公开(公告)号：US20180372696A1

公开(公告)日：2018-12-27

申请号：US15780829

申请日：2015-12-04

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/72 ,  H01J49/04 ,  H01J49/10

CPC classification number: G01N30/724 ,  G01N27/62 ,  G01N30/72 ,  G01N30/7273 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/107 ,  H01J49/165

Abstract: A liquid sample analyzing system including an ion analyzer having a first ion source receiving a target sample and a second ion source receiving a reference sample; a liquid sample introduction mechanism 3 including a passage-switching section introducing reference samples into the second ion source; and a controller for repeatedly performing a series of steps in the ion analyzer, the steps including: a pre-measurement step for initiating a measurement; a measurement step for introducing a target sample into the first ion source and performing a measurement on an ion originating from the target sample along with an ion originating from a reference sample introduced into the second ion source by the liquid sample introduction mechanism; and a post-measurement step where the liquid sample introduction mechanism operates concurrently with the predetermined post-measurement step to switch the passage-switching section to a passage having a reference sample for the next analysis.

公开(公告)号：US20250012767A1

公开(公告)日：2025-01-09

申请号：US18691492

申请日：2022-02-04

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/86 ,  G01N30/72

Abstract: A chromatograph mass spectrometer includes a data processing unit to process data collected by chromatograph mass spectrometry, the data processing unit including: first peak detection units to generate a chromatogram reflecting signal intensities at a m/z on the basis of the collected data and perform peak detection on the chromatogram; an EIC creation unit to create an EIC for m/z of a centroid peak observed in a mass spectrum obtained in a time range of the peak for at least one of the detected peaks; a second peak detection unit to perform peak detection on the created EIC and obtain a retention time of a peak top of the detected peak; a grouping unit to classify peak tops into groups having substantially the same retention time; and a selection unit to select one or more m/zs or EICs corresponding to m/zs as a representative for each group.

公开(公告)号：US20230349879A1

公开(公告)日：2023-11-02

申请号：US18041748

申请日：2021-05-06

Applicant: SHIMADZU CORPORATION

Inventor： Masahito YAHATA ,  Kazuma MAEDA ,  Tatsuya KATAOKA ,  Yuichi MASUDA ,  Nobuhiro NAMIKAWA ,  Akioki NAKAMORI ,  Tatsuya IWAMA

IPC: G01N33/18 ,  G01N1/14 ,  G01N27/06

CPC classification number: G01N33/1846 ,  G01N1/14 ,  G01N33/1893 ,  G01N27/06 ,  C02F1/72

Abstract: An inspection apparatus includes a measurement unit, a flow-in tube for flow of sample water into the measurement unit, a connection portion that connects a sample tube and the measurement unit to each other, a liquid sending portion that sends sample water to the measurement unit, a pressurization pump that increases a pressure in the inside of the sample tube, and a controller. The controller controls operations of the liquid sending portion and the pressurization pump to suppress within a prescribed range, variation in pressure applied to sample water until sample water reaches the measurement unit from the inside of the sample tube.

公开(公告)号：US20220246415A1

公开(公告)日：2022-08-04

申请号：US17597046

申请日：2019-07-04

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: H01J49/04 ,  G01N30/72 ,  H01J49/00

Abstract: A chromatograph mass spectrometer includes: a chromatograph unit configured to separate components in a sample; a mass spectrometer configured to perform measurement on ions having a specific mass-to-charge ratio derived from each compound temporally separated by the chromatograph unit, an analysis condition setting unit configured to allow a user to set, as an analysis condition, molecular-weight-related information and a mass-spectrometry-related parameter including an ion polarity, a type of an adduct, a number of polymerizations of a multimer and/or an ion valence for each measurement target compound; and an analysis method creator configured to calculate a mass-to-charge ratio of one or a plurality of types of ions according to the analysis condition set by the analysis condition setting unit for the each measurement target compound, and create an analysis method for performing mass spectrometry on the one or a plurality of types of ions in a time division manner.

