公开(公告)号：US5784162A

公开(公告)日：1998-07-21

申请号：US571047

申请日：1995-12-12

Applicant: Dario Cabib ,  Robert A. Buckwald ,  Zvi Malik ,  Yuval Garini ,  Nir Katzir ,  Dirk G. Soeknsen

Inventor： Dario Cabib ,  Robert A. Buckwald ,  Zvi Malik ,  Yuval Garini ,  Nir Katzir ,  Dirk G. Soeknsen

IPC: G01B11/00 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  A61B10/00 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/443 ,  G01J3/45 ,  G01J3/453 ,  G01N21/27 ,  G01N21/64 ,  G01N33/48 ,  G01N33/483 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G02B21/36 ,  G06K9/00 ,  G06K9/76 ,  G01B9/02

CPC classification number: G01N21/6458 ,  C12Q1/6841 ,  C12Q1/6883 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/6428 ,  G01N21/6486 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/582 ,  G06K9/00127 ,  G06K9/76 ,  G01J2003/2866 ,  G01J3/02 ,  G01N2021/6417 ,  G01N2021/6423

Abstract: According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connected to an imaging spectrometer, the optical device and the imaging spectrometer obtaining a spectrum of each pixel of the sample by: (i) collecting incident light simultaneously from all pixels of the sample using collimating optics; (ii) passing the incident collimated light through an interferometer system having a number of elements, to form an exiting light beam; (iii) passing the exiting light beam through a focusing optical system which focuses the exiting light beam on a detector having a two-dimensional array of detector elements, so that at each instant each of the detector elements is the image of one pixel of the sample, so that the real image of the sample is stationary on the plane of the detector array, and so that each of the detector elements produces a signal which is a particular linear combination of light intensity emitted by the pixel at different wavelengths, wherein the linear combination is a function of the instantaneous optical path difference; (iv) rotating one or more of the elements of the interferometer system, so that the optical path difference between the two coherent beams generated by the interferometer system is scanned simultaneously for all the pixels of the sample; and (v) recording signals of each of the detector elements as function of time using a recording device to form a first spectral cube of data; and (c) interpreting the first spectral cube of data using a mathematical algorithm.

Abstract translation: 根据本发明，提供了用于生物学研究，医学诊断和治疗的光谱成像方法，其包括以下步骤：（a）制备待成像的样品; （b）通过光学装置观察样品，光学装置光学连接到成像光谱仪，光学装置和成像光谱仪通过以下步骤获得样品的每个像素的光谱：（i）从所有像素同时收集入射光 的样品使用准直光学; （ii）使入射的准直光通过具有多个元件的干涉仪系统，以形成出射的光束; （iii）使出射的光束通过聚焦光学系统，该聚焦光学系统将出射的光束聚焦在具有检测器元件的二维阵列的检测器上，使得在每个瞬间，每个检测器元件是 样本，使得样本的真实图像在检测器阵列的平面上是静止的，并且使得每个检测器元件产生信号，其是由不同波长的像素发射的光强度的特定线性组合，其中 线性组合是瞬时光程差的函数; （iv）旋转干涉仪系统的一个或多个元件，使得由干涉仪系统产生的两个相干光束之间的光程差同时扫描样品的所有像素; 以及（v）使用记录装置记录每个检测器元件的信号作为时间的函数，以形成数据的第一光谱立方体; 和（c）使用数学算法解释数据的第一个频谱立方体。

公开(公告)号：US5771096A

公开(公告)日：1998-06-23

申请号：US836609

申请日：1997-05-13

Applicant: Hans Villemoes Andersen

Inventor： Hans Villemoes Andersen

IPC: G01J3/28 ,  G01J3/45 ,  G01J3/453 ,  G01N21/27 ,  G01R33/32 ,  G01B9/02

CPC classification number: G01J3/45 ,  G01J3/453

Abstract: A method is suggested for obtaining information on the electromagnetic spectrum of a sample, the method comprising (a) generating a plurality of substantially identical signals, (b) determining the shape of a first number of the signals by performing a first number of scans of a first range of signal width, (c) determining the shape of a second number of the signals by performing a second number of scans of a second range of signal width, the second range being comprised by the first range and comprising a portion of the first range in which the signals have maximum absolute amplitude, (d) combining data from the first number of scans and the second number of scans so as to obtain data corresponding to the shape of the signals, and (e) performing a mathematical transformation of the combined data so as to obtain the information on the electromagnetic spectrum of the sample. According to this method, the electromagnetic spectrum--and especially an absorption spectrum for use in quantitative analysis of the sample--may be obtained faster than is possible using prior art methods.

