公开(公告)号：US20130040094A1

公开(公告)日：2013-02-14

申请号：US13651103

申请日：2012-10-12

Applicant: PANASONIC CORPORATION

Inventor： Masaya NAKATANI ,  Hiroshi USHIO ,  Soichiro HIRAOKA ,  Akiyoshi OSHIMA ,  Makoto TAKAHASHI

IPC: B32B5/02

CPC classification number: G01N33/48728 ,  B81B2201/0214 ,  B81B2201/052 ,  B81C1/00206 ,  Y10T428/23943

Abstract: A silicon structure of the present invention is provided with a silicon substrate (1) to become a base, and a plurality of fibrous projections (2) made of silicon dioxide and directly joined to a silicon-made surface (1a) of the silicon substrate (1). By arbitrarily constructing an area where these fibrous projections (2) are formed in a predetermined area, it is possible to render the area to have at least either hydrophilicity or water retentivity, so as to provide a silicon structure useful for a variety of devices.

Abstract translation: 本发明的硅结构设置有成为基底的硅基板（1）和由二氧化硅制成的直接接合到硅基板的硅制表面（1a）的多个纤维突起（2） （1）。 通过任意构造这些纤维状突起（2）形成在预定区域的区域，可以使该区域具有至少亲水性或保水性，以提供可用于各种装置的硅结构。

公开(公告)号：US20130005614A1

公开(公告)日：2013-01-03

申请号：US13608801

申请日：2012-09-10

Applicant: Takeki YAMAMOTO ,  Masaya Nakatani ,  Makoto Takahashi

Inventor： Takeki YAMAMOTO ,  Masaya Nakatani ,  Makoto Takahashi

IPC: C40B60/14 ,  B05D3/06 ,  B05D3/02 ,  B05D1/36

CPC classification number: C12M23/16 ,  B01L3/502707 ,  B01L3/5085 ,  B81B2201/0214 ,  B81B2207/056 ,  B81C1/00206 ,  C12M23/20 ,  G01N27/327 ,  G01N33/54366 ,  G01N2035/00158

Abstract: A silicon structure has a substrate, a first layer formed on a surface of the substrate, and a fibrous film formed on a surface of the first layer. The first layer and the fibrous film are silicon compounds made of the same elements, and the first layer and the fibrous film are directly bonded together.

Abstract translation: 硅结构具有基板，形成在基板的表面上的第一层和形成在第一层的表面上的纤维膜。 第一层和纤维膜是由相同元件制成的硅化合物，第一层和纤维膜直接粘合在一起。

公开(公告)号：US08236595B2

公开(公告)日：2012-08-07

申请号：US12376993

申请日：2006-08-11

Applicant: Ajay Agarwal ,  Navab Singh ,  Rakesh Kumar ,  Ieng Kin Lao ,  Narayanan Balasubramanian

Inventor： Ajay Agarwal ,  Navab Singh ,  Rakesh Kumar ,  Ieng Kin Lao ,  Narayanan Balasubramanian

IPC: H01L21/00

CPC classification number: B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00612 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B81B2201/0214 ,  B81B2203/0338 ,  B81B2207/07 ,  B81C1/00119 ,  B82Y15/00 ,  C40B60/12 ,  Y10S977/957 ,  Y10S977/958

Abstract: A method of fabricating a sensor comprising a nanowire on a support substrate with a first semiconductor layer arranged on the support substrate is disclosed. The method comprises forming a fin structure from the first semiconductor layer, the fin structure comprising at least two supporting portions and a fin portion arranged there between; oxidizing at least the fin portion of the fin structure thereby forming the nanowire being surrounded by a first layer of oxide; and forming an insulating layer above the supporting portions; wherein the supporting portions and the first insulating layer form a microfluidic channel. A nanowire sensor is also disclosed. The nanowire sensor comprises a support substrate, a semiconducting fin structure arranged on the support substrate, the fin structure comprising at least two semiconducting supporting portions and a nanowire arranged there between; and a first insulating layer on a contact surface of the supporting portions; wherein the supporting portions and the first insulating layer form a microfluidic channel.

