公开(公告)号：US3725385A

公开(公告)日：1973-04-03

申请号：US3725385D

申请日：1970-11-02

Applicant: ABBOTT LAB

Inventor： FREIBERG L

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: The 3-dimethyl amino substituent of the desosamine and mycaminose moieties of macrolide antibiotics are mono- and didemethylated by reaction with halogen, preferably iodine, in the presence of base at a controlled pH. The resulting compounds have antibiotic activity, and furthermore are useful as intermediates for alkylation and the like.

Abstract translation: 通过在碱的存在下，在受控的pH下，通过与卤素，优选碘反应，将大环内酯类抗生素的脱氨基胺和霉酚酸部分的3-二甲基氨基取代基单取代和未甲基化。 所得化合物具有抗菌活性，此外可用作烷基化等的中间体。

公开(公告)号：US3720768A

公开(公告)日：1973-03-13

申请号：US3720768D

申请日：1971-11-22

Applicant: ABBOTT LAB

Inventor： JONES P ,  MARTIN Y

IPC: A61K31/445 ,  C07D213/89 ,  C07D241/18 ,  A61K27/00

CPC classification number: C07D213/89 ,  A61K31/445 ,  C07D241/18

Abstract: METHOD OF TREATING HYPERTENSION BY ADMINISTERING TO A HYPERTENSIVE PATIENT A THERAPWUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF THE FORMULA

O=N
HO-N
WHEREIN X IIS C OR N; AND R1, R2, R3 AND R4 EACH ARE HYDROGEN, ALKYL, CYCLOALKYL OR ARYL, WITH THE LIMITATION THAT R4 IS PRESENT ONLY WHEN X IS C.

公开(公告)号：US3714345A

公开(公告)日：1973-01-30

申请号：US3714345D

申请日：1971-02-22

Applicant: ABBOTT LAB

Inventor： HIRATA A

IPC: G01N33/556 ,  A01N1/00 ,  G01N31/00 ,  G01N33/16

CPC classification number: G01N33/556 ,  A01N1/0231 ,  Y10T436/101666 ,  Y10T436/105831 ,  Y10T436/107497 ,  Y10T436/108331

Abstract: A method for obtaining an improved aldehyde-treated erythrocyte preparation having an increased hemagglutination titer. The erythrocytes are stabilized by sequential exposure to dilute solutions of pyruvic aldehyde and formaldehyde.

Abstract translation: 获得具有增加的血细胞凝集滴度的改进的醛处理的红细胞制剂的方法。 通过连续暴露于丙酮醛和甲醛的稀溶液来稳定红细胞。

公开(公告)号：US3714142A

公开(公告)日：1973-01-30

申请号：US3714142D

申请日：1971-01-18

Applicant: ABBOTT LAB

Inventor： MARTIN J ,  GOLDSTEIN A

IPC: C07H17/08 ,  C07G11/00

CPC classification number: C07H17/08 ,  Y10S435/886

Abstract: Erythromycin E is useful as an antibiotic. The compounds is prepared by the fermentation of erythromycin with Streptomyces erythreus NRRL 3887 in suitable nutrient media.

Abstract translation: 红霉素E可用作抗生素。 通过在合适的营养培养基中将红霉素与红链霉菌NRRL 3887发酵来制备化合物。

公开(公告)号：US3708581A

公开(公告)日：1973-01-02

申请号：US3708581D

申请日：1971-06-09

Applicant: ABBOTT LAB

Inventor： RODERICK W

IPC: A61K31/00

CPC classification number: A61K31/00

Abstract: 3-AMINO-2-PYRIDINETHIOL HAS BEEN FOUND TO HAVE EXCELLENT ANTI-EDEMA, ANTI-PYRETIC AND ANALGESIC EFFECTS WHEN ADMINISTERED ORALLY TO WARM-BLOODED ANIMALS AT A DOSAGE OF BETWEEN 0.5 AND 50 MG./KG.

公开(公告)号：US3701785A

公开(公告)日：1972-10-31

申请号：US3701785D

申请日：1971-02-04

Applicant: ABBOTT LAB

Inventor： SWETT LEO RALPH ,  PARIS GERARD YVON

IPC: C07D231/38 ,  C07D57/02

CPC classification number: C07D231/38 ,  Y10S514/916

Abstract: 1,3-DIMETHYL-4,6-DI(P-SUBSTITUTED PHENYL)-6H-PYRROLO(2,3-C)PYRAZOLES AND NOVEL INTERMEDIATES USEFUL IN THEIR SYNTHESIS. THE COMPOUNDS ARE USEFUL AS ANTI-INFLAMMATORY AND ANTI-PYRETIC AGENTS.