Abstract translation: PCT No.PCT / DK95 / 00492 Sec。 371日期1997年5月13日 102（e）日期1997年5月13日PCT提交1995年12月7日PCT公布。 WO96 / 18089 PCT公开 日期1996年6月13日提出了一种用于获得关于样本的电磁频谱的信息的方法，所述方法包括（a）产生多个基本相同的信号，（b）通过执行一个步骤来确定第一数量的信号的形状 第一范围的信号宽度的第一次扫描，（c）通过执行第二范围的信号宽度的第二次扫描来确定第二数量的信号的形状，第二范围由第一范围和 包括信号具有最大绝对幅度的第一范围的一部分，（d）组合来自第一扫描次数和第二扫描次数的数据，以获得对应于信号形状的数据，以及（e） 执行组合数据的数学变换，以获得关于样本的电磁光谱的信息。 根据该方法，可以比使用现有技术方法更快地获得电磁光谱，特别是用于样品定量分析的吸收光谱。

公开(公告)号：US5715055A

公开(公告)日：1998-02-03

申请号：US619951

申请日：1996-03-18

Applicant: Tomoaki Nanko ,  Takeo Tanaami ,  Akihiro Murata

Inventor： Tomoaki Nanko ,  Takeo Tanaami ,  Akihiro Murata

IPC: G01J3/45 ,  G01J3/453 ,  G01B9/02

CPC classification number: G01J3/4535

Abstract: A spectroscope comprising an optical fiber placed in a light path to a sample chamber, wherein a light beam outputted from the optical fiber is divided into two using an optical coupler, and wherein the two divided light beams are made incident on a measurement optical fiber and a reference optical fiber, respectively, whereby accuracy of measurement of the spectral characteristics of samples is enhanced because the outgoing light is made incident on the measurement and reference optical fibers concurrently when the light to the sample chamber becomes non-uniform due to environmental changes.

Abstract translation: 一种分光器，包括放置在到样品室的光路中的光纤，其中从光纤输出的光束使用光耦合器被分成两个，并且其中两个分开的光束入射在测量光纤上， 分别对应于样品室的光由于环境变化而变得不均匀的同时由于出射光入射到测量基准光纤上而使样本的光谱特性的测量精度提高的参考光纤。

公开(公告)号：US5706135A

公开(公告)日：1998-01-06

申请号：US538656

申请日：1995-10-03

Applicant: Peter Joseph Codella

Inventor： Peter Joseph Codella

IPC: G01J3/45 ,  G01J3/453 ,  G02B1/02 ,  G02B5/04 ,  G02B27/14

CPC classification number: G02B27/1073 ,  G01J3/453 ,  G02B1/02 ,  G02B27/144

Abstract: A structurally robust beamsplitter that has substantially constant transmittance values over a wide range of wavelengths includes a freestanding monolithic synthetic polycrystalline diamond optical plate that has a thickness in the range of about 1 .mu.m to about 1 mm. The optical plate further typically has a transmittance in the range between 55% and 75% for incident radiation over almost all wavelengths of radiation from the infrared to the visible. A beamsplitter in accordance with the present invention is readily adapted for use in a interferometric spectroscopy system, such as a system using infrared and far infrared radiation for spectroscopic analysis.