Abstract translation: 公开了一种制造包括在支撑衬底上的纳米线的传感器的方法，其中第一半导体层布置在支撑衬底上。 该方法包括从第一半导体层形成翅片结构，鳍结构包括至少两个支撑部分和布置在其间的翅片部分; 至少氧化翅片结构的翅片部分，从而形成由第一氧化物层包围的纳米线; 以及在所述支撑部分上方形成绝缘层; 其中所述支撑部分和所述第一绝缘层形成微流体通道。 还公开了一种纳米线传感器。 纳米线传感器包括支撑衬底，布置在支撑衬底上的半导体翅片结构，鳍结构包括至少两个半导电支撑部分和布置在其上的纳米线; 以及在所述支撑部分的接触表面上的第一绝缘层; 其中所述支撑部分和所述第一绝缘层形成微流体通道。

公开(公告)号：US08236571B2

公开(公告)日：2012-08-07

申请号：US11827175

申请日：2007-07-10

Applicant: John W. Hartzell ,  Pooran Chandra Joshi ,  Paul J. Schuele

Inventor： John W. Hartzell ,  Pooran Chandra Joshi ,  Paul J. Schuele

IPC: G01N21/00

CPC classification number: B81C1/00246 ,  B81B2201/0214 ,  B81C2203/075 ,  Y10S436/805

Abstract: A method of producing a precursor, active-matrix, fluid-assay micro-structure including the steps of (1) utilizing low-temperature TFT and Si technology, establishing preferably on a glass or plastic substrate a matrix array of non-functionalized pixels, and (2) preparing at least one of these pixels for individual, digitally-addressed (a) functionalization, and (b) reading out, ultimately, of completed assay results.

Abstract translation: 一种制备前体，活性基质，流体测定微结构的方法，包括以下步骤：（1）利用低温TFT和Si技术，优选在玻璃或塑料基材上建立非官能化像素的矩阵阵列， 和（2）准备用于个体，数字寻址（a）功能化的这些像素中的至少一个，以及（b）最终读出完成的测定结果。

公开(公告)号：US20120142135A1

公开(公告)日：2012-06-07

申请号：US13308878

申请日：2011-12-01

Applicant: Cornel P. COBIANU

Inventor： Cornel P. COBIANU

IPC: H01L21/02

CPC classification number: G01N29/022 ,  B01L3/502707 ,  B81B2201/0214 ,  B81B2203/0118 ,  B81B2207/015 ,  B81C1/00214 ,  B81C2201/0185 ,  B81C2203/0118 ,  B81C2203/0714 ,  B81C2203/0735 ,  B82Y40/00 ,  G01N29/036 ,  G01N29/222 ,  G01N2291/021 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427

Abstract: Some embodiments relate to method of fabricating a sensor. The method includes providing a substrate wafer that includes a suspended beam; adding an adhesive layer to the substrate wafer such that the adhesive layer covers portions of the substrate without covering the suspended beam; positioning a cover wafer onto the adhesive layer such that the suspend beam is exposed to ambient air through openings in the cover wafer; and functionalizing the suspended beam by contacting the suspended beam with materials through the opening in the cover wafer.

Abstract translation: 一些实施例涉及制造传感器的方法。 该方法包括提供包括悬挂梁的衬底晶片; 向所述基板晶片添加粘合剂层，使得所述粘合剂层覆盖所述基板的部分而不覆盖所述悬挂梁; 将覆盖晶片定位在粘合剂层上，使得悬挂梁通过盖晶片中的开口暴露于环境空气; 并且通过使悬挂的梁与材料通过覆盖晶片中的开口接触使悬臂的功能化。

