公开(公告)号：US20140016116A1

公开(公告)日：2014-01-16

申请号：US13987046

申请日：2013-06-28

Applicant: Chemlmage Corporation

Inventor： John Maier ,  Jeffrey Cohen ,  Ryan Priore

IPC: G01N21/84

CPC classification number: G01N21/84 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J5/0846 ,  G01J2005/0077 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/129 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

Abstract translation: 本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。 可以照射生物样品，从而产生一个或多个相互作用的光子。 可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。 可以将生成的光谱数据集与至少一个参考数据集进行比较。 每个参考数据集可以与已知分析物的已知暴露相关联。 本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。 可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。

公开(公告)号：US20130335735A1

公开(公告)日：2013-12-19

申请号：US13916813

申请日：2013-06-13

Applicant: The Royal Institution for the Advancement of Learning / McGill University

Inventor： Patanjali Kambhampati ,  Jonathan Saari ,  Pooja Tyagi

IPC: G01J3/10 ,  G01J3/12

CPC classification number: G01J3/10 ,  G01J3/0224 ,  G01J3/08 ,  G01J3/1256 ,  G01J3/433 ,  G01J3/453 ,  G01J9/02

Abstract: Two dimensional (2D) optical spectroscopy, wherein the spectrum has an excitation and an emission axis, reveals information formerly hidden in one-dimensional (1D) optical spectroscopy. However, current two dimensional optical spectroscopy systems are complex laboratory arrangements and accordingly limited in deployment. According to embodiments of the invention a monolithic platform providing significantly reduced complexity and increased robustness is provided allowing for “black-box” modules allowing commercial deployment of 2D optical spectroscopy instruments. Additionally, the invention supports high pulse repetition rates as well as one quantum and two quantum measurements under electronic control.

Abstract translation: 二维（2D）光谱，其中光谱具有激发和发射轴，揭示了先前隐藏在一维（1D）光谱中的信息。 然而，目前的二维光谱系统是复杂的实验室布置，因此在部署中受到限制。 根据本发明的实施例，提供了提供显着降低的复杂性和增强的鲁棒性的单片平台，允许允许商业部署2D光谱仪器的“黑箱”模块。 此外，本发明支持高脉冲重复率以及电子控制下的一个量子和两个量子测量。

公开(公告)号：US08384045B2

公开(公告)日：2013-02-26

申请号：US12829070

申请日：2010-07-01

Applicant: Koji Takasaki ,  Katsuhiro Seo ,  Mitsuru Toishi ,  Shinji Yamada ,  Atsushi Fukumoto ,  Gary Durack

Inventor： Koji Takasaki ,  Katsuhiro Seo ,  Mitsuru Toishi ,  Shinji Yamada ,  Atsushi Fukumoto ,  Gary Durack

IPC: G01N21/64

CPC classification number: G01N15/1434 ,  G01J3/024 ,  G01J3/1256 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/645 ,  G02B6/14 ,  G02B6/32 ,  G02B6/4215

Abstract: A minute particle analyzing device includes: a light source; a first condenser lens for condensing light from the light source to a first end of a multimode optical fiber; a second condenser lens for condensing the light emerging from a second end of the multimode optical fiber to a minute particle; and a detector for detecting light generated from the minute particle by the application of the light from the light source.

Abstract translation: 微粒分析装置包括：光源; 用于将来自光源的光聚焦到多模光纤的第一端的第一聚光透镜; 第二聚光透镜，用于将从多模光纤的第二端出射的光聚焦到微小颗粒; 以及检测器，用于通过施加来自光源的光来检测由微粒产生的光。

公开(公告)号：US20110192991A1

公开(公告)日：2011-08-11

申请号：US13017554

申请日：2011-01-31

Applicant: Atsushi Fukumoto ,  Mitsuru Toishi

Inventor： Atsushi Fukumoto ,  Mitsuru Toishi

IPC: G01J1/58

CPC classification number: G01J3/1256 ,  G01J3/4406 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/51 ,  G01N21/645 ,  G01N2021/4707

Abstract: Disclosed herein is a microparticle analysis device including: a light source configured to irradiate a microparticle with light; an acousto-optic modulator configured to diffract fluorescence generated from the microparticle due to the light irradiation; a slit configured to allow transmission of only diffracted light in a diffraction center wavelength region among diffracted light beams from the acousto-optic modulator; and a detector configured to detect the diffracted light in the diffraction center wavelength region transmitted through the slit.

