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    SYSTEMS AND METHODS FOR HUMIDITY AND/OR TEMPERATURE CONTROL IN A SAMPLE ANALYSIS SYSTEM
    11.
    发明公开
    SYSTEMS AND METHODS FOR HUMIDITY AND/OR TEMPERATURE CONTROL IN A SAMPLE ANALYSIS SYSTEM 审中-公开

    公开(公告)号：US20240168046A1

    公开(公告)日：2024-05-23

    申请号：US18283367

    申请日：2022-03-21

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Thomas R. Covey ,  Chang Liu

    IPC: G01N35/10 ,  G01N35/00

    CPC classification number: G01N35/10 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/1034

    Abstract: GT Systems and methods are disclosed for controlling humidity and/or temperature during chemical analysis of a sample material. Specifically, the present application relates to microfluidics systems and methods, e.g. involving ADE, open port interface (OPI) and/or mass spectrometry (MS), for controlling humidity and/or temperature during chemical analysis of a sample material. The present systems and methods allow a user to modify the temperature of a microplate during dispensing. This allows the user to study reactions that occur at temperatures different than room temperature, e.g. at body temperature. Additionally, modifying and/or controlling the temperature of a microplate during dispensing can allow a user to maintain quality of a sample through maintaining a proper temperature, e.g. a cool temperature to prevent degradation of a sample. As part of the present invention, Applicant determined how to avoid phase changes, e.g. evaporation, that are particularly concerning because of the small amounts of sample involved.

    Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis
    13.
    发明授权
    Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis 有权

    公开(公告)号：US11476106B2

    公开(公告)日：2022-10-18

    申请号：US17225622

    申请日：2021-04-08

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: H01J49/04 ,  G01N1/40 ,  H01J49/16 ,  G01N30/00

    Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).

    Electromagnetic Assemblies for Processing Fluids
    14.
    发明申请
    Electromagnetic Assemblies for Processing Fluids 审中-公开

    公开(公告)号：US20200011773A1

    公开(公告)日：2020-01-09

    申请号：US16480491

    申请日：2018-01-23

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: G01N1/38 ,  G01N1/40 ,  B03C1/01 ,  B03C1/033 ,  B03C1/28 ,  B01F13/08

    Abstract: Methods and apparatus for processing fluids are described. In various aspects, a fluid processing system may include a magnetic assembly that includes a plurality of magnetic structures configured to generate a magnetic field gradient within a fluid container. The magnetic structures may be formed as a plurality of electromagnets configured to be individually actuated by a controller. Each of the electromagnets may generate a magnetic field within the fluid container. The electromagnets may be differentially actuated to create a magnetic field gradient within the fluid container to agitate, mix, or otherwise influence magnetic particles disposed within the fluid container. Activation of the electromagnets of an electromagnetic structure may generate a magnetic field gradient that influences magnetic particles in an x-y direction. In addition, activation of the electromagnets of a plurality of electromagnetic structures may generate magnetic field gradients that influences magnetic particles in an x-y direction and z-direction.

    Method and system for vacuum driven mass spectrometer interface with adjustable resolution and selectivity
    16.
    发明授权
    Method and system for vacuum driven mass spectrometer interface with adjustable resolution and selectivity 有权
    真空驱动质谱仪界面的方法和系统，分辨率和选择性可调

    公开(公告)号：US09171711B2

    公开(公告)日：2015-10-27

    申请号：US13967589

    申请日：2013-08-15

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Bradley B. Schneider ,  Thomas R. Covey

    IPC: H01J49/24 ,  H01J49/26 ,  G01N27/62 ,  H01J49/00 ,  H01J49/04

    CPC classification number: H01J49/26 ,  G01N27/622 ,  H01J49/004 ,  H01J49/0404 ,  H01J49/0468 ,  H01J49/24

    Abstract: A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit.

    Abstract translation: 提供了质谱仪系统及其操作方法。 该系统包括用于接收离子的离子导管; 限定包含离子导管的帘式气室的边界构件; 用于向离子管道的入口提供帘式气体以提供气体流入管道中的帘式气体供应，以及帘式气体从帘式气体室入口流出; 至少部分地密封并与导管流体连通的用于从导管接收离子的质谱仪; 围绕质谱仪的真空室可操作以将包括离子的气流通过导管抽入真空室; 以及气体出口，用于从位于导管和质谱仪之间的气流引出气体流出，以增加通过导管的气体流速。

    Systems and methods for effective gap filtering and atmospheric pressure RF heating of ions
    17.
    发明授权
    Systems and methods for effective gap filtering and atmospheric pressure RF heating of ions 有权

    公开(公告)号：US12247947B2

    公开(公告)日：2025-03-11

    申请号：US17325483

    申请日：2021-05-20

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Bradley B. Schneider ,  Erkinjon Nazarov ,  Thomas R. Covey

    IPC: G01N27/624 ,  H01J49/00 ,  H01J49/16

    Abstract: An apparatus includes a first electrode and a second electrode. The second electrode is placed in parallel with the first electrode to provide constant gap distance. The gap between the first electrode and the second electrode is at atmospheric pressure. Ions are introduced into the center of the gap and travel through the apparatus in a direction parallel to the first electrode and the second electrode. The apparatus is configured as a high-field symmetric-waveform apparatus for filtering high mobility ions or for fragmenting ions. The apparatus is also configured for three modes of operation: as a conventional DMS; as a filter high mobility ions; and as fragmentation device. A symmetric electric field is produced in the gap with a maximum density normalized field strength greater than 10 Td to filter high mobility ions and with a maximum density normalized field strength greater than 100 Td to fragment ions.

    Methods and systems utilizing ultrasound-assisted sampling interfaces for mass spectrometric analysis
    20.
    发明授权
    Methods and systems utilizing ultrasound-assisted sampling interfaces for mass spectrometric analysis 有权

    公开(公告)号：US11348780B2

    公开(公告)日：2022-05-31

    申请号：US16765910

    申请日：2018-11-20

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: H01J49/00 ,  H01J49/04 ,  G01B17/06 ,  G01F23/296 ,  G01N1/14 ,  G01N1/40 ,  H01J49/16 ,  H01J49/42

    Abstract: An ultrasonic transmitter (95) and detector (e.g., integrated as an ultrasound transducer) utilized in a feedback control system automatically monitors and/or detects surface profile (e.g., shape) of the liquid-air interface and adjusts the flow rate of sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. The feedback control can provide for automated adjustment of the surface profile of the liquid-air interface in accordance with changes in desired set point according to an experimental workflow (e.g., automated adjustment between an interface corresponding to a vortex sampling set point and an overflow cleaning set point). Improvements in desorption efficiency and quality of mass spectrometry data by degassing of the liquid solvent utilized within the sampling interfaces, and/or utilization in a feedback control system for generating data indicative of a surface profile of the liquid-air interface within the interface's sampling port may be realized.

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