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    Apparatus and method for liquid sample introduction
    15.
    发明授权
    Apparatus and method for liquid sample introduction 有权
    液体样品引入装置及方法

    公开(公告)号：US09541479B2

    公开(公告)日：2017-01-10

    申请号：US14163622

    申请日：2014-01-24

    Applicant: Thermo Electron Manufacturing Limited

    Inventor： Ruan Hattingh ,  Neil Bird ,  Paul Neal ,  Olivier Moteau

    IPC: G01N1/00 ,  G01N1/38 ,  H01J49/04 ,  B01L3/02

    CPC classification number: G01N1/38 ,  B01L3/0268 ,  H01J49/0454

    Abstract: A method and apparatus for mixing droplets of liquid sample and droplets of a diluent and/or a standard produced by droplet-on-demand generators for use with an analysis device. Two different liquids may be introduced to an analysis device for simultaneous analysis. The method preferably comprises using a first droplet-on-demand generator to provide a first stream of droplets of a first liquid; using a second droplet-on-demand generator to provide a second stream of droplets of a second liquid; and combining the first and second streams of droplets before they enter the analysis device.

    Abstract translation: 一种用于混合液体样品的液滴和稀释剂液滴和/或液滴按需发生器产生的用于分析装置的标准的方法和装置。 可以将两种不同的液体引入用于同时分析的分析装置。 该方法优选地包括使用第一液滴按需发生器来提供第一液体的第一液滴流; 使用第二液滴按需发生器来提供第二液体的第二液滴流; 并且在第一和第二液滴流进入分析装置之前组合。

    COLLISION ION GENERATOR AND SEPARATOR
    16.
    发明申请
    COLLISION ION GENERATOR AND SEPARATOR 审中-公开
    碰撞离子发生器和分离器

    公开(公告)号：US20160247668A1

    公开(公告)日：2016-08-25

    申请号：US15050286

    申请日：2016-02-22

    Applicant: MICROMASS UK LIMITED

    Inventor： Daniel Szalay ,  Lajos Godorhazy ,  Zoltan Takats

    IPC: H01J49/14 ,  H01J49/04

    CPC classification number: H01J49/142 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/0454 ,  H01J49/14 ,  H01J49/16

    Abstract: According to some embodiments, systems and methods for surface impact ionization of liquid phase and aerosol samples are provided. The method includes accelerating a liquid or aerosol sample, colliding the sample with a solid collision surface thereby disintegrating the sample into both molecular ionic species (e.g., gaseous molecular ions) and molecular neutral species (e.g., gaseous sample), and transporting the disintegrated sample to an ion analyzer. Some embodiments of the method further comprise discarding the molecular neutral species. Such embodiments transport substantially only the molecular ionic species to the ion analyzer.

    Abstract translation: 根据一些实施例，提供了液相和气溶胶样品的表面碰撞电离的系统和方法。 该方法包括加速液体或气溶胶样品，将样品与固体碰撞表面碰撞，从而将样品分解成分子离子物质（例如气态分子离子）和分子中性物质（例如气态样品），并将分解的样品 到离子分析仪。 该方法的一些实施方案还包括丢弃分子中性物质。 这样的实施例基本上只将分子离子物质转移到离子分析器。

    Methods and systems for mass spectrometry
    18.
    发明授权
    Methods and systems for mass spectrometry 失效
    质谱方法和系统

    公开(公告)号：US08692192B2

    公开(公告)日：2014-04-08

    申请号：US13858594

    申请日：2013-04-08

    Applicant: University of Washington Through Its Center for Commercialization ,  University of Glasgow

    Inventor： David R. Goodlett ,  Scott R. Heron ,  Jon Cooper

    IPC: H01J49/26 ,  G01N23/00

    CPC classification number: H01J49/0454 ,  H01J49/0031

    Abstract: The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI.

