公开(公告)号：US20180153456A1

公开(公告)日：2018-06-07

申请号：US15881109

申请日：2018-01-26

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Peter Rule

IPC: A61B5/15 ,  A61B5/153 ,  A61B5/145 ,  A61B5/1455 ,  G16H10/40 ,  G01N21/27 ,  A61M5/172 ,  A61B5/00 ,  A61B5/157 ,  A61B5/155 ,  A61M5/142 ,  A61M5/168 ,  A61B5/1486 ,  A61M5/36 ,  G01N21/35 ,  A61M5/38

CPC classification number: A61B5/150992 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150854 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/274 ,  G01N21/35 ,  G01N2201/1293 ,  G06F19/3468 ,  G16H10/40 ,  G16H20/17

Abstract: In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.

公开(公告)号：US20170363540A1

公开(公告)日：2017-12-21

申请号：US15639486

申请日：2017-06-30

Applicant: Saudi Arabian Oil Company

Inventor： Omer Refa Koseoglu ,  Adnan Al-Hajji

IPC: G01N21/3504 ,  G01N33/28

CPC classification number: G01N21/3504 ,  G01N21/3577 ,  G01N21/359 ,  G01N33/2823 ,  G01N2201/12 ,  G01N2201/1293

Abstract: A system and a method for calculating and assigning one or more indicative properties (e.g., cetane number, pour point, cloud point, aniline point) of a fraction of an oil sample based on an index calculated and assigned based on near infrared spectroscopy data of the sample.

公开(公告)号：US20170160296A1

公开(公告)日：2017-06-08

申请号：US15330019

申请日：2016-07-26

Applicant: I-Tsung Shih

Inventor： I-Tsung Shih

IPC: G01N33/92 ,  G01N33/94 ,  G01N21/33 ,  G01N33/68 ,  G01N21/25 ,  G01N21/31

CPC classification number: G01N33/92 ,  G01N21/255 ,  G01N21/31 ,  G01N21/314 ,  G01N21/33 ,  G01N33/6854 ,  G01N33/94 ,  G01N2021/3129 ,  G01N2201/1293

Abstract: The present invention relates to methods of spectrophotometric determination of the presence of particular substances in a complex mixture of compounds. This invention relates to methods for determining the concentration of various components of complex biological samples including the determination of the concentration of polyoxyethylene containing compounds including polysorbate in protein containing samples as well as determining the ratio of drug to antibody ratios in antibody-drug conjugate solutions

公开(公告)号：US20160266033A1

公开(公告)日：2016-09-15

申请号：US15031641

申请日：2013-12-19

Applicant: HALLIBURTON ENERGY SERVICES INC.

Inventor： Michael N. Simcock ,  David L. Perkins

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01J3/2803 ,  G01J3/32 ,  G01J2003/1226 ,  G01N21/255 ,  G01N21/65 ,  G01N2021/3166 ,  G01N2021/6471 ,  G01N2201/127 ,  G01N2201/1293

Abstract: An optical computing device utilizes an Integrated Computational Element (“ICE”) core to correct calibration transfer errors in the device.

Abstract translation: 光学计算设备利用集成计算元件（“ICE”）核来校正设备中的校准传递错误。

公开(公告)号：US09383308B2

公开(公告)日：2016-07-05

申请号：US13654146

申请日：2012-10-17

Applicant: Thermo Electron Scientific Instruments LLC

Inventor： Michael S. Bradley ,  Garry L. Ritter ,  Alexander I. Grenov

IPC: G06F15/00 ,  G01N21/35 ,  G01J3/28 ,  G01N21/27 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/3577

CPC classification number: G01N21/35 ,  G01J3/2803 ,  G01N21/272 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/3577 ,  G01N2201/1293

Abstract: MCR provided estimated pure component time series spectra as extracted from infrared or other spectroscopy is capable of being compared to spectra in a reference library to find the best matches. The best match spectra can then each in turn be combined with the reference spectra, with the combinations also being screened for best matches versus any one of the estimated pure component time series spectra. These resulting best matches can then also undergo the foregoing combination and comparison steps. The process can repeat in this manner in an unbounded fashion if desired until an appropriate stopping point is reached, for example, when a desired number of best matches are identified, when some predetermined number of iterations has been performed, etc. This methodology is able to return best-match spectra with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.

