公开(公告)号：US06953928B2

公开(公告)日：2005-10-11

申请号：US10700300

申请日：2003-10-31

Applicant: Marvin L. Vestal ,  Kevin M. Hayden ,  Philip J. Savickas

Inventor： Marvin L. Vestal ,  Kevin M. Hayden ,  Philip J. Savickas

IPC: H01J27/24 ,  H01J49/16 ,  H01J49/40 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0418 ,  H01J49/061 ,  H01J49/164

Abstract: Provided are MALDI ion sources, methods of forming ions and mass analyzer systems. In various embodiments, provided are MALDI ion sources configured to irradiate a sample on a sample surface with a pulse of laser energy at angle within 10 degrees or less of the surface normal, and a first ion optics system configured to extract sample ions in a direction within 5 degrees or less of the surface normal. In various embodiments, MALDI ion sources having substantially coaxial sample irradiation and ion extraction are provided. In various embodiments, methods are provided, which produce sample ions by MALDI and extract sample ions using an accelerating electrical field to form an ion beam, such that, the angle of the trajectory at the exit from the accelerating electrical field of sample ions substantially at the center of the ion beam is substantially independent of sample ion mass.

公开(公告)号：US20050199802A1

公开(公告)日：2005-09-15

申请号：US11075671

申请日：2005-03-10

Applicant: Yoshihiro Ueno

Inventor： Yoshihiro Ueno

IPC: G01N27/62 ,  B01D59/44 ,  G01N27/64 ,  G01N30/26 ,  G01N30/72 ,  H01J49/00 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/061 ,  G01N30/7206

Abstract: A mass spectrometer includes: an ion source; a mass separator for separating ions with respect to mass to charge ratios of the ions; an ion detector; an ion deflector including a pair of electrodes placed opposite each other across an ion optical axis, the ion deflector being placed between the ion source and the mass separator or between the mass separator and the ion detector; and a voltage generator for applying AC voltages of opposite polarities respectively to the pair of electrodes, where a frequency of the AC voltages is determined so that lighter ions are more deflected and prevented from entering the mass separator or the ion detector and heavier ions are less deflected and allowed to enter the mass separator or the ion detector. Only helium ions which are deleterious to the mass spectrometry can be efficiently eliminated while object sample ions are hardly affected. This enables a high-sensitivity and high-accuracy mass analysis of ions whose mass to charge ratios are close to that of helium ions, which until now has been difficult.

Abstract translation: 质谱仪包括：离子源; 用于分离离子相对于离子的质荷比的质量分离器; 离子检测器 离子偏转器，其包括通过离子光轴彼此相对放置的一对电极，离子偏转器被放置在离子源和质量分离器之间或者在质量分离器和离子检测器之间; 以及电压发生器，用于分别向一对电极施加相反极性的交流电压，其中确定了交流电压的频率，使得较轻的离子被更多地偏转并防止进入质量分离器或离子检测器，较重的离子较少 偏转并允许进入质量分离器或离子检测器。 只有对质谱有害的氦离子才能被有效地消除，而对象样品离子几乎不受影响。 这使得能够对其质荷比接近于氦离子的离子进行高灵敏度和高精度的质量分析，迄今为止难以进行。

公开(公告)号：US06933497B2

公开(公告)日：2005-08-23

申请号：US10327471

申请日：2002-12-20

Applicant: Marvin L. Vestal

Inventor： Marvin L. Vestal

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/40

CPC classification number: H01J49/40 ,  H01J49/025 ,  H01J49/061

Abstract: A TOF mass analyzer having multiple flight paths is described. The TOF mass analyzer includes a pulsed ion source that generates a packet of ions and that accelerates the packet of ions. An ion deflector directs a first group of ions from the packet of ions to a first ion path, and a second group of ions to a second ion path for each of a first and second predetermined time interval after the pulsed ion source generates the packet of ions. A first TOF mass separator separates the first group of ions according to their mass to-charge ratio and a first detector is positioned to receive the first group of ions A second TOF mass separator separates a second group of ions according to their mass to-charge ratio and a second detector is positioned to receive the second group of ions. Additional ion paths may be employed, and any type of TOF mass separator may be used in each ion path.