Abstract translation: 在宽波长范围内具有基本恒定的透射率值的结构稳健的分束器包括具有约1μm至约1mm范围内的厚度的独立的单片合成多晶金刚石光学板。 在从红外线到可见光的几乎所有波长的辐射上，入射辐射的光学板还通常具有在55％和75％之间的范围内的透射率。 根据本发明的分束器易于适用于干涉光谱系统，例如使用红外和远红外辐射进行光谱分析的系统。

公开(公告)号：US5675413A

公开(公告)日：1997-10-07

申请号：US710616

申请日：1996-09-20

Applicant: Ivan Prikryl ,  Hollis O'Neal Hall

Inventor： Ivan Prikryl ,  Hollis O'Neal Hall

IPC: G01B9/02 ,  G01J3/45 ,  G01J3/453 ,  G01J9/02

CPC classification number: G01J3/45 ,  G01J3/4535 ,  G01J9/02

Abstract: An adjustable optical system for determining aberration in a source beam by comparison of a test beam with a reference beam. The system includes a test source for producing a source beam having a spacial intensity distribution including an aberration component, a wavefront analyzer for processing a fringe signal associated with the aberration component, and an interferometer interposed between the test source and wavefront analyzer. The interferometer includes a beamsplitter for splitting the source beam into a test beam and a reference beam, a mirror disposed in the test beam path, and a micromirror disposed in the reference beam path. The micromirror reflects a central portion of the reference beam toward an imaging device and allows an outer portion of the reference beam to pass thereby. The interferometer is also provided with an alignment image assembly for collecting and detecting the outer portion of the reference beam so that the micromirror and test source may be independently adjusted relative to the central and outer portions of the reference beam.

Abstract translation: 一种可调光学系统，用于通过将测试光束与参考光束进行比较来确定源光束中的像差。 该系统包括用于产生具有包括像差分量的空间强度分布的源束的测试源，用于处理与像差分量相关联的条纹信号的波前分析器以及插入在测试源和波前分析器之间的干涉仪。 干涉仪包括用于将源束分解成测试光束和参考光束的分束器，设置在测试光束路径中的反射镜和设置在参考光束路径中的微镜。 微镜将参考光束的中心部分朝向成像装置反射，并允许参考光束的外部部分通过。 干涉仪还设置有对准图像组件，用于收集和检测参考光束的外部部分，使得微镜和测试光源可以相对于参考光束的中心部分和外部部分独立地调节。

公开(公告)号：US5561521A

公开(公告)日：1996-10-01

申请号：US452586

申请日：1995-05-25

Applicant: Stillman C. Chase ,  Raymond W. Metz

Inventor： Stillman C. Chase ,  Raymond W. Metz

IPC: G01J3/45 ,  G01J3/453 ,  G01B9/02

CPC classification number: G01J3/4535

Abstract: Two dichroic mirrors (26, 30) and a dichroic beamsplitter (36) are introduced into the conventional Michelson Fourier transform spectrometer to accommodate two spectral bands. A conventional Michelson Fourier transform spectrometer (FTS) uses two mirrors (20, 22), one fixed (20) and the other moving (22). The present invention replaces each of the two mirrors (20, 22) with a pair of mirrors, one of which is a dichroic mirror (26, 30). The present invention involves inserting the first dichroic mirror (26) fixed in position between the beamsplitter (12) and the first plane mirror (20) and inserting a second dichroic minor (30), which can be moved in a direction normal to the plane surface, between the beamsplitter (12) and the second plane mirror (22). The first dichroic mirror (26) and second dichroic mirror (30) transmit long wavelength radiation and reflect short wavelength radiation. A dichroic beamsplitter (36) is also inserted in the interferometer assembly (10) to separate the two spectral bands in the third beam (24). By moving the second plane mirror (22) and the second dichroic mirror (30) a different amount to change the optical path difference between the second plane mirror (22) and the beamsplitter (12), and the optical path difference between the second dichroic mirror (30) and the beamsplitter (12), two spectral bands can be processed with different spectral resolutions.

Abstract translation: 将两个分色镜（26,30）和二向色分束器（36）引入到常规的迈克尔逊傅里叶变换光谱仪中以适应两个光谱带。 常规的迈克尔逊傅里叶变换光谱仪（FTS）使用两个反射镜（20,22），一个固定（20）和另一个移动（22）。 本发明用一对反射镜代替两个反射镜（20,22）中的每一个，其中一个反射镜是二向色镜（26,30）。 本发明涉及将固定在分束器（12）和第一平面镜（20）之间的位置的第一分色镜（26）插入并插入可沿垂直于平面的方向移动的第二分色器（30） 在分束器（12）和第二平面镜（22）之间。 第一分色镜（26）和第二分色镜（30）透射长波长的辐射并反射短波长的辐射。 二分色分束器（36）也插入到干涉仪组件（10）中以分离第三光束（24）中的两个光谱带。 通过使第二平面镜（22）和第二分色镜（30）移动不同的量来改变第二平面镜（22）和分束器（12）之间的光程差，并且第二二向色镜 反射镜（30）和分束器（12），可以以不同的光谱分辨率处理两个光谱带。