Abstract translation: MCR提供从红外或其他光谱提取的估计纯分量时间序列光谱能够与参考文库中的光谱进行比较以找到最佳匹配。 然后，最佳匹配光谱可以随后与参考光谱组合，同时筛选组合以获得与任何一种估计的纯分量时间序列光谱的最佳匹配。 所得到的最佳匹配然后也可以经历上述组合和比较步骤。 如果需要，该过程可以以无界的方式以这种方式重复，直到达到适当的停止点，例如，当已经执行了一些预定数量的迭代时，当识别出期望数量的最佳匹配时，该方法能够 如果考虑到参考光谱的所有可能组合，则以更少的计算步骤和更高的速度返回最佳匹配光谱。

公开(公告)号：US20160131577A1

公开(公告)日：2016-05-12

申请号：US14899093

申请日：2014-06-16

Applicant: Ulrik Merrild NIELSEN

Inventor： Ulrik Merrild NIELSEN

IPC: G01N21/49 ,  G01N21/3577

CPC classification number: G01N21/49 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/108 ,  G01J2003/104 ,  G01N21/3577 ,  G01N21/51 ,  G01N2021/3196 ,  G01N2201/0221 ,  G01N2201/1293

Abstract: A method of contactless detection of indications of psychoactive components in a liquid and an apparatus therefor, by emitting a substantially monochromatic light at least at two different wavelengths and detecting the reflection in a free surface of the liquid by a photo detector, analyzing an output signal from the photo detector to identify output parts caused by light emitted from the first and second emitters, respectively, and determining whether the liquid contains at least one psychoactive component.

Abstract translation: 一种通过发射至少两个不同波长的基本单色光并通过光电检测器检测液体的自由表面的反射来对液体及其装置中的精神活性成分进行非接触式检测的方法，分析输出信号 从所述光检测器分别识别由从所述第一和第二发射器发射的光引起的输出部分，并且确定所述液体是否包含至少一个精神分量。

公开(公告)号：US09182282B2

公开(公告)日：2015-11-10

申请号：US12447591

申请日：2007-11-01

Applicant: Michael L. Myrick ,  Robert P. Freese ,  David L. Perkins ,  Terrell Teague ,  William Soltmann

Inventor： Michael L. Myrick ,  Robert P. Freese ,  David L. Perkins ,  Terrell Teague ,  William Soltmann

IPC: G01N21/00 ,  G01J3/28 ,  G01J3/02 ,  G01J3/08 ,  G01J3/42 ,  G01J3/12

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/08 ,  G01J3/42 ,  G01J2003/1213 ,  G01N2201/128 ,  G01N2201/1293

Abstract: The present subject matter relates to methods of high-speed analysis of product samples. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward an optical detector. Signals for the detector are compared with reference signals based on a portion of the illuminating light passing through a reference element to determine characteristics of the product under analysis. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass.

Abstract translation: 本主题涉及产品样品的高速分析方法。 光被引导到被分析的产品的一部分，从产品反射或透过产品朝向光学检测器。 基于通过参考元件的照明光的一部分，将检测器的信号与参考信号进行比较，以确定被分析产品的特性。 被分析的产品可以是固定的，由检查点通过输送机或其他方式移动，或者可以容纳在容器内，该容器包括产品照明光通过的窗口部分。

公开(公告)号：US09134227B2

公开(公告)日：2015-09-15

申请号：US13504977

申请日：2010-10-21

Applicant: Leslie Joseph Janik ,  Andreas Paul Loibner ,  Juergen Kattner ,  Eva Edelmann

