公开(公告)号：US12097050B2

公开(公告)日：2024-09-24

申请号：US17434333

申请日：2020-02-27

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Stephen Baek ,  Yusen He ,  Xiaodong Wu ,  Yusung Kim ,  Bryan G. Allen ,  John Buatti ,  Brian J. Smith

IPC: A61B5/00 ,  G06T7/11

CPC classification number: A61B5/7264 ,  A61B5/7275 ,  G06T7/11 ,  G06T2200/04 ,  G06T2207/10081 ,  G06T2207/10104 ,  G06T2207/20084 ,  G06T2207/30096

Abstract: Methods and systems for image segmentation and analysis are described. A predictive model may be trained to identify and/or extract a rich set of image features with extensive prognostic value. For example, the predictive model may be trained to identify and/or extract features that that may be visualized to identify areas of interest (e.g., high-risk regions, etc.) within or adjacent to an object of interest, such a tumor. The predictive model may be trained to identify and/or extract features that that may predict a health related outcome, such as cancer patient survival/death, and modify therapeutic outcomes, such as diagnosis and treatment.

公开(公告)号：US12090071B2

公开(公告)日：2024-09-17

申请号：US16787291

申请日：2020-02-11

Applicant: The University of Iowa Research Foundation

Inventor： Benjamin Dickerhoff ,  Robert S. Farivar ,  Madhavan L. Raghavan ,  Vijay Kumar

IPC: A61F2/24 ,  A61F2/86 ,  A61F2/95 ,  A61L27/20 ,  A61L27/50 ,  B29C39/02 ,  B29C39/10 ,  C21D1/18 ,  C22F1/10 ,  A61F2/07 ,  B29K1/00

CPC classification number: A61F2/86 ,  A61F2/2415 ,  A61F2/95 ,  A61L27/20 ,  A61L27/507 ,  B29C39/025 ,  B29C39/10 ,  C21D1/18 ,  C22F1/10 ,  A61F2/07 ,  A61F2220/0025 ,  A61F2240/001 ,  B29K2001/00 ,  Y10T29/49826 ,  A61L27/20 ,  C08L1/02

Abstract: Vascular prosthetic assemblies (e.g., heart valves), such as those, for example, configured to be deployed percutaneously.

公开(公告)号：US12083137B2

公开(公告)日：2024-09-10

申请号：US17332324

申请日：2021-05-27

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Sarah Holstein ,  David Wiemer

IPC: A61K31/683 ,  A61K45/06 ,  C07F9/6518

CPC classification number: A61K31/683 ,  A61K45/06 ,  C07F9/6518

Abstract: Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof:




wherein the substituents are described.

公开(公告)号：US20240269149A1

公开(公告)日：2024-08-15

申请号：US18454012

申请日：2023-08-22

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

Inventor： Christopher M. ADAMS ,  Steven D. KUNKEL ,  Michael WELSH

IPC: A61K31/58 ,  A61K31/215 ,  A61K31/352 ,  A61K31/353 ,  A61K31/36 ,  A61K31/382 ,  A61K31/404 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/56 ,  A61K31/565 ,  C12Q1/6809 ,  G01N33/50

CPC classification number: A61K31/58 ,  A61K31/215 ,  A61K31/352 ,  A61K31/353 ,  A61K31/36 ,  A61K31/382 ,  A61K31/404 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/56 ,  A61K31/565 ,  C12Q1/6809 ,  G01N33/5023 ,  C12Q2600/136 ,  G01N2800/10 ,  G01N2800/52

Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula:




or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).

公开(公告)号：US12059403B2

公开(公告)日：2024-08-13

申请号：US16322709

申请日：2017-08-04

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Rajan Sah

IPC: A61K31/192 ,  A61K31/138 ,  A61K31/40 ,  A61P3/08

CPC classification number: A61K31/40 ,  A61K31/138 ,  A61K31/192

Abstract: The invention provides the use of SWELL1 inhibitors and modulators for therapeutic use, e.g., to treat obesity and type 2 diabetes.

