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公开(公告)号：US20130056632A1
公开(公告)日：2013-03-07
申请号：US13659586
申请日：2012-10-24
Applicant: Alastair Clark , Stephen John Taylor , William Angus Munro , Richard Turner
Inventor： Alastair Clark , Stephen John Taylor , Robert Brian Turner , William Angus Munro
CPC classification number: H01J49/14 , H01J49/0095 , H01J49/10 , H01J49/107 , H01J49/145 , H01J49/168
Abstract: A field asymmetric ion mobility spectrometer (FAIMS) has an analyte ion source assembly by which an analyte substance is ionized and supplied to the inlet of the spectrometer. The ion source assembly has an upstream source of clean, dry air and two ion sources of opposite polarity arranged at the same distance along the flow path. The ion sources are arranged so that the overall charge of the plasma produced is substantially neutral. The analyte substance is admitted via an inlet downstream of the ion sources and flows into a reaction region of enlarged cross section to slow the flow and increase the time for which the analyte molecules are exposed to the plasma.
Abstract translation: 场非对称离子迁移谱仪（FAIMS）具有分析物离子源组件，通过该分析物离子源组件将分析物质电离并提供给光谱仪的入口。 离子源组件具有清洁干燥空气的上游源和沿着流动路径相同距离排列的两个相反极性的离子源。 离子源被布置成使得所产生的等离子体的总电荷基本上是中性的。 分析物质通过离子源下游的入口进入，并流入扩大横截面的反应区域以减缓流动并增加分析物分子暴露于等离子体的时间。
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公开(公告)号：US08368013B2
公开(公告)日：2013-02-05
申请号：US13084930
申请日：2011-04-12
Applicant: Masako Ishimaru , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Masuyuki Sugiyama , Hidetoshi Morokuma
Inventor： Masako Ishimaru , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Masuyuki Sugiyama , Hidetoshi Morokuma
CPC classification number: H01J49/145
Abstract: An analyzer performs dielectric barrier discharge and ionization of a sample by a reaction between the sample and excited molecules or ions generated by the dielectric barrier discharge at a pressure lower than an atmospheric pressure.
Abstract translation: 分析仪通过在低于大气压的压力下通过介电阻挡放电产生的样品和激发的分子或离子之间的反应来进行介电阻挡放电和样品的离子化。
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23.发明授权公开(公告)号：US08299421B2
公开(公告)日：2012-10-30
申请号：US12754475
申请日：2010-04-05
Applicant: Gregory J. Wells
Inventor： Gregory J. Wells
IPC: H01J49/00
CPC classification number: H01J49/145
Abstract: A sample is ionized by chemical ionization by flowing the sample and a reagent gas into an ion source at a pressure below 0.1 Torr. While maintaining the ion source at a pressure below 0.1 Torr, the reagent gas is ionized in the ion source by electron ionization to produce reagent ions. The sample is reacted with the reagent ions at a pressure below 0.1 Torr to produce product ions of the sample. The product ions are transmitted into an ion trap for mass analysis.
Abstract translation: 通过在低于0.1托的压力下将样品和反应气体流入离子源，通过化学电离将样品电离。 在将离子源保持在低于0.1托的压力的同时，通过电子电离在离子源中离子化反应气体以产生试剂离子。 将样品与低于0.1托的压力下的试剂离子反应，以产生样品的产物离子。 将产物离子传输到离子阱中进行质量分析。
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公开(公告)号：US20120241642A1
公开(公告)日：2012-09-27
申请号：US13118541
申请日：2011-05-30
Applicant: Andreas Hieke
Inventor： Andreas Hieke
IPC: H01J27/02
CPC classification number: H01J49/145 , H01J49/164
Abstract: An innovative ion source is disclosed that in some embodiments provides an injected independent ion beam to increase the ionization efficiency of the ion source.
