公开(公告)号：US10192830B2

公开(公告)日：2019-01-29

申请号：US15477865

申请日：2017-04-03

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Jonathan Fan ,  Woon-Hong Yeo ,  Yewang Su ,  Yonggang Huang ,  Yihui Zhang

IPC: H01L23/538 ,  H05K1/02 ,  H01L23/00 ,  H01L23/552 ,  H01L29/786

Abstract: The present invention provides electronic circuits, devices and device components including one or more stretchable components, such as stretchable electrical interconnects, electrodes and/or semiconductor components. Stretchability of some of the present systems is achieved via a materials level integration of stretchable metallic or semiconducting structures with soft, elastomeric materials in a configuration allowing for elastic deformations to occur in a repeatable and well-defined way. The stretchable device geometries and hard-soft materials integration approaches of the invention provide a combination of advance electronic function and compliant mechanics supporting a broad range of device applications including sensing, actuation, power storage and communications.

公开(公告)号：US20240358259A1

公开(公告)日：2024-10-31

申请号：US18285271

申请日：2022-04-05

Applicant: NORTHWESTERN UNIVERSITY ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Keum San Chun ,  Jong Yoon Lee ,  Youn Joung Kang ,  Hyoyoung Jeong ,  John A. Rogers ,  Shuai Xu

IPC: A61B5/00 ,  A61B5/11

CPC classification number: A61B5/0093 ,  A61B5/1126 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6832 ,  A61B5/725 ,  A61B5/7257 ,  A61B5/7267 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2560/045 ,  A61B2560/0462 ,  A61B2562/0219 ,  A61B2562/14 ,  A61B2562/164 ,  A61B2562/166 ,  A61B2562/225

Abstract: This invention in one aspect relates to an acousto-mechanic sensor includes at least one inertial measurement unit (IMU) for operably detecting vibratory and motion signatures of physiological processes; and a plurality of electronic components comprising a microcontroller unit coupled to the at least one IMU for receiving data from the at least one IU and processing the received data, and a wireless communication system for wireless data transmission. The novel acousto-mechanic sensor has broad applications ranging from the assessing the efficacy of drugs for conditions that cause itch to monitoring disease severity and treatment response.

公开(公告)号：US12023170B2

公开(公告)日：2024-07-02

申请号：US18014362

申请日：2021-07-08

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Roozbeh Ghaffari ,  Kyeongha Kwon ,  Jong Uk Kim

IPC: A61B5/00 ,  A61B5/01 ,  F24F11/63 ,  G05B19/042

CPC classification number: A61B5/4266 ,  A61B5/002 ,  A61B5/01 ,  A61B5/6833 ,  A61B5/7225 ,  F24F11/63 ,  G05B19/042 ,  A61B2562/0271 ,  A61B2562/164 ,  G05B2219/2614

Abstract: This invention discloses a sensor for measuring parameters of sweat from a skin, comprising a flexible structure comprising a fluid passage having inlet and outlet, the flexible structure being detachably attached to the skin and configured such that sweat enters the inlet as the sweat releases from the skin and flows through the fluid passage into the outlet; a thermal actuator disposed on the flexible structure over the fluid passage and configured to operably provide heat to flow of the sweat through the fluid passage; a first thermistor disposed on the flexible structure over the fluid passage between the inlet and the thermal actuator and configured to operably measure a first temperature of the sweat thereon; and a second thermistor disposed on the flexible structure over the fluid passage between the thermal actuator and the outlet and configured to operably measure a second temperature of the sweat thereon.

