公开(公告)号：US20230100053A1

公开(公告)日：2023-03-30

申请号：US17940970

申请日：2022-09-08

Applicant: Purdue Research Foundation

Inventor： Joseph V Sinfield ,  Yu-Chung Lin

IPC: G01J3/44 ,  G01J3/02 ,  G01N21/65

Abstract: A Raman spectroscopy system, including an optical excitation source, an objective lens, a mirror for redirecting optical excitation to the objective lens, an optical switch, an excitation beam optical fiber operationally connected to the objective lens and to the optical switch, a plurality of Raman probes, a plurality of probe optical fibers, each respective probe optical fiber operationally connected to the optical switch and a respective Raman probe, and a spectrometer. Each respective Raman probe is operationally connected to the spectrometer.

公开(公告)号：US11604341B2

公开(公告)日：2023-03-14

申请号：US16837512

申请日：2020-04-01

Applicant: THERMO ELECTRON SCIENTIFIC INSTRUMENTS LLC

Inventor： Michael S. Georgiadis ,  Francis J. Deck

IPC: G02B21/00 ,  G02B21/36 ,  G01N21/64 ,  G01N21/65 ,  G01J3/44

Abstract: Methods and apparatuses are disclosed whereby structured illumination microscopy (SIM) is applied to a scanning microscope, such as a confocal laser scanning microscope or sample scanning microscope, in order to improve spatial resolution. Particular aspects of the disclosure relate to the discovery of important advances in the ability to (i) increase light throughput to the sample, thereby increasing the signal/noise ratio and/or decreasing exposure time, as well as (ii) decrease the number of raw images to be processed, thereby decreasing image acquisition time. Both effects give rise to significant improvements in overall performance, to the benefit of users of scanning microscopy.

公开(公告)号：US11598724B2

公开(公告)日：2023-03-07

申请号：US16931672

申请日：2020-07-17

Applicant: SYSMEX CORPORATION

Inventor： Yasuaki Tsuruoka ,  Tomohiro Tsuji ,  Hiroo Tatsutani ,  Motoi Kinishi ,  Yuji Masuda

IPC: G01N21/64 ,  G01J3/28 ,  G01J3/36 ,  G01J3/44 ,  G01N15/10 ,  G01N21/27 ,  G01N15/14 ,  G01N33/58 ,  G01N21/53

Abstract: A measuring apparatus includes a flow cell through which a sample containing particles flows, a light source for irradiating light on the sample flowing through the flow cell, a fluorescence detector for detecting the fluorescence generated from the sample irradiated with light from the light source, and a control unit for flowing a positive control sample containing a fluorescent dye through the flow cell, measuring the fluorescence generated from the positive control sample irradiated by the light from the light source via the fluorescence detector, comparing the obtained measurement value and a reference value, and adjusting the detection sensitivity of the fluorescence detector according to the comparison result.

公开(公告)号：US11591557B2

公开(公告)日：2023-02-28

申请号：US16487450

申请日：2018-02-21

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Gregory J. Kintz ,  Adam J. Young ,  Patrick Murphy ,  Joshua Glenn Anthony ,  Paul Fleming ,  Brett Gorham ,  Ryan Griswold ,  Bruce Richardson

IPC: C12M3/06 ,  C12M1/32 ,  G01J3/42 ,  G01J3/44 ,  G01N21/51 ,  G01N21/53 ,  G01N21/64 ,  G01N33/02 ,  G01N21/17

Abstract: The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips.

公开(公告)号：US20230055190A1

公开(公告)日：2023-02-23

申请号：US17982860

申请日：2022-11-08

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Ho Jun CHANG ,  Sung Hyun NAM ,  Alexey ANIKANOV ,  Yun S PARK ,  Eui Seok SHIN ,  Woochang LEE

IPC: G01J3/02 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/44

Abstract: A Raman sensor includes a light source assembly having a plurality of light sources configured to emit light to a plurality of skin points of skin, each of the plurality of skin points having a predetermined separation distance from a light collection region of the skin from which Raman scattered light is collected; a light collector configured to collect the Raman scattered light from the light collection region of the skin; and a detector configured to detect the collected Raman scattered light.