公开(公告)号：US5550373A

公开(公告)日：1996-08-27

申请号：US367491

申请日：1994-12-30

Applicant: Barrett E. Cole ,  Bernard S. Fritz ,  Robert D. Horning

Inventor： Barrett E. Cole ,  Bernard S. Fritz ,  Robert D. Horning

IPC: B81B1/00 ,  G01J3/26 ,  G01J3/28 ,  G01J5/20 ,  G02B26/00 ,  G01B9/02 ,  G01J3/45

CPC classification number: G01J3/2823 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0256 ,  G01J3/26 ,  G01J5/20 ,  G02B26/001

Abstract: A monolithically constructed infrared, tunable Fabry-Perot cavity filter-detector for spectroscopic detection of particular substances having an absorption line in the wavelength range from 2 to 12 microns. The filter-detector has a hermetically sealed Fabry-Perot cavity that has a mirror which has an adjustable distance relative to another mirror of the cavity. The former mirror is adjusted by piezoelectric film on the mirror support or with piezoelectric stacks or wall supporting the mirror. There may be electrodes situated near the mirrors for capacitive sensing of the distance between the mirrors. Light to be filtered and detected comes in through a window wafer which may have diffractive or refractive microlenses, plus an optional spatial filter. After passing through the window wafer, the light is filtered by the tunable mirrors of the Fabry-Perot cavity. The portion of the light that is passed by the cavity is detected by an infrared microbolometer or a CCD array. The cavity and detector are hermetically sealed in a vacuum.

Abstract translation: 用于光谱检测具有2至12微米波长范围内的吸收线的特定物质的单片构造的红外可调谐法布里 - 珀罗腔滤波器检测器。 过滤器检测器具有气密密封的法布里 - 珀罗腔，其具有相对于空腔的另一反射镜具有可调距离的反射镜。 前镜由反射镜支架上的压电膜或支撑镜子的压电叠层或墙壁调节。 可能存在位于反射镜附近的用于电容感测反射镜之间的距离的电极。 要过滤和检测的光通过可能具有衍射或折射微透镜的窗玻璃加上可选的空间滤光片进入。 通过窗玻璃后，光被法布里 - 珀罗腔的可调镜过滤。 由空腔通过的光的部分由红外微辐射热计或CCD阵列检测。 空腔和检测器在真空中气密密封。

公开(公告)号：US5459317A

公开(公告)日：1995-10-17

申请号：US195709

申请日：1994-02-14

Applicant: Gary W. Small ,  Mark Arnold

Inventor： Gary W. Small ,  Mark Arnold

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/45 ,  G01N21/35 ,  G01J3/28

CPC classification number: G01J3/45 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7257 ,  G01N21/35 ,  G01N21/359

Abstract: Non-invasive measurements of physiological chemicals such as glucose are made using infrared radiation and a signal processing system that permits the construction of a device suited for home use. The level of a selected physiological chemical in a test subject is determined in a non-invasive and quantitative manner by a method comprising the steps of: (a) irradiating a portion of the test subject with near-infrared radiation such that the radiation is transmitted through or reflected from the test subject; (b) collecting data concerning the transmitted or reflected infrared radiation using a detector; (c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and (d) determining the amount of physiological chemical in the test subject by applying a defined mathematical model to the digitally filtered data. The data collected may be in the form of an absorbance spectrum, i.e., a representation of the variation in absorbance as a function of wavelength; or in the form of an interferogram, i.e., a representation of infrared light intensity as a function of the retardation of the moving mirror in the interferometer, and thus of time.

