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Patent Agency Ranking
公开(公告)号：US20210109076A1
公开(公告)日：2021-04-15
申请号：US17128270
申请日：2020-12-21
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , Sarah Stidham , Valerie Villareal , Adam J. Young , Joshua Glenn Anthony , Patrick Murphy , John H. Kepler , Adam Jacobs
Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
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公开(公告)号：US11591557B2
公开(公告)日：2023-02-28
申请号：US16487450
申请日：2018-02-21
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Gregory J. Kintz , Adam J. Young , Patrick Murphy , Joshua Glenn Anthony , Paul Fleming , Brett Gorham , Ryan Griswold , Bruce Richardson
IPC: C12M3/06 , C12M1/32 , G01J3/42 , G01J3/44 , G01N21/51 , G01N21/53 , G01N21/64 , G01N33/02 , G01N21/17
Abstract: The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips.
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公开(公告)号：US10908139B2
公开(公告)日：2021-02-02
申请号：US16084996
申请日：2017-03-10
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , Sarah Stidham , Valerie Villareal , Adam J. Young , Joshua Glenn Anthony , Patrick Murphy , John H. Kepler , Adam Jacobs
IPC: B01L3/00 , B01L1/00 , G01N33/02 , C12M1/34 , G01N1/08 , C12N15/115 , G01N1/14 , G01N1/28 , G01N33/53 , G01N33/58
Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
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公开(公告)号：US20190079063A1
公开(公告)日：2019-03-14
申请号：US16084996
申请日：2017-03-10
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , Sarah Stidham , Valerie Villareal , Adam J. Young , Joshua Glenn Anthony , Patrick Murphy , John H. Kepler , Adam Jacobs
Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
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公开(公告)号：US20200071647A1
公开(公告)日：2020-03-05
申请号：US16487450
申请日：2018-02-21
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Gregory J. Kintz , Adam J. Young , Patrick Murphy , Joshua Glenn Anthony , Paul Fleming , Brett Gorham , Ryan Griswold , Bruce Richardson
Abstract: The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips.
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