公开(公告)号：US11162936B2

公开(公告)日：2021-11-02

申请号：US15595489

申请日：2017-05-15

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Timothy Smith ,  Joy Roy ,  Alexander Loo

IPC: G01N33/00 ,  G01N21/00 ,  G01N33/50 ,  G01N21/07 ,  G01N35/00 ,  G01N21/51 ,  G01N21/76 ,  G01N30/88 ,  G01N21/64 ,  G01N15/10

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20210140876A1

公开(公告)日：2021-05-13

申请号：US16952654

申请日：2020-11-19

Applicant: Labrador Diagnostics LLC

Inventor： Karan Mohan ,  Samartha Anekal

IPC: G01N21/25 ,  G01N21/76 ,  G01N21/64

Abstract: The devices and systems disclosed herein provide multiple optical capabilities in a single device or system. Methods for using these devices and systems are provided. These devices and systems are configurable for operation in each of a spectroscopy mode, a fluorescence mode, and a luminescence mode, and are capable of performing spectroscopic, fluorescence, and luminescence observations, measurements, and analyses when operated in the corresponding spectroscopy mode, fluorescence mode, or luminescence mode. These devices and systems include mirror dispersion elements having multiple faces including an optical dispersion element on one face (e.g., a diffraction grating or a prism) and a reflective element on another face (e.g., a mirror). These multiple capabilities eliminate the need to move or load a sample in multiple devices when subjecting a sample to multiple analyses, and thus provide greater accuracy, precision, and speed while reducing complexity and cost of sample analysis.

公开(公告)号：US20210123862A1

公开(公告)日：2021-04-29

申请号：US17011197

申请日：2020-09-03

Applicant: Labrador Diagnostics LLC

Inventor： Karan Mohan ,  Chinmay Pangarkar

IPC: G01N21/47 ,  G01N15/14 ,  G01N21/64 ,  G02B26/00 ,  B01L3/00

Abstract: Methods, devices, apparatus, and systems are provided for image analysis. Methods of image analysis may include observation, measurement, and analysis of images of biological and other samples; devices, apparatus, and systems provided herein are useful for observation, measurement, and analysis of images of such samples. The methods, devices, apparatus, and systems disclosed herein provide advantages over other methods, devices, apparatus, and systems.

公开(公告)号：US20210115496A1

公开(公告)日：2021-04-22

申请号：US17067257

申请日：2020-10-09

Applicant: Labrador Diagnostics LLC

Inventor： Daniel Young ,  Elizabeth A. Holmes

IPC: C12Q1/6804 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/68

Abstract: Methods, devices, systems, and kits for use in detecting and measuring infectious diseases are provided. In particular embodiments, methods, devices, systems, and kits for detecting and measuring Ebola virus, including Ebola Zaire strain virus, are provided. Devices and systems may be used within regions suffering from Ebola or other infections, providing local, rapid, and effective diagnosis of infectious diseases such as Ebola, improving treatment and reducing or preventing spread of such infectious diseases.

公开(公告)号：US20230050745A1

公开(公告)日：2023-02-16

申请号：US17707597

申请日：2022-03-29

Applicant: Labrador Diagnostics LLC

Inventor： Zachary Morrison

IPC: B01L3/00 ,  A61B5/151 ,  A61B5/15

Abstract: Methods and devices are provided for sample collection. In one example, a device is provided comprising at least one capillary tube or collection channel directed to a sample vessel, wherein in a one-step removal step of detaching the sample vessel from the collection channel, a vacuum force is created within the sample vessel, due in part of the pulling of the sealed vessel away from the device, wherein this vacuum force draw out residual sample that may still be resident in the collection channel.

公开(公告)号：US20220229051A1

公开(公告)日：2022-07-21

申请号：US17556060

申请日：2021-12-20

Applicant: Labrador Diagnostics LLC

Inventor： Alex Ho Fai Lee

IPC: G01N33/543 ,  C12N15/10

Abstract: A composition is described comprising superparamagnetic particles. Optionally, the particles comprise microbeads. Optionally, the particles comprise nanobeads. Optionally, the particles are non-spherical particles. Optionally, the particles are non-spherical particles suitable for RNA or DNA extraction. A method is described for forming microparticles. Optionally, the method comprises using citrate precipitation. Optionally, a kit comprising one or more of the particles is described. Optionally, a kit for sample preparation for nucleic acid extraction is described comprising non-spherical microparticles or nanoparticles.

公开(公告)号：US20220196657A1

公开(公告)日：2022-06-23

申请号：US17516462

申请日：2021-11-01

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons

IPC: G01N33/569 ,  B01L3/00 ,  C12Q1/70 ,  G01N33/543

Abstract: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.

公开(公告)号：US11304638B2

公开(公告)日：2022-04-19

申请号：US16870066

申请日：2020-05-08

Applicant: Labrador Diagnostics LLC

Inventor： Zachary Morrison

IPC: A61B5/15

Abstract: Methods and devices are provided for sample collection. In one example, a device is provided comprising at least one capillary tube or collection channel directed to a sample vessel, wherein in a one-step removal step of detaching the sample vessel from the collection channel, a vacuum force is created within the sample vessel, due in part of the pulling of the sealed vessel away from the device, wherein this vacuum force draw out residual sample that may still be resident in the collection channel.

公开(公告)号：US20220113322A1

公开(公告)日：2022-04-14

申请号：US17507320

申请日：2021-10-21

Applicant: Labrador Diagnostics LLC

Inventor： Tina Noyes

IPC: G01N33/82

Abstract: Assays for rapid measurement of total vitamin D in blood are provided. Vitamin D is measured following the rapid and irreversible release of vitamin D due to denaturation and digestion of vitamin D binding proteins by aspartyl peptidases (e.g., pepsin) under acidic conditions. Such measurements may be made using a vitamin D binder (e.g., an antibody) to measure competition between free vitamin D and added, labeled vitamin D. Synergy between denaturation and degradation is believed to provide more rapid and more complete release of vitamin D than would occur with acid or enzyme alone.
These measurements may be made using small amounts of whole blood, serum, or plasma, and are suitable for use in automated devices. These methods provide the advantages of reduced cost, increased speed, reduced discomfort to the subject, and increased availability and ease of use. Reagents, kits, devices, and systems for these assays are also disclosed.

公开(公告)号：US20220093269A1

公开(公告)日：2022-03-24

申请号：US17543330

申请日：2021-12-06

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. HOLMES ,  Ian GIBBONS ,  Daniel YOUNG ,  Seth G. MICHELSON

IPC: G16H50/50 ,  G16H50/70 ,  G16H50/20 ,  G16H50/80 ,  G16Z99/00

Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.