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    Method and apparatus for coating of substrates
    31.
    发明授权
    Method and apparatus for coating of substrates 失效
    用于涂布基材的方法和装置

    公开(公告)号：US07958840B2

    公开(公告)日：2011-06-14

    申请号：US10976193

    申请日：2004-10-27

    Applicant: Ralph A. Chappa

    Inventor： Ralph A. Chappa

    IPC: B05C5/02

    CPC classification number: B05B13/0228

    Abstract: The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an embodiment, the invention includes a method with a bi-directional indexing movement. In an embodiment, the invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus. In an embodiment, the invention includes a device retaining member. In an embodiment, the invention includes an air nozzle or an air knife. In an embodiment, the invention includes a method including removing a static charge from a small diameter medical device.

    Abstract translation: 本发明涉及减少装置涂覆期间遇到的问题的方法和装置，例如具有圆柱形形状的医疗装置。 在一个实施例中，本发明包括一种包括双向旋转构件的装置。 在一个实施例中，本发明包括具有双向分度运动的方法。 在一个实施方案中，本发明包括具有平行于涂覆设备上的辊之间的间隙定向的长轴的涂布溶液供应构件。 在一个实施例中，本发明包括装置保持构件。 在一个实施例中，本发明包括空气喷嘴或气刀。 在一个实施例中，本发明包括一种包括从小直径医疗装置中去除静电荷的方法。

    COATINGS WITH CRYSTALLIZED ACTIVE AGENT(S) AND METHODS
    33.
    发明申请
    COATINGS WITH CRYSTALLIZED ACTIVE AGENT(S) AND METHODS 有权
    具有结晶活性剂（S）和方法的涂料

    公开(公告)号：US20100093686A1

    公开(公告)日：2010-04-15

    申请号：US12636164

    申请日：2009-12-11

    Applicant: Ralph A. Chappa ,  Kimberly K.M. Lindsoe

    Inventor： Ralph A. Chappa ,  Kimberly K.M. Lindsoe

    IPC: A61K47/32 ,  A61K31/565 ,  A61K31/573

    CPC classification number: A61L31/16 ,  A61K6/0017 ,  A61K31/56 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

    Abstract: Coatings with crystallized active agent(s) and related methods are disclosed. One method includes selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. Also disclosed is an elution control coating which includes active agent that is at least about 80% crystallized within one week of being disposed on a medical device. One method enhances the formation of active agent crystals within a coating layer by adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. Another method includes increasing the rate of active agent nucleation within the coating.

    Abstract translation: 公开了具有结晶活性剂的涂层和相关方法。 一种方法包括选择溶剂和聚合物，选择至少一定量饱和度的活性剂的浓度，形成具有选定浓度的活性剂的涂料组合物，以及将涂料组合物施用于医疗装置。 还公开了一种洗脱控制涂层，其包含在被置于医疗装置上一周内至少约80％结晶的活性剂。 一种方法通过调节涂层溶液中活性剂的浓度达到活性剂饱和点的一定百分比来增强涂层内活性剂晶体的形成。 另一种方法包括增加涂层内的活性剂成核速率。

    Porous Drug Delivery Devices and Related Methods
    34.
    发明申请
    Porous Drug Delivery Devices and Related Methods 审中-公开
    多种药物输送装置及相关方法

    公开(公告)号：US20090214601A1

    公开(公告)日：2009-08-27

    申请号：US12238641

    申请日：2008-09-26

    Applicant: Ralph A. Chappa ,  James H. Arps ,  Steven J. Keough

    Inventor： Ralph A. Chappa ,  James H. Arps ,  Steven J. Keough

    IPC: A61K9/00 ,  A61K47/02 ,  A61K31/7036

    CPC classification number: A61K9/0024 ,  A61K9/167 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5073 ,  A61K9/5084 ,  A61K31/7036

    Abstract: The invention relates to porous drug delivery devices and related methods. In an embodiment, the invention includes an active agent delivery system including a reservoir body defining a plurality of interconnected pores, an active agent disposed within the interconnected pores, and a first polymeric layer disposed over the reservoir body. In an embodiment, the invention includes an implantable medical device including a porous substrate defining a plurality of interconnected pores, an active agent disposed within the interconnected pores, and a first polymeric layer disposed over the reservoir body. In an embodiment, the invention includes a method of making an active agent delivery system including forming a porous reservoir body, inserting an active agent within the porous reservoir body, and applying a polymeric layer over the porous reservoir body. Other embodiments are also included herein.

