公开(公告)号：US20150111023A1

公开(公告)日：2015-04-23

申请号：US14509226

申请日：2014-10-08

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Dongyang Kang

IPC: C09D165/04 ,  B05D1/02 ,  B05D3/02

CPC classification number: C09D165/04 ,  B05D1/60 ,  C03C17/328 ,  C03C2217/20 ,  C03C2217/76 ,  C03C2218/152 ,  C08G2261/3424 ,  C08G2261/65 ,  Y10T428/249958

Abstract: Coating porous material, such as PDMS, with parylene N, C, D, and AF-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.

Abstract translation: 描述了通过气相沉积聚合将聚对二甲苯N，C，D和AF-4等多孔材料涂覆在多孔材料中，其中被覆多孔材料的表面的温度被加热至60℃至120℃。 ，或80℃和85℃。 聚对二甲苯形成多孔材料内的纳米根，其与聚对二甲苯的共形表面涂层连接。 在一些实施方案中，集成的微流体液相色谱装置中的水密分离室通过在微制造的PDMS中加热隧道并在加热的隧道内沉积聚对二甲苯来制造。

公开(公告)号：US20140227437A1

公开(公告)日：2014-08-14

申请号：US14256845

申请日：2014-04-18

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Charles DeBoer ,  Yu-Chong Tai ,  Mark Humayun ,  Wendian Shi

IPC: B29D11/00

CPC classification number: B29D11/00009 ,  A61F2/1624 ,  A61F2/1635 ,  A61F2/1659 ,  A61F2240/001 ,  A61F2240/004 ,  A61F2250/0003 ,  A61L27/18 ,  A61L2430/04 ,  A61L2430/16 ,  B29D11/023 ,  C08L83/04

Abstract: Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable to air. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens.

Abstract translation: 系统，装置和方法用于假体可注射的眼内透镜。 透镜可以由硅酮，氟硅酮和苯基取代的硅氧烷制成，并且对透气半透膜。 可以通过外科手术针来访问位于前侧但远离赤道的光路外侧的一个或多个有机硅弹性体贴片，以便填充或调整透镜内的光学透明流体。 可以调节流体以便设置透镜的基础屈光度，并在其初始插入之后调整透镜。 弹性体贴片的尺寸使得它们在针被取出后自我密封。 贴片中的直的或阶梯的狭缝可以使钝针更容易地进入透镜的内部。

公开(公告)号：US08805542B2

公开(公告)日：2014-08-12

申请号：US13946338

申请日：2013-07-19

Applicant: California Institute of Technology ,  The Regents of the University of California ,  University of Louisville Research Foundation, Inc.

Inventor： Yu-Chong Tai ,  Mandheerej S. Nandra ,  Joel W. Burdick ,  Damien Craig Rodger ,  Andy Fong ,  Victor Reggie Edgerton ,  Roland R. Roy ,  Yury Gerasimenko ,  Igor Lavrov ,  Susan J. Harkema ,  Claudia A. Angeli

IPC: A61N1/05

CPC classification number: A61N1/0551 ,  A61N1/0553 ,  A61N1/0558

Abstract: An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings and a second portion that includes a plurality of second openings. Electrodes and traces are positioned inside a peripheral portion of a body portion of the device and alongside the layer. At least one of the first openings is adjacent each of the electrodes to provide a pathway through which the electrode may provide electrical stimulation to the spinal cord. At least one of the second openings is adjacent each of the traces to provide a pathway through which the trace may receive electrical stimulation. At least one trace is connected to each electrode and configured to conduct electrical stimulation received by the trace(s) to the electrode.

Abstract translation: 构造成对脊髓施加电刺激的可植入电极阵列组件。 装置的基本上不导电的层具有可沿着脊髓定位的第一部分，其包括多个第一开口和包括多个第二开口的第二部分。 电极和迹线位于装置的主体部分的周边部分的内部并且沿着该层。 第一开口中的至少一个邻近每个电极，以提供电极可以通过该通路向脊髓提供电刺激的通路。 第二开口中的至少一个与每个迹线相邻，以提供轨迹可以接收电刺激的路径。 至少一个迹线连接到每个电极并且被配置为将迹线接收的电刺激传导到电极。

公开(公告)号：US08721892B2

公开(公告)日：2014-05-13

申请号：US14065210

申请日：2013-10-28

Applicant: California Institute of Technology

Inventor： Chi-Yuan Shih ,  Yu-Chong Tai ,  Jun Xie ,  Darron K. Young ,  Po-Jui Chen

IPC: B01D15/08 ,  G01N30/02 ,  C02F1/28

CPC classification number: B01D15/22 ,  G01N30/02 ,  G01N30/461 ,  G01N30/466 ,  G01N30/6095 ,  G01N30/78 ,  G01N30/96 ,  G01N2030/524 ,  Y10T29/49826 ,  B01D15/363 ,  B01D15/3804 ,  B01D15/362 ,  B01D15/34 ,  B01D15/325 ,  B01D15/361

Abstract: Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.

