公开(公告)号：US20190263971A1

公开(公告)日：2019-08-29

申请号：US16281400

申请日：2019-02-21

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Maria F. Gubitosi Raspino ,  Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Augustine Twum Kumi ,  Zach Munoz ,  Weihong Lang

IPC: C08G77/442 ,  G02B1/04 ,  C08J3/24 ,  B29D11/00

Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.

公开(公告)号：US20190235277A1

公开(公告)日：2019-08-01

申请号：US16260544

申请日：2019-01-29

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Richard Charles Breitkopf ,  Weihong Lang ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Frank Chang ,  Thomas M. Moy ,  Troy Vernon Holland

IPC: G02C7/04 ,  C09D143/00 ,  C08J7/04 ,  C08F230/00

CPC classification number: G02C7/049 ,  C08F230/00 ,  C08J7/047 ,  C08J2329/14 ,  C08J2443/00 ,  C09D143/00 ,  G02B1/043

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

公开(公告)号：US20180354214A1

公开(公告)日：2018-12-13

申请号：US16000928

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Daqing Wu ,  Steve Yun Zhang ,  Xinming Qian ,  Zach Munoz ,  Frank Chang ,  Wei Liang ,  Ying Zheng ,  Richard Charles Breitkopf ,  Matthew D. Nelson ,  Augustine Twum Kumi

IPC: B29D11/00 ,  G02B1/04

CPC classification number: B29D11/00134 ,  B29D11/00067 ,  B29D11/00076 ,  C08G77/442 ,  C08L83/04 ,  G02B1/043

Abstract: The present invention generally relates to a method for producing inherently wettable silicone hydrogel contact lenses with a robusteness of lens shape and having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus.

公开(公告)号：US09738813B2

公开(公告)日：2017-08-22

申请号：US15298298

申请日：2016-10-20

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: G02C7/02 ,  G02C7/04 ,  G02C7/00 ,  C09D177/06 ,  G02B1/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  B29D11/00 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US09239409B2

公开(公告)日：2016-01-19

申请号：US14571350

申请日：2014-12-16

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: G02C7/00 ,  G02C7/02 ,  G02C7/04 ,  G02B1/10 ,  G02B1/04

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US20130308093A1

公开(公告)日：2013-11-21

申请号：US13948206

申请日：2013-07-23

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: G02B1/04

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.