Abstract translation: 描述具有多个飞行路径的TOF质量分析器。 TOF质量分析器包括产生离子束并脉冲离子源的脉冲离子源。 离子偏转器将第一组离子从第一离子路径引导到第一离子路径，并且将第二组离子引导到第二离子路径，以在脉冲离子源产生第一和第二预定时间间隔之后的第一和第二预定时间间隔 离子。 第一TOF质量分离器根据其质荷比分离第一组离子，并且将第一检测器定位成接收第一组离子。第二TOF质量分离器根据其质量与质量分离第二组离子 并且第二检测器被定位成接收第二组离子。 可以采用额外的离子路径，并且可以在每个离子路径中使用任何类型的TOF质量分离器。

公开(公告)号：US20050092916A1

公开(公告)日：2005-05-05

申请号：US10700300

申请日：2003-10-31

Applicant: Marvin Vestal ,  Kevin Hayden ,  Philip Savickas

Inventor： Marvin Vestal ,  Kevin Hayden ,  Philip Savickas

IPC: H01J27/24 ,  H01J49/16 ,  H01J49/40

CPC classification number: H01J49/0418 ,  H01J49/061 ,  H01J49/164

Abstract: Provided are MALDI ion sources, methods of forming ions and mass analyzer systems. In various embodiments, provided are MALDI ion sources configured to irradiate a sample on a sample surface with a pulse of laser energy at angle within 10 degrees or less of the surface normal, and a first ion optics system configured to extract sample ions in a direction within 5 degrees or less of the surface normal. In various embodiments, MALDI ion sources having substantially coaxial sample irradiation and ion extraction are provided. In various embodiments, methods are provided, which produce sample ions by MALDI and extract sample ions using an accelerating electrical field to form an ion beam, such that, the angle of the trajectory at the exit from the accelerating electrical field of sample ions substantially at the center of the ion beam is substantially independent of sample ion mass.

Abstract translation: 提供的是MALDI离子源，形成离子的方法和质量分析仪系统。 在各种实施例中，提供了配置成用样品表面上的样品以表面法线的10度或更小的角度的激光能量的脉冲照射的MALDI离子源，以及第一离子光学系统，被配置为沿着方向提取样品离子 在5度以内的表面正常。 在各种实施例中，提供具有基本上同轴的样品照射和离子提取的MALDI离子源。 在各种实施例中，提供了通过MALDI产生样品离子并使用加速电场提取样品离子以形成离子束的方法，使得在离开加速电场的出口处的轨迹的角度基本上在 离子束的中心基本上与样品离子质量无关。

公开(公告)号：US06815667B2

公开(公告)日：2004-11-09

申请号：US10362510

申请日：2003-02-25

Applicant: Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

Inventor： Scott D. Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

IPC: H01J4900

CPC classification number: H01J49/061 ,  H01J49/044

Abstract: A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An inn-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles, whereby only ions pass on to the reaction/collision cell section. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

Abstract translation: 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供了一个inn-neutral去耦装置，以提供离子和中性粒子之间的实质性分离，从而只有离子传递到反应/碰撞电池部分。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。

公开(公告)号：US06781120B2

公开(公告)日：2004-08-24

申请号：US10165851

申请日：2002-06-07

Applicant: Nicholas LeCursi ,  Lawrence J. LeGore ,  Robert H. Jackson, III ,  C. Bronson H. Crothers ,  Peter H. Kleban ,  Brian G. Frederick

Inventor： Nicholas LeCursi ,  Lawrence J. LeGore ,  Robert H. Jackson, III ,  C. Bronson H. Crothers ,  Peter H. Kleban ,  Brian G. Frederick

IPC: H01R4300

CPC classification number: G21K1/087 ,  G01N23/05 ,  H01J49/0018 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/446 ,  H01L2924/0002 ,  Y10T29/4902 ,  Y10T29/49082 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  H01L2924/00

Abstract: A technique for providing a grid for a gate such as utilized in gating a stream of ions or other particles in a spectrometer instrument. The grid of wires may, for example, be a so-called Bradbury-Nielson Gate that consists of a set of two electrically isolated sets of equally spaced wires that lie substantially in the same plane and alternate in potential. The method utilized to provide is to first fabricate a frame of an insulating substrate having a hole and depositing metal film patterns such that conductive portions are formed on either side of the hole. Conductive portions on either side form a series of terminating pads on the portion of the substrate closest to the hole and a bus bar. Grid wires are then formed by stretching a section of wire with desired constant tension across the hole and bonding the ends of the wire to a respective one of the pads on one side and bus bar on the other side. The method provides a rapid, inexpensive way to fabricate such modulating devices.