Abstract translation: 本发明公开了一种微粒分析装置，其特征在于，包括：被配置为用光照射微粒的光源; 配置为衍射由于光照射而从微粒产生的荧光的声光调制器; 狭缝，被配置为允许在来自声光调制器的衍射光束中的衍射中心波长区域中仅衍射衍射光; 以及检测器，被配置为检测通过狭缝透射的衍射中心波长区域中的衍射光。

公开(公告)号：US07899506B2

公开(公告)日：2011-03-01

申请号：US10532669

申请日：2003-09-25

Applicant: Kexin Xu ,  Yiwen Ma ,  Renda Wang

Inventor： Kexin Xu ,  Yiwen Ma ,  Renda Wang

IPC: A61B5/1455

CPC classification number: A61B5/0059 ,  G01J3/10 ,  G01J3/1256 ,  G01N21/359 ,  G01N2021/3144

Abstract: The present invention discloses a spectral measurement method via continuous light source and discrete light source, and a measurement instrument for non-invasive detection of human body tissue components. Said instrument includes an incident unit, a probe, a receiving unit and a data processing unit. Said composite spectral measurement method improves or strengthens the output light intensity at the wavelength that carries information of the target component within human body. It enables the spectral detection in the whole wavelength range, and thus significantly enhances the SNR of the detecting system. In the non-invasive detection instrument, light from both the continuous light source and discrete light source can be firstly selectively light-split by AOTF, or AOTF conducts light-splitting for the continuous light source, while the discrete light source LD is controlled by a spatial chopper. When data of the spectral curves achieved from said continuous light source and discrete light source are processed, data acquired under different measuring modes can be compared.

Abstract translation: 本发明公开了一种通过连续光源和离散光源的光谱测量方法，以及用于人体组织成分非侵入性检测的测量仪器。 所述仪器包括入射单元，探测器，接收单元和数据处理单元。 所述复合光谱测量方法改善或加强了携带人体内目标成分信息的波长处的输出光强度。 它能够在整个波长范围内进行光谱检测，从而显着提高检测系统的信噪比。 在非侵入式检测仪器中，来自连续光源和离散光源的光可以首先被AOTF选择性地光分裂，或者AOTF对连续光源进行光分裂，而离散光源LD由 空中砍刀 当从所述连续光源和离散光源获得的光谱曲线的数据被处理时，可以比较在不同测量模式下获得的数据。

公开(公告)号：US20100214648A1

公开(公告)日：2010-08-26

申请号：US12391997

申请日：2009-02-24

Applicant: Peiliang GAO

Inventor： Peiliang GAO

IPC: G02F1/33

CPC classification number: G02F1/125 ,  G01J3/1256 ,  G02F1/11 ,  G02F1/116 ,  G02F1/29

Abstract: An acousto-optical tunable filter is disclosed. The filter includes a medium having one or more indices of refractions alterable by the application of acoustic waves to the medium. The filter also includes an acoustic transducer coupled to the medium to generate the acoustic waves Altering the frequency of the acoustic wave selects among the different wavelengths in the incident light ray. The device also includes an optical mirror for reflecting a wave diffracted by the medium back to the medium so that it can again be diffracted. The first diffracted wave has its frequency shifted in one direction by the frequency of the acoustic wave while the second diffracted wave has its frequency shifted in the opposite direction, thereby compensating for the first shift. The result is an output ray with little or no frequency shift.

Abstract translation: 公开了一种声光可调谐滤波器。 过滤器包括具有一个或多个折射指数的介质，所述折射指数可以通过将声波施加到介质而改变。 滤波器还包括耦合到介质以产生声波的声换能器改变在入射光线中的不同波长之间的声波选择的频率。 该装置还包括用于将由介质衍射的波反射回介质的光学镜，使得其可以再次衍射。 第一衍射波在一个方向上以声波的频率偏移，而第二衍射波在相反方向上频移，从而补偿第一偏移。 结果是输出光线很少或没有频移。

公开(公告)号：US07564541B2

公开(公告)日：2009-07-21

申请号：US11393395

申请日：2006-03-30

Applicant: David Tuschel

Inventor： David Tuschel

IPC: G01N21/00 ,  G01J3/44

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/32 ,  G01N21/21 ,  G01N21/23 ,  G01N21/31 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/6456 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/6471 ,  G01N2021/6493

Abstract: An integrated system including one or more light sources, at least one processor, an optical lens, a two-dimensional tunable filter, one or more two-dimensional array of detection elements and instructions and a method using the integrated system. The system includes a plurality of modes: a Raman mode, an absorption mode, a luminescence mode, a crossed polarization mode, a crossed polarization absorption mode, bright field transmission or reflectance modes and a birefringence mode. The system includes instructions, executable by Sequential outputs from the two-dimensional array of detection elements is combined to generate a chemical image of the sample, wherein each of the sequential outputs from the first two-dimensional array of detection elements corresponds to spatially accurate wavelength-resolved images. The system is also used to detect dynamic changes in a sample over time by monitoring the sample using one or more of the modes.

