公开(公告)号：US20180195961A1

公开(公告)日：2018-07-12

申请号：US15837901

申请日：2017-12-11

Applicant: Illumina, Inc.

Inventor： John Gerhardt Earney ,  Joseph Francis Pinto ,  M. Shane Bowen ,  Michael S. Graige ,  Arthur Pitera ,  Bala Murali K. Venkatesan ,  Dajun A. Yuan

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01J3/0289 ,  G01J3/18 ,  G01J3/4406 ,  G01J2003/1861 ,  G01N21/278 ,  G01N21/643 ,  G01N2201/127

Abstract: An inspection apparatus is provided that comprises an optical target including a solid host material and a fluorescing material embedded in the solid host material. The solid host material has a predetermined phonon energy HOSTPE. The fluorescing material exhibits a select ground energy level and a target excitation (TE) energy level separated from the ground energy level by a first energy gap corresponding to a fluorescence emission wavelength of interest. The fluorescing material has a next lower lying (NLL) energy level relative to the TE energy level. The NLL energy level is spaced a second energy gap FMEG2 below the TE energy level, wherein a ratio of the FMEG2/HOSTPE is three or more.

公开(公告)号：US09936904B2

公开(公告)日：2018-04-10

申请号：US14405187

申请日：2013-06-03

Applicant: Alan J. Leszinske

Inventor： Alan J. Leszinske

IPC: A61B5/1455 ,  A61B5/145 ,  G01N21/21 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/15 ,  A61B5/155 ,  A61B5/1495 ,  G01J4/04 ,  A61B5/153

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4836 ,  A61B5/6866 ,  A61B5/7246 ,  A61B2505/05 ,  A61B2560/0233 ,  G01J4/04 ,  G01N21/21 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/127

Abstract: Perioperative patient blood glucose concentrations are determined by imposing patient effluent ultrafiltrate through a sample cell incorporated in an automated polarimeter. The device includes an optical platform, fluid handling subassembly, controlling electronics, and integration software. A stable collimated light source of known intensity and distinct specified wavelength is passed through an optical platform including a polarizer, retarder, bandpass filters, sample flow cell, analyzer and detector. The angular rotation of the transmitted light resulting from the glucose contained in patient ultrafiltrate collected in the sample flow cell is recorded and provides a measure of the glucose concentration.

公开(公告)号：US09915606B2

公开(公告)日：2018-03-13

申请号：US14904634

申请日：2014-07-10

Applicant: Topnir Systems SAS

Inventor： Didier Lambert ,  Claude Saint Martin ,  Sanchez Miguel ,  Bernard Ribero

IPC: G01J5/02 ,  G01N21/359 ,  G01N21/27 ,  G01N21/35

CPC classification number: G01N21/359 ,  G01N21/274 ,  G01N21/35 ,  G01N2201/127

Abstract: The present invention relates to a method for characterizing a sample-product X by spectral analysis by means of a novel spectrometer II using information acquired by means of a first spectrometer I.

公开(公告)号：US20180067140A1

公开(公告)日：2018-03-08

申请号：US15690430

申请日：2017-08-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Rolf Knobel

IPC: G01N35/00

CPC classification number: G01N35/00693 ,  G01J3/28 ,  G01N21/03 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N21/82 ,  G01N35/00 ,  G01N2201/127

Abstract: A method for determining a background shift is presented. The method includes obtaining a plurality of optical measurement sets of a sample taken by a sample analyzer at different points in time. Each set includes one measurement taken in a first channel and another measurement taken in a second channel different from the first channel. The plurality of optical measurement sets includes one set group and another set group. The measurements in the one set group show a higher signal change than the measurements in the other group. A first background signal is determined based on a relation of measurements in the first and second channels in the one group. A second background signal is determined based on a relation of measurements in the first and second channels in the one group and the other group. A background shift is determined based on the first and second background signals.

公开(公告)号：US09857283B1

公开(公告)日：2018-01-02

申请号：US15634858

申请日：2017-06-27

Applicant: MANTA Instruments, Inc.

Inventor： Jan J. Tatarkiewicz

IPC: G01N15/02 ,  G01N15/10 ,  G01N15/14 ,  G01N21/51 ,  G02B21/06 ,  G02B21/36 ,  G01N15/00 ,  H04N7/18

CPC classification number: G01N15/1012 ,  G01N15/0211 ,  G01N15/0227 ,  G01N15/1463 ,  G01N21/51 ,  G01N2015/0038 ,  G01N2015/0053 ,  G01N2015/1486 ,  G01N2021/513 ,  G01N2201/127 ,  G02B21/06 ,  G02B21/365 ,  H04N7/181

Abstract: A method for calibrating a dark field microcopy setup is disclosed. The method includes preparing a plurality of particle samples, each with a known concentration and particle size, the plurality having more than one particle size and, optionally, more than one refractive index and more than one diluent. For each sample in the plurality, the sample is measured in the setup and the scattered light intensity and number of particles is measured. From this data, a relationship between the scattered light intensity, particle size and calibrated investigated volume can be determined. The calibrated investigated volume is used to obtain the proper particle size distribution in a given diluent.