    Abstract translation: 本发明涉及多孔药物输送装置及相关方法。 在一个实施方案中，本发明包括活性剂递送系统，其包括限定多个互连孔的贮存器主体，布置在互连孔内的活性剂和设置在贮存器主体上的第一聚合物层。 在一个实施方案中，本发明包括可植入医疗装置，其包括限定多个互连孔的多孔基质，设置在互连孔内的活性剂，以及设置在贮存器主体上方的第一聚合物层。 在一个实施方案中，本发明包括制备活性剂递送系统的方法，包括形成多孔储存器体，将活性剂插入多孔储存器体内，以及在多孔储存器体上施加聚合物层。 本文还包括其它实施例。

    Additives And Methods For Enhancing Active Agent Elution Kinetics
    37.
    发明申请
    Additives And Methods For Enhancing Active Agent Elution Kinetics 审中-公开
    添加剂和增强活性剂洗脱动力学的方法

    公开(公告)号：US20080075779A1

    公开(公告)日：2008-03-27

    申请号：US11862868

    申请日：2007-09-27

    Applicant: Ralph A. Chappa

    Inventor： Ralph A. Chappa

    IPC: A61K9/10 ,  A61K31/56 ,  A61K47/30

    CPC classification number: A61K31/56 ,  A61K9/0024 ,  A61K9/0048 ,  A61K47/32 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/602 ,  C08L39/06 ,  C08L33/10 ,  C08L29/04

    Abstract: The present invention relates to methods and additives for increasing active agent elution rates from elution control coatings and elution control coatings including the same. In an embodiment the invention includes an elution control coating comprising a polymeric matrix and at least about 0.1 wt. % of an additive dispersed within the polymeric matrix. The additive can include polyvinylpyrrolidone or a copolymer thereof. An active agent can be dispersed within the polymeric matrix, the active agent having limited solubility in water. Embodiments of the invention also include a method of forming an elution control coating with accelerated release kinetics. Other embodiments are also included herein.

    Abstract translation: 本发明涉及用于增加洗脱控制涂层和包括其的洗脱控制涂层的活性剂洗脱速率的方法和添加剂。 在一个实施方案中，本发明包括洗脱控制涂层，其包含聚合物基质和至少约0.1wt。 分散在聚合物基体内的添加剂的％。 添加剂可以包括聚乙烯吡咯烷酮或其共聚物。 活性剂可以分散在聚合物基质内，活性剂在水中的溶解度有限。 本发明的实施方案还包括形成具有加速释放动力学的洗脱控制涂层的方法。 本文还包括其它实施例。

    Bioactive agent release coating and controlled humidity method
    38.
    发明申请
    Bioactive agent release coating and controlled humidity method 有权
    生物活性剂释放涂层和受控湿度法

    公开(公告)号：US20070248637A1

    公开(公告)日：2007-10-25

    申请号：US11207380

    申请日：2005-08-19

    Applicant: Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    Inventor： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    IPC: A61F2/02 ,  B05D3/00

    CPC classification number: A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606

    Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

    Abstract translation: 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂层组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。

    Advanced coating apparatus and method
    39.
    发明授权
    Advanced coating apparatus and method 有权
    先进的涂装设备及方法

    公开(公告)号：US07192484B2

    公开(公告)日：2007-03-20

    申请号：US10256349

    申请日：2002-09-27

    Applicant: Ralph A. Chappa ,  Mark F. Carlson

    Inventor： Ralph A. Chappa ,  Mark F. Carlson

    IPC: B05C15/00

    CPC classification number: B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05D1/002 ,  B05D1/02

    Abstract: A coating apparatus for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.

    Abstract translation: 描述了一种用于涂覆可卷绕装置的涂覆装置，其包括具有一对辊和喷嘴的装置旋转体。 喷嘴产生喷涂的涂料，该喷涂材料指向一对间的间隙。 在涂布过程中，大部分没有沉积在可滚动装置上的喷雾通过辊之间的间隙。

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