Abstract translation: 使用红外辐射和信号处理系统制造生物化学品如葡萄糖的非侵入性测量，其允许构造适于家庭使用的装置。 通过包括以下步骤的方法以非侵入性和定量的方式测定受检对象中所选择的生理化学物质的水平：（a）用近红外辐射照射被测物体的一部分，使得辐射被传输 通过或反映在考试科目; （b）使用检测器收集关于发射或反射的红外辐射的数据; （c）对所收集的数据进行数字滤波以分离指示生理化学品的数据的一部分; 和（d）通过将定义的数学模型应用于数字滤波数据来确定测试对象中生理化学物质的量。 收集的数据可以是吸收光谱的形式，即作为波长的函数的吸光度变化的表示; 或者以干涉图的形式，即作为干涉仪中的移动镜的延迟的函数的红外光强度的表示，以及因此的时间。

公开(公告)号：US5450196A

公开(公告)日：1995-09-12

申请号：US289160

申请日：1994-08-11

Applicant: Andrew J. Turner

Inventor： Andrew J. Turner

IPC: G01J3/45 ,  G01J3/447 ,  G01B9/02

CPC classification number: G01J3/447

Abstract: In FT-DIRLD (Dynamic Infra Red Linear Dichroism) apparatus partly represented in FIG. 1, units 100-105, responding to interferometer output IB (indicated elsewhere), cause unit 106 to yield an interferogram combining static and dynamic dichroism interferograms. Reference signals respectively in phase and quadrature with cyclic sample strain are derived from rheometer 102. At each OPD point of predetermined uninterrupted scans, controller 108 routes simultaneously a data point of the combined interferogram and the reference signals to respective channels of multiplexer 107. A microprocessor (shown elsewhere) subsequently performs a best-fit-to-an ellipse sorting of the data and for each OPD derives: A) the value of the interferogram unaffected by sample modulation; B) the corresponding in phase term; and C) the corresponding in quadrature term; furthermore, from the A, B,C data-point series it generates the interferogram of each series and transforms it into a spectrum. DIRLD analysis is achieved asynchronously and in continuous fast scanning.

Abstract translation: 在图1中部分表示的FT-DIRLD（动态红外线性二色性）装置中。 如图1所示，单元100-105响应于干涉仪输出IB（在别处指示），使单元106产生组合静态和动态二色性干涉图的干涉图。 参考信号分别与循环样本应变相位和正交来自流变仪102.在预定的不间断扫描的每个OPD点，控制器108同时将组合的干涉图和参考信号的数据点路由到多路复用器107的相应通道。微处理器 （其他地方显示）随后对数据进行最佳拟合到一个椭圆分类，并且对于每个OPD导出：A）不受样本调制影响的干涉图的值; B）对应的相位项; 和C）相应的正交项; 此外，从A，B，C数据点系列，它产生每个系列的干涉图并将其转换成光谱。 DIRLD分析是在异步和连续快速扫描中实现的。

公开(公告)号：US5349439A

公开(公告)日：1994-09-20

申请号：US860997

申请日：1992-03-31

Applicant: Philippe Graindorge ,  Denis Trouchet

Inventor： Philippe Graindorge ,  Denis Trouchet

IPC: G01J3/26 ,  G01B9/02 ,  G01D5/26 ,  G01J3/45

CPC classification number: G01B9/02065 ,  G01B9/02032 ,  G01B9/02057 ,  G01B9/0209 ,  G01D5/266

Abstract: A measuring device comprises a light source with a wide spectrum feeding an optical sensor through an optical fiber. The sensor comprises an interferometer adjusted to a dull tint and an optical component sensitive to a measured parameter, which may be either a pressure, a measured displacement or an index of refraction of a fluid, a readout device includes the photodetector, a processing unit and an optical wedge for producing fringes, whose lateral positions, in contrast, are representative of the spectrum of the flux leaving the interferometer and analyzed by the photodetector. The processing unit measures the lateral position of the fringe and converts it into a value of the parameter P.

Abstract translation: 测量装置包括具有宽光谱的光源，通过光纤馈送光学传感器。 传感器包括调整为暗淡色调的干涉仪和对测量参数敏感的光学部件，测量参数可以是流体的压力，测量位移或折射率，读出装置包括光电检测器，处理单元和 相反，其横向位置代表离开干涉仪的光束的光谱并由光电检测器分析的用于产生条纹的光楔。 处理单元测量边缘的横向位置并将其转换为参数P的值。