公开(公告)号：US20220155268A1

公开(公告)日：2022-05-19

申请号：US17479073

申请日：2021-09-20

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA ,  Toshiya MATSUBARA

IPC: G01N30/72 ,  G01N30/86 ,  H01J49/00

Abstract: In a chromatograph mass spectrometer having a measurement unit (1) including a chromatograph is combined with a tandem mass spectrometry section capable of an MS/MS analysis, a controller (40) performs chromatograph mass spectrometry by controlling the measurement unit so as to operate the tandem mass spectrometry section to cyclically perform analysis cycles, where each of the analysis cycles includes a first mass spectrometric analysis in which a measurement of ions is performed over a predetermined m/z range and an MS/MS analysis by DIA in which ions included within each of a plurality of windows formed by dividing the m/z range are designated as a precursor ion. A window selector (42, 43) selects, during an execution of an analysis cycle, a window among the plurality of windows for an MS/MS analysis by DDA which is irregularly performed in an ongoing analysis cycle, based on intensity information obtained for each of the plurality of windows from an MS/MS spectrum acquired by the MS/MS analysis by DIA. A precursor-ion determiner (44) determines a precursor ion corresponding to the window selected by the window selector in a mass spectrum acquired by the first mass spectrometric analysis in the ongoing analysis cycle, based on peak information included within the m/z range of the window. A data-dependent-acquisition condition setter (45) informs the controller of the precursor ion determined by the precursor-ion determiner, as the precursor ion for the MS/MS analysis by DDA which is irregularly performed in the ongoing analysis cycle.

公开(公告)号：US20210242008A1

公开(公告)日：2021-08-05

申请号：US17052570

申请日：2018-05-14

Applicant: SHIMADZU CORPORATION

Inventor： Tomoyuki OSHIRO ,  Yoshikatsu UMEMURA ,  Kazuma MAEDA

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/40 ,  H01J49/16 ,  H01J49/06 ,  H01J49/02

Abstract: To acquire a mass spectrum for a wide mass range, a normal analysis execution controlling unit controls components to repeatedly perform measurement while changing setting m/z by a predetermined m/z at a time, and a mass spectrum summarizing processing unit summarizes data pieces each obtained by each time of measurement to generate the mass spectrum. Radio-frequency voltage applied to an ion guide and the like is changed based on the setting m/z. The radio-frequency voltage for the setting m/z is determined using a table in which a relationship between a position on an axis between upper and lower limits of the mass range and the radio-frequency voltage is substantially the same regardless of the mass range.

公开(公告)号：US20210134577A1

公开(公告)日：2021-05-06

申请号：US17028363

申请日：2020-09-22

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: H01J49/06 ,  H01J49/16 ,  H01J49/42 ,  H01J49/24

Abstract: In a mass spectrometer including ion optical elements for transporting ions or controlling their behavior by electric fields, a device state determiner (41, 52) determines whether or not the mass spectrometer is in a normal state based on an ion intensity signal acquired by analyzing a predetermined sample. If the mass spectro is in an abnormal state, a charge-up determiner (42, 53) determines whether or not charge-up is present in the ion optical elements based on a change in ion intensity signal in an analysis on the predetermined sample observed when the voltages applied to the ion optical elements are changed according to a predetermined sequence. If charge-up is present, the charge-up determiner determines which ion optical element is likely to have the charge-up. A notifier (8, 61) notifies a user of the results of the determination by the device state determiner and the charge-up determiner.

公开(公告)号：US20180106771A1

公开(公告)日：2018-04-19

申请号：US15294928

申请日：2016-10-17

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/86 ,  G01N30/72

CPC classification number: G01N30/8631 ,  G01N30/72

Abstract: When there are a plurality of concentration value candidates, an extreme value of the calibration curve is detected, and the number of calibration points respectively contained in a region having a low concentration and a region having a high concentration is calculated using the extreme value as a boundary. If there is a difference between the numbers of calibration points of both regions, a concentration value candidate present in the region having a larger number of calibration points is selected as a quantitation result. When the numbers of calibration points are the same, the sign of the coefficient of the term of the second degree of the calibration curve is assessed, and a concentration value candidate present in a region in which the relationship between peak area values and concentration values is monotonically increasing is selected as a quantitation result.