公开(公告)号：US11217438B2

公开(公告)日：2022-01-04

申请号：US15555758

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/04 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/04 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/68 ,  G01N33/92 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/26 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  G16B20/00 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

公开(公告)号：US11139156B2

公开(公告)日：2021-10-05

申请号：US15555888

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Julia Balog ,  Tamas Karancsi ,  Steven Derek Pringle ,  Zoltan Takats ,  James Kinross ,  Jeremy K Nicholson

IPC: A61B10/02 ,  H01J49/04 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

Abstract: An apparatus is disclosed including a tool comprising a first device for generating aerosol from a target, the first device being deployed through an opening in a tubing of the tool, wherein the tubing is provided with aspiration ports or fenestrations such that the generated aerosol is aspirated into the tubing via the aspiration ports or fenestrations. The aspirated aerosol is then transferred to a mass spectrometer for subsequent mass analysis.

公开(公告)号：US11081329B2

公开(公告)日：2021-08-03

申请号：US15555758

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

公开(公告)号：US11031231B2

公开(公告)日：2021-06-08

申请号：US16306834

申请日：2017-06-05

Applicant: MICROMASS UK LIMITED

Inventor： Steven Derek Pringle ,  Emrys Jones ,  Stephen O'Brien ,  Anthony Hesse ,  Mike Morris ,  Zoltan Takats

IPC: H01J49/16 ,  G01N1/40 ,  H01J49/14

Abstract: There is provided an apparatus comprising a first ion source (10) arranged and adapted to emit a spray of charged droplets (11), and a control system arranged and adapted to control one or more spatial properties of said spray of charged droplets (11) in use by automatically varying or adjusting one or more parameters of said first ion source.

公开(公告)号：US10978284B2

公开(公告)日：2021-04-13

申请号：US15556037

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Michael Raymond Morris ,  Julia Balog ,  Emrys Jones ,  Keith Richardson ,  James Ian Langridge ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B18/14 ,  A61B18/20 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  G16H30/40 ,  A61B90/00 ,  A61B8/08 ,  G16C20/20 ,  G16H30/20 ,  A61B34/20 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B10/00 ,  A61B17/00 ,  A61B18/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  A61B34/30 ,  A61B18/12 ,  A61B17/32 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  A61B8/13 ,  G06F19/00

Abstract: A method is disclosed comprising obtaining or acquiring image or other data from one or more regions of a target using an imaging sensor. The image or other data may then be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.

公开(公告)号：US10971346B2

公开(公告)日：2021-04-06

申请号：US16662881

申请日：2019-10-24

Applicant: Micromass UK Limited

Inventor： Tamas Karancsi ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats ,  Julia Balog ,  Steven Derek Pringle ,  Daniel Simon

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H70/00 ,  G16H20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

公开(公告)号：US10916415B2

公开(公告)日：2021-02-09

申请号：US15554626

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Tamas Karancsi ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats ,  Julia Balog ,  Steven Derek Pringle ,  Daniel Simon

IPC: H01J49/00 ,  H01J49/04 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/055 ,  A61B5/0507 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/04 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61B90/13 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/68 ,  G01N33/92 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/26 ,  G16H70/00 ,  G16H20/00 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20

Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

公开(公告)号：US10679836B2

公开(公告)日：2020-06-09

申请号：US15554626

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Tamas Karancsi ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats ,  Julia Balog ,  Steven Derek Pringle ,  Daniel Simon

IPC: H01J49/00 ,  H01J49/04 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/05 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61B18/04 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N3/00 ,  G01N9/00 ,  G01N27/62 ,  G01N30/72 ,  G01N33/487 ,  G01N33/68 ,  G01N33/92 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

公开(公告)号：US20200168445A1

公开(公告)日：2020-05-28

申请号：US16778423

申请日：2020-01-31

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Lajos Godorhazy ,  Daniel Simon ,  Daniel Szalay ,  Zoltan Takats ,  Tamas Karancsi

IPC: H01J49/04 ,  G01N21/65 ,  G01N21/31 ,  G01N33/483

Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish 4 and contacting e.g. the rear surface of the insulating substrate with a first electrode 9. The method further comprises contacting the sample with a second electrode 2 and applying an AC or RF voltage to the first and second electrodes 9,2 in order to generate an aerosol from the sample.

公开(公告)号：US10335123B2

公开(公告)日：2019-07-02

申请号：US14676720

申请日：2015-04-01

Applicant: Micromass UK Limited

Inventor： Zoltan Takats

IPC: G01N1/02 ,  G01N1/04 ,  G01N1/28 ,  A61B10/02 ,  G01N27/62 ,  H01J49/04 ,  H01J49/16

Abstract: The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples, (b) transporting the gaseous tissue particles from the site to an analyzer, (c) using the analyzer for generating tissue-related data based on the gaseous tissue particles, and (d) analyzing, localizing and/or identifying the one or more tissue samples based on the tissue-related data. The invention can either be used in close conjunction with a surgical procedure, when one or more surgical tools are an integrated part of ionization, or as a separate mass spectrometric probe for the analysis of one or more tissue parts.