公开(公告)号：US08187865B2

公开(公告)日：2012-05-29

申请号：US12455186

申请日：2009-05-29

Applicant: Minhee Yun ,  Nosang Myung ,  Richard Vasquez ,  Margie Homer ,  Margaret Ryan ,  Shiao-Pin Yen ,  Jean-Pierre Fleurial ,  Ratnakumar Bugga ,  Daniel Choi ,  William Goddard ,  Abhijit Shevade ,  Mario Blanco ,  Tahir Cagin ,  Wely Floriano

Inventor： Minhee Yun ,  Nosang Myung ,  Richard Vasquez ,  Margie Homer ,  Margaret Ryan ,  Shiao-Pin Yen ,  Jean-Pierre Fleurial ,  Ratnakumar Bugga ,  Daniel Choi ,  William Goddard ,  Abhijit Shevade ,  Mario Blanco ,  Tahir Cagin ,  Wely Floriano

IPC: C12M1/34 ,  C12M3/00

CPC classification number: C25D1/04 ,  B81B3/0021 ,  B81B2201/0214 ,  B81C1/00031 ,  C25D5/022 ,  C25D11/045 ,  C25D11/18 ,  G01N2030/645 ,  Y10S977/762

Abstract: The present invention relates to a nanowire sensor and method for forming the same. More specifically, the nanowire sensor comprises at least one nanowire formed on a substrate, with a sensor receptor disposed on a surface of the nanowire, thereby forming a receptor-coated nanowire. The nanowire sensor can be arranged as a sensor sub-unit comprising a plurality of homogeneously receptor-coated nanowires. A plurality of sensor subunits can be formed to collectively comprise a nanowire sensor array. Each sensor subunit in the nanowire sensor array can be formed to sense a different stimulus, allowing a user to sense a plurality of stimuli. Additionally, each sensor subunit can be formed to sense the same stimuli through different aspects of the stimulus. The sensor array is fabricated through a variety of techniques, such as by creating nanopores on a substrate and electrodepositing nanowires within the nanopores.

Abstract translation: 纳米线传感器及其制造方法技术领域本发明涉及一种纳米线传感器及其形成方法。 更具体地，纳米线传感器包括至少一个形成在衬底上的纳米线，传感器接收器设置在纳米线的表面上，从而形成受体包被的纳米线。 纳米线传感器可以被布置为包括多个均匀受体包被的纳米线的传感器子单元。 可以形成多个传感器子单元以共同地包括纳米线传感器阵列。 可以形成纳米线传感器阵列中的每个传感器子单元以感测不同的刺激，允许用户感测多个刺激。 另外，每个传感器子单元可以形成为通过刺激的不同方面感测相同的刺激。 传感器阵列通过各种技术制造，例如通过在衬底上形成纳米孔并在纳米孔内电沉积纳米线。

公开(公告)号：US20120107194A1

公开(公告)日：2012-05-03

申请号：US12914675

申请日：2010-10-28

Applicant: Leon M. Bellan ,  Harold G. Craighead ,  Elizabeth A. Strychalski

Inventor： Leon M. Bellan ,  Harold G. Craighead ,  Elizabeth A. Strychalski

IPC: B29C33/42 ,  B01L3/00

CPC classification number: B81C1/00071 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2300/0816 ,  B81B2201/0214 ,  B81B2201/051 ,  B81B2203/0338 ,  B81C2201/034

Abstract: A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material.

Abstract translation: 通过在基底模具上形成牺牲纤维来制造器件。 纤维和模具被第一材料覆盖。 去除基底模具，然后除去覆盖的纤维以在第一材料中形成通道。

公开(公告)号：US20120101540A1

公开(公告)日：2012-04-26

申请号：US13016253

申请日：2011-01-28

Applicant: Richard J. O'Brien ,  John K. Day ,  Paul F. Gerrish ,  Michael F. Mattes ,  David A. Ruben ,  Malcolm K. Grief

Inventor： Richard J. O'Brien ,  John K. Day ,  Paul F. Gerrish ,  Michael F. Mattes ,  David A. Ruben ,  Malcolm K. Grief

