FLOW CELL AND SYSTEM FOR SIMULTANEOUS MEASUREMENT OF ABSORBANCE AND EMISSION IN A SAMPLE

    公开(公告)号:US20170370826A1

    公开(公告)日:2017-12-28

    申请号:US15631618

    申请日:2017-06-23

    Inventor: David Coombs

    Abstract: The flow cell of the present application simultaneously monitors and measures light absorbance and fluorescence of particles in a flowing liquid. The flow cell comprises a housing having a light input face, an absorbance output face and first and second emission output faces; a fluid flow section within the housing that comprises a bottom funnel through which fluid enters the flow cell, a core chamber into which fluid flows from the bottom funnel, and a top funnel into which fluid flows from the core chamber, wherein the bottom and top funnels each comprise a first end which extends at an angle to a second end that is wider in diameter than the first end, and said second end of each is adjacent to and aligned with the core chamber; and a center section within the housing center having a recess formed therein which houses the core chamber of the fluid flow section, wherein said center section comprises a first pair of opposing channels formed in the light input face and the absorbance output face, respectively, and a second pair of opposing channels formed in the first emission output face and the second emission output face and which are perpendicular to the first pair of opposing channels, and wherein the first pair of opposing channels and second pair of opposing channels are in communication with the core chamber. An apparatus comprising the flow cell is also provided.

    Detection device
    44.
    发明授权

    公开(公告)号:US09726606B2

    公开(公告)日:2017-08-08

    申请号:US15320099

    申请日:2015-06-16

    Abstract: A detection device comprises a chip holder, a light source, a light-guide rod, a wavelength separation filter, and an optical sensor. Given the relationship between the angle of incidence and light intensity of fluorescence on a light reception surface of the optical sensor, the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of fluorescence incident on the light reception surface at a peak angle of incidence at which the light intensity is the highest is greater than the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of excitation light incident on the light reception surface at the peak angle of incidence and is higher than the optical transmittance of the wavelength separation filter at the dominant wavelength of the rays of fluorescence incident on the light reception surface at an angle of incidence of 0 DEG.

    LIQUID AND PLATE SENSORS FOR MICROPLATE INJECTOR SYSTEM
    45.
    发明申请
    LIQUID AND PLATE SENSORS FOR MICROPLATE INJECTOR SYSTEM 有权
    液体和板式传感器用于微型注射器系统

    公开(公告)号:US20160169808A1

    公开(公告)日:2016-06-16

    申请号:US14566708

    申请日:2014-12-10

    Abstract: In a sample analyzing apparatus, an injector assembly injects a reagent onto a sample, and luminescent light from the sample is transmitted to a detector. The assembly may be movable toward and away from the sample. The assembly may include one or more needles that communicate with one or more reservoirs supplying reagent or other liquids. The assembly may include a light guide for communicating with the detector. A cartridge may be provided in which the assembly, one or more reservoirs, and one or more pumps are disposed. The cartridge and/or the apparatus may be configured for enabling rinsing or priming to be done outside the apparatus. The cartridge and/or the apparatus may include one or more types of sensors configured for detecting, for example, the presence of liquid or bubbles in one or more locations of the apparatus and/or the cartridge.

    Abstract translation: 在样品分析装置中,注射器组件将试剂注射到样品上,并将来自样品的发光发射到检测器。 组件可以朝向和远离样品移动。 组件可以包括与供应试剂或其它液体的一个或多个储存器连通的一个或多个针。 组件可以包括用于与检测器通信的光导。 可以提供盒,其中设置组件,一个或多个储存器和一个或多个泵。 墨盒和/或设备可以被配置为使得能够在设备外进行冲洗或启动。 药筒和/或装置可以包括一种或多种类型的传感器,其被配置用于例如在装置和/或药筒的一个或多个位置中检测液体或气泡的存在。

    Apparatus for photometric measurement of biological liquids
    46.
    发明授权
    Apparatus for photometric measurement of biological liquids 有权
    生物液体光度测量装置

    公开(公告)号:US09115395B2

    公开(公告)日:2015-08-25

    申请号:US14471346

    申请日:2014-08-28

    Abstract: An apparatus for photometric measurement of biological liquids and a method of simultaneously measuring the presence or quantity of an analyte in a sample region are disclosed. The apparatus includes a plurality of spaced apart sample regions; a light source adapted to emit light including at least one frequency; a lens system including a light coupling system, wherein the light coupling system is disposed between the light source and the plurality of sample regions. A method is also disclosed including illuminating the sample region with a light beam emitted from a light source, wherein said light beam passes a light coupling system, the light coupling system including a telecentric element and a plurality of light mixing rods, wherein the light coupling system is disposed between the light source and the sample region such that the light beam is directed into the sample region.

