公开(公告)号：US20240377367A1

公开(公告)日：2024-11-14

申请号：US18691378

申请日：2022-03-18

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/10 ,  B01D19/00 ,  G01N30/02 ,  G01N30/74 ,  G01N31/00

Abstract: A gas-liquid separator includes a reception port to which a sample is supplied, a gas flow pipe through which gas in the sample supplied to the reception port is sent to the outside, a storage pipe where liquid in the sample supplied to the reception port is stored, and a waste solution disposition port for disposition of liquid stored in the storage pipe to the outside. The storage pipe includes a first storage portion that communicates with the reception port and is arranged in an area vertically below the reception port, a second storage portion that communicates with the waste solution disposition port and is arranged in an area vertically below the waste solution disposition port, and a communication portion that allows communication between a vertically lower end of the first storage portion and a vertically lower end of the second storage portion.

公开(公告)号：US20220178888A1

公开(公告)日：2022-06-09

申请号：US17437263

申请日：2019-03-27

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/72 ,  G01N27/70

Abstract: Provided is a chromatograph mass spectrometer that includes a component separation unit 13 that temporally separates components in a sample, a first detector 15 that acquires measurement data of components included in an outflowing liquid from the component separation unit 13 by an analysis method different from mass spectrometry, a mass spectrometer 2 that acquires mass spectrometry data including intensity information for each of mass-to-charge ratios of ions derived from the components contained in the outflowing liquid from the component separation unit 13, a chromatogram creation unit 45 that creates a chromatogram representing an intensity change of the measurement data with time based on the measurement data of the first detector 15, an information extraction unit 46 that detects a peak based on the intensity change of the mass spectrometry data with time, and extracts information including a representative time of the peak, and a chromatogram display unit 48 that displays the chromatogram together with additional information corresponding to the extracted time.

公开(公告)号：US20220196614A1

公开(公告)日：2022-06-23

申请号：US17601742

申请日：2019-06-20

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/72 ,  H01J49/00 ,  G01N30/86

Abstract: A chromatograph mass spectrometer according to an aspect of the present invention is a chromatograph mass spectrometer including: a chromatograph unit (LC unit 1) configured to separate components in a sample; and a mass spectrometer (MS unit 2) configured to execute mass spectrometry on ions having a specific mass-to-charge ratio derived from a compound for each compound temporally separated by the chromatograph unit, the chromatograph mass spectrometer further including: an analysis condition setting unit (30) configured to allow a user to input a width of a peak on a chromatogram as one of analysis parameters; a data point number storage (311) configured to store information on an appropriate number of data points corresponding to one peak; a sampling time interval calculator (312) configured to calculate a sampling time interval, which is a timing for acquiring data for creating the chromatogram, from the inputted peak width and data point number; and an analysis control unit (32) configured to control an operation of the mass spectrometer so as to acquire ion intensity data in the mass spectrometer according to the sampling time interval.

公开(公告)号：US20190011406A1

公开(公告)日：2019-01-10

申请号：US15763951

申请日：2015-09-29

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/72 ,  H01J49/04

CPC classification number: G01N30/7266 ,  G01N27/62 ,  H01J49/0409 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/165

Abstract: A liquid sample introduction system for an ion source which ionizes a liquid sample by supplying the liquid sample to an ionization probe in an ion source and blowing an atomization-promoting gas at the liquid sample exiting from the tip of the ionization probe, the system including: a hermetically closable liquid sample container for holding a liquid sample; a liquid-supply-gas passage having one end connected to a point in a passage for an atomization-promoting gas leading to the ion source, and the other end connected to a space above a liquid level in the liquid sample container; a sample supply passage having one end connected to a space below the liquid level in the liquid sample container and the other end connected to the ionization probe; and a passage-switching unit in the sample supply passage for switching the sample supply passage between the communicating state and the closed state.

公开(公告)号：US20230245875A1

公开(公告)日：2023-08-03

申请号：US18160016

申请日：2023-01-26

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/42 ,  H01J49/24

CPC classification number: H01J49/005 ,  H01J49/401 ,  H01J49/4215 ,  H01J49/24 ,  H01J49/0036

Abstract: In a mass spectrometer provided with a measurement section (1) including a collision cell (17) and a mass separator (20-23) for a mass spectrometric analysis of product ions, a CES-method-condition determiner (321) determines collision-energy (CE) values for a collision energy spread (CES) method according to given conditions including the range and number of CE values, in such a manner that n+1 CE values to be used when the number is n+1 (where n is an integer equal to or greater than three) include n collision-energy values used when the number is n and one additional CE value different from the n CE values. An analysis controller (30) sequentially changes the collision energy to the n+1 CE values and controls the measurement section to execute an MS/MS analysis under each CE value. A data processor (33) obtains a cumulative mass spectrum by accumulating mass spectra respectively obtained under different CE values.

