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    Method and apparatus for measuring a concentration of a component in a subject
    51.
    发明申请
    Method and apparatus for measuring a concentration of a component in a subject 有权
    用于测量受试者中组分浓度的方法和装置

    公开(公告)号：US20040186361A1

    公开(公告)日：2004-09-23

    申请号：US10801612

    申请日：2004-03-17

    Inventor： In-duk Hwang ,  Gil-won Yoon ,  Sang-joon Han ,  Kye-jin Jeon

    IPC: A61B005/00

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01J3/1256 ,  G01N21/31

    Abstract: A method of measuring a concentration of a component in a subject includes setting an intensity relationship equation between a positive-order beam and a negative-order beam with respect to a reference matter at a particular wavelength, applying a light having a first wavelength band absorbed by the component and detecting an intensity of a positive-order beam output from the subject and an intensity of a negative-order beam output from the reference matter, the positive-order beam and the negative-order beam having a second wavelength band, calculating an intensity of a positive-order beam input to the subject by applying the intensity of the negative-order beam output from the reference matter to the intensity relationship equation, and calculating absorbance using the intensity of the positive-order beam output from the subject and the intensity of the positive-order beam input to the subject and measuring a concentration of the component using the absorbance.

    Abstract translation: 测定被检体内成分浓度的方法包括：在特定波长下设定正序光束与负光束之间的强度关系方程式，将具有吸收的第一波长带的光 通过分量并检测从对象输出的正阶光束的强度和从参考物质输出的负光束的强度，正阶光束和负光束具有第二波长带，计算 通过将从参考物质输出的负光束的强度施加到强度关系式来输入到对象的正阶光束的强度，并且使用从被摄体输出的正阶光束的强度来计算吸光度，以及 输入到对象的正阶光束的强度，并使用吸光度测量成分的浓度。

    Optical spectrum analyzer and optical spectrum detecting method
    52.
    发明申请
    Optical spectrum analyzer and optical spectrum detecting method 失效

    公开(公告)号：US20040075832A1

    公开(公告)日：2004-04-22

    申请号：US10720146

    申请日：2003-11-25

    Applicant: Fujitsu Limited

    Inventor： Takeo Iwama

    IPC: G01J003/28

    CPC classification number: G01J9/0246 ,  G01J3/1256 ,  G01J3/2803

    Abstract: In an optical spectrum analyzer comprising a spectrograph and a photodevice array, and an optical spectrum detecting method, a wavelength deviation, from an assigned wavelength, of a light detected by a photodevice array which detects a wavelength of a diffraction light or a non-diffraction light from an acoustooptic device, is detected and a feedback control to a diffraction angle of the acoustooptic device is performed. Also, without using a feedback control, an exit light and a diffraction light from the acoustooptic device are respectively received by two photodevice arrays and the photodevices are arranged in order to mutually compensate gaps between the photodevices, whereby a center of each photodevice is similarly made coincide with a peak of an optical beam to be received.

    Hemispherical detector
    54.
    发明授权
    Hemispherical detector 失效
    半球形探测器

    公开(公告)号：US06534768B1

    公开(公告)日：2003-03-18

    申请号：US09699702

    申请日：2000-10-30

    Applicant: Emil W. Ciurczak ,  Kevin C. Bynum

    Inventor： Emil W. Ciurczak ,  Kevin C. Bynum

    IPC: G01J528

    CPC classification number: G01N21/35 ,  G01J1/0455 ,  G01J1/4228 ,  G01J3/0243 ,  G01J3/10 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/2803 ,  G01J2003/123 ,  G01J2003/1243 ,  G01J2003/1828 ,  G01J2003/2866 ,  G01N21/359 ,  G01N21/59

    Abstract: A hemispherical detector comprising a plurality of photodetectors arranged in a substantially contiguous array, the array being substantially in the shape of a half-sphere, the half-sphere defining a closed end and an open end, the open end defining a substantially circular face. Also provided is a method for constructing a hemispherical detector comprising the steps of making a press mold of the desired shape of the hemispherical detector, pouring a material into the press mold to form a cast, finishing the cast to remove any defects, coating the cast with a coating material, and attaching a plurality of photodetectors to the cast.