Abstract translation: 使用集成色谱系统和设备实时监测分析物的系统和方法。 集成的微流体液相色谱装置和系统包括集成到单个底物中的多个分离柱。 使用这样的器件，可以同时执行多个样本的并行分析和/或可以在单个芯片或衬底上同时执行单个样本的顺序分析。 该装置和系统非常适用于高压液相色谱（HPLC）应用。 包括嵌入式聚对二甲苯通道的HPLC芯片和器件可以使用单一掩模工艺制造。

公开(公告)号：US20140038271A1

公开(公告)日：2014-02-06

申请号：US14020313

申请日：2013-09-06

Applicant: University of Southern California ,  California Institute of Technology

Inventor： Amir Goldkorn ,  Yu-Chong Tai ,  Tong Xu ,  Bo Lu

IPC: G01N33/50

CPC classification number: G01N33/57496 ,  C12N5/0693 ,  C12N2503/00 ,  C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Y207/07049 ,  G01N1/30 ,  G01N1/4077 ,  G01N33/5094 ,  G01N2001/4088 ,  G01N2333/9128 ,  Y10T436/25375

Abstract: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.

Abstract translation: 本发明提供一种用于诊断癌症的方法，预测患者样品中的疾病结果或对治疗的反应。 该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞（CTC），例如可行的CTC，所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器， 尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。 本发明还提供了使用在各种应用中实时捕获的细胞的方法。

公开(公告)号：US20130137135A1

公开(公告)日：2013-05-30

申请号：US13686866

申请日：2012-11-27

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Wendian Shi ,  Harvey Kasdan

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/05 ,  G01N21/6428 ,  G01N2021/0346 ,  G01N2021/6441 ,  G01N2021/6482

Abstract: The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population.

Abstract translation: 本发明提供使用荧光检测对白细胞群体中的白细胞进行分类的组合物和方法。 所述方法包括将具有一种或多种白细胞类型的样品中的白细胞群与诊断组合物接触，用光源激发白细胞群; 并测量来自所述一种或多种白细胞类型中的每一种的发射光以分类白细胞群体。

公开(公告)号：US20250127610A1

公开(公告)日：2025-04-24

申请号：US18508701

申请日：2023-11-14

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Mark S. Humayun

IPC: A61F2/16

Abstract: An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.

公开(公告)号：US11890097B2

公开(公告)日：2024-02-06

申请号：US17179018

申请日：2021-02-18

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Shane S. Shahrestani

IPC: A61B5/245 ,  A61B5/00 ,  A61B5/06

CPC classification number: A61B5/245 ,  A61B5/067 ,  A61B5/4839 ,  A61B5/6803 ,  A61B5/684 ,  A61B5/7246 ,  A61B2562/0223

Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

公开(公告)号：US11318225B2

公开(公告)日：2022-05-03

申请号：US15184934

申请日：2016-06-16

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Bo Lu ,  Mark Humayun

IPC: C12N5/00 ,  A61L27/16 ,  B01D71/44 ,  A61L27/50 ,  A61L27/56

Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.

公开(公告)号：US11291377B2

公开(公告)日：2022-04-05

申请号：US15076184

申请日：2016-03-21

Applicant: California Institute of Technology

Inventor： Yu-Chong Tai ,  Yang Liu ,  Aubrey M. Shapero

IPC: A61B5/03 ,  A61B5/0215 ,  G01L9/00 ,  A61B5/021

Abstract: An implantable medical device is described. In an example, the implantable medical device includes an electromechanical substrate and sensor, such as a pressure sensor, disposed on the substrate. At least a portion of the sensor is packaged via a liquid encapsulation. The packaging includes a shaped flexible outer membrane that surrounds at least the portion of the sensor. The packaging also includes a hydrophobic liquid disposed between at least the portion of the pressure sensor and the flexible outer membrane. The implantable medical device can be a part of a medical system used for monitoring medical conditions or performing medical operations based on the implantable medical device. Additionally, manufacturing methods are described for packaging the sensor in a liquid encapsulation.