公开(公告)号：US12080534B2

公开(公告)日：2024-09-03

申请号：US17869016

申请日：2022-07-20

Applicant: Micromass UK Limited

Inventor： Jason Lee Wildgoose ,  Keith Richardson ,  David J. Langridge ,  Martin Raymond Green ,  Steven Derek Pringle

IPC: H01J49/00 ,  G01N27/62 ,  G01N27/623 ,  H01J49/42

CPC classification number: H01J49/004 ,  G01N27/62 ,  G01N27/623 ,  H01J49/4235 ,  H01J49/427

Abstract: A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

公开(公告)号：US11764048B2

公开(公告)日：2023-09-19

申请号：US18149468

申请日：2023-01-03

Applicant: Micromass UK Limited

Inventor： Zoltán Takáts ,  Frances Bolt ,  Tamás Karancsi ,  Emrys Jones ,  Keith Richardson ,  Lajos Godorhazy ,  Daniel Szalay ,  Julia Balog ,  Steven Derek Pringle ,  Daniel Simon

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  G01N27/623 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

CPC classification number: H01J49/049 ,  A61B1/041 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/055 ,  A61B5/0507 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/623 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/044 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26 ,  A61B1/00013 ,  A61B1/31 ,  A61B5/14542 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  G01N33/48735 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

公开(公告)号：US11688598B2

公开(公告)日：2023-06-27

申请号：US16604713

申请日：2018-04-11

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Jeffery Mark Brown

IPC: H01J49/16 ,  H01J49/00

CPC classification number: H01J49/165 ,  H01J49/0068

Abstract: A method of producing ions from a sample is disclosed. The method comprises directing a spray of droplets onto a sample, and causing droplets comprising analyte from the sample to impact upon a surface so as to generate analyte ions.

公开(公告)号：US20220367162A1

公开(公告)日：2022-11-17

申请号：US17869016

申请日：2022-07-20

Applicant: Micromass UK Limited

Inventor： Jason Lee Wildgoose ,  Keith Richardson ,  David J. Langridge ,  Martin Raymond Green ,  Steven Derek Pringle

IPC: H01J49/00 ,  H01J49/42 ,  G01N27/62

Abstract: A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

公开(公告)号：US20220163480A1

公开(公告)日：2022-05-26

申请号：US17599312

申请日：2020-03-27

Applicant: Micromass UK Limited

Inventor： Martin Palmer ,  Eleanor Riches ,  Jakub Ujma ,  Jason Lee Wildgoose ,  Martin Raymond Green ,  David J. Langridge ,  Kevin Giles ,  Steven Derek Pringle ,  Daniel James Kenny

IPC: G01N27/622 ,  H01J49/00 ,  H01J49/40

Abstract: A method of selecting ions comprises selecting ions corresponding to a target ion of interest by separating analyte ions according to their ion mobility, isolating first ions of the analyte ions, separating the first ions according to their ion mobility, and isolating second ions of the first ions. Preferably, the separation is accomplished by using a cyclic or closed-loop separator.

公开(公告)号：US11031221B2

公开(公告)日：2021-06-08

申请号：US15555758

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Tamas Karancsi ,  Steven Derek Pringle ,  Julia Balog ,  Daniel Simon ,  Lajos Godorhazy ,  Daniel Szalay ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/622 ,  G01N27/624 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

公开(公告)号：US10777399B2

公开(公告)日：2020-09-15

申请号：US15764791

申请日：2016-09-22

Applicant: Micromass UK Limited

Inventor： Steven Derek Pringle ,  Lajos Godorhazy ,  Daniel Simon ,  Daniel Szalay ,  Zoltan Takats ,  Tamas Karancsi

IPC: H01J49/04 ,  G01N33/483 ,  G01N21/31 ,  G01N21/65

Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.

公开(公告)号：US10714325B2

公开(公告)日：2020-07-14

申请号：US15357461

申请日：2016-11-21

Applicant: Micromass UK Limited

Inventor： Jeffery Mark Brown ,  Martin Raymond Green ,  Steven Derek Pringle

IPC: H01J49/12 ,  H01J49/00 ,  H01J49/10 ,  H01J49/16 ,  G01N24/00 ,  H01J49/04

Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.

公开(公告)号：US20200161119A1

公开(公告)日：2020-05-21

申请号：US16631874

申请日：2018-07-23

Applicant: Micromass UK Limited

Inventor： Keith George Richardson ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose ,  David J. Langridge

IPC: H01J49/28 ,  G01N27/62 ,  H01J49/00

Abstract: A method of ion mobility and/or mass spectrometry is disclosed in which the ion mobility and/or mass to charge ratio of an ion is determined using an algorithm or relationship that relates the transit time or average ion velocity of the ion through an ion separation device in which one or more time-varying electric field is used to separate ions passing therethrough to one or more parameters for the device, the mass to charge ratio of the ion and the ion mobility of the ion.

公开(公告)号：US10658166B2

公开(公告)日：2020-05-19

申请号：US16083230

申请日：2017-03-06

Applicant: Micromass UK Limited

Inventor： Keith George Richardson ,  Steven Derek Pringle

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/26

Abstract: A method of mass or mobility spectrometry comprising obtaining one or more sample spectra for a sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the sample. Before the sample spectra are acquired, a library of background spectra, each background spectrum relating to a certain class of sample material, is constructed. The background spectra in this library are used to subtract the background from a sample spectrum during the pre-processing of this sample spectrum.