公开(公告)号：US12051134B2

公开(公告)日：2024-07-30

申请号：US17194946

申请日：2021-03-08

Applicant: University of Iowa Research Foundation ,  Shandong University ,  Shandong Public Health Clinical Center ,  Rensselaer Polytechnic Institute

Inventor： Wenxiang Cong ,  Ye Yangbo ,  Ge Wang ,  Shuwei Mao ,  Yingmei Wang

IPC: A61B6/03 ,  G06T11/00

CPC classification number: G06T11/006 ,  A61B6/032 ,  G06T11/003 ,  G06T11/005 ,  G06T2211/408 ,  G06T2211/424

Abstract: The disclosed apparatus, systems and methods relate to a framelet-based iterative algorithm for polychromatic CT which can reconstruct two components using a single scan. The algorithm can have various steps including a scaled-gradient descent step of constant or variant step sizes; a non-negativity step; a soft thresholding step; and a color reconstruction step.

公开(公告)号：US12016336B2

公开(公告)日：2024-06-25

申请号：US18115700

申请日：2023-02-28

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Ned B. Bowden ,  Justin M. Carter ,  Eric M. Brown ,  Nimesh Ranasinghe ,  Arjun Paudel ,  Erin E. Irish

IPC: A01N57/12 ,  A01N57/16 ,  A01N59/02 ,  A01P21/00 ,  C07F9/06 ,  C07F9/6571 ,  C07F9/6578

CPC classification number: A01N57/12 ,  A01N57/16 ,  A01N59/02 ,  A01P21/00 ,  C07F9/06 ,  C07F9/657118 ,  C07F9/6578

Abstract: The invention provides a compound of formula I:




wherein X, Y, Z, R1, R2, and X+ have any of the values described in the specification. The compounds are useful to increase plant growth and/or to increase harvest yield.

公开(公告)号：US20240161039A1

公开(公告)日：2024-05-16

申请号：US18451340

申请日：2023-08-17

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： STEPHEN BAEK ,  NATHAN B. FETHKE ,  JEAN ROBILLARD ,  JOSEPH A.V. BUCKWALTER ,  PAMELA VILLACORTA

IPC: G06Q10/0635 ,  G06N20/00 ,  G06Q10/0631 ,  G06V40/20

CPC classification number: G06Q10/0635 ,  G06N20/00 ,  G06Q10/063114 ,  G06V40/23

Abstract: A prevention and safety management system utilizes a non-intrusive imaging sensor (e.g. surveillance cameras, smartphone cameras) and a computer vision system to record videos of workers not wearing sensors. The videos are analyzed using a deep machine learning algorithm to detect kinematic activities (set of predetermined body joint positions and angles) of the workers and recognizing various physical activities (walk/posture, lift, push, pull, reach, force, repetition, duration etc.). The measured kinematic variables are then parsed into metrics relevant to workplace ergonomics, such as number of repetitions, total distance travelled, range of motion, and the proportion of time in different posture categories. The information gathered by this system is fed into an ergonomic assessment system and is used to automatically populate exposure assessment tools and create risk assessments.

公开(公告)号：US11981943B2

公开(公告)日：2024-05-14

申请号：US16340657

申请日：2017-10-02

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Vinit B. Mahajan ,  Alexander G. Bassuk ,  Diana F. Colgan ,  Gabriel Velez ,  Kellie Schaefer ,  Marcus Toral ,  Shu Wu ,  Lokesh Gakhar

IPC: C12N9/64 ,  A61K9/08 ,  A61K38/00 ,  A61P27/02 ,  A61P29/00 ,  C07K14/49 ,  C07K14/81 ,  G01N33/573 ,  C07K7/64

CPC classification number: C12N9/6472 ,  A61K9/08 ,  A61P27/02 ,  A61P29/00 ,  C07K14/49 ,  C07K14/81 ,  C07K14/8139 ,  C12Y304/22 ,  G01N33/573 ,  A61K38/00 ,  C07K7/64 ,  C07K2319/00

Abstract: The present disclosure provides CAPN5 substrates and CAPN5 inhibitors, nucleic acids encoding CAPN5 substrates or CAPN5 inhibitors, methods to deliver CAPN5 substrate or CAPN5 inhibitor agents to the eye, and methods of identifying inhibitors of CAPN5.

公开(公告)号：US11972568B2

公开(公告)日：2024-04-30

申请号：US16440480

申请日：2019-06-13

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael Abramoff ,  Milan Sonka

IPC: A61B3/00 ,  A61B3/10 ,  A61B3/12 ,  G06T7/00

CPC classification number: G06T7/0016 ,  A61B3/0025 ,  A61B3/102 ,  A61B3/1225 ,  G06T2207/10101 ,  G06T2207/30041

Abstract: Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. In an aspect, the systems and methods can map regions and layers of the eye to determine structural characteristics to compare to functional characteristics.