公开(公告)号：US11725984B2

公开(公告)日：2023-08-15

申请号：US17408976

申请日：2021-08-23

Applicant: CytoVeris Inc.

Inventor： Alan Kersey ,  Rishikesh Pandey ,  David Fournier ,  Gary Root

IPC: G01J3/44 ,  G01J3/02 ,  G01N21/65 ,  G02B26/08

CPC classification number: G01J3/0208 ,  G01J3/44 ,  G01N21/65 ,  G02B26/0833 ,  G01N2201/12

Abstract: A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.

公开(公告)号：US11686621B2

公开(公告)日：2023-06-27

申请号：US17517743

申请日：2021-11-03

Applicant: Ariel Scientific Innovations Ltd.

Inventor： Shmuel Sternklar ,  Ziv Glasser

IPC: G01J3/44

CPC classification number: G01J3/44

Abstract: A method of spectroscopy, comprises: transmitting output radiation to a sample; collecting from the sample input radiation being indicative of interaction between the output radiation and the sample; modulating at least one of the output radiation and the input radiation, wherein at least one of the output radiation and the modulation is characterized by a scanned parameter; combining the input radiation, following the modulation, with a reference signal to provide a combined signal; processing the combined signal to construct a vector describing a dependence of a radiation property of the input radiation on the parameter; and at least partially identifying the sample or a change in comprises sample based on at least the vector.

公开(公告)号：US20230160829A1

公开(公告)日：2023-05-25

申请号：US17990887

申请日：2022-11-21

Applicant: JANSSEN BIOTECH, INC. ,  OHIO STATE INNOVATION FOUNDATION

Inventor： Karin M. BALSS ,  Zachary SCHULTZ ,  Courtney J. MORDER

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/569

CPC classification number: G01N21/658 ,  G01J3/44 ,  G01N33/56983 ,  G01N2201/1293 ,  G06F17/10

Abstract: Disclosed is a method of quantifying virus titer in a sample using Raman spectroscopy. This method comprises providing a sample; providing a model for determining viral titer in the sample; irradiating the sample with a light source; and acquiring a Raman spectrum of the sample. The method further involves quantifying the viral titer of the sample by applying a virus component of the Raman spectrum to the model for determining viral titer. Other aspects of the disclosure relate to a method for generating a model suitable for quantifying viral titer in a sample.

公开(公告)号：US20190250105A1

公开(公告)日：2019-08-15

申请号：US16342318

申请日：2017-11-03

Applicant: Vanderbilt University

Inventor： Anita MAHADEVAN-JANSEN ,  Oscar D. AYALA ,  Eric P. SKAAR ,  Catherine A. WAKEMAN ,  Jay A. WERKHAVEN

IPC: G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/0218 ,  G01J3/44 ,  G01N33/56911 ,  G01N2021/656 ,  G01N2201/0833 ,  G01N2333/212 ,  G01N2333/285 ,  G01N2333/31 ,  G01N2333/315 ,  G01N2800/14

Abstract: The invention relates to a method for identification and discrimination of bacteria and/or mutant bacterial strains in a biological fluid. The method includes illuminating the biological fluid with a beam of light; obtaining Raman data from light scattered from the illuminated biological fluid; and finding Raman signatures corresponding to each type of bacteria and/or mutant bacterial strains from the obtained Raman data, so as to identify and discriminate each type of bacteria and/or mutant bacterial strains in the biological fluid from the Raman signatures.

公开(公告)号：US20190246907A1

公开(公告)日：2019-08-15

申请号：US16308306

申请日：2017-06-10

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Sinisa VUKELIC ,  Gerard A. ATESHIAN

IPC: A61B5/00 ,  G01J3/44

CPC classification number: A61B5/0075 ,  A61B5/4514 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/44

Abstract: The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.

公开(公告)号：US20190242751A1

公开(公告)日：2019-08-08

申请号：US16126998

申请日：2018-09-10

Applicant: MKS TECHNOLOGY (D/B/A SNOWY RANGE INSTRUMENTS)

Inventor： Keith T. Carron ,  Shane A. Buller ,  Mark A. Watson ,  Sean Patrick Woodward

IPC: G01J3/44 ,  G01J3/02 ,  G01N21/65 ,  G01J3/10

CPC classification number: G01J3/4412 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/4711 ,  G01N2201/0612 ,  G01N2201/068 ,  G01N2201/12

Abstract: Spectrometers and methods for determining the presence or absence of a material in proximity to and/or combined with another material are provided. In one particular example, a spectrometer is provided that includes a light source, a detector and an optical system. In this implementation, the light source is configured to provide an excitation incident beam. The detector is configured to detect a spectroscopy signal. The optical system is configured to direct the excitation incident beam toward a sample at a non-zero angle from a zero-angle reference. The optical system is further configured to receive a spectroscopy signal from the sample and provide the spectroscopy signal to the detector. The detector is configured to remove a spectral interference component of the spectroscopy signal.