Abstract translation: 提供用于门的栅格的技术，例如用于在光谱仪器中门控离子或其他颗粒物流。 电线的网格可以是例如所谓的Bradbury-Nielson门，其由两组基本上位于同一平面中且交替潜在的等间隔的导线的两组电隔离组合组成。 用于提供的方法是首先制造具有孔的绝缘基板的框架并沉积金属膜图案，使得导电部分形成在孔的任一侧上。 任一侧上的导电部分形成在最靠近该孔的基板部分上的一系列端接焊盘和汇流条。 然后通过将所需的恒定张力的一段导线拉伸穿过该孔并且将导线的端部粘合到另一侧的一侧上的焊盘和另一侧的母线上而形成网格线。 该方法提供了制造这种调制装置的快速，便宜的方式。

公开(公告)号：US20040056189A1

公开(公告)日：2004-03-25

申请号：US10362510

申请日：2003-02-25

Inventor： Scott D Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

IPC: G02F001/15

CPC classification number: H01J49/061 ,  H01J49/044

Abstract: A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An ion-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles, whereby only ions pass on to the reaction/collision cell section. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

Abstract translation: 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供离子中性去耦装置，以提供离子和中性粒子之间的实质性分离，从而只有离子传递到反应/碰撞电池部分。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。

公开(公告)号：US06664545B2

公开(公告)日：2003-12-16

申请号：US10230606

申请日：2002-08-28

Applicant: Joel R. Kimmel ,  Friedrich Engelke ,  Richard N. Zare

Inventor： Joel R. Kimmel ,  Friedrich Engelke ,  Richard N. Zare

IPC: H01J146

CPC classification number: H01J49/061 ,  H01J9/14

Abstract: Bradbury-Nielson gates for the modulation of beams of charged particles, particularly ion beams in mass spectrometry, have been produced with an adjustable wire spacing down to 0.075 mm or a smaller spacing. The gates are robust, they can be fabricated in less than 3 hours, and the method of production is reproducible. In time-of-flight mass spectrometers, fine wire spacing leads to improvements in mass resolution and modulation rates. Gates that were produced using this new method have been installed in a Hadamard transform time-of-flight mass spectrometer in order to demonstrate their utility.

Abstract translation: 已经制造了用于调制带电粒子束，特别是质谱中的离子束的Bradbury-Nielson门，其可调节的线间距可以降到0.075mm或更小的间隔。 门是坚固的，它们可以在不到3小时内制造，并且生产方法是可重现的。 在飞行时间质谱仪中，细线间距导致质量分辨率和调制率的提高。 使用这种新方法生产的门已经安装在Hadamard变换飞行时间质谱仪中，以证明其实用性。

公开(公告)号：US06596989B2

公开(公告)日：2003-07-22

申请号：US10135674

申请日：2002-05-01

Applicant: Yoshiaki Kato

Inventor： Yoshiaki Kato

IPC: H01J4904

CPC classification number: H01J49/107 ,  H01J49/04 ,  H01J49/061

Abstract: A mass analysis apparatus is capable of performing a plurality of measurements in parallel by mounting a plurality of ion sources onto one mass spectrometer and speedily switching the ion sources. The mass analysis apparatus comprises a plurality of ion sources; and a deflecting means for deflecting ions from at least one ion source among the plurality of ion sources so that the ions travel toward the mass spectrometer by producing an electric field.

公开(公告)号：US06541769B1

公开(公告)日：2003-04-01

申请号：US09660359

申请日：2000-09-12

Applicant: Yasuaki Takada ,  Yasushi Terui ,  Kiyomi Yoshinari ,  Takayuki Nabeshima ,  Minoru Sakairi

Inventor： Yasuaki Takada ,  Yasushi Terui ,  Kiyomi Yoshinari ,  Takayuki Nabeshima ,  Minoru Sakairi

IPC: B01D5944

CPC classification number: H01J49/424 ,  H01J49/061

Abstract: An ion-deflecting device is located between a mass spectrometer and a detector, and undesired signal sources are prevented from reaching the detector during the ion-trapping period by switching the voltage applied to the detector between the ion-trapping period and the mass-analyzing period. A first voltage is applied to the detector during an ion-trapping period while a second voltage is applied to the detector during a mass-analyzing period. An ion-deflecting device deflects ions such that they do not reach the detector during an ion-trapping period while they do reach the detector during a mass-analyzing period. This way, the life of the detector is increased.

Abstract translation: 离子偏转装置位于质谱仪和检测器之间，并且在离子捕获期间通过切换在离子捕获期和质量分析之间施加到检测器的电压来防止不期望的信号源到达检测器 期。 在离子捕获期间将第一电压施加到检测器，同时在质量分析期间将第二电压施加到检测器。 离子偏转装置使离子偏转，使得它们在离子捕获期间不会在质量分析期间到达检测器时到达检测器。 这样，检测器的寿命就会增加。