Abstract translation: 公开了一种创新的离子源，在一些实施方案中提供注入的独立离子束以增加离子源的离子化效率。
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25.发明授权Ionizer for vapor analysis decoupling the ionization region from the analyzer 有权用于蒸气分析的离子发生器将电离区域与分析仪分离公开(公告)号：US08217342B2
公开(公告)日：2012-07-10
申请号：US12686669
申请日：2010-01-13
Applicant: Guillermo Vidal-De-Miguel
Inventor： Guillermo Vidal-De-Miguel
CPC classification number: H01J49/0422 , H01J49/145
Abstract: A method and apparatus are described to increase the efficiency with which a sample vapor is ionized prior to being introduced into an analyzer. Excellent contact between the vapor and the charging agent is achieved in the ionization chamber by separating it from the analyzer by means of a perforated impaction plate. As a result, some desired fraction of the gas going into the analyzer or coming out of the analyzer can be controlled independently from the flow of sample through the ionization chamber. Furthermore, penetration into said ionization chamber of said desired fraction of the gas going into or out of the analyzer is minimized by controlling the dimensions of said perforated impaction plate. Ions formed in the ionization chamber are driven partly by electric fields through said hole in said perforated impaction plate into the inlet to the analyzer. As a result, most of the gas sampled into the analyzer carries ionized vapors, even when the sample flow of vapor is very small, and even when the analyzer uses counterflow gas.
Abstract translation: 描述了一种方法和装置，以提高样品蒸气在被引入分析仪之前被电离的效率。 蒸汽和充电剂之间的良好接触是通过使用穿孔冲击板将其从分析器分离出来在电离室中实现的。 结果，可以独立于通过电离室的样品流动来控制进入分析器或从分析器出来的气体的一些所需部分。 此外，通过控制所述穿孔撞击板的尺寸，使进入或离开分析器的气体的所需部分的渗透进入所述电离室中。 在电离室中形成的离子部分地由电场驱动穿过穿孔撞击板中的孔进入分析器的入口。 因此，即使当蒸汽的样品流量非常小，甚至当分析仪使用逆流气体时，采样到分析仪中的大部分气体携带电离蒸汽。
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Patent Agency Ranking
公开(公告)号：US20120132796A1
公开(公告)日：2012-05-31
申请号：US13366824
申请日：2012-02-06
Applicant: Alan G. MARSHALL , Priyanka JUYAL , Ryan P. RODGERS
Inventor： Alan G. MARSHALL , Priyanka JUYAL , Ryan P. RODGERS
IPC: H01J49/26
CPC classification number: H01J49/165 , G01N33/28 , H01J49/145
Abstract: A method of enhanced speciation of both positive and negatives species in an analyte is disclosed. The method can include producing a first analyte solution comprising an analyte composition and an effective amount of silver triflate, and analyzing the first analyte solution with an electrospray ionization mass spectrometer. The method can also include producing a second analyte solution comprising a portion of the analyte composition and an effective amount of a compound of formula I, and analyzing the second analyte solution with an electrospray ionization mass spectrometer. The compound of formula I is [NX+][OH−], where X is a linear, branched, or cyclic C1-C10 alkane; an aryl; a heterocyclic aromatic; or a heterocyclic moiety.
Abstract translation: 公开了一种在分析物中增强正负物种形态的方法。 该方法可以包括产生包含分析物组合物和有效量的三氟甲磺酸银的第一分析物溶液，并用电喷雾离子化质谱仪分析第一分析物溶液。 该方法还可以包括产生包含一部分分析物组合物和有效量的式I化合物的第二分析物溶液，并用电喷雾离子化质谱仪分析第二分析物溶液。 式I的化合物是[NX +] [OH-]，其中X是直链，支链或环状的C 1 -C 10烷烃; 芳基; 杂环芳烃; 或杂环部分。
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27.发明申请Combined Ion Source for Electrospray and Atmospheric Pressure Chemical Ionization 有权用于电喷雾和大气压化学电离的组合离子源公开(公告)号：US20120104248A1
公开(公告)日：2012-05-03
申请号：US13280069
申请日：2011-10-24
Applicant: Mark HARDMAN , Jean-Jacques Dunyach , R. Paul Atherton , Michael W. Belford
Inventor： Mark HARDMAN , Jean-Jacques Dunyach , R. Paul Atherton , Michael W. Belford
CPC classification number: H01J49/167 , H01J49/107 , H01J49/145 , H01J49/165
Abstract: A ion source for a mass spectrometer comprises: a capillary having a nozzle for emitting a nebulized fluid sample; an electrode of the capillary; a high voltage power supply; a second electrode disposed within or configurable to be disposed within a path of the nebulized fluid sample; and at least one switch for selecting application of an electrical potential provided by the high voltage power supply to either or both of the capillary electrode or the second electrode, wherein the capillary and capillary electrode are configurable so as to ionize the nebulized fluid sample by electrospray ionization and the second electrode is configurable so as to ionize the nebulized sample by atmospheric pressure chemical ionization.