    Abstract translation: 一种半球形检测器，包括以基本上邻接的阵列布置的多个光电检测器，所述阵列基本上为半球形，所述半球限定封闭端和开口端，所述开口端限定基本圆形的面。 还提供了一种用于构造半球形检测器的方法，包括以下步骤：制造半球形检测器所需形状的压模，将材料注入压模中以形成铸件，精加工铸件以除去任何缺陷，涂覆铸件 涂覆材料，并将多个光电检测器附接到铸件上。

    Advanced synchronous luminescence system for the detection of biological agents and infectious pathogens
    56.
    发明授权
    Advanced synchronous luminescence system for the detection of biological agents and infectious pathogens 失效
    先进的同步发光系统，用于检测生物制剂和感染性病原体

    公开(公告)号：US5938617A

    公开(公告)日：1999-08-17

    申请号：US760165

    申请日：1996-12-03

    Applicant: Tuan Vo-Dinh

    Inventor： Tuan Vo-Dinh

    IPC: A61B5/00 ,  G01J3/12 ,  G01N21/64 ,  A61B6/00

    CPC classification number: G01N21/6402 ,  A61B5/0059 ,  G01J3/1256 ,  G01N21/6456 ,  G01N21/6486

    Abstract: A method and apparatus for detecting and identifying biological pathogens in a sample includes exposing the sample to an excitation radiation and thereby generating an emission radiation, synchronously scanning the wavelength of the excitation radiation and the wavelength of the emission radiation to produce a spectrum, and correlating the spectrum to a biological pathogen in the sample. In another aspect, a method and apparatus for imaging chemical and biological agents in a sample includes exposing the sample to an excitation radiation and thereby generating an emission radiation and synchronously imaging the wavelength of the excitation radiation and the wavelength of the emission radiation to produce an imaged spectrum.

    Abstract translation: 用于检测和识别样品中生物病原体的方法和装置包括将样品暴露于激发辐射，从而产生发射辐射，同步扫描激发辐射的波长和发射辐射的波长以产生光谱，并且将相关 样品中生物病原体的光谱。 在另一方面，用于对样品中的化学和生物试剂进行成像的方法和装置包括将样品暴露于激发辐射，从而产生发射辐射并同步成像激发辐射的波长和发射辐射的波长，以产生 成像光谱。

    Spectral bio-imaging methods for biological research, medical diagnostics and therapy
    58.
    发明授权
    Spectral bio-imaging methods for biological research, medical diagnostics and therapy 失效
    用于生物研究，医学诊断和治疗的光谱生物成像方法

    公开(公告)号：US5784162A

    公开(公告)日：1998-07-21

    申请号：US571047

    申请日：1995-12-12

    Applicant: Dario Cabib ,  Robert A. Buckwald ,  Zvi Malik ,  Yuval Garini ,  Nir Katzir ,  Dirk G. Soeknsen

    Inventor： Dario Cabib ,  Robert A. Buckwald ,  Zvi Malik ,  Yuval Garini ,  Nir Katzir ,  Dirk G. Soeknsen

    IPC: G01B11/00 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  A61B10/00 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/443 ,  G01J3/45 ,  G01J3/453 ,  G01N21/27 ,  G01N21/64 ,  G01N33/48 ,  G01N33/483 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G02B21/36 ,  G06K9/00 ,  G06K9/76 ,  G01B9/02

    CPC classification number: G01N21/6458 ,  C12Q1/6841 ,  C12Q1/6883 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/6428 ,  G01N21/6486 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/582 ,  G06K9/00127 ,  G06K9/76 ,  G01J2003/2866 ,  G01J3/02 ,  G01N2021/6417 ,  G01N2021/6423

    Abstract: According to the present invention there are provided spectral imaging methods for biological research, medical diagnostics and therapy comprising the steps of (a) preparing a sample to be spectrally imaged; (b) viewing the sample through an optical device, the optical device being optically connected to an imaging spectrometer, the optical device and the imaging spectrometer obtaining a spectrum of each pixel of the sample by: (i) collecting incident light simultaneously from all pixels of the sample using collimating optics; (ii) passing the incident collimated light through an interferometer system having a number of elements, to form an exiting light beam; (iii) passing the exiting light beam through a focusing optical system which focuses the exiting light beam on a detector having a two-dimensional array of detector elements, so that at each instant each of the detector elements is the image of one pixel of the sample, so that the real image of the sample is stationary on the plane of the detector array, and so that each of the detector elements produces a signal which is a particular linear combination of light intensity emitted by the pixel at different wavelengths, wherein the linear combination is a function of the instantaneous optical path difference; (iv) rotating one or more of the elements of the interferometer system, so that the optical path difference between the two coherent beams generated by the interferometer system is scanned simultaneously for all the pixels of the sample; and (v) recording signals of each of the detector elements as function of time using a recording device to form a first spectral cube of data; and (c) interpreting the first spectral cube of data using a mathematical algorithm.

