测量性质。

公开(公告)号：US20160187251A1

公开(公告)日：2016-06-30

申请号：US14583288

申请日：2014-12-26

Applicant: General Electric Company

Inventor： Nagapriya Kavoori Sethumadhavan ,  Sandip Maity ,  Samhitha Palanganda Poonacha ,  Moitrayee Mukherjee ,  Purbasha Halder ,  Harish Sasikumar ,  Prasenjit Pandey

IPC: G01N21/31 ,  G01N21/03

CPC classification number: G01N21/31 ,  G01J3/433 ,  G01N21/03 ,  G01N21/3504 ,  G01N21/39 ,  G01N2201/061

Abstract: A method for determining a concentration of at least one individual gas present in a gas-mixture includes irradiating a first component by incident modulated-light-beams characterized by a determined absorption wavelength range, modulation frequencies and a modulation amplitudes to generate first transmitted-light-beams, irradiating a second component, comprising a determined concentration of the at least one individual gas, by the first incident modulated-light-beams to generate second transmitted-light-beams, generating noise signals representative of a characteristic of the first transmitted-light-beams, generating noise-free signals representative of a characteristic of the second transmitted-light-beams, selecting an optimal modulation frequency and an optimal modulation amplitude from the modulation frequencies and the modulation amplitudes based on the noise signals and the noise-free signals, and determining a concentration of the at least one individual gas in the gas-mixture based on the optimal modulation frequency and the optimal modulation amplitude of the determined absorption wavelength range.

Abstract translation: 用于确定气体混合物中存在的至少一种单独气体的浓度的方法包括通过入射的调制光束照射第一分量，其特征在于确定的吸收波长范围，调制频率和调制幅度，以产生第一透射光 - 通过所述第一入射调制光束照射包含所述至少一种单独气体的确定浓度的第二组分以产生第二透射光束，产生表示所述第一透射光束的特性的噪声信号， 产生表示第二透射光束的特性的无噪声信号，基于噪声信号和无噪声从调制频率和调制幅度中选择最佳调制频率和最佳调制幅度 信号，并确定气体混合物中的至少一种单独气体的浓度 基于所确定的吸收波长范围的最佳调制频率和最佳调制幅度。