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公开(公告)号：US20160326395A1
公开(公告)日：2016-11-10
申请号：US15216125
申请日：2016-07-21
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Yongxing Qiu , John Dallas Pruitt , Chung-Yuan Chiang , Venkat Shankar , Robert Scott , Yash Kapoor
IPC: C09D133/24 , C07D205/04 , C08F220/56 , B29D11/00 , C08F224/00 , C09D137/00 , C08F283/12 , C09D151/08 , C08F220/54 , C09D133/26
CPC classification number: C09D133/24 , B29D11/00865 , C07D205/04 , C08F20/00 , C08F26/00 , C08F220/54 , C08F220/56 , C08F224/00 , C08F283/124 , C08F2500/26 , C09D133/26 , C09D137/00 , C09D139/04 , C09D151/085
Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.
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公开(公告)号：US09005700B2
公开(公告)日：2015-04-14
申请号：US13648522
申请日：2012-10-10
Applicant: Novartis AG
Inventor： Harald Bothe , Yongxing Qiu , Peter Hagmann
CPC classification number: B05D5/06 , B29D11/00125 , B29D11/00634 , B29D11/00865 , G02B1/043
Abstract: Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves dipping a contact lens in a solution of UV-absorbing polymer comprising carboxyl-containing monomeric units and UV-absorbing monomeric units to form a UV-absorbing coating on the contact lens.
Abstract translation: 本文描述了制造紫外线吸收隐形眼镜的成本效益和时间有效的方法。 与用于制备包含紫外线吸收性乙烯基单体的透镜形成组合物共聚的紫外线吸收隐形眼镜的常规方法相反，本发明的方法包括将隐形眼镜浸入含有羧基的紫外线吸收聚合物的溶液中 单体单元和紫外线吸收单体单元，以在隐形眼镜上形成紫外线吸收涂层。
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公开(公告)号：US08944592B2
公开(公告)日：2015-02-03
申请号：US13948206
申请日：2013-07-23
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
Abstract translation: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。
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公开(公告)号：US20130250234A1
公开(公告)日：2013-09-26
申请号：US13900136
申请日：2013-05-22
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
IPC: G02C7/04
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
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公开(公告)号：US10920102B2
公开(公告)日：2021-02-16
申请号：US16720932
申请日：2019-12-19
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , G02B1/18 , G02B1/04 , G02C7/04 , G02B1/10 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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Patent Agency Ranking
公开(公告)号：US10589479B2
公开(公告)日：2020-03-17
申请号：US15704188
申请日：2017-09-14
Applicant: Novartis AG
Inventor： Robert Carey Tucker , John Dallas Pruitt , Yongxing Qiu
IPC: G02B1/04 , B29D11/00 , C09D177/00 , G02C7/02
Abstract: The invention is generally related to colored contact lenses which comprise a hydrogel lens body having an opaque color image therein and/or thereon and a durable lubricious coating thereon. The coating comprises an anchoring layer of a polyanionic polymer having carboxyl groups and a hydrogel layer which is derived from a hydrophilic polymeric material having azetidinium groups and is covalently attached onto the anchoring layer of the polyanionic polymer through linkages each formed between one carboxyl group and one azetidinium groups. The colored contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and a friction rating of about 2 or lower after 7 cycles of manual rubbing.
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公开(公告)号：US10513628B2
公开(公告)日：2019-12-24
申请号：US16166379
申请日：2018-10-22
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
IPC: G02B1/18 , C09D177/06 , B29D11/00 , G02B1/04 , G02C7/04 , G02B1/10 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
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公开(公告)号：US20180079889A1
公开(公告)日：2018-03-22
申请号：US15704176
申请日：2017-09-14
Applicant: Novartis AG
Inventor： Chung-Yuan Chiang , Yongxing Qiu , Kelly Kayi Tallau , Angela Driver-Scott
IPC: C08K5/3412 , C08K5/00 , C07D205/04
CPC classification number: C08K5/3412 , B29D11/00038 , C07D205/04 , C08G65/08 , C08G73/00 , C08G73/022 , C08K5/0025 , C08K2003/321 , C08L71/02 , C08L79/00 , C09D4/00 , C08K3/24
Abstract: The invention is related to a cost-effective method for producing water-soluble thermally-crosslinkable hydrophilic polymeric materials. Resultant materials can find particular use in preparing a packaging solution used for packaging and autoclaving medical devices, especially contact lenses. Those packaging solutions are especially suitable for forming a relatively-thick and soft hydrogel coatings on contact lenses or medical devices according to an in-package-crosslinking (IPC) processes. The resultant non-silicone hydrogel coatings can have a superior lubricity (a friction rating of 0) with minimized or no surface cracking.
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公开(公告)号：US20170306178A1
公开(公告)日：2017-10-26
申请号：US15646291
申请日：2017-07-11
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , C08G77/388 , C08J5/00 , C08J7/04 , C08L83/04 , G02B1/18 , G02C7/04 , G02B1/10 , G02B1/04 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20160377885A1
公开(公告)日：2016-12-29
申请号：US15202759
申请日：2016-07-06
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
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