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公开(公告)号：US09348061B2
公开(公告)日：2016-05-24
申请号：US14102723
申请日：2013-12-11
Applicant: Novartis AG
Inventor： John Dallas Pruitt , Lynn Cook Winterton
CPC classification number: G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
Abstract: The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
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公开(公告)号：US09341744B2
公开(公告)日：2016-05-17
申请号：US14617310
申请日：2015-02-09
Applicant: Novartis AG
Inventor： Frank Chang , Robert Scott , Jinyu Huang , Arturo N. Medina , Dawn A. Smith , Laura A. Sanders , John Dallas Pruitt
IPC: G02B1/04 , C08G77/388 , C08G77/458 , C08F290/06
CPC classification number: G02B1/043 , C08F290/068 , C08G77/388 , C08G77/458 , C08G2210/00 , C08L2205/02 , C08L83/04 , C08L51/085 , C08L101/14 , C08F220/56 , C08F220/28
Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.
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公开(公告)号：US20140096484A1
公开(公告)日：2014-04-10
申请号：US14102723
申请日：2013-12-11
Applicant: Novartis AG
Inventor： John Dallas Pruitt , Lynn Cook Winterton
IPC: G02B1/04
CPC classification number: G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
Abstract: The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
Abstract translation: 本发明涉及改进的隐形眼镜产品，其不仅具有初始插入舒适性，而且佩戴舒适时间超过约6小时。 本发明通过将包含两种或更多种可浸出的聚合润滑剂的水凝胶透镜包装并储存在包含相对低分子量聚乙二醇（PEG）和增粘亲水性聚合物的相对粘稠的包装溶液中来实现。 本发明还提供了制造本发明隐形眼镜产品的方法。
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公开(公告)号：US10920102B2
公开(公告)日：2021-02-16
申请号：US16720932
申请日：2019-12-19
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , G02B1/18 , G02B1/04 , G02C7/04 , G02B1/10 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US10676608B2
公开(公告)日：2020-06-09
申请号：US16036983
申请日：2018-07-17
Applicant: Novartis AG
Inventor： Frank Chang , Feng Jing , Troy Vernon Holland , Chung-Yuan Chiang , John Dallas Pruitt
Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.
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Patent Agency Ranking
公开(公告)号：US10589479B2
公开(公告)日：2020-03-17
申请号：US15704188
申请日：2017-09-14
Applicant: Novartis AG
Inventor： Robert Carey Tucker , John Dallas Pruitt , Yongxing Qiu
IPC: G02B1/04 , B29D11/00 , C09D177/00 , G02C7/02
Abstract: The invention is generally related to colored contact lenses which comprise a hydrogel lens body having an opaque color image therein and/or thereon and a durable lubricious coating thereon. The coating comprises an anchoring layer of a polyanionic polymer having carboxyl groups and a hydrogel layer which is derived from a hydrophilic polymeric material having azetidinium groups and is covalently attached onto the anchoring layer of the polyanionic polymer through linkages each formed between one carboxyl group and one azetidinium groups. The colored contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and a friction rating of about 2 or lower after 7 cycles of manual rubbing.
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公开(公告)号：US10513628B2
公开(公告)日：2019-12-24
申请号：US16166379
申请日：2018-10-22
Applicant: Novartis AG
Inventor： Yongxing Qiu , John Dallas Pruitt , Sibichen J. Thekveli , Robert Carey Tucker , Jared Nelson
IPC: G02B1/18 , C09D177/06 , B29D11/00 , G02B1/04 , G02C7/04 , G02B1/10 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
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公开(公告)号：US10254567B2
公开(公告)日：2019-04-09
申请号：US15434105
申请日：2017-02-16
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Troy Vernon Holland , John Dallas Pruitt , Jared Nelson
IPC: C07D249/20 , G02C7/10 , C08F220/70 , C08F230/08 , G02B1/04 , G02C7/04 , B29D11/00 , C08F20/36 , G02B5/20 , G02B5/22 , C07C233/38 , B29K105/00
Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.
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公开(公告)号：US20190023935A1
公开(公告)日：2019-01-24
申请号：US16036988
申请日：2018-07-17
Applicant: Novartis AG
Inventor： Frank Chang , Feng Jing , Troy Vernon Holland , Chung-Yuan Chiang , John Dallas Pruitt
IPC: C09D133/26 , C08F220/56 , C08F220/28 , C08F220/38 , C09D133/14 , C09D179/08 , C09D5/02 , G02B1/04
Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.
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公开(公告)号：US20170306178A1
公开(公告)日：2017-10-26
申请号：US15646291
申请日：2017-07-11
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , C08G77/388 , C08J5/00 , C08J7/04 , C08L83/04 , G02B1/18 , G02C7/04 , G02B1/10 , G02B1/04 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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