Abstract translation: 用于质谱仪的离子源包括：具有用于发射雾化流体样品的喷嘴的毛细管; 毛细管的电极; 高压电源; 设置在所述喷雾流体样本的路径内或可配置为设置在所述雾化流体样本的路径内的第二电极; 以及至少一个开关，用于选择将所述高电压电源提供给所述毛细管电极或所述第二电极中的任一个或两者的电位施加，其中所述毛细管和毛细管电极可配置为通过电喷雾使雾化的流体样品电离 电离和第二电极是可配置的，以便通过大气压化学电离使雾化的样品离子化。
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28.发明申请MASS SPECTROMETRIC DETERMINATION OF NON-DERIVATIZED, NON-METABOLIZED VITAMIN D 审中-公开非衍生的非代谢维生素D的质谱分光光度法测定公开(公告)号：US20120025067A1
公开(公告)日：2012-02-02
申请号：US12964710
申请日：2010-12-09
Applicant: Brett Holmquist , Nigel Clarke
Inventor： Brett Holmquist , Nigel Clarke
IPC: H01J49/26
CPC classification number: G01N33/82 , G01N30/7233 , G01N2030/009 , G01N2030/027 , G01N2030/8813 , H01J49/004 , H01J49/145
Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
Abstract translation: 本发明涉及非代谢维生素D的检测。在一个特定方面，本发明涉及通过质谱检测未代谢的非代谢维生素D的方法。
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公开(公告)号：US20110253889A1
公开(公告)日：2011-10-20
申请号：US13084930
申请日：2011-04-12
Applicant: Masako ISHIMARU , Yuichiro HASHIMOTO , Hideki HASEGAWA , Masuyoshi YAMADA , Masuyuki SUGIYAMA , Hidetoshi MOROKUMA
Inventor： Masako ISHIMARU , Yuichiro HASHIMOTO , Hideki HASEGAWA , Masuyoshi YAMADA , Masuyuki SUGIYAMA , Hidetoshi MOROKUMA
CPC classification number: H01J49/145
Abstract: An analyzer performs dielectric barrier discharge and ionization of a sample by a reaction between the sample and excited molecules or ions generated by the dielectric barrier discharge at a pressure lower than an atmospheric pressure.
Abstract translation: 分析仪通过在低于大气压的压力下通过介电阻挡放电产生的样品和激发的分子或离子之间的反应来进行介电阻挡放电和样品的离子化。
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30.发明申请LOW-PRESSURE ELECTRON IONIZATION AND CHEMICAL IONIZATION FOR MASS SPECTROMETRY 有权低压电子离子化学和大分子量子化学离子化公开(公告)号：US20110240848A1
公开(公告)日：2011-10-06
申请号：US12754475
申请日：2010-04-05
Applicant: Gregory J. Wells
Inventor： Gregory J. Wells
CPC classification number: H01J49/145
Abstract: A sample is ionized by chemical ionization by flowing the sample and a reagent gas into an ion source at a pressure below 0.1 Torr. While maintaining the ion source at a pressure below 0.1 Torr, the reagent gas is ionized in the ion source by electron ionization to produce reagent ions. The sample is reacted with the reagent ions at a pressure below 0.1 Torr to produce product ions of the sample. The product ions are transmitted into an ion trap for mass analysis.
Abstract translation: 通过在低于0.1托的压力下将样品和反应气体流入离子源，通过化学电离将样品电离。 在将离子源保持在低于0.1托的压力的同时，通过电子电离在离子源中离子化反应气体以产生试剂离子。 将样品与低于0.1托的压力下的试剂离子反应，以产生样品的产物离子。 将产物离子传输到离子阱中进行质量分析。
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