公开(公告)号：US3693612A

公开(公告)日：1972-09-26

申请号：US3693612D

申请日：1970-04-21

Applicant: ABBOTT LAB

Inventor： DONAHOE JOSEPH F ,  MACALALAD FIDEL V

IPC: A61B5/0215 ,  A61M5/168 ,  G01L7/18 ,  A61B5/02

CPC classification number: A61M5/16854 ,  A61B5/02152 ,  A61M2205/3348 ,  G01L7/18

Abstract: Disclosed herein is an improved manometer in which the calibrated scale for reading the fluid pressure is provided on a transparent sheath rather than directly on the manometer tube, the sheath being slidably mounted on the manometer tube. This sheathing permits the zero point of the scale to be readily adjusted and includes a cylindrical portion integral with a wing, the wing carrying the scale either as a direct imprint or as an insert in the wing. An indicator for marking the meniscus level encapsulates the sheathing. The indicator is slidable on the sheathing and has a mark for establishing the pressure reading for subsequent reference.

Abstract translation: 本文公开了一种改进的压力计，其中用于读取流体压力的校准标尺设置在透明护套上而不是直接在压力计管上，护套可滑动地安装在压力计管上。 该护套允许容易调整刻度盘的零点，并且包括与翼片成一体的圆柱形部分，翼片作为直接印记或作为翼片中的插入物承载标尺。 用于标记弯月面水平的指示器封装护套。 指示器可在护套上滑动，并具有用于建立压力读数的标记以供后续参考。

公开(公告)号：US3689644A

公开(公告)日：1972-09-05

申请号：US3689644D

申请日：1971-01-27

Applicant: ABBOTT LAB

Inventor： PLOTNIKOFF NICHOLAS PETER

IPC: A61K33/00 ,  A61K33/08 ,  A61K27/00

CPC classification number: A61K33/00 ,  A61K33/08 ,  A61K31/42 ,  A61K2300/00

Abstract: Covers the use of the combination of 2-imino-5-phenyl-4oxazolidinone or a salt thereof and a potentiating agent comprising an aluminum or alkaline earth metal salt or base in treating Parkinson''s disease.

Abstract translation: 涵盖使用2-亚氨基-5-苯基-4-恶唑烷酮或其盐和包含铝或碱土金属盐或碱的增效剂来治疗帕金森病的用途。

公开(公告)号：US3689643A

公开(公告)日：1972-09-05

申请号：US3689643D

申请日：1971-01-27

Applicant: ABBOTT LAB

Inventor： PLOTNIKOFF NICHOLAS PETER

IPC: A61K33/06 ,  A61K27/00

CPC classification number: A61K33/06 ,  A61K2300/00

Abstract: Covers a composition comprising the combination of 1-dopa, 2imino-5-phenyl-4-oxazolidinone or salt thereof and a third agent comprising an aluminum or alkaline earth metal salt or base and use of said composition in treating Parkinson''s disease.

Abstract translation: 涵盖包含1-多巴，2-亚氨基-5-苯基-4-恶唑烷酮或其盐的组合的组合物和包含铝或碱土金属盐或碱的第三试剂，并使用所述组合物治疗帕金森病。

公开(公告)号：US3686187A

公开(公告)日：1972-08-22

申请号：US3686187D

申请日：1970-05-25

Applicant: ABBOTT LAB

Inventor： COLE JOHN WAYNE ,  HALLAS ROBERT

IPC: C07D211/58 ,  C07D211/72 ,  C07D29/28

CPC classification number: C07D211/58 ,  C07D211/72

Abstract: A NEW SERIES OF PIPERDINE DERIVATIVES HAS BEEN DISCOVERED; THEY ARE COMPOUNDS CARRYING, IN THE 4-POSITION OF THE PIPERIDINE RING, A SUBSTITUTED ANILINO GROUP AND IN THE 1-POSITION, A P-FLUOROPHENYL RING SEPARATED FROM THE PIPERIDINE RING BY A CARBON CHAIN OF 4. THESE NEW COMPOUNDS AND THEIR NON-TOXIC ACID ADDITION SALTS ARE HIGHLY EFFECTIVE ANALGEICES OF LOW TOXICITY.