公开(公告)号：US20210389245A1

公开(公告)日：2021-12-16

申请号：US17282807

申请日：2019-10-04

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Alan Lloyd Weeks ,  Valerie Villareal ,  Patrick Murphy ,  Eric Anthony Robertson ,  Deirdre Ellen Day ,  Matthew Bernard Dean ,  Todd Glendon Campbell ,  Brian Christopher Burke ,  Tyler S. Smith ,  Thomas Christopher Hartner ,  Stanley Owen Thompson ,  Nhat Nam Trinh ,  David Carpenter ,  Gregory J. Kintz ,  Paul Koh ,  David Jennings Dostal ,  Kevin Doherty ,  Joel F. Jensen ,  William Law ,  Russell C. Mead, Jr. ,  J. Efraín Alcorta

IPC: G01N21/64 ,  B01L3/00

Abstract: The present disclosure is drawn to devices and systems for target detection in samples, particularly allergen detection in food samples. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. The allergen detection utilizes nucleic acid molecules as detection agents and detection probes.

公开(公告)号：US20210311032A1

公开(公告)日：2021-10-07

申请号：US16971701

申请日：2019-02-21

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Alan Lloyd Weeks ,  Valerie Villareal ,  Patrick Murphy ,  Eric Anthony Robertson ,  David Carpenter ,  Deirdre Ellen Day ,  Matthew Bernard Dean ,  Todd Glendon Campbell ,  Gregory J. Kintz ,  Paul Koh ,  David Jennings Dostal ,  Kevin Doherty ,  Joel F. Jensen ,  William Law ,  Russell C. Mead, Jr. ,  J. Efraín Alcorta

IPC: G01N33/53 ,  G01N33/543 ,  C12Q1/6816 ,  G01N33/02

Abstract: The present invention is drawn to devices and systems for allergen detection in food samples. The allergen detection system includes a disposable analysis cartridge and a detection device with an optimized optical system.

公开(公告)号：US20210109076A1

公开(公告)日：2021-04-15

申请号：US17128270

申请日：2020-12-21

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  Sarah Stidham ,  Valerie Villareal ,  Adam J. Young ,  Joshua Glenn Anthony ,  Patrick Murphy ,  John H. Kepler ,  Adam Jacobs

IPC: G01N33/02 ,  C12M1/34 ,  G01N1/08 ,  C12N15/115 ,  G01N1/14 ,  G01N1/28 ,  G01N33/53 ,  G01N33/58

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

公开(公告)号：US20200071647A1

公开(公告)日：2020-03-05

申请号：US16487450

申请日：2018-02-21

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Gregory J. Kintz ,  Adam J. Young ,  Patrick Murphy ,  Joshua Glenn Anthony ,  Paul Fleming ,  Brett Gorham ,  Ryan Griswold ,  Bruce Richardson

IPC: C12M3/06 ,  C12M1/32 ,  G01J3/42 ,  G01J3/44 ,  G01N21/51 ,  G01N21/64 ,  G01N21/53 ,  G01N33/02

Abstract: The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips.

公开(公告)号：US11591557B2

公开(公告)日：2023-02-28

申请号：US16487450

申请日：2018-02-21

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Gregory J. Kintz ,  Adam J. Young ,  Patrick Murphy ,  Joshua Glenn Anthony ,  Paul Fleming ,  Brett Gorham ,  Ryan Griswold ,  Bruce Richardson

IPC: C12M3/06 ,  C12M1/32 ,  G01J3/42 ,  G01J3/44 ,  G01N21/51 ,  G01N21/53 ,  G01N21/64 ,  G01N33/02 ,  G01N21/17

Abstract: The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips.

公开(公告)号：US10908139B2

公开(公告)日：2021-02-02

申请号：US16084996

申请日：2017-03-10

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  Sarah Stidham ,  Valerie Villareal ,  Adam J. Young ,  Joshua Glenn Anthony ,  Patrick Murphy ,  John H. Kepler ,  Adam Jacobs

IPC: B01L3/00 ,  B01L1/00 ,  G01N33/02 ,  C12M1/34 ,  G01N1/08 ,  C12N15/115 ,  G01N1/14 ,  G01N1/28 ,  G01N33/53 ,  G01N33/58

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

公开(公告)号：US20190079063A1

公开(公告)日：2019-03-14

申请号：US16084996

申请日：2017-03-10

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  Sarah Stidham ,  Valerie Villareal ,  Adam J. Young ,  Joshua Glenn Anthony ,  Patrick Murphy ,  John H. Kepler ,  Adam Jacobs

IPC: G01N33/02 ,  G01N33/53 ,  G01N33/58 ,  G01N1/28

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

公开(公告)号：US20220298570A1

公开(公告)日：2022-09-22

申请号：US17636403

申请日：2020-08-20

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Valerie Villareal ,  Patrick Murphy ,  Nhat Nam Trinh

IPC: C12Q1/6876 ,  C12Q1/6834

Abstract: The present disclosure relates to optimized nucleic acid probes, nucleic acid chips, and assays and methods for detection of an analyte of interest in a sample, for example, an allergen in a food sample.