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    Cost-effective Raman probe assembly for single-use bioreactor vessels
    22.
    发明授权
    Cost-effective Raman probe assembly for single-use bioreactor vessels 有权

    公开(公告)号：US10261020B2

    公开(公告)日：2019-04-16

    申请号：US15398096

    申请日：2017-01-04

    Applicant: Kaiser Optical Systems Inc.

    Inventor： James M. Tedesco ,  Joseph B. Slater

    IPC: G01N21/65 ,  G01N21/03 ,  G01J3/02 ,  C12M1/00 ,  C12M1/34 ,  G01J3/44 ,  G01N21/85

    Abstract: Systems and methods are used to couple an optical sampling probe to a port in a single-use bioreactor bag for in-process monitoring. A combination of re-useable and disposable components maintain precision while reducing costs. A disposable barb with an integral window, received by the port of the reaction vessel, is coupled to a re-useable optic component with a focusing lens. A separate focus alignment tool is used to set the lens position to a precise focal point before placement of the optic component into the barb. The fixture includes a window to simulate the window in a barb component, a target with a known spectral signature, and a probe head coupled to a spectral analyzer. The axial position of the lens is adjusted with respect to the spacer component to maximize the spectral signature from a sample target, whereupon the spacer component is bonded to the lens mount.

    MONOLITHIC ELEMENT AND SYSTEM FOR COLLIMATING OR FOCUSING LASER LIGHT FROM OR TO AN OPTICAL FIBER
    23.
    发明申请
    MONOLITHIC ELEMENT AND SYSTEM FOR COLLIMATING OR FOCUSING LASER LIGHT FROM OR TO AN OPTICAL FIBER 有权
    用于将激光照射或照射到光纤的单片元件和系统

    公开(公告)号：US20160041341A1

    公开(公告)日：2016-02-11

    申请号：US14455235

    申请日：2014-08-08

    Applicant: Kaiser Optical Systems Inc.

    Inventor： James M. Tedesco

    IPC: G02B6/32 ,  G02B3/02 ,  G01N21/65 ,  G02B3/00

    CPC classification number: G02B6/32 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/44 ,  G02B3/0087 ,  G02B3/02 ,  G02B6/322 ,  G02B6/3624 ,  G02B6/3869 ,  G02B6/4201

    Abstract: A monolithic optical element and system is used for collimating or focusing laser light from or to optical fibers. The optical fiber terminates in a tip that directly abuts against the first surface of the optical element. The optical element may provide a collimation or focusing function depending upon whether the abutting fiber delivers light for collimation or receives focused light from a collimated beam. The optical element may be a standard or modified barrel or drum lens, with the first and second surfaces being convex curved surfaces having the same or different radii of curvature. The end of the optical element to which the fiber abuts may have a diameter to match the inner diameter of a ferrule for positioning the fiber. A pair of the elements may be used for collimation and focusing in a Raman probehead or other optical detection system.

    Abstract translation: 单片光学元件和系统用于对来自光纤或来自光纤的激光进行准直或聚焦。 光纤终止于直接抵靠光学元件的第一表面的尖端。 光学元件可以根据邻接光纤是否提供准直光或从准直光束接收聚焦光来提供准直或聚焦功能。 光学元件可以是标准或改进的镜筒或镜筒，其中第一和第二表面是具有相同或不同曲率半径的凸曲面。 纤维邻接的光学元件的端部可以具有与用于定位光纤的套圈的内径相匹配的直径。 一对元件可用于拉曼探头或其他光学检测系统中的准直和聚焦。

    Methods for collection, dark correction, and reporting of spectra from array detector spectrometer
    25.
    发明授权
    Methods for collection, dark correction, and reporting of spectra from array detector spectrometer 有权

    公开(公告)号：US10260942B2

    公开(公告)日：2019-04-16

    申请号：US15588005

    申请日：2017-05-05

    Applicant: Kaiser Optical Systems, Inc.

    Inventor： Patrick Wiegand ,  James M. Tedesco ,  Joseph B. Slater ,  Francis Esmonde-White

    IPC: G01J3/02 ,  G01J3/44 ,  G01J3/28

    Abstract: Methods and systems for spectrometer dark correction are described which achieve more stable baselines, especially towards the edges where intensity correction magnifies any non-zero results of dark subtraction, and changes in dark current due to changes in temperature of the camera window frame are typically more pronounced. The resulting induced curvature of the baseline makes quantitation difficult in these regions. Use of the invention may provide metrics for the identification of system failure states such as loss of camera vacuum seal, drift in the temperature stabilization, and light leaks. In system aspects of the invention, a processor receives signals from a light detector in the spectrometer and executes software programs to calculate spectral responses, sum or average results, and perform other operations necessary to carry out the disclosed methods. In most preferred embodiments, the light signals received from a sample are used for Raman analysis.

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