IPC: A61N1/05 ,  H01L23/538 ,  H01L29/84 ,  H01L31/12

CPC classification number: H01L23/12 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/03 ,  A61B5/11 ,  A61N1/37211 ,  A61N1/3758 ,  B81B2201/0214 ,  B81B2207/012 ,  B81C1/0023 ,  H01L23/58 ,  H01L25/0655 ,  H01L2223/6677 ,  H01L2224/16145 ,  H01L2224/16225 ,  H01L2924/1461 ,  H01L2924/15153 ,  H01L2924/15192 ,  H01L2924/15313 ,  H01L2924/16195 ,  H01L2924/16251 ,  H01L2924/19105 ,  H01L2924/00

Abstract: A medical device includes a first substrate, a second substrate, a control module, and an energy storage device. The first substrate includes at least one of a first semiconductor material and a first insulating material. The second substrate includes at least one of a second semiconductor material and a second insulating material. The second substrate is bonded to the first substrate such that the first and second substrates define an enclosed cavity between the first and second substrates. The control module is disposed within the enclosed cavity. The control module is configured to at least one of determine a physiological parameter of a patient and deliver electrical stimulation to the patient. The energy storage device is disposed within the cavity and is configured to supply power to the control module.

Abstract translation: 医疗装置包括第一基板，第二基板，控制模块和能量存储装置。 第一基板包括第一半导体材料和第一绝缘材料中的至少一个。 第二基板包括第二半导体材料和第二绝缘材料中的至少一个。 第二基板被结合到第一基板，使得第一和第二基板在第一和第二基板之间限定封闭的空腔。 控制模块设置在封闭腔内。 控制模块被配置为至少确定患者的生理参数并向患者传递电刺激中的至少一个。 能量存储装置设置在空腔内并被配置为向控制模块供电。

公开(公告)号：US20120059156A1

公开(公告)日：2012-03-08

申请号：US13319989

申请日：2010-05-10

Applicant: F. Raymond Salemme ,  Patricia C. Weber

Inventor： F. Raymond Salemme ,  Patricia C. Weber

IPC: C07K16/46 ,  B82Y5/00 ,  B82Y40/00

CPC classification number: G01N33/54386 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00725 ,  B81B2201/0214 ,  B81C1/00206 ,  B82Y30/00

Abstract: A method of assembling a protein nanostructure on a surface including selectively patterning a surface with a fixation site, bringing a protein node into contact with the surface, and allowing the protein node to bond with the fixation site, so that the position and/or orientation of the protein node is constrained, and compositions.

Abstract translation: 一种在表面上组装蛋白质纳米结构的方法，包括用固定部位选择性地图案化表面，使蛋白质节点与表面接触，并使蛋白质节点与固定部位结合，使得位置和/或取向 的蛋白质节点被约束，并且组成。

公开(公告)号：US07993905B2

公开(公告)日：2011-08-09

申请号：US12166287

申请日：2008-07-01

Applicant: Rahul Singhvi ,  Amit Kumar ,  George M. Whitesides ,  Donald E. Ingber ,  Gabriel P. Lopez ,  Daniel I. C. Wang ,  Gregory Stephanopoulos

Inventor： Rahul Singhvi ,  Amit Kumar ,  George M. Whitesides ,  Donald E. Ingber ,  Gabriel P. Lopez ,  Daniel I. C. Wang ,  Gregory Stephanopoulos

IPC: C12N1/00 ,  C12N11/00 ,  C12N11/08

CPC classification number: C12N1/00 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/0072 ,  B81B2201/0214 ,  B81C1/00206 ,  B81C2201/034 ,  B82Y5/00 ,  B82Y30/00 ,  C12N5/0068 ,  C12N5/067 ,  C12N2535/10 ,  C12Q1/02 ,  C40B60/14

Abstract: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).

Abstract translation: 本发明提供一种用于将细胞粘附在特定和预定位置的装置以及相关方法。 该装置包括限定表面的板和多个细胞亲和岛，其附着细胞，由细胞不粘附的细胞渗透区隔离，与细胞色素岛邻接。 岛或区域或两者可以由自组装单层（SAM）形成。