Inventor： Leslie Joseph Janik ,  Andreas Paul Loibner ,  Juergen Kattner ,  Eva Edelmann

IPC: G01J5/02 ,  G01N21/3563 ,  G01N21/27 ,  G01N21/31 ,  G01N21/93 ,  G01N21/3504 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/552 ,  G01N21/35

CPC classification number: G01N21/3563 ,  G01N21/274 ,  G01N21/314 ,  G01N21/3504 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/552 ,  G01N21/93 ,  G01N2021/3133 ,  G01N2021/3155 ,  G01N2021/3595 ,  G01N2201/1293

Abstract: Method for determining polycyclic aromatic hydrocarbon (PAH) concentration in a solid state sample. The method includes exposing the sample to diffuse reflectance infrared spectroscopy, recording at least one spectroscopic parameter of infrared diffuse reflection of the sample, which is a signal obtained at one or more frequencies within a range of frequencies (+/−10 cm−1) selected from the group consisting of 3000-3100 cm−1, 740, 777, 814, 842, 1430, 1510, 1600, 4055-4056, 4642-4646, 5924, and 5951-5953 cm−1, and performing data analysis by correlating the at least one spectroscopic parameter with variables of a trained multivariate calibration model related to PAH concentrations, thereby determining PAH concentrations in the sample.

Abstract translation: 确定固态样品中多环芳烃（PAH）浓度的方法。 该方法包括将样品暴露于漫反射红外光谱，记录样品的红外漫反射的至少一个光谱参数，该频谱参数是在频率范围（+/- 10cm -1）内以一个或多个频率获得的信号， 选自3000-3100cm-1,740,777,814,842,1430,1510,1600,4055-4056,4642-4646,5924和5951-5953cm-1，并且通过以下步骤进行数据分析： 将至少一个光谱参数与与PAH浓度相关的经训练的多变量校准模型的变量相关联，从而确定样品中的PAH浓度。

公开(公告)号：US09091676B2

公开(公告)日：2015-07-28

申请号：US13156295

申请日：2011-06-08

Applicant: Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

IPC: G01N33/49 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/153 ,  A61B5/00 ,  G01N21/31 ,  G01N21/35

CPC classification number: G01N33/491 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150801 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/7275 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0437 ,  A61B2560/0443 ,  A61B2562/0238 ,  A61B2562/08 ,  G01N21/35 ,  G01N2021/3174 ,  G01N2201/1215 ,  G01N2201/1293 ,  G06F19/00

Abstract: Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.

Abstract translation: 提供了用于分析流体样品的多个组分的系统和方法。 在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。 在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。 在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。 在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分 的样品分离后。

公开(公告)号：US20150142333A1

公开(公告)日：2015-05-21

申请号：US14606812

申请日：2015-01-27

Applicant: CIRECA THERANOSTICS, LLC ,  NORTHEASTERN UNIVERSITY

Inventor： Max DIEM ,  Benjamin BIRD ,  Milos MILJKOVIC ,  Stanley H. REMISZEWSKI ,  Clay M. THOMPSON

IPC: G01N21/31 ,  G06F19/00

CPC classification number: G01N21/31 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7257 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/552 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2021/6417 ,  G01N2021/653 ,  G01N2201/1293 ,  G01N2201/1296 ,  G06F19/00 ,  G06K9/00134 ,  G06K9/00147 ,  G06K2009/4657 ,  G06T7/30 ,  G06T2207/20101 ,  G06T2207/30024 ,  G16H50/20

Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.

Abstract translation: 通过光谱成像分析生物标本以提供医学诊断的方法包括获得生物标本的光谱和视觉图像并登记图像以检测细胞异常，癌前细胞和癌细胞。 该方法消除了标准组织病理学和其他光谱方法固有的诊断的偏倚和不可靠性。 此外，用于校正在细胞和组织的显微取得的红外光谱中经常观察到的混杂光谱贡献的方法包括对光谱数据执行相位校正。 该相位校正方法可用于校正被反射组件污染的各种类型的吸收光谱。