    Abstract translation: 本发明一般涉及质谱法。 本发明更具体地涉及用于各种分析物（包括高分子量物质如蛋白质）的质谱鉴定中的方法和系统。 本发明的一个实施方案是分析分析物的方法。 该方法包括将分析物在溶剂中的悬浮液与表面声波换能器雾化; 并对雾化悬浮液进行质谱分析。 例如，表面声波换能器可以用于将大气压下的非挥发性肽和蛋白质（以及其它分析物，例如寡核苷酸和聚合物）转移到气相中。 使用表面声波的雾化可以以不连续或脉冲模式进行，类似于在MALDI中使用的模式，或者以连续模式进行，如在ESI中。

    Charged particle source with droplet control for mass spectrometry
    19.
    发明授权
    Charged particle source with droplet control for mass spectrometry 有权
    带液滴控制的带电粒子源进行质谱分析

    公开(公告)号：US06906322B2

    公开(公告)日：2005-06-14

    申请号：US10113897

    申请日：2002-03-29

    Applicant: William Travis Berggren ,  Michael Scott Westphall ,  Lloyd Michael Smith

    Inventor： William Travis Berggren ,  Michael Scott Westphall ,  Lloyd Michael Smith

    IPC: H01J40/04 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    CPC classification number: H01J49/0454 ,  H01J49/167

    Abstract: The invention provides devices, device configurations and methods for improved sensitivity, detection level and efficiency in mass spectrometry particularly as applied to biological molecules, including biological polymers, such as proteins and nucleic acids. In one aspect, the invention relates to charged droplet sources and their use as ion sources and as components in ion sources. In another aspect, the invention relates to charged droplet traps and their use as ion sources and as elements of ion sources. Further, the invention relates to the use of aerodynamic lenses for high efficiency ion transport to a charge particle analyzer, particularly a mass analyzer. Devices of this invention allow mass spectral analysis of a single charged droplet. The ion sources of this invention can be combined with any charge particle detector or mass analyzer, but are a particularly benefit when used in combination with a time of flight mass spectrometer.

    Abstract translation: 本发明提供用于提高质谱的灵敏度，检测水平和效率的装置，装置配置和方法，特别是应用于包括生物聚合物如蛋白质和核酸在内的生物分子。 一方面，本发明涉及带电液滴源及其作为离子源和作为离子源中的组分的用途。 另一方面，本发明涉及带电液滴阱及其作为离子源和离子源元素的用途。 此外，本发明涉及使用空气动力学透镜进行高效率离子迁移到电荷粒子分析仪，特别是质量分析器。 本发明的装置允许单个带电液滴的质谱分析。 本发明的离子源可以与任何电荷粒子检测器或质量分析仪组合，但是当与飞行时间质谱仪组合使用时是特别有益的。

    Method and system using acoustic ejection for preparing and analyzing a cellular sample surface
    20.
    发明授权
    Method and system using acoustic ejection for preparing and analyzing a cellular sample surface 失效
    用于制备和分析细胞样品表面的声弹出方法和系统

    公开(公告)号：US06809315B2

    公开(公告)日：2004-10-26

    申请号：US10087372

    申请日：2002-03-01

    Applicant: Richard N. Ellson ,  Mitchell W. Mutz ,  Richard Michael Caprioli

    Inventor： Richard N. Ellson ,  Mitchell W. Mutz ,  Richard Michael Caprioli

    IPC: H01J4904

    CPC classification number: H01J49/0454 ,  G01N33/54393 ,  Y10T436/2575

    Abstract: The invention relates to a method and system for acoustically depositing a fluid on a surface of a cell sample. A reservoir containing a fluid is provided, and the cell sample surface is positioned in droplet-receiving relationship to the reservoir. Once the reservoir and the cell sample surface are appropriately positioned, focused acoustic energy is applied to eject a droplet of the fluid from the reservoir. As a result, the droplet is deposited on the sample surface at a designated site. Optionally, the fluid may be an analysis-enhancing fluid that contains a label moiety or a mass-spectrometry matrix material. When an analysis-enhancing fluid is used, the sample is typically subjected to conditions effective to allow the analysis-enhancing fluid to interact with the sample surface so as to render the sample surface suitable for analysis. Then, the sample may be analyzed at the designated site.

    Abstract translation: 本发明涉及用于在细胞样品的表面上声学沉积流体的方法和系统。 提供了包含流体的储存器，并且细胞样品表面位于与储存器的液滴接收关系中。 一旦容器和细胞样品表面被适当地定位，则聚焦的声能被施加以从储存器喷射流体液滴。 结果，液滴在指定的位置沉积在样品表面上。 任选地，流体可以是包含标记部分或质谱法基质材料的分析增强流体。 当使用分析增强流体时，样品通常经受有效的条件以允许分析增强流体与样品表面相互作用，以使样品表面适合于分析。 然后，可以在指定的位置分析样品。

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