公开(公告)号：US20210093737A1

公开(公告)日：2021-04-01

申请号：US17114195

申请日：2020-12-07

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam ,  Philip S. Low ,  Mohammad Noshi

IPC: A61K49/00 ,  A61B5/00 ,  G01N33/574 ,  G01N33/58

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

公开(公告)号：US10881747B2

公开(公告)日：2021-01-05

申请号：US16508826

申请日：2019-07-11

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne

IPC: A61K51/00 ,  A61M36/14 ,  A61K49/00 ,  A61B5/00 ,  G01N33/574 ,  G01N33/58

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

公开(公告)号：US09341629B2

公开(公告)日：2016-05-17

申请号：US14715799

申请日：2015-05-19

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam ,  Philip S. Low

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  G01N33/574 ,  C07D475/04 ,  G01N33/58 ,  A61K49/00

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US20140271476A1

公开(公告)日：2014-09-18

申请号：US14207130

申请日：2014-03-12

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam ,  Philip S. Low

IPC: A61K49/00 ,  G01N33/566 ,  G01N33/569

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Abstract translation: 本公开涉及可用作近红外荧光探针的化合物，其中所述化合物包括i）与靶受体蛋白结合的蝶啶配体，ii）染料分子，和iii）包含氨基酸的连接分子 或其衍生物。 本公开进一步描述了制备和使用化合物的方法和组合物，并入化合物的方法，以及并入化合物的试剂盒。

公开(公告)号：US20250108039A1

公开(公告)日：2025-04-03

申请号：US18977274

申请日：2024-12-11

Applicant: Purdue Research Foundation

Inventor： Philip Stewart LOW ,  Sumith A. Kularatne

IPC: A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K47/54 ,  A61K47/64 ,  A61K49/00 ,  A61K51/04 ,  A61K51/08 ,  C07C323/52 ,  C07D207/416 ,  C07K5/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US12133900B2

公开(公告)日：2024-11-05

申请号：US17105308

申请日：2020-11-25

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam

IPC: A61K51/00 ,  A61B5/00 ,  A61K49/00 ,  A61M36/14 ,  G01N33/574 ,  G01N33/58

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds. The disclosure also relates to compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

公开(公告)号：US20220098564A1

公开(公告)日：2022-03-31

申请号：US17497085

申请日：2021-10-08

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K49/00 ,  A61K51/04 ,  A61K47/54

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20220096445A1

公开(公告)日：2022-03-31

申请号：US17358726

申请日：2021-06-25

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Sumith A. Kularatne

IPC: A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64

Abstract: Described herein are prostate specific membrane, antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US11083710B2

公开(公告)日：2021-08-10

申请号：US16749827

申请日：2020-01-22

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K31/426 ,  A61K47/54 ,  A61K47/64 ,  A61K31/4745 ,  A61K31/475 ,  A61K49/00 ,  A61K51/04 ,  A61K51/08 ,  C07K5/08 ,  C07C323/52 ,  C07D207/416

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20200155695A1

公开(公告)日：2020-05-21

申请号：US16507713

申请日：2019-07-10

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K51/08 ,  A61K49/00 ,  A61K31/475 ,  A61K31/4745 ,  A61K31/426 ,  C07K5/08 ,  A61K51/04 ,  C07D207/416 ,  C07C323/52

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.