公开(公告)号：US20030215882A1

公开(公告)日：2003-11-20

申请号：US10455986

申请日：2003-06-07

Applicant: Applera Corporation

Inventor： Paul D. Grossman ,  Jeffery D. Frazier

IPC: G01N033/53 ,  C12M001/34 ,  G01J003/42

CPC classification number: G01N27/44782 ,  G01N27/44721

Abstract: A side-entry excitation arrangement is provided with a multi-channel analyte-separation device. In various embodiments, a plurality of channels are disposed in an array, with a laser disposed to direct an excitation beam of light along a beam path that crosses the longitudinal axes of the channels, so as to simultaneously irradiate a region of each of the channels. Devices of the invention can be useful, for example, in the separation and analysis of bio-molecules, such as DNA, RNA, etc.

公开(公告)号：US20030202180A1

公开(公告)日：2003-10-30

申请号：US10422558

申请日：2003-04-24

Inventor： Juergen Gobel ,  Werner Hoyme ,  Martin Goetz ,  Wilhelm Schebesta

IPC: G01J003/42 ,  G01J003/28 ,  G01J005/02

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/36 ,  G01J2001/0481 ,  G01N21/31 ,  G01N21/3563 ,  G01N21/474 ,  G01N21/59 ,  G01N21/8901 ,  G01N2021/3155

Abstract: An optical measuring arrangement, particularly for quality control in continuous material flow processes, comprising a measuring head which is arranged immediately adjacent to a measurement object, a measurement light source which is held at the measuring head for illuminating a measurement spot on the measurement object, a measurement light reception device, at least one spectrometer which is optically coupled with the measurement light reception device via a light-conducting device, wherein the spectrometer and the light-conducting device are received in the measuring head, and a signal processing device which is likewise received in the measuring head. This results in a compact arrangement for reflection measurement which is easy to assemble and which, beyond this, supplies very accurate measurement results. Further, a measuring arrangement operating on the principle of spectroscopy is suggested for transmission measurement. The disclosure further relates to a combined reflection and transmission measurement device which carries out both measuring processes simultaneously.

公开(公告)号：US20030151744A1

公开(公告)日：2003-08-14

申请号：US10077721

申请日：2002-02-14

Inventor： C.J. Anthony Fernando ,  James E. Swon

IPC: G01J003/42

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/42 ,  G01N21/31

Abstract: A spectroscopic apparatus comprises a housing, a light source supported by the housing, a sample optical detector supported by the housing, an optical input selection device supported by the housing, a plurality of optical source lines, and a plurality of optical return lines. The optical input selection device is rotatable about a first axis and comprises a first internal optical fiber having a first input end and a first output end. The first input end is disposed collinearly with the first axis, and the first output end disposed at a radially offset distance from the first axis. The optical source lines have respective source line input ends. Each source line input end is selectively optically alignable with the first output end. The optical return lines have respective return line output ends. Each return line output end is supported by the housing and selectively communicates with the sample optical detector.

Abstract translation: 分光装置包括壳体，由壳体支撑的光源，由壳体支撑的样本光学检测器，由壳体支撑的光学输入选择装置，多个光源线以及多个光学返回线。 光学输入选择装置可围绕第一轴线旋转并且包括具有第一输入端和第一输出端的第一内部光纤。 第一输入端与第一轴线共线设置，第一输出端设置在与第一轴线径向偏移的距离处。 光源线具有相应的源极线输入端。 每个源极线输入端与第一输出端选择性地光学对准。 光学返回线具有各自的返回线输出端。 每个返回线输出端由壳体支撑并选择性地与样品光学检测器通信。

公开(公告)号：US20030058441A1

公开(公告)日：2003-03-27

申请号：US09957085

申请日：2001-09-20

Applicant: Metso Paper Automation Oy,

Inventor： John Shakespeare ,  Tarja Shakespeare

IPC: G01J003/42

CPC classification number: G01J3/36 ,  G01J3/28 ,  G01J3/42 ,  G01N21/276

Abstract: The invention relates to a method and an apparatus according to the method. A sample is illuminated by a band of optical radiation the illumination state of which is variable as a function of time. Reference measurements of the spectrum of the optical band illuminating the sample are made at least at three separate instants of time. A spectrum of a band of the optical radiation that has interacted with the sample is measured at the corresponding separate instants of time as the reference measurement, and the radiance transfer factor matrix of the sample is estimated from the set of reference measurements and the set of sample measurements.