公开(公告)号：US11883165B2

公开(公告)日：2024-01-30

申请号：US17027887

申请日：2020-09-22

Applicant: NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： John A. Rogers ,  Jungil Choi ,  Tyler R. Ray ,  Johnathan T. Reeder ,  Yurina Sekine ,  Amay J. Bandodkar ,  Yi Zhang ,  Hexia Guo ,  Sungbong Kim ,  Diana Ostojich

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/053 ,  A61B5/103 ,  A61B5/1455 ,  B01L3/00

CPC classification number: A61B5/14539 ,  A61B5/0002 ,  A61B5/053 ,  A61B5/1032 ,  A61B5/1455 ,  A61B5/14517 ,  A61B5/14546 ,  A61B5/4842 ,  A61B5/6806 ,  B01L3/502715 ,  A61B5/6833 ,  A61B2562/028 ,  A61B2562/164 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0688

Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

公开(公告)号：US20240000322A1

公开(公告)日：2024-01-04

申请号：US18034893

申请日：2021-11-02

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Shuai Xu ,  Hyoyoung Jeong ,  Jong Yoon Lee ,  Kun Hyuck Lee ,  John A. Rogers

IPC: A61B5/0205 ,  A61B5/113 ,  A61B5/00

CPC classification number: A61B5/02055 ,  A61B5/1135 ,  A61B5/7214 ,  A61B2562/0219 ,  A61B5/6832 ,  A61B5/4803 ,  A61B5/4205

Abstract: This invention discloses an electronic device for measuring physiological parameters of a living subject including at least a first inertial measurement unit (IMU) and a second IMU, the first IMU and the second IMU are time-synchronized to and spatially and mechanically separated from each other; and a microcontroller unit (MCU) electronically coupled to the first IMU and the second IMU for processing of data streams from the first IMU and the second IMU.

公开(公告)号：US11596329B2

公开(公告)日：2023-03-07

申请号：US16872522

申请日：2020-05-12

Applicant: The Board of Trustees of the University of Illinois ,  Northwestern University

Inventor： John A. Rogers ,  Jungil Choi ,  Sungbong Kim

IPC: A61B5/145 ,  A61B5/00 ,  B01L3/00 ,  G01N33/50

Abstract: The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems of some aspects provide for collection and/or analysis of biofluids from conformal, watertight tissue interfaces over time intervals allowing for quantitative temporal and/or volumetric characterization of biofluid release, such as release rates and release volumes.

公开(公告)号：US11571586B2

公开(公告)日：2023-02-07

申请号：US17056094

申请日：2019-05-17

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Shuai Xu ,  Chenkai Xu ,  Hao Zhang ,  Hangbo Zhao ,  John A. Rogers

IPC: A61N5/06 ,  A61M37/00

Abstract: Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device may comprise a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member and a substrate that supports the tissue penetrating members, wherein the substrate is optionally a flexible substrate.

公开(公告)号：US20220226651A1

公开(公告)日：2022-07-21

申请号：US17579218

申请日：2022-01-19

Applicant: The George Washington University ,  Northwestern University

Inventor： Igor R. Efimov ,  Jaclyn Ann Brennan ,  John A. Rogers

IPC: A61N1/362 ,  A61N1/368 ,  A61M25/10 ,  A61B18/14

Abstract: Systems and methods are disclosed for an electrical sensing, pacing, and ablation device comprising a bendable and stretchable balloon catheter and a bendable and stretchable first layer connected to or embedded in said balloon catheter, where the first layer has an electrode array with a plurality of electrodes. The is also a bendable and stretchable second layer connected to or embedded in the balloon catheter, and the second layer has a pressure sensor array with a plurality of pressure sensors.

公开(公告)号：US11259754B2

公开(公告)日：2022-03-01

申请号：US17043111

申请日：2019-03-29

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Siddharth Krishnan ,  Tyler R. Ray ,  Amit B. Ayer ,  Philipp Gutruf ,  Jonathan T. Reeder ,  Kun Hyuck Lee ,  Chun-Ju Su

IPC: A61B5/00 ,  A61B5/01

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

公开(公告)号：US10969395B2

公开(公告)日：2021-04-06

申请号：US16616859

申请日：2018-06-01

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Jungil Choi ,  Johnathan T. Reeder

IPC: G01N33/68 ,  A61B5/145 ,  A61B5/00 ,  C12M3/06 ,  G01N33/543

Abstract: Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.