    Abstract translation: 根据本发明，提供了用于生物学研究，医学诊断和治疗的光谱成像方法，其包括以下步骤：（a）制备待成像的样品; （b）通过光学装置观察样品，光学装置光学连接到成像光谱仪，光学装置和成像光谱仪通过以下步骤获得样品的每个像素的光谱：（i）从所有像素同时收集入射光 的样品使用准直光学; （ii）使入射的准直光通过具有多个元件的干涉仪系统，以形成出射的光束; （iii）使出射的光束通过聚焦光学系统，该聚焦光学系统将出射的光束聚焦在具有检测器元件的二维阵列的检测器上，使得在每个瞬间，每个检测器元件是 样本，使得样本的真实图像在检测器阵列的平面上是静止的，并且使得每个检测器元件产生信号，其是由不同波长的像素发射的光强度的特定线性组合，其中 线性组合是瞬时光程差的函数; （iv）旋转干涉仪系统的一个或多个元件，使得由干涉仪系统产生的两个相干光束之间的光程差同时扫描样品的所有像素; 以及（v）使用记录装置记录每个检测器元件的信号作为时间的函数，以形成数据的第一光谱立方体; 和（c）使用数学算法解释数据的第一个频谱立方体。

    Real time spectroscopic imaging system and method
    59.
    发明授权
    Real time spectroscopic imaging system and method 失效
    实时光谱成像系统及方法

    公开(公告)号：US5606413A

    公开(公告)日：1997-02-25

    申请号：US374055

    申请日：1995-01-19

    Applicant: Peter A. Bellus ,  Terry L. McKinney

    Inventor： Peter A. Bellus ,  Terry L. McKinney

    IPC: G01J3/12 ,  G01J3/28 ,  G01N21/31 ,  G01N21/35

    CPC classification number: G01J3/1256 ,  G01J3/2823

    Abstract: To dramatically reduce image data processing requirements in spectroscopic imaging systems, an optical filter is alternatingly tuned to a pair of selected passband wavelengths related to an absorption wavelength of a sample under test, such that only light of the two selected wavelengths received from the test sample are recorded as alternating image frames by a CCD optical detector. Successive pairs of consecutive image frames are computer processed, on a corresponding pixel-by-pixel basis, to generate a series of composite image frames that may be displayed in enhanced contrast to permit real time analysis of a sample characteristic of interest.

    Abstract translation: 为了显着降低分光成像系统中的图像数据处理要求，将滤光器交替地调谐到与待测试样品的吸收波长相关的一对选定的通带波长，使得仅从测试样品接收到的两个选定波长的光 通过CCD光学检测器记录为交替图像帧。 连续成对的连续图像帧在相应逐个像素的基础上被计算机处理，以产生可以以增强的对比度显示的一系列合成图像帧，以允许感兴趣的样本特征的实时分析。

    Advanced synchronous luminescence system
    60.
    发明授权
    Advanced synchronous luminescence system 失效
    先进的同步发光系统

    公开(公告)号：US5599717A

    公开(公告)日：1997-02-04

    申请号：US300202

    申请日：1994-09-02

    Applicant: Tuan Vo-Dinh

    Inventor： Tuan Vo-Dinh

    IPC: A61B5/00 ,  G01J3/12 ,  G01N21/64

    CPC classification number: G01N21/6402 ,  A61B5/0059 ,  G01J3/1256 ,  G01N21/6456 ,  G01N21/6486

    Abstract: A method and apparatus for determining the condition of tissue or otherwise making chemical identifications includes exposing the sample to a light source, and using a synchronous luminescence system to produce a spectrum that can be analyzed for tissue condition.

    Abstract translation: 用于确定组织状况或以其他方式进行化学鉴定的方法和装置包括将样品暴露于光源，并使用同步发光系统产生可分析组织状况的光谱。

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