Abstract translation: 本发明涉及一种根据该方法的方法和装置。 样品由其照射状态作为时间的函数而变化的光辐射带照射。 至少在三个不同的时刻进行照射样品的光学带的光谱的参考测量。 在相应的不同时刻作为参考测量，测量与样品相互作用的光辐射的光谱的频谱，并且从参考测量集合中估计样品的辐射传递因子矩阵， 样品测量。

公开(公告)号：US20030013103A1

公开(公告)日：2003-01-16

申请号：US10126139

申请日：2002-04-19

Inventor： Bruce J. Bryan ,  Stephen Gaalema ,  Randall B. Murphy

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/542 ,  C12M001/34 ,  G01J003/42 ,  G01J003/427

CPC classification number: G01N33/582 ,  G01N21/253 ,  G01N21/763 ,  G01N33/54366 ,  Y10S435/808 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/805 ,  Y10T436/186

Abstract: Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biomineralization for depositing silicon on a matrix support are also provided. A synthetic synapse is also provided.

公开(公告)号：US20020196437A1

公开(公告)日：2002-12-26

申请号：US09863042

申请日：2001-05-22

Applicant: Xerox Corporation

Inventor： Jagdish C. Tandon ,  Lingappa K. Mestha ,  Fred F. Hubble III

IPC: G01J003/42

CPC classification number: H04N1/6033 ,  G01J3/501 ,  G01J3/513 ,  G01J3/524 ,  G03G15/01 ,  G03G2215/00063 ,  G03G2215/00067

Abstract: A color spectrophotometer incorporating a low cost commercial imaging chip, which normally forms part of a document imaging bar used for imaging documents in scanners, etc., having multiple photo-sites with three different rows of color filters. Each chip is mounted on the optical axis of an imaging lens system, in the image plane of that lens system, to image the reflected illumination from an illuminated color test target area on the chip. The optical axis of the imaging lens system is oriented at 45null to the illuminated color test patches, and the photodetector chip is physically mounted perpendicular to the plane of the illuminated color test patches. Respective photo-sensor chips and associated 1:1 optics may be mounted on opposing sides of the spectrophotometer physically oriented at 90null to the test target area plane receiving the reflected light from the test target optically oriented at 45null to the illuminated test target.

Abstract translation: 一种彩色分光光度计，其结合了低成本的商业成像芯片，其通常构成用于在扫描仪等中成像文档的文档成像条的一部分，具有具有三个不同行彩色滤光片的多个光照位置。 每个芯片安装在成像透镜系统的光轴上，在该透镜系统的图像平面中，以对来自芯片上的被照亮颜色测试对象区域的反射照明进行成像。 成像透镜系统的光轴与被照明的彩色测试贴片定向成45°，并且光电检测器芯片物理地安装成垂直于被照亮的彩色测试贴片的平面。 相应的光传感器芯片和相关的1：1光学器件可以安装在分光光度计的相对侧上，物理地定向为90°，接收来自与照明测试目标以45°光学定向的测试对象的反射光的测试对象区域平面。

公开(公告)号：US20020135755A1

公开(公告)日：2002-09-26

申请号：US10047454

申请日：2002-01-14

Inventor： Victor B. Kley

IPC: G01J003/42 ,  G01N021/00

CPC classification number: G01Q60/02 ,  G01Q20/02 ,  G01Q30/02 ,  G01Q60/04 ,  G01Q60/16 ,  G01Q60/22 ,  G01Q60/40 ,  G02B21/002 ,  G03F1/84 ,  G03F7/70375 ,  G03F7/704 ,  G03F7/70483 ,  G03F7/70616 ,  G11B5/232 ,  G11B5/3116 ,  Y10S977/879

Abstract: A scanning probe microscope assembly (100) is disclosed that has an atomic force measurement (AFM) mode (137), a scanning tunneling measurement (STM) mode (138), a near-field spectronomy mode (143), a near-field optical mode (151), and a hardness testing mode for examining an object (104).

Abstract translation: 公开了一种扫描探针显微镜组件（100），其具有原子力测量（AFM）模式（137），扫描隧道测量（STM）模式（138），近场光谱雷达模式（143），近场 光学模式（151）和用于检查物体（104）的硬度测试模式。

公开(公告)号：US20020001078A1

公开(公告)日：2002-01-03

申请号：US09797154

申请日：2001-03-01

Inventor： Juergen Gobel ,  Werner Hoyme ,  Martin Goetz ,  Wilhelm Schebesta

IPC: G01J003/42

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/36 ,  G01J2001/0481 ,  G01N21/31 ,  G01N21/3563 ,  G01N21/474 ,  G01N21/59 ,  G01N21/8901 ,  G01N2021/3155

Abstract: An optical measuring arrangement, particularly for quality control in continuous material flow processes, comprising a measuring head which is arranged immediately adjacent to a measurement object, a measurement light source which is held at the measuring head for illuminating a measurement spot on the measurement object, a measurement light reception device, at least one spectrometer which is optically coupled with the measurement light reception device via a light-conducting device, wherein the spectrometer and the light-conducting device are received in the measuring head, and a signal processing device which is likewise received in the measuring head. This results in a compact arrangement for reflection measurement which is easy to assemble and which, beyond this, supplies very accurate measurement results. Further, a measuring arrangement operating on the principle of spectroscopy is suggested for transmission measurement. The disclosure further relates to a combined reflection and transmission measurement device which carries out both measuring processes simultaneously.