公开(公告)号：US09757027B2

公开(公告)日：2017-09-12

申请号：US15227839

申请日：2016-08-03

Applicant: ADOM, Advanced Optical Technologies Ltd

Inventor： Yoel Arieli ,  Yoel Cohen ,  Shlomi Epstein ,  Dror Arbel ,  Ra'anan Gefen

IPC: A61B3/14 ,  A61B3/10 ,  G01B9/02 ,  G01B11/06 ,  A61B3/00 ,  A61B3/15 ,  G01N21/27 ,  G02B3/08

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/1005 ,  A61B3/152 ,  G01B9/02021 ,  G01B9/02025 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/0209 ,  G01B11/06 ,  G01B11/0625 ,  G01B11/0675 ,  G01B2290/45 ,  G01N21/274 ,  G01N2201/066 ,  G01N2201/127 ,  G02B3/08

Abstract: A system and method are described for performing tear film structure measurement. A broadband light source illuminates the tear film. A spectrometer measures respective spectra of reflected light from at least one point of the tear film. A color camera performs large field of view imaging of the tear film, so as to obtain color information for all points of the tear film imaged by the color camera. A processing unit calibrates the camera at the point measured by the spectrometer so that the color obtained by the camera at the point matches the color of the spectrometer at the same point. The processing unit determines, from the color of respective points of the calibrated camera, thicknesses of one or more layers of the tear film at the respective points. Other applications are also described.

公开(公告)号：US20170184501A1

公开(公告)日：2017-06-29

申请号：US15456581

申请日：2017-03-13

Applicant: Wistron Corporation

Inventor： Wen-Hui Shih

IPC: G01N21/64 ,  G02B21/06 ,  G02B21/16 ,  G02B21/36

CPC classification number: G01N21/6428 ,  G01D18/00 ,  G01N21/274 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/127 ,  G02B21/0096 ,  G02B21/06 ,  G02B21/16 ,  G02B21/365

Abstract: An operating method of a biological detection calibration system, adapted for a biological detection device which includes a light source for emitting a light to detect a biological sample. A step is performed to detect whether a light calibration device exists on the biological detection device, wherein the light calibration device includes a carrier and a calibration sample disposed on the carrier, and the calibration sample includes a light detector. If the light calibration device exists, the intensity of the light detected by the light detector is read to determine whether the intensity of the light detected by the light detector is less than a predetermined value. If the intensity of the light detected by the light detector is less than the predetermined value, a driving voltage of the light source is enhanced, such that the intensity of the light detected by the light detector reaches the predetermined value.

公开(公告)号：US09671324B2

公开(公告)日：2017-06-06

申请号：US14695764

申请日：2015-04-24

Applicant: Aerosol d.o.o.

Inventor： Luka Drinovec ,  Grisa Mocnik ,  Anthony D. A. Hansen

IPC: G01N15/06 ,  G01N15/10 ,  G01N21/31 ,  G01N21/59

CPC classification number: G01N15/0625 ,  G01N1/2273 ,  G01N15/1012 ,  G01N21/31 ,  G01N21/59 ,  G01N2201/127

Abstract: An apparatus and method are presented for the analysis of materials. The apparatus includes two or more similar analyzers, with the output of the analyzers combined to provide improved measurements. The apparatus may be, for example, a differential photometric analyzer, such as the AETHALOMETER®. The apparatus includes a processor programmed to accept an instrument constant determined at low filter loadings and use the constant to compensate for non-linear instrument responses. A method is also presented for conditioning filters before use.

公开(公告)号：US20170122961A1

公开(公告)日：2017-05-04

申请号：US15317619

申请日：2015-06-19

Applicant: GE Healthcare Bio-Sciences AB

Inventor： Olof Karlsson

IPC: G01N33/68 ,  G01N21/552

CPC classification number: G01N33/6827 ,  G01N21/274 ,  G01N21/553 ,  G01N2201/127

Abstract: The invention relates to a method for normalization of a label-free system for calibration-free concentration analysis. The method comprises (1) providing a solution containing a control macromolecular particle of a known concentration at a pH lower than the pI of the macromolecular particle and a low ionic strength; (2) contacting the solution with a negatively charged optical sensor surface at a first flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a first sensorgram; (3) contacting the solution with the optical sensor surface at a second flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a second sensorgram; and (4) fitting the sensorgrams to a binding equation to determine a measured concentration of the control; wherein the optical sensor surface is not immobilized with a ligand for the control and the contacting steps are performed under mass transport limitations. Also provided is a kit for performing the method, as well as a method for determining a concentration of an analyte.

公开(公告)号：US09625390B2

公开(公告)日：2017-04-18

申请号：US15194630

申请日：2016-06-28

Applicant: MannKind Corporation

Inventor： Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

IPC: G01J3/44 ,  G01N21/65 ,  G01G9/00 ,  G01N15/06

CPC classification number: G01N21/65 ,  G01G9/00 ,  G01N15/06 ,  G01N2201/06113 ,  G01N2201/121 ,  G01N2201/127

Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.