公开(公告)号：US20190203255A1

公开(公告)日：2019-07-04

申请号：US16284050

申请日：2019-02-25

Applicant: Seraph Biosciences, Inc. ,  Wayne State University

Inventor： Gregory William Auner ,  Charles Shanley ,  Michelle Brusatori ,  Tara Twomey ,  David Sant

IPC: C12Q1/04 ,  G01J3/02 ,  G01J3/44 ,  C12Q1/14 ,  A61B5/00 ,  G01N21/65

CPC classification number: C12Q1/04 ,  A61B5/0075 ,  A61B5/445 ,  A61B5/6815 ,  A61B5/6819 ,  A61B5/682 ,  A61B5/6846 ,  C12Q1/14 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/4412 ,  G01N21/65 ,  G01N2201/0221 ,  G01N2333/11 ,  G01N2333/31 ,  G01N2333/34

Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.

公开(公告)号：US20190178798A1

公开(公告)日：2019-06-13

申请号：US15840393

申请日：2017-12-13

Applicant: International Business Machines Corporation

Inventor： Juntao Li ,  Kangguo Cheng ,  Qing Cao

IPC: G01N21/552 ,  G01N21/65 ,  C23C14/04 ,  C23C14/54 ,  B82Y15/00 ,  G02B5/00 ,  G01J3/44

CPC classification number: G01N21/554 ,  B82Y15/00 ,  C23C14/044 ,  C23C14/543 ,  G01J3/44 ,  G01N21/658 ,  G02B5/008

Abstract: A method of forming a semiconductor structure includes patterning one or more fin structures disposed over a top surface of a substrate, a given one of the fin structures comprising a first semiconductor layer comprising a first material disposed over the top surface of the substrate and a second semiconductor layer comprising a second material disposed over a top surface of the first semiconductor layer. The method further includes forming a liner over the one or more fin structures, and performing an anneal process to form one or more nanoscale features in a top surface of the second semiconductor layer. The second material exhibits enhanced diffusion, relative to the first material, at an interface of the liner and sidewalls of the given fin structure.

公开(公告)号：US20190049300A1

公开(公告)日：2019-02-14

申请号：US16058927

申请日：2018-08-08

Applicant: Tian GU ,  Derek Matthew KITA ,  Juejun HU

Inventor： Tian GU ,  Derek Matthew KITA ,  Juejun HU

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/453

CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/0272 ,  G01J3/453 ,  G01J3/4532 ,  G01N21/65

Abstract: State-of-the-art portable Raman spectrometers use discrete free-space optical components that must be aligned well and that don't tolerate vibrations well. Conversely, the inventive spectrometers are made with monolithic photonic integration to fabricate some or all optical components on one or more planar substrates. Photonic integration enables dense integration of components, eliminates manual alignment and individual component assembly, and yields superior mechanical stability and resistance to shock or vibration. These features make inventive spectrometers especially suitable for use in high-performance portable or wearable sensors. They also yield significant performance advantages, including a large (e.g., 10,000-fold) increase in Raman scattering efficiency resulting from on-chip interaction of the tightly localized optical mode and the analyte and a large enhancement in spectral resolution and sensitivity resulting from the integration of an on-chip Fourier-transform spectrometer.

公开(公告)号：US20180329196A1

公开(公告)日：2018-11-15

申请号：US15592506

申请日：2017-05-11

Applicant: Kaiser Optical Systems Inc.

Inventor： James M. Tedesco

IPC: G02B23/24 ,  G01J3/02

CPC classification number: G02B23/243 ,  A61B1/00064 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N21/8507 ,  G02B23/2446 ,  G02B23/2469

Abstract: In one aspect of the present disclosure, improved end optics are disclosed that maximize the numerical aperture focused at a sample point while minimizing unwanted artifacts such as vignetting. The configurations also maintain centering of the excitation/collection beam on the objective if the probe tilts or bends. The disclosed configurations are particularly suited to probes wherein the excitation and/or collection paths between the probe and the laser/analyzer are coupled through multimode fibers, such as in Raman and other forms of laser spectroscopy. The disclosure includes the insertion of one or more additional lenses between the probe head and the focusing objective at the probe tip.