    Abstract translation: 公开了一种生物液体光度测量装置和同时测量样品区域中分析物的存在或量的方法。 该装置包括多个间隔开的样品区域; 适于发射包括至少一个频率的光的光源; 包括光耦合系统的透镜系统,其中所述光耦合系统设置在所述光源和所述多个样本区域之间。 还公开了一种方法,其包括用从光源发射的光束照射样品区域,其中所述光束通过光耦合系统,所述光耦合系统包括远心元件和多个光混合棒,其中所述光耦合 系统设置在光源和样品区域之间,使得光束被引导到样品区域中。

    APPARATUS FOR PHOTOMETRIC MEASUREMENT OF BIOLOGICAL LIQUIDS
    47.
    发明申请
    APPARATUS FOR PHOTOMETRIC MEASUREMENT OF BIOLOGICAL LIQUIDS 有权
    用于生物液体光度测量的装置

    公开(公告)号:US20150064699A1

    公开(公告)日:2015-03-05

    申请号:US14471346

    申请日:2014-08-28

    Abstract: An apparatus for photometric measurement of biological liquids and a method of simultaneously measuring the presence or quantity of an analyte in a sample region are disclosed. The apparatus includes a plurality of spaced apart sample regions; a light source adapted to emit light including at least one frequency; a lens system including a light coupling system, wherein the light coupling system is disposed between the light source and the plurality of sample regions. A method is also disclosed including illuminating the sample region with a light beam emitted from a light source, wherein said light beam passes a light coupling system, the light coupling system including a telecentric element and a plurality of light mixing rods, wherein the light coupling system is disposed between the light source and the sample region such that the light beam is directed into the sample region.

    Abstract translation: 公开了一种生物液体光度测量装置和同时测量样品区域中分析物的存在或量的方法。 该装置包括多个间隔开的样品区域; 适于发射包括至少一个频率的光的光源; 包括光耦合系统的透镜系统,其中所述光耦合系统设置在所述光源和所述多个样本区域之间。 还公开了一种方法,其包括用从光源发射的光束照射样品区域,其中所述光束通过光耦合系统,所述光耦合系统包括远心元件和多个光混合棒,其中所述光耦合 系统设置在光源和样品区域之间,使得光束被引导到样品区域中。

    Scanner type fluorescence detection apparatus for treating numerous samples
    50.
    发明授权
    Scanner type fluorescence detection apparatus for treating numerous samples 失效
    用于处理多种样品的扫描仪型荧光检测装置

    公开(公告)号:US06396581B1

    公开(公告)日:2002-05-28

    申请号:US09492302

    申请日:2000-01-27

    Abstract: A fluorescence detection apparatus is provided which comprises a sample holder for holding stationarily sample vessels deployed along a circle line or concentric circle lines having different radiuses, a partition plate connected to a driving means to be rotatable around the center of the circle line or concentric circle lines, an optical means for excitation light and an optical means for fluorescence light fixed respectively to the partition plate to be rotatable in integration therewith, a first light guide constituted of numerous optical fibers, a photosensor, and a light source for generating the excitation light, wherein the partition plate, the optical means for excitation light, and the optical means for fluorescence are integrally rotated, and thereby the fluorescence of the sample arranged along the circle line is successively detected and the detected fluorescence is transmitted to the photosensor. This fluorescence detection apparatus is useful in real-time monitoring of fluorescence signals, and satisfies the requirements of precise temperature control, quick treatment of many samples, high sensitivity, high reliability, low cost, and small size of the apparatus.

    Abstract translation: 提供了一种荧光检测装置,其包括用于保持沿着圆线展开的固定样品容器的样本保持器或具有不同半径的同心圆线,连接到驱动装置的分隔板,以可围绕圆线或同心圆的中心旋转 线路,用于激发光的光学装置和用于荧光的光学装置分别固定在分隔板上以使其一体旋转;由多个光纤构成的第一导光体,光电传感器和用于产生激发光的光源 其中分隔板,用于激发光的光学装置和用于荧光的光学装置一体地旋转,从而连续检测沿着圆线排列的样品的荧光,并将检测到的荧光传输到光电传感器。 该荧光检测装置可用于实时监测荧光信号,满足精密温度控制,快速处理多种样品,高灵敏度,高可靠性,低成本,体积小的要求。

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