公开(公告)号：US20210123537A1

公开(公告)日：2021-04-29

申请号：US17041375

申请日：2019-03-04

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: F16K11/074 ,  G01N30/20

Abstract: A multiport valve used for a water quality analyzer is provided with: a valve head having a plurality of ports for receiving pipings for connections therebetween, the ports being provided on an outer surface of the valve head, the valve head including a connection surface in which ends of flow paths communicating with the respective ports are arranged in the same plane, the valve head being made of a resin material having corrosion resistance against a chemical used in the water quality analyzer; a rotor having a flat surface provided with a groove for switching a connection state between the ends of the flow paths arranged on the connection surface, the flat surface being arranged so as to face the connection surface; and a drive mechanism configured to rotate the rotor.

公开(公告)号：US20250104992A1

公开(公告)日：2025-03-27

申请号：US18726904

申请日：2022-02-03

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: H01J49/42 ,  G01N30/72

Abstract: A mass spectrometer capable of performing scan measurement, includes: a provisional event time determining unit to determine a provisional event time to be assigned to a scan measurement event, which is a measurement unit for performing one scan measurement, in accordance with an analysis condition specified by a user; a scan speed selection unit to select a scan speed from candidates such that a measurement time required for one scan measurement does not exceed the provisional event time of the scan measurement event; an event time determining unit to correct the provisional event time of the scan measurement event to a time required for scan measurement under the selected scan speed, and set the provisional event time that has been corrected as an event time of the scan measurement event; and a control information creation unit to create control information for controlling the mass spectrometer based on the event time.

公开(公告)号：US20220199385A1

公开(公告)日：2022-06-23

申请号：US17692370

申请日：2022-03-11

Applicant: SHIMADZU CORPORATION

Inventor： Daisuke OKUMURA ,  Shingo FUJIOKA ,  Kazuma MAEDA

IPC: H01J49/04 ,  G01N27/623 ,  G01N1/00

Abstract: The other end of an individual sample supply channel one end of which is connected to a gas buffer container the inside of which is empty is connected to one sub-port of a valve that selects one of standard samples to be supplied to an ESI probe. During analysis, the standard sample stored in one of liquid sample containers is selected by switching a connection state of the valve. The standard sample supplied by being pushed by a gas sent to the liquid sample containers through liquid supply gas branch channels is sent to the ESI probe through a sample supply main channel. At the time of finishing analysis, when the valve is switched such that the sub-port and a main port are communicatively connected, a nitrogen gas is sent to the sample supply main channel, and the remaining liquid is discharged.

公开(公告)号：US20210313163A1

公开(公告)日：2021-10-07

申请号：US16613160

申请日：2017-08-10

Applicant: SHIMADZU CORPORATION

Inventor： Daisuke OKUMURA ,  Shingo FUJIOKA ,  Kazuma MAEDA

IPC: H01J49/04 ,  G01N27/623

Abstract: The other end of an individual sample supply channel one end of which is connected to a gas buffer container the inside of which is empty is connected to one sub-port of a valve that selects one of standard samples to be supplied to an ESI probe. During analysis, the standard sample stored in one of liquid sample containers is selected by switching a connection state of the valve. The standard sample supplied by being pushed by a gas sent to the liquid sample containers through liquid supply gas branch channels is sent to the ESI probe through a sample supply main channel. At the time of finishing analysis, when the valve is switched such that the sub-port and a main port are communicatively connected, a nitrogen gas is sent to the sample supply main channel, and the remaining liquid is discharged.

公开(公告)号：US20210249250A1

公开(公告)日：2021-08-12

申请号：US17053128

申请日：2018-05-31

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA ,  Daisuke OKUMURA

IPC: H01J49/42 ,  H01J49/02 ,  H01J49/40 ,  H01J49/06

Abstract: When a Q-TOF type mass spectrometer is operated in an MS1 mode, a controller (40), at the time of measurement, controls voltage generators (31 to 33) such that only a V voltage (radio-frequency voltage for mass separation) and a direct-current bias voltage are applied to main rod electrodes of a quadrupole mass filter (12) without application of a U voltage (direct-current voltage for mass separation). During a measurement preparation period between a plurality of measurements to obtain one mass spectrum, the controller (40) controls a U voltage generator (31) so as to apply the U voltage to the main rod electrodes of the quadrupole mass filter (12). Accordingly, a direct-current electric field is formed between adjacent main rod electrodes around an ion optical axis (C) due to a potential difference, and electric charges accumulated in rod holders (122) holding the main rod electrodes are rapidly removed by an effect of this electric field. As a result, it is possible to eliminate a charge-up that has not been eliminated by a conventional method in which a polarity of a direct-current bias voltage applied to the rod electrodes is merely reversed.