公开(公告)号：US11323345B2

公开(公告)日：2022-05-03

申请号：US16561477

申请日：2019-09-05

Applicant: Labrador Diagnostics LLC

Inventor： Sunny Balwani

IPC: H04L12/26 ,  H04L43/0811 ,  G16H10/20 ,  H04W76/18 ,  H04L41/0654 ,  H04L45/00 ,  H04L45/28 ,  H04L47/726 ,  H04L47/74 ,  G06F13/00 ,  H04L67/1023 ,  H04L43/10

Abstract: Methods and systems are provided for connecting an electronic device to a network. In some situations, the electronic device connects to a first network provider and pings a first server having a static internet protocol address and a second server having a dedicated uniform resource locator. If the electronic device receives a response from the first and second server, the electronic device maintains its connection to the first network provider. Otherwise, the electronic device connects to a second network provider and pings the first and second servers.

公开(公告)号：US11320355B2

公开(公告)日：2022-05-03

申请号：US16259511

申请日：2019-01-28

Applicant: Labrador Diagnostics LLC

Inventor： Mark Dayel ,  Samartha Anekal ,  Elizabeth A. Holmes

IPC: G01N15/04 ,  G01N15/05 ,  G01N33/49 ,  G01N15/00

Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.

公开(公告)号：US11309856B2

公开(公告)日：2022-04-19

申请号：US17011129

申请日：2020-09-03

Applicant: Labrador Diagnostics LLC

Inventor： Karan Mohan ,  Marcelo Martinez

IPC: H03G3/00 ,  H01L31/02 ,  G01N15/14 ,  H03F3/08 ,  H03M1/06 ,  H03F3/45 ,  G01N21/64 ,  G01N15/06 ,  G01N15/10

Abstract: In one embodiment, a femtowatt sensitivity optical detector is provided using one or more photodiodes, intended as a replacement for the photomultiplier based photon counting unit.

公开(公告)号：US11249799B2

公开(公告)日：2022-02-15

申请号：US14181486

申请日：2014-02-14

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young

IPC: G06F15/16 ,  G06F9/48 ,  G01N35/00 ,  H04L67/10 ,  H04L67/12

Abstract: Provided herein are medical testing devices, systems, and methods that integrate multiplex, multi-technology, multi-configuration, multisample, or multi-threading capabilities. These capabilities are achieved using one or more of a level operations and communications architecture, a protocol execution engine, and a machine vision and processing system, method, or device in order to make testing of biologic or other samples more efficient in terms of cost, time, energy, or by prioritizing at least one other objective.

公开(公告)号：US11215610B2

公开(公告)日：2022-01-04

申请号：US15951720

申请日：2018-04-12

Applicant: Labrador Diagnostics LLC

Inventor： Ian Gibbons ,  Michael O'Connell

IPC: B01L3/00 ,  G01N33/53 ,  G01N33/536

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces interference with an optical signal which is indicative of the presence of an analyte in a bodily sample.

公开(公告)号：US11195624B2

公开(公告)日：2021-12-07

申请号：US15952983

申请日：2018-04-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Daniel Young ,  Seth G. Michelson

IPC: G16H50/50 ,  G16H50/70 ,  G16H50/20 ,  G16H50/80 ,  G16Z99/00

Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.

公开(公告)号：US20210333127A1

公开(公告)日：2021-10-28

申请号：US17228391

申请日：2021-04-12

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Timothy Smith ,  Scott Ridel ,  John Kent Frankovich ,  Michael Siegel

IPC: G01D5/14 ,  B04B9/14 ,  B04B5/04 ,  B04B13/00 ,  B04B9/10 ,  B04B7/08 ,  B04B15/02 ,  G01P3/488 ,  G01D5/347

Abstract: In one nonlimiting example, an automated system is provided for separating one or more components in a biological fluid, wherein the system comprises: (a) a centrifuge comprising one or more bucket configured to receive a container to effect said separating of one or more components in a fluid sample; and (b) the container, wherein the container includes one or more shaped feature that is complementary to a shaped feature of the bucket.

公开(公告)号：US11156618B1

公开(公告)日：2021-10-26

申请号：US15996955

申请日：2018-06-04

Applicant: Labrador Diagnostics LLC

Inventor： Tina Noyes

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/82

Abstract: Assays for rapid measurement of total vitamin D in blood are provided. Vitamin D is measured following the rapid and irreversible release of vitamin D due to denaturation and digestion of vitamin D binding proteins by aspartyl peptidases (e.g., pepsin) under acidic conditions. Such measurements may be made using a vitamin D binder (e.g., an antibody) to measure competition between free vitamin D and added, labeled vitamin D. Synergy between denaturation and degradation is believed to provide more rapid and more complete release of vitamin D than would occur with acid or enzyme alone.

公开(公告)号：US11137391B2

公开(公告)日：2021-10-05

申请号：US15952966

申请日：2018-04-13

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20210186393A1

公开(公告)日：2021-06-24

申请号：US17111831

申请日：2020-12-04

Applicant: Labrador Diagnostics LLC

Inventor： Patricia McHale ,  Michael Chen ,  Pey-Jiun Ko ,  Tammy Burd ,  Adrit Lath ,  Elizabeth A. Holmes ,  Joy Roy

IPC: A61B5/15 ,  G01N1/10 ,  A61B10/00 ,  A61B5/154 ,  A61B5/151 ,  A61B5/155 ,  B01L3/00 ,  G01N1/14

Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.