Abstract translation: 包括一个或多个光源的集成系统，至少一个处理器，光学透镜，二维可调滤波器，检测元件和指令的一个或多个二维阵列以及使用该集成系统的方法。 该系统包括多种模式：拉曼模式，吸收模式，发光模式，交叉偏振模式，交叉偏振吸收模式，亮场透射或反射模式和双折射模式。 该系统包括可由来自检测元件的二维阵列的顺序输出执行的指令，以组合以产生样本的化学图像，其中来自检测元件的第一二维阵列的每个顺序输出对应于空间上准确的波长 解决的图像。 该系统还用于通过使用一种或多种模式监测样品来随时间检测样品中的动态变化。

公开(公告)号：US07317526B2

公开(公告)日：2008-01-08

申请号：US11399032

申请日：2006-04-06

Applicant: Thomas C. Voigt ,  David Tuschel ,  John S. Maier

Inventor： Thomas C. Voigt ,  David Tuschel ,  John S. Maier

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/6456 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/1269 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/65

Abstract: A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.

Abstract translation: 一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。 在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。 然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。 该过程在第二时间间隔期间重复以产生样品的第二化学图像。 基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

公开(公告)号：US07107087B2

公开(公告)日：2006-09-12

申请号：US10801612

申请日：2004-03-17

Applicant: In-duk Hwang ,  Gil-won Yoon ,  Sang-joon Han ,  Kye-jin Jeon

Inventor： In-duk Hwang ,  Gil-won Yoon ,  Sang-joon Han ,  Kye-jin Jeon

IPC: A61B5/00 ,  G01J3/42

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01J3/1256 ,  G01N21/31

Abstract: A method of measuring a concentration of a component in a subject includes setting an intensity relationship equation between a positive-order beam and a negative-order beam with respect to a reference matter at a particular wavelength, applying a light having a first wavelength band absorbed by the component and detecting an intensity of a positive-order beam output from the subject and an intensity of a negative-order beam output from the reference matter, the positive-order beam and the negative-order beam having a second wavelength band, calculating an intensity of a positive-order beam input to the subject by applying the intensity of the negative-order beam output from the reference matter to the intensity relationship equation, and calculating absorbance using the intensity of the positive-order beam output from the subject and the intensity of the positive-order beam input to the subject and measuring a concentration of the component using the absorbance.

Abstract translation: 测定被检体内成分浓度的方法包括：在特定波长下设定正序光束与负光束之间的强度关系方程式，将具有吸收的第一波长带的光 通过分量并检测从对象输出的正阶光束的强度和从参考物质输出的负光束的强度，正阶光束和负光束具有第二波长带，计算 通过将从参考物质输出的负光束的强度施加到强度关系式来输入到对象的正阶光束的强度，并且使用从被摄体输出的正阶光束的强度来计算吸光度，以及 输入到对象的正阶光束的强度，并使用吸光度测量成分的浓度。

公开(公告)号：US20060044144A1

公开(公告)日：2006-03-02

申请号：US10928328

申请日：2004-08-28

Applicant: Landon Duval

Inventor： Landon Duval

IPC: G08B23/00 ,  G01J5/02 ,  B60Q1/00

CPC classification number: A61B5/14546 ,  A61B5/1455 ,  B60K28/063 ,  G01J3/0291 ,  G01J3/1256 ,  G01N21/35

Abstract: A spectrometer for infrared reflectance measurements of samples for identification of the sample materials is built into a steering wheel assembly. The spectrometer includes a window and optics on a bench adjacent the window, so that the optics will be aligned with the sample when the device is placed in optical alignment with or directly against the sample. The optics include a broad-band IR light source (ordinary lamp) shining onto an acousto-optic tunable filter (AOTF), which passes narrow-band IR light with a swept frequency; a lens focusing the IR through the window onto the sample; and a reflectance detector aligned with the window of the spectrometer to pick up reflected light. A computer, which may be mounted in the spectrometer, compares the detected reflectance spectrum with stored sample data spectra, and identifies the material or the components of the material and their proportions. When a control substance is detected an alarm signal is produced.

Abstract translation: 用于样品的红外反射测量的光谱仪用于鉴定样品材料被嵌入到方向盘组件中。 光谱仪包括窗口和靠近窗户的台面上的光学器件，使得当器件与样品光学对准或直接对准样品时，光学元件将与样品对准。 光学器件包括照射到声光可调滤波器（AOTF）上的宽带IR光源（普通灯），其通过扫频的窄带IR光; 将IR通过窗口聚焦到样品上的透镜; 以及与光谱仪的窗口对准的反射检测器以拾取反射光。 可以安装在光谱仪中的计算机将检测到的反射光谱与存储的样品数据光谱进行比较，并且识别材料的材料或成分及其比例。 当检测到控制物质时，产生报警信号。