Abstract translation: 一种光学测量装置，特别是用于连续材料流动过程中的质量控制的光学测量装置，包括紧邻测量对象设置的测量头，保持在测量头上用于照射测量对象上的测量点的测量光源， 测量光接收装置，至少一个光谱仪，其通过导光装置与测量光接收装置光学耦合，其中光谱仪和导光装置被接收在测量头中，并且信号处理装置是 同样被接收在测量头上。 这导致反射测量的紧凑布置，其易于组装，并且除此之外，提供非常精确的测量结果。 此外，建议以光谱学原理工作的测量装置用于透射测量。 本公开还涉及同时进行两个测量过程的组合反射和透射测量装置。

公开(公告)号：US20010055116A1

公开(公告)日：2001-12-27

申请号：US09932210

申请日：2001-08-17

Inventor： Anthony K. Maczura ,  Erich R. Gross ,  Anthony S. Lee ,  David M. Mayes

IPC: G01J003/42

CPC classification number: G01N21/276 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0272 ,  G01J3/28 ,  G01J3/42 ,  G01J3/46 ,  G01J3/502 ,  G01J3/524 ,  G01J2003/2866 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/85

Abstract: The present invention relates to spectral analysis systems and methods for determining physical and chemical properties of a sample by measuring the optical characteristics of light emitted from the sample. In one embodiment, a probe head for use with a spectrometer includes an optical blocking element for forcing the optical path between the light source and an optical pick-up optically connected to the spectrometer into the sample. The probe head also includes a reference shutter for selectively blocking light emitted from the sample from reaching the optical pick-up to facilitate calibration of the spectrometer.

Abstract translation: 本发明涉及通过测量从样品发射的光的光学特性来确定样品的物理和化学性质的光谱分析系统和方法。 在一个实施例中，与光谱仪一起使用的探针头包括用于迫使光源和光学连接到光谱仪的光学拾取器之间的光路进入样品的光学阻挡元件。 探头还包括用于选择性地阻挡从样品发射的光到达光学拾波器以便于校准光谱仪的参考快门。

公开(公告)号：US20040223149A1

公开(公告)日：2004-11-11

申请号：US10811094

申请日：2004-03-26

Inventor： Thomas J. Skierski ,  Thomas L. Cope

IPC: G01J003/42

CPC classification number: G01J3/46 ,  G01J3/0251 ,  G01J2003/466 ,  G01N21/251 ,  G01N21/274 ,  G01N21/474 ,  G01N33/46 ,  G01N2021/8416 ,  G01N2201/0634 ,  G01N2201/065

Abstract: A method of verifying the color and tinting strength of a manufactured batch of a semi-transparent wood stain. In accordance with the method, a standard batch of the wood stain is formed and then mixed with a specified amount of a white colorant to form a standard measurement batch. A test sample of the manufactured batch is obtained and is also mixed with a specified amount of the white colorant to form a test measurement sample. Layers of the standard measurement batch and the test measurement sample are formed on the substrates and complete hide obtained. Reflectance measurements of the layers are made using a spectrophotometer. The reflectance measurements are used to determine if the color and the tinting strength of the manufactured batch is within an acceptable deviation range of the color and tinting strength of the standard batch. This allows for objective color difference and tint strength difference calculations, and adjustments can be made therefrom, therefore eliminating the past visual trial and error methods.

Abstract translation: 一种验证制造的半透明木纹的批次的颜色和着色强度的方法。 根据该方法，形成标准批次的木纹，然后与指定量的白色着色剂混合以形成标准测量批料。 获得制造的批次的测试样品，并将其与指定量的白色着色剂混合以形成测试测量样品。 在基板上形成标准测量批次和测试测量样品的层，并获得完整的隐藏。 层的反射率测量使用分光光度计进行。 使用反射率测量来确定制造的批次的颜色和着色强度是否在标准批次的颜色和着色强度的可接受的偏差范围内。 这允许目标色差和色调强度差计算，并且可以进行调整，从而消除过去的视觉试验和误差方法。