公开(公告)号：US11576571B2

公开(公告)日：2023-02-14

申请号：US16639962

申请日：2018-08-20

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： Seok-Hyun Yun ,  Amira Eltony

IPC: A61B3/10 ,  A61B3/117 ,  A61B5/00 ,  G01J3/02 ,  G01J3/26 ,  G01J3/44 ,  G01N21/63

Abstract: Systems and methods are provided for measuring the mechanical properties of ocular tissue, such as the lens or corneal tissue, for diagnosis as well as treatment monitoring purposes. A laser locking feedback system is provided to achieve frequency accuracy and sensitivity that facilitates operations and diagnosis with great sensitivity and accuracy. Differential comparisons between eye tissue regions of a patient, either on the same eye or a fellow eye, can further facilitate early diagnosis and monitoring.

公开(公告)号：US20230044886A1

公开(公告)日：2023-02-09

申请号：US17759031

申请日：2020-11-24

Applicant: NOVA MEASURING INSTRUMENTS LTD.

Inventor： Elad Schleifer ,  Yonatan Oren ,  Amir Shayari ,  Eyal Hollander ,  Valery Deich ,  Shimon YALOV ,  Gilad BARAK

IPC: G01J3/44 ,  G01J3/02

Abstract: A method, a system, and a non-transitory computer readable medium for accurate Raman spectroscopy. The method may include executing at least one iteration of the steps of: (i) performing, by an optical measurement system, a calibration process that comprises (a) finding a misalignment between a region of interest defined by a spatial filter, and an impinging beam of radiation that is emitted from an illuminated area of a sample, the impinging beam impinges on the spatial filter; and (b) determining a compensating path of propagation of the impinging beam that compensates the misalignment; and (ii) performing a measurement process, while the optical measurement system is configured to provide the compensating path of propagation of the impinging beam, to provide one or more Raman spectra.

公开(公告)号：US11566995B2

公开(公告)日：2023-01-31

申请号：US17191780

申请日：2021-03-04

Applicant: Life Technologies Corporation

Inventor： Gregory Kaduchak ,  Michael Ward

IPC: G01N21/00 ,  G01N15/14 ,  G01N21/53 ,  G01N15/02 ,  G01N21/64 ,  G01J3/44 ,  B01L3/00 ,  G01N15/00 ,  G01N15/10

Abstract: The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.

公开(公告)号：US11566941B2

公开(公告)日：2023-01-31

申请号：US16799608

申请日：2020-02-24

Applicant: Ventana Medical Systems, Inc.

Inventor： Karl Garsha ,  Michael Otter

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/44 ,  G01N21/27 ,  G01J3/10 ,  G06T7/80 ,  G02B21/36 ,  G06V20/69

Abstract: A system and method for characterization and/or calibration of performance of a multispectral imaging (MSI) system equipping the MSI system for use with a multitude of different fluorescent specimens while being independent on optical characteristics of a specified specimen and providing an integrated system level test for the MSI system. A system and method are adapted to additionally evaluate and express operational parameters performance of the MSI system in terms of standardized units and/or to determine the acceptable detection range of the MSI system.

公开(公告)号：US11559204B2

公开(公告)日：2023-01-24

申请号：US17078955

申请日：2020-10-23

Applicant: Martin Feldman ,  Dooyoung Hah

Inventor： Martin Feldman ,  Dooyoung Hah

IPC: A61B5/00 ,  G01N21/65 ,  A61B1/06 ,  A61B1/00 ,  G01J3/44 ,  G01J3/02 ,  A61B1/002

Abstract: A contact-type endoscope surface enhanced Raman scattering (SERS) probe includes a gradient-index (GRIN) lens, a transparent substrate adhered to the GRIN lens, and a rough metallic layer adhered to an opposite side of the transparent substrate from the GRIN lens. The GRIN lens focuses light from a Raman spectrometer onto the rough metallic layer, and the rough metallic layer is positioned at the